Phage HK022 Nun protein represses translation of phage lambda N (transcription termination/translation repression).

abstract：:Three naturally occurring dermorphin-like peptides from the skin of the frog Phyllomedusa bicolor, the related carboxyl-terminal amides, and some substituted analogs were synthesized, their binding profiles to opioid receptors were determined, and their biological activities were studied in isolated organ preparations...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Negri L,Erspamer GF,Severini C,Potenza RL,Melchiorri P,Erspamer V

更新日期：1992-08-01 00:00:00

abstract：:The development of antimicrobials is critical in this time of increasing antibiotic resistance of most clinically relevant bacteria. To date, all current antibiotics focus on inhibiting crucial enzymatic activities of their protein targets (i.e., trimethoprim for dihydrofolate reductase), thus disrupting in vitro esse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shakhnovich EA,Hung DT,Pierson E,Lee K,Mekalanos JJ

更新日期：2007-02-13 00:00:00

abstract：:Although antibodies to HLA play a role in the pathogenesis of diseases processes such as rejection of transplanted organs, the precise mechanisms by which antibodies cause tissue injury are not completely understood. We hypothesized that antibodies to host tissues cause inflammation in part by activating endothelial e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamakuchi M,Kirkiles-Smith NC,Ferlito M,Cameron SJ,Bao C,Fox-Talbot K,Wasowska BA,Baldwin WM 3rd,Pober JS,Lowenstein CJ

更新日期：2007-01-23 00:00:00

abstract：:Methods for the construction of ordered nanoscale arrays have been implicated in fields ranging from separation technologies to microelectronics. Yet, despite the plethora of nanoscale structures assembled in nature that use a templating strategy, chemists have been unable to replicate this success. A technology is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willis B,Eubanks LM,Wood MR,Janda KD,Dickerson TJ,Lerner RA

更新日期：2008-02-05 00:00:00

abstract：:Coimmunoprecipitation of members of the phytochrome red/farred photoreceptor family from plant extracts has been used to analyze their heteromeric binding interactions. Phytochrome (phy)B or phyD apoproteins with six myc epitopes fused to their N termini are biologically active when expressed in Arabidopsis. Immunopre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharrock RA,Clack T

更新日期：2004-08-03 00:00:00

abstract：:A general theory of the structure of complexes of the transition metals is developed on the basis of the enneacovalence of the metals and the requirements of the electroneutrality principle. An extra orbital may be provided through the small but not negligible amount of f and g character of spd bond orbitals, and an e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1977-12-01 00:00:00

abstract：:Ring-shaped hexameric helicases and translocases support essential DNA-, RNA-, and protein-dependent transactions in all cells and many viruses. How such systems coordinate ATPase activity between multiple subunits to power conformational changes that drive the engagement and movement of client substrates is a fundame...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomsen ND,Lawson MR,Witkowsky LB,Qu S,Berger JM

更新日期：2016-11-29 00:00:00

abstract：:The use of carbon dioxide as a renewable and environmentally friendly source of carbon in organic synthesis is a highly attractive approach, but its real world applications remain a great challenge. The major obstacles for commercialization of most current protocols are their low catalytic performances, harsh reaction...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu D,Zhang Y

更新日期：2010-11-23 00:00:00

abstract：:Cells are dynamical systems of biomolecular interactions that process information from their environment to mount diverse yet specific responses. A key property of many self-organized systems is that of criticality: a state of a system in which, on average, perturbations are neither dampened nor amplified, but are pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nykter M,Price ND,Aldana M,Ramsey SA,Kauffman SA,Hood LE,Yli-Harja O,Shmulevich I

更新日期：2008-02-12 00:00:00

abstract：:Cysteine-bound hemes are key components of many enzymes and biological sensors. Protonation (deprotonation) of the Cys ligand often accompanies redox transformations of these centers. To characterize these phenomena, we have engineered a series of Thr78Cys/Lys79Gly/Met80X mutants of yeast cytochrome c (cyt c) in which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhong F,Lisi GP,Collins DP,Dawson JH,Pletneva EV

更新日期：2014-01-21 00:00:00

abstract：:A recombinant vaccinia virus that directs the synthesis of bacteriophage T7 RNA polymerase provides the basis for the expression of genes that are regulated by T7 promoters in mammalian cells. The T7 transcripts, which account for as much as 30% of the total cytoplasmic RNA at 24 hr after infection, are largely uncapp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elroy-Stein O,Fuerst TR,Moss B

更新日期：1989-08-01 00:00:00

abstract：:Formation of duplex DNA from varphiX174 single-stranded DNA by extracts of E. coli was previously shown to require the gene product of dna B. Using as an assay the stimulation of varphiX174 DNA-dependent synthesis in inactivated extracts of dna B temperature-sensitive cells, we purified the dna B gene product from wil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wright M,Wickner S,Hurwitz J

更新日期：1973-11-01 00:00:00

abstract：:Echoviruses have been implicated in multiple human disease syndromes, including aseptic meningitis, paralysis, and heart disease, but no animal model is available for studying the pathogenesis of infection. Production of human integrin very late antigen 2, a receptor for echovirus type 1, in transgenic mice conferred ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes SA,Thaker HM,Racaniello VR

更新日期：2003-12-23 00:00:00

abstract：:Many of the mutagenic or lethal effects of ionization radiation can be attributed to damage caused to the DNA by low-energy electrons. To gain insight on the parameters affecting this process, we measured the low-energy electron (<2 eV) transmission yield through self-assembled monolayers of short DNA oligomers. The e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray SG,Daube SS,Naaman R

更新日期：2005-01-04 00:00:00

abstract：:In the mitochondrial genome of the hemichordate Balanoglossus carnosus, the codon AAA, which is assigned to lysine in most metazoans but to asparagine in echinoderms, is absent. Furthermore, the lysine tRNA gene carries an anticodon substitution that renders its gene product unable to decode AAA codons, whereas the as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castresana J,Feldmaier-Fuchs G,Pääbo S

更新日期：1998-03-31 00:00:00

abstract：:The dorsolateral striatum (DLS) is essential for motor and procedure learning, but the role of DLS spiny projection neurons (SPNs) of direct and indirect pathways, as marked, respectively, by D1 and D2 receptor (D1R and D2R) expression, remains to be clarified. Long-term two-photon calcium imaging of the same neuronal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sheng MJ,Lu D,Shen ZM,Poo MM

更新日期：2019-05-28 00:00:00

abstract：:The identification and targeting of key molecular drivers of melanoma and breast and lung cancer have substantially improved their therapy. However, subtypes of each of these three common, lethal solid tumors lack identified molecular drivers, and are thus not amenable to targeted therapies. Here we show that pleckstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Semir D,Bezrookove V,Nosrati M,Dar AA,Wu C,Shen J,Rieken C,Venkatasubramanian M,Miller JR 3rd,Desprez PY,McAllister S,Soroceanu L,Debs RJ,Salomonis N,Schadendorf D,Cleaver JE,Kashani-Sabet M

更新日期：2018-06-19 00:00:00

abstract：:The brain is assumed to be hypoactive during cardiac arrest. However, the neurophysiological state of the brain immediately following cardiac arrest has not been systematically investigated. In this study, we performed continuous electroencephalography in rats undergoing experimental cardiac arrest and analyzed change...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borjigin J,Lee U,Liu T,Pal D,Huff S,Klarr D,Sloboda J,Hernandez J,Wang MM,Mashour GA

更新日期：2013-08-27 00:00:00

abstract：:Serotonin (5-HT) controls a wide range of biological functions. In the brain, its implication as a neurotransmitter and in the control of behavioral traits has been largely documented. At the periphery, its modulatory role in physiological processes, such as the cardiovascular function, is still poorly understood. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Côté F,Thévenot E,Fligny C,Fromes Y,Darmon M,Ripoche MA,Bayard E,Hanoun N,Saurini F,Lechat P,Dandolo L,Hamon M,Mallet J,Vodjdani G

更新日期：2003-11-11 00:00:00

abstract：:The overall structure of the transition-state and intermediate ensembles observed experimentally for dihydrofolate reductase and interleukin-1beta can be obtained by using simplified models that have almost no energetic frustration. The predictive power of these models suggests that, even for these very large proteins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clementi C,Jennings PA,Onuchic JN

更新日期：2000-05-23 00:00:00

abstract：:Specific rabbit antisera against purified bovine pituitary carboxypeptidase processing enzyme (which has also been referred to as "enkephalin convertase") have been prepared and characterized. The antisera recognized both the purified soluble and the membrane-bound forms of the enzyme with equal affinity, suggesting t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hook VY,Mezey E,Fricker LD,Pruss RM,Siegel RE,Brownstein MJ

更新日期：1985-07-01 00:00:00

abstract：:This paper examines the relationship between various treatment parameters within a latent variable model when the effects of treatment depend on the recipient's observed and unobserved characteristics. We show how this relationship can be used to identify the treatment parameters when they are identified and to bound ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heckman JJ,Vytlacil EJ

更新日期：1999-04-13 00:00:00

abstract：:Skeletal and smooth muscle can mutually transdifferentiate, but little molecular insight exists as to how each muscle program may be subverted to the other. The myogenic basic helix-loop-helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Long X,Creemers EE,Wang DZ,Olson EN,Miano JM

更新日期：2007-10-16 00:00:00

abstract：:Adult workers in honeybee (Apis mellifera) colonies exhibit plasticity in hormonally regulated, age-based division of labor by altering their pattern of behavioral development in response to changes in colony conditions. One form of this plasticity is precocious development: levels of juvenile hormone increase prematu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang ZY,Robinson GE

更新日期：1992-12-15 00:00:00

abstract：:Cholinergic neuromodulation is involved in all aspects of sensory processing and is crucial for processes such as attention, learning and memory, etc. However, despite the known roles of acetylcholine (ACh), we still do not how to disentangle ACh contributions from sensory or task-evoked changes in functional magnetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaldivar D,Rauch A,Logothetis NK,Goense J

更新日期：2018-12-18 00:00:00

abstract：:Adaptation of photosynthesis in marine environment has been examined in two strains of the green, picoeukaryote Ostreococcus: OTH95, a surface/high-light strain, and RCC809, a deep-sea/low-light strain. Differences between the two strains include changes in the light-harvesting capacity, which is lower in OTH95, and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cardol P,Bailleul B,Rappaport F,Derelle E,Béal D,Breyton C,Bailey S,Wollman FA,Grossman A,Moreau H,Finazzi G

更新日期：2008-06-03 00:00:00

abstract：:The rate of change of climate codetermines the global warming impacts on natural and socioeconomic systems and their capabilities to adapt. Establishing past rates of climate change from temperature proxy data remains difficult given their limited spatiotemporal resolution. In contrast, past greenhouse gas radiative f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joos F,Spahni R

更新日期：2008-02-05 00:00:00

abstract：:C1q-like genes (C1ql1-C1ql4) encode small, secreted proteins that are expressed in differential patterns in the brain but whose receptors and functions remain unknown. BAI3 protein, in contrast, is a member of the cell-adhesion class of G protein-coupled receptors that are expressed at high levels in the brain but who...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolliger MF,Martinelli DC,Südhof TC

更新日期：2011-02-08 00:00:00

abstract：:The recent development of small-molecule tyrosine kinase (TK) inhibitors offers increasing opportunities for the treatment of autoimmune diseases. In this study, we investigated the potential of this new class of drugs to treat and cure type 1 diabetes (T1D) in the NOD mouse. Treatment of prediabetic and new onset dia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Louvet C,Szot GL,Lang J,Lee MR,Martinier N,Bollag G,Zhu S,Weiss A,Bluestone JA

更新日期：2008-12-02 00:00:00

abstract：:A synthetic polyribonucleotide, poly(U5,G), was used to study the codon specificity of wild-type and UGA suppressor tRNATrp from Escherichia coli. Phe (UUU) incorporation directed by this synthetic messenger is reduced somewhat by omission from the incubation mixtures of Val (GUU), Leu (UUG), or Cys (UGU). In contrast...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buckingham RH,Kurland CG

更新日期：1977-12-01 00:00:00