Evidence that brain prostaglandin E2 is involved in physiological sleep-wake regulation in rats.

abstract：:Brain src protooncogene is expressed in two forms, one identical to message in other tissues, and one containing an 18-nucleotide insert specific to brain. We have mapped mRNA for the two forms of src in rat brain with selective antisense oligonucleotide probes to the brain (src+) and peripheral (src-) forms. Fetal ra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross CA,Wright GE,Resh MD,Pearson RC,Snyder SH

更新日期：1988-12-01 00:00:00

abstract：:We have isolated and sequenced cDNA clones corresponding to the DR beta 1 and DR beta 2 loci from two homozygous B-cell lines typed as DR7 (Burkhart) and DR9 (ISK). These nucleotide sequences were compared to beta 1 and beta 2 chains of other DR haplotypes. The first-domain sequences of beta 2 chains are identical in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregersen PK,Moriuchi T,Karr RW,Obata F,Moriuchi J,Maccari J,Goldberg D,Winchester RJ,Silver J

更新日期：1986-12-01 00:00:00

abstract：:Fungi of the recently defined order Sebacinales (Basidiomycota) are involved in a wide spectrum of mutualistic symbioses (including mycorrhizae) with various plants, thereby exhibiting a unique potential for biocontrol strategies. The axenically cultivable root endophyte Piriformospora indica is a model organism of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshmukh S,Hückelhoven R,Schäfer P,Imani J,Sharma M,Weiss M,Waller F,Kogel KH

更新日期：2006-12-05 00:00:00

abstract：:Recent functional imaging studies have revealed coactivation in a distributed network of cortical regions that characterizes the resting state, or default mode, of the human brain. Among the brain regions implicated in this network, several, including the posterior cingulate cortex and inferior parietal lobes, have al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greicius MD,Srivastava G,Reiss AL,Menon V

更新日期：2004-03-30 00:00:00

abstract：:Site-specific recombination is responsible for a broad range of biological phenomena, including DNA inversion, resolution of transposition intermediates, and the integration and excision of bacteriophage genomes. Integration of mycobacteriophage L5 is catalyzed by a phage-encoded integrase with recombination occurring...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peña CE,Kahlenberg JM,Hatfull GF

更新日期：2000-07-05 00:00:00

abstract：:MXenes, a new family of 2D materials, combine hydrophilic surfaces with metallic conductivity. Delamination of MXene produces single-layer nanosheets with thickness of about a nanometer and lateral size of the order of micrometers. The high aspect ratio of delaminated MXene renders it promising nanofiller in multifunc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling Z,Ren CE,Zhao MQ,Yang J,Giammarco JM,Qiu J,Barsoum MW,Gogotsi Y

更新日期：2014-11-25 00:00:00

abstract：:An earthquake of magnitude M and linear source dimension L(M) is preceded within a few years by certain patterns of seismicity in the magnitude range down to about (M - 3) in an area of linear dimension about 5L-10L. Prediction algorithms based on such patterns may allow one to predict approximately 80% of strong eart...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keilis-Borok VI

更新日期：1996-04-30 00:00:00

abstract：:We have found that phagocytic leukocytes exposed to the tumor-promoting agent, 12-O-tetradecanoyl phorbol-13-acetate, efficiently release carbon-1 of 2-deoxyglucose in the form of CO2 with concurrent intracellular accumulation of a phosphorylated 5-carbon intermediate. In the absence of 12-O-tetradecanoyl phorbol-13-a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zabos P,Kyner D,Mendelsohn N,Schreiber C,Waxman S,Christman J,Acs G

更新日期：1978-11-01 00:00:00

abstract：:Despite intense investigation over the past century, the molecular mechanisms that regulate maintenance and adaptation of the heart during postnatal development are poorly understood. Myocardin is a remarkably potent transcriptional coactivator expressed exclusively in cardiac myocytes and smooth muscle cells during p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang J,Min Lu M,Cheng L,Yuan LJ,Zhu X,Stout AL,Chen M,Li J,Parmacek MS

更新日期：2009-11-03 00:00:00

abstract：:Antibody specific for the native form of Chinese hamster hypoxanthine/guanine phosphoribosyltransferase (HPRT; IMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) was used to detect the synthesis of HPRT protein in a rabbit reticulocyte lysate translation system primed with mRNA from Chinese hamster tissues and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Melton DW,Konecki DS,Ledbetter DH,Hejtmancik JF,Caskey CT

更新日期：1981-11-01 00:00:00

abstract：:Children with reading impairments have deficits in phonological awareness, phonemic categorization, speech-in-noise perception, and psychophysical tasks such as frequency and temporal discrimination. Many of these children also exhibit abnormal encoding of speech stimuli in the auditory brainstem, even though response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hornickel J,Skoe E,Nicol T,Zecker S,Kraus N

更新日期：2009-08-04 00:00:00

abstract：:During transcription, RNA polymerase II (RNAPII) must select the correct nucleotide, catalyze its addition to the growing RNA transcript, and move stepwise along the DNA until a gene is fully transcribed. In all kingdoms of life, transcription must be finely tuned to ensure an appropriate balance between fidelity and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larson MH,Zhou J,Kaplan CD,Palangat M,Kornberg RD,Landick R,Block SM

更新日期：2012-04-24 00:00:00

abstract：:Alzheimer's disease (AD) comprises multifactorial ailments for which current therapeutic strategies remain insufficient to broadly address the underlying pathophysiology. Epigenetic gene regulation relies upon multifactorial processes that regulate multiple gene and protein pathways, including those involved in AD. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volmar CH,Salah-Uddin H,Janczura KJ,Halley P,Lambert G,Wodrich A,Manoah S,Patel NH,Sartor GC,Mehta N,Miles NTH,Desse S,Dorcius D,Cameron MD,Brothers SP,Wahlestedt C

更新日期：2017-10-24 00:00:00

abstract：:West Nile virus, which is transmitted by Culex mosquitoes while feeding on birds and humans, has emerged as the dominant vector borne disease in North America. We have identified natural compounds from humans and birds, which are detected with extreme sensitivity by olfactory receptor neurons (ORNs) on the antennae of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Syed Z,Leal WS

更新日期：2009-11-03 00:00:00

abstract：:The gene V protein of bacteriophage f1 is a single-stranded DNA and RNA-binding protein composed of two identical subunits. We have constructed single-chain variants of the protein using short peptide linkers of five or six amino acids to connect the carboxyl terminus of one monomer to the amino terminus of the second...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang H,Sandberg WS,Terwilliger TC

更新日期：1993-08-01 00:00:00

abstract：:Nucleosomes in eukaryotes act as platforms for the dynamic integration of epigenetic information. Posttranslational modifications are reversibly added or removed and core histones exchanged for paralogous variants, in concert with changing demands on transcription and genome accessibility. Histones are also common in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stevens KM,Swadling JB,Hocher A,Bang C,Gribaldo S,Schmitz RA,Warnecke T

更新日期：2020-12-29 00:00:00

abstract：:The results of electron-nuclear double resonance and electron paramagnetic resonance (EPR) studies on the hydrogen peroxide compound of yeast cytochrome c peroxidase are inconsistent with previous proposals for the source of the EPR signal in this compound, in particular with its identification with an aromatic amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman BM,Roberts JE,Brown TG,Kang CH,Margoliash E

更新日期：1979-12-01 00:00:00

abstract：:The importance of therapeutic recombinant proteins in medicine has led to a variety of tactics to increase their circulation time or to enable routes of administration other than injection. One clinically successful tactic to improve both protein circulation and delivery is to fuse the Fc domain of IgG to therapeutic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sockolosky JT,Tiffany MR,Szoka FC

更新日期：2012-10-02 00:00:00

abstract：:T cells are essential for immune defenses against pathogens, such that viability of naïve T cells before antigen encounter is critical to preserve a polyclonal repertoire and prevent immunodeficiencies. The viability of naïve T cells before antigen recognition is ensured by IL-7, which drives expression of the prosurv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller ML,Mashayekhi M,Chen L,Zhou P,Liu X,Michelotti M,Tramontini Gunn N,Powers S,Zhu X,Evaristo C,Alegre ML,Molinero LL

更新日期：2014-05-20 00:00:00

abstract：:Cachectin (tumor necrosis factor) is a powerful macrophage hormone released during infection, which circulates in blood to produce diverse effects in the organism. We examined the effect of cachectin on release of anterior pituitary hormones from either hemipituitaries or dispersed pituitary cells incubated in vitro. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milenkovic L,Rettori V,Snyder GD,Beutler B,McCann SM

更新日期：1989-04-01 00:00:00

abstract：:Three major oxidation products of 2'-deoxycytidine (dC)--5-hydroxy-2'-deoxycytidine (oh5dC), 5-hydroxy-2'-deoxyuridine (oh5dU), and 5,6-dihydroxy-5,6-dihydro-2'-deoxyuridine (dUg)--were analyzed from enzymatically hydrolyzed DNA with reversed-phase high-performance liquid chromatography coupled to electrochemical dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner JR,Hu CC,Ames BN

更新日期：1992-04-15 00:00:00

abstract：:The homotypic fusion of endoplasmic reticulum (ER) membranes is mediated by atlastin (ATL), which consists of an N-terminal cytosolic domain containing a GTPase module and a three-helix bundle followed by two transmembrane (TM) segments and a C-terminal tail (CT). Fusion depends on a GTP hydrolysis-induced conformatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu TY,Bian X,Sun S,Hu X,Klemm RW,Prinz WA,Rapoport TA,Hu J

更新日期：2012-08-07 00:00:00

abstract：:The recent intensification of agriculture, and the prospects of future intensification, will have major detrimental impacts on the nonagricultural terrestrial and aquatic ecosystems of the world. The doubling of agricultural food production during the past 35 years was associated with a 6.87-fold increase in nitrogen ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilman D

更新日期：1999-05-25 00:00:00

abstract：:Near-zero-index (NZI) supercoupling, the transmission of electromagnetic waves inside a waveguide irrespective of its shape, is a counterintuitive wave effect that finds applications in optical interconnects and engineering light-matter interactions. However, there is a limited knowledge on the local properties of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liberal I,Lobet M,Li Y,Engheta N

更新日期：2020-09-29 00:00:00

abstract：:Picomole amounts of oligodeoxynucleotides [polydeoxyadenylic acids, (dA)40-60] were baseline resolved and analyzed in less than 8 min by high-performance capillary electrophoresis with polyacrylamide gels. In addition, fast analysis of a crude 70-mer oligodeoxynucleotide and a slab gel-purified 99-mer oligodeoxynucleo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen AS,Najarian DR,Paulus A,Guttman A,Smith JA,Karger BL

更新日期：1988-12-01 00:00:00

abstract：:Current issues pertaining to theoretical simulations of materials, with a focus on systems of nanometer-scale dimensions, are discussed. The use of atomistic simulations as high-resolution numerical experiments, enabling and guiding formulation and testing of analytic theoretical descriptions, is demonstrated through ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Landman U

更新日期：2005-05-10 00:00:00

abstract：:Measurements of the water proton spinlattice relaxation (T(1)) in 106 human tumors confirms earlier results with animals [Damadian, R. (1971) Science 171, 1151-1153]. T(1) of all the tumors studied were significantly longer than T(1) of the corresponding normal tissues. Mean standard error and range were reported for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damadian R,Zaner K,Hor D,DiMaio T

更新日期：1974-04-01 00:00:00

abstract：:Cytoskeletal filaments assemble into dense parallel, antiparallel, or disordered networks, providing a complex environment for active cargo transport and positioning by molecular motors. The interplay between the network architecture and intrinsic motor properties clearly affects transport properties but remains poorl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richard M,Blanch-Mercader C,Ennomani H,Cao W,De La Cruz EM,Joanny JF,Jülicher F,Blanchoin L,Martin P

更新日期：2019-07-23 00:00:00

abstract：:A convenient technique for the partial purification of large quantities of functional, poly(adenylic acid)-rich mRNA is described. The method depends upon annealing poly(adenylic acid)-rich mRNA to oligothymidylic acid-cellulose columns and its elution with buffers of low ionic strength. Biologically active rabbit glo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aviv H,Leder P

更新日期：1972-06-01 00:00:00

abstract：:Full-length tissue factor (flTF), the coagulation initiator, is overexpressed in breast cancer (BrCa), but associations between flTF expression and clinical outcome remain controversial. It is currently not known whether the soluble alternatively spliced TF form (asTF) is expressed in BrCa or impacts BrCa progression....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kocatürk B,Van den Berg YW,Tieken C,Mieog JS,de Kruijf EM,Engels CC,van der Ent MA,Kuppen PJ,Van de Velde CJ,Ruf W,Reitsma PH,Osanto S,Liefers GJ,Bogdanov VY,Versteeg HH

更新日期：2013-07-09 00:00:00