Honeybee colony integration: worker-worker interactions mediate hormonally regulated plasticity in division of labor.

abstract：:The POT1 (protection of telomeres 1) protein binds the ssDNA overhangs at the ends of chromosomes in diverse eukaryotes. POT1 is essential for chromosome end-protection, as best demonstrated in fission yeast. In human cells, hPOT1 is also involved in telomere-length regulation. We now show that telomeric oligonucleoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaug AJ,Podell ER,Cech TR

更新日期：2005-08-02 00:00:00

abstract：:Large-scale analysis of the GC-content distribution at the gene level reveals both common features and basic differences in genomes of different groups of species. Sharp changes in GC content are detected at the transcription boundaries for all species analyzed, including human, mouse, rat, chicken, fruit fly, and wor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang L,Kasif S,Cantor CR,Broude NE

更新日期：2004-11-30 00:00:00

abstract：:Conformationally compromised oncogenic mutants of the tumor suppressor protein p53 can, in principle, be rescued by small molecules that bind the native, but not the denatured state. We describe a strategy for the rational search for such molecules. A nine-residue peptide, CDB3, which was derived from a p53 binding pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Friedler A,Hansson LO,Veprintsev DB,Freund SM,Rippin TM,Nikolova PV,Proctor MR,Rüdiger S,Fersht AR

更新日期：2002-01-22 00:00:00

abstract：:The local conformations of proteins and peptides are determined by the amino acid sequence. However, the 20 amino acids encoded by the genome allow the peptide backbone to fold into many conformations, so that even for a small peptide it becomes very difficult to predict the three-dimensional structure. By using empir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burgess AW

更新日期：1994-03-29 00:00:00

abstract：:One goal of regenerative medicine is to repair damaged tissue. This requires not only generating new cells of the proper phenotype, but also selecting for those that properly integrate into sites of injury. In our laboratory we are using a cell-migration-based in vivo selection system to generate antibodies that induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han KH,Arlian BM,Macauley MS,Paulson JC,Lerner RA

更新日期：2018-01-16 00:00:00

abstract：:In an earlier paper, the author jointly with S. Suryawanshi proposed statistical analysis of shape through triangulation of landmarks on objects. It was observed that the angles of the triangles are invariant to scaling, location, and rotation of objects. No distinction was made between an object and its reflection. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao CR

更新日期：2000-03-28 00:00:00

abstract：:Staphylococcus aureus surface protein SasG promotes cell-cell adhesion during the accumulation phase of biofilm formation, but the molecular basis of this interaction remains poorly understood. Here, we unravel the mechanical properties of SasG on the surface of living bacteria, that is, in its native cellular environ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Formosa-Dague C,Speziale P,Foster TJ,Geoghegan JA,Dufrêne YF

更新日期：2016-01-12 00:00:00

abstract：:Tyr-SV40E transgenic mice are susceptible to melanoma due to simian virus 40 oncogenic sequences specifically expressed in pigment cells. Skin melanomas form relatively late. Therefore, melanocyte cell lines have been established from very young transgenic animals, when they showed no skin lesions, so that the spontan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larue L,Dougherty N,Mintz B

更新日期：1992-10-15 00:00:00

abstract：:Chlorophyll d-producing cyanobacteria are a recently described group of phototrophic bacteria that is a major focus of photosynthesis research, previously known only from marine environments in symbiosis with eukaryotes. We have discovered a free-living member of this group from a eutrophic hypersaline lake. Phylogene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller SR,Augustine S,Olson TL,Blankenship RE,Selker J,Wood AM

更新日期：2005-01-18 00:00:00

abstract：:Mucopolysaccharidosis type VII is a lysosomal storage disorder resulting from inherited deficiency of beta-glucuronidase (GUS). Mucopolysaccharidosis type VII is characterized by glycosaminoglycan storage in most tissues, including brain. In these disorders, enzyme delivery across the blood-brain barrier (BBB) is the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urayama A,Grubb JH,Sly WS,Banks WA

更新日期：2004-08-24 00:00:00

abstract：:Muscle plasminogen activators (PAs), such as urokinase-like PA and, to a lesser extent, tissue PA, increase dramatically after denervation induced by axotomy. The PA/plasmin system has also been implicated in degradation of specific components of the muscle fiber basement membrane after local activation of plasminogen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hantaï D,Rao JS,Festoff BW

更新日期：1990-04-01 00:00:00

abstract：:In previous work we identified a basilar papilla protein (BPP23) that appears to be one of the most abundant soluble proteins in the basilar papilla of the chick cochlea. Here we report the purification of protein BPP23 from chick cochlea and the generation of a specific antiserum. Immunoblotting and immunoprecipitati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oberholtzer JC,Buettger C,Summers MC,Matschinsky FM

更新日期：1988-05-01 00:00:00

abstract：:The thymus lacks self-renewing hematopoietic cells, and thymopoiesis fails rapidly when the migration of progenitor cells to the thymus ceases. Hence, the process of thymus homing is an essential step for T-cell development and cellular immunity. Despite decades of research, the molecular details of thymus homing have...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calderón L,Boehm T

更新日期：2011-05-03 00:00:00

abstract：:The human aspects of conservation are often overlooked but will be critical for identifying strategies for biological conservation in the face of climate change. We surveyed the behavioral intentions of coastal landowners with respect to various conservation strategies aimed at facilitating ecosystem migration for tid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Field CR,Dayer AA,Elphick CS

更新日期：2017-08-22 00:00:00

abstract：:Developing tools for investigating the cellular activity of glycans will help to delineate the molecular basis for aberrant glycosylation in pathological processes such as cancer. Metabolic oligosaccharide engineering, which inserts sugar-reporting groups into cellular glycoconjugates, represents a powerful method for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu TL,Hanson SR,Kishikawa K,Wang SK,Sawa M,Wong CH

更新日期：2007-02-20 00:00:00

abstract：:We describe the effect of a 200-microns wavelength free electron laser beam on the ability of asynchronized and synchronized mammalian tissue culture cells to incorporate tritiated thymidine. Compared to controls (unexposed cells), a significant proportion of exposed cells exhibited a reduction in isotope incorporatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berns MW,Bewley W,Sun CH,Templin P

更新日期：1990-04-01 00:00:00

abstract：:Pollen tubes are highly polarized plant cells specialized in delivering sperm for fertilization. Pollen tube growth is rapid, occurs exclusively at the tip, and can reach distances thousands of times the diameter of the pollen grain without cell division, thus representing an excellent model system for studying asymme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AY,Niroomand S,Zou Y,Wu HM

更新日期：2010-09-14 00:00:00

abstract：:Multiple protein subcomplexes of the kinetochore cooperate as a cohesive molecular unit that forms load-bearing microtubule attachments that drive mitotic chromosome movements. There is intriguing evidence suggesting that central kinetochore components influence kinetochore-microtubule attachment, but the mechanism re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kudalkar EM,Scarborough EA,Umbreit NT,Zelter A,Gestaut DR,Riffle M,Johnson RS,MacCoss MJ,Asbury CL,Davis TN

更新日期：2015-10-13 00:00:00

abstract：:We have previously identified two species of the low-affinity human Fc receptor for IgE, Fc epsilon RIIa and Fc epsilon RIIb, which differ only in a short stretch of amino acids at the N-terminal cytoplasmic end. Their differential expressions on B cells and monocytes suggest that Fc epsilon RIIa and Fc epsilon RIIb a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yokota A,Yukawa K,Yamamoto A,Sugiyama K,Suemura M,Tashiro Y,Kishimoto T,Kikutani H

更新日期：1992-06-01 00:00:00

abstract：:Mitochondria isolated from maize plants with S-type male-sterile cytoplasms are capable of synthesizing four species of RNA at concentrations of actinomycin D that eliminate all DNA-directed RNA synthesis. No RNA synthesis occurs under the same conditions with mitochondria from plants possessing normal (N) cytoplasm o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finnegan PM,Brown GG

更新日期：1986-07-01 00:00:00

abstract：:Methyl groups placed on varphiXsB1 replicative form DNA by the Escherichia coli B modification enzyme are located in the overlap between fragments Mbo II-3 and Alu I-2, a 61-base-pair DNA segment. Mutations that led to loss of susceptibility to restriction by E. coli B occurred within this segment at three positions s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lautenberger JA,Kan NC,Lackey D,Linn S,Edgell MH,Hutchison CA 3rd

更新日期：1978-05-01 00:00:00

abstract：:This work describes the rational design, synthesis, and study of a ligand that selectively complexes CUG repeats in RNA (and CTG repeats in DNA) with high nanomolar affinity. This sequence is considered a causative agent of myotonic dystrophy type 1 (DM1) because of its ability to sequester muscleblind-like (MBNL) pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arambula JF,Ramisetty SR,Baranger AM,Zimmerman SC

更新日期：2009-09-22 00:00:00

abstract：:Using [3H]quinuclidinyl benzilate as a specific cholinergic muscarinic ligand, it has been demonstrated that lymphocytes have muscarinic binding sites. There are approximately 200 sites per cell and the dissociation constant for quinuclidinyl benzilate is approximately 1 X 10(-9) M. Quinuclidinyl benzilate receptor bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gordon MA,Cohen JJ,Wilson IB

更新日期：1978-06-01 00:00:00

abstract：:Gaseous molecular ions containing argon and perchlorethylene, Ar(n)(C(2)Cl(4))(m) (+) in which n >/= 1-29 and m >/= 1-4, are produced by electron bombardment of van der Waals clusters formed by expanding an Ar/C(2)Cl(4) mixture through a supersonic nozzle. Previous attempts to observe such ions in a high-pressure mass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buelow SJ,Worsnop DR,Herschbach DR

更新日期：1981-12-01 00:00:00

abstract：:The effects of temperature and of the action of a purified phospholipase C enzyme preparation on human red blood cell membranes has been investigated by chemical analyses, circular dichroism, and proton magnetic resonance measurements. The results indicate that a substantial fraction of the phospholipids and the prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glaser M,Simpkins H,Singer SJ,Sheetz M,Chan SI

更新日期：1970-03-01 00:00:00

abstract：:Increased plasminogen-activator inhibitor 1 (PAI-1) activity is a common finding in patients with coronary heart disease. Here we provide evidence for an independent, etiological role of PAI-1 in myocardial infarction. The 4G allele of a recently described common 4/5-guanine-tract (4G/5G) polymorphism in the PAI-1 pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eriksson P,Kallin B,van 't Hooft FM,Båvenholm P,Hamsten A

更新日期：1995-03-14 00:00:00

abstract：:The neuropeptides oxytocin and vasopressin are evolutionarily conserved regulators of social perception and behavior. Evidence is building that they are critically involved in the development of social recognition skills within rodent species, primates, and humans. We investigated whether common polymorphisms in the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skuse DH,Lori A,Cubells JF,Lee I,Conneely KN,Puura K,Lehtimäki T,Binder EB,Young LJ

更新日期：2014-02-04 00:00:00

abstract：:We performed a genome-wide analysis of gene expression in primary human CD15(+) myeloid progenitor cells. By using the serial analysis of gene expression (SAGE) technique, we obtained quantitative information for the expression of 37,519 unique SAGE-tag sequences. Of these unique tags, (i) 25% were detected at high an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee S,Zhou G,Clark T,Chen J,Rowley JD,Wang SM

更新日期：2001-03-13 00:00:00

abstract：:The mouse genes encoding the constitutively expressed complement component C4 and its closely related isoform C4-Slp (sex-limited protein), which is expressed only in male animals of several strains, provide a unique model to study sequence elements and trans-acting factors responsible for androgen responsiveness. Our...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varin-Blank N,Dondi E,Tosi M,Hernandez C,Boucontet L,Gotoh H,Shiroishi T,Moriwaki K,Meo T

更新日期：1998-07-21 00:00:00

abstract：:In humans, septal defects are among the most prevalent congenital heart diseases, but their cellular and molecular origins are not fully understood. We report that transcription factor Tbx5 is present in a subpopulation of endocardial cells and that its deletion therein results in fully penetrant, dose-dependent atria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nadeau M,Georges RO,Laforest B,Yamak A,Lefebvre C,Beauregard J,Paradis P,Bruneau BG,Andelfinger G,Nemer M

更新日期：2010-11-09 00:00:00