Subcortical differentiation of stop consonants relates to reading and speech-in-noise perception.

abstract：:A joint analysis of all-atom molecular dynamics (MD) calculations and picosecond time-resolved x-ray structures was performed to gain single-molecule insights into mechanisms of protein function. Ensemble-averaged MD simulations of the L29F mutant of myoglobin after ligand dissociation reproduce the direction, amplitu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummer G,Schotte F,Anfinrud PA

更新日期：2004-10-26 00:00:00

abstract：:The nicotinic acetylcholine (ACh) receptor (nAChR) plays a crucial role in excitatory neurotransmission and is an important target for drugs and insecticides. Diverse nAChR subtypes with various subunit combinations confer differential selectivity for nicotinic drugs. We investigated the subtype selectivity of nAChR a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomizawa M,Maltby D,Talley TT,Durkin KA,Medzihradszky KF,Burlingame AL,Taylor P,Casida JE

更新日期：2008-02-05 00:00:00

abstract：:Highly multiplexed assays using antibody coated, fluorescent (xMap) beads are widely used to measure quantities of soluble analytes, such as cytokines and antibodies in clinical and other studies. Current analyses of these assays use methods based on standard curves that have limitations in detecting low or high abund...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Won JH,Goldberger O,Shen-Orr SS,Davis MM,Olshen RA

更新日期：2012-02-21 00:00:00

abstract：:Hydrogen/deuterium exchange followed by trapping of the labeled species in the aprotic solvent DMSO has been used to elucidate structure in both the burst-phase molten globule-folding intermediate of apomyoglobin and in an equilibrium intermediate that models the kinetic intermediate. Precise estimates can be made of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishimura C,Dyson HJ,Wright PE

更新日期：2005-03-29 00:00:00

abstract：:We argue that folding of the compact domains of proteins can occur with adequate rapidity in the absence of a unique directed mechanism, provided that native-like local structure dominates the folding process. We further suggest that the evolution of amino acid sequences should favor multiple paths to the folded state...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrison SC,Durbin R

更新日期：1985-06-01 00:00:00

abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. The Rag heterodimer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen K,Sabatini DM

更新日期：2018-09-18 00:00:00

abstract：:The importance of founder events in promoting evolutionary changes on islands has been a subject of long-running controversy. Resolution of this debate has been hindered by a lack of empirical evidence from naturally founded island populations. Here we undertake a genetic analysis of a series of historically documente...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clegg SM,Degnan SM,Kikkawa J,Moritz C,Estoup A,Owens IP

更新日期：2002-06-11 00:00:00

abstract：:In Saccharomyces cerevisiae, utilization of galactose requires four inducible enzyme activities. Three of these activities (galactose-1-phosphate uridyl transferase, EC 2.7.7.10; uridine diphosphogalactose 4-epimerase, EC 5.1.3.2; and galactokinase, EC 2.7.1.6) are specified by three tightly linked genes (GAL7, GAL10,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hopper JE,Broach JR,Rowe LB

更新日期：1978-06-01 00:00:00

abstract：:The nature of color categories in the world's languages is contested. One major view holds that color categories are organized around universal focal colors, whereas an opposing view holds instead that categories are defined at their boundaries by linguistic convention. Both of these standardly opposed views are chall...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Regier T,Kay P,Khetarpal N

更新日期：2007-01-23 00:00:00

abstract：:The complex prokaryote, Myxococcus xanthus, undergoes a program of multicellular development when starved for nutrients, culminating in sporulation. M. xanthus makes MglA, a 22-kDa, soluble protein that is required for both multicellular development and gliding motility. MglA is similar in sequence to the Saccharomyce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartzell PL

更新日期：1997-09-02 00:00:00

abstract：:For many intraoperative decisions surgeons depend on frozen section pathology, a technique developed over 150 y ago. Technical innovations that permit rapid molecular characterization of tissue samples at the time of surgery are needed. Here, using desorption electrospray ionization (DESI) MS, we rapidly detect the tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santagata S,Eberlin LS,Norton I,Calligaris D,Feldman DR,Ide JL,Liu X,Wiley JS,Vestal ML,Ramkissoon SH,Orringer DA,Gill KK,Dunn IF,Dias-Santagata D,Ligon KL,Jolesz FA,Golby AJ,Cooks RG,Agar NY

更新日期：2014-07-29 00:00:00

abstract：:Iron/sulfur cluster (ISC)-containing proteins are essential components of cells. In most eukaryotes, Fe/S clusters are synthesized by the mitochondrial ISC machinery, the cytosolic iron/sulfur assembly system, and, in photosynthetic species, a plastid sulfur-mobilization (SUF) system. Here we show that the anaerobic h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsaousis AD,Ollagnier de Choudens S,Gentekaki E,Long S,Gaston D,Stechmann A,Vinella D,Py B,Fontecave M,Barras F,Lukeš J,Roger AJ

更新日期：2012-06-26 00:00:00

abstract：:The voltage-dependent gating of the colicin channel involves a substantial structural rearrangement that results in the transfer of about 35% of the 200 residues in its pore-forming domain across the membrane. This transfer appears to represent an unusual type of protein translocation that does not depend on a large, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slatin SL,Nardi A,Jakes KS,Baty D,Duché D

更新日期：2002-02-05 00:00:00

abstract：:Serine is the only amino acid that is encoded by two disjoint codon sets so that a tandem substitution of two nucleotides is required to switch between the two sets. Previously published evidence suggests that, for the most evolutionarily conserved serines, the codon set switch occurs by simultaneous substitution of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogozin IB,Belinky F,Pavlenko V,Shabalina SA,Kristensen DM,Koonin EV

更新日期：2016-11-15 00:00:00

abstract：:In previous papers of this series, emphasis has been placed on the steady-state phase transition and critical properties of large lattices of interacting, symmetrical, and identical enzyme molecules. The present paper is concerned with a number of examples of enzyme--enzyme interactions that do not belong to the class...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL

更新日期：1978-03-01 00:00:00

abstract：:Saccharomyces cerevisiae myristoyl-CoA:protein N-myristoyltransferase (Nmt1p; EC 2.3.1.97) is an essential enzyme that is highly selective for myristoyl-CoA in vivo. It is unclear why myristate (C14:0), a rare cellular fatty acid, has been selected for this covalent protein modification over more abundant fatty acids ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rudnick DA,Lu T,Jackson-Machelski E,Hernandez JC,Li Q,Gokel GW,Gordon JI

更新日期：1992-11-01 00:00:00

abstract：:Activation of protein kinase C (PKC) by phorbol ester facilitates hormonal secretion and transmitter release, and phorbol ester-induced synaptic potentiation (PESP) is a model for presynaptic facilitation. A variety of PKC isoforms are expressed in the central nervous system, but the isoform involved in the PESP has n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saitoh N,Hori T,Takahashi T

更新日期：2001-11-20 00:00:00

abstract：:A major problem facing the effective treatment of patients with cancer is how to get the specific antitumor agent into every tumor cell. In this report we describe the use of a strategy that, by using retroviral vectors encoding a truncated human CD5 cDNA, allows the selection of only the infected cells, and we show t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García-Hernández B,Castellanos A,López A,Orfao A,Sánchez-García I

更新日期：1997-11-25 00:00:00

abstract：:In virtually all multicellular eukaryotes, mitochondria are transmitted exclusively through one parent, usually the mother. In this short review, we discuss some of the major consequences of uniparental transmission of mitochondria, including deleterious effects in males and selection for increased transmission throug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perlman SJ,Hodson CN,Hamilton PT,Opit GP,Gowen BE

更新日期：2015-08-18 00:00:00

abstract：:Plasmons, the collective oscillations of interacting electrons, possess emergent properties that dramatically alter the optical response of metals. We predict the existence of a new class of plasmons-chiral Berry plasmons (CBPs)-for a wide range of 2D metallic systems including gapped Dirac materials. As we show, in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song JC,Rudner MS

更新日期：2016-04-26 00:00:00

abstract：:The human beta-globin locus is activated transcriptionally by a complex series of events that culminate in appropriate temporal and tissue-specific control over five separate genes during embryonic and early postnatal development. One cis-regulatory element in the locus, originally identified as an enhancer 3' to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Q,Tanimoto K,Bungert J,Engel JD

更新日期：1998-08-18 00:00:00

abstract：:Niemann-Pick C1 (NPC1) and NPC2 proteins are indispensable for the export of LDL-derived cholesterol from late endosomes. Mutations in these proteins result in Niemann-Pick type C disease, a lysosomal storage disease. Despite recent reports of the NPC1 structure depicting its overall architecture, the function of its ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Lu F,Trinh MN,Schmiege P,Seemann J,Wang J,Blobel G

更新日期：2017-08-22 00:00:00

abstract：:During reverse transcription of retroviral RNA, synthesis of (-) strand DNA is primed by a cellular tRNA that anneals to an 18-nt primer binding site within the 5' long terminal repeat. For (+) strand synthesis using a (-) strand DNA template linked to the tRNA primer, only the first 18 nt of tRNA are replicated to re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burnett BP,McHenry CS

更新日期：1997-07-08 00:00:00

abstract：:The Zika virus (ZIKV) causes microcephaly and the Guillain-Barré syndrome. Little is known about how ZIKV causes these conditions or which ZIKV viral protein(s) is responsible for the associated ZIKV-induced cytopathic effects, including cell hypertrophy, growth restriction, cell-cycle dysregulation, and cell death. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li G,Poulsen M,Fenyvuesvolgyi C,Yashiroda Y,Yoshida M,Simard JM,Gallo RC,Zhao RY

更新日期：2017-01-17 00:00:00

abstract：:The properties of inositol 1,4,5-trisphosphate (InsP3) receptor sites in the anterior pituitary were evaluated by binding studies with InsP3 labeled with 32P to high specific radioactivity. Specific binding of Ins[32P]P3 was demonstrable in pituitary membrane preparations and was linearly proportional to the amount of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guillemette G,Balla T,Baukal AJ,Catt KJ

更新日期：1987-12-01 00:00:00

abstract：:To test the hypothesis that the nonrandom organization of the contents of interphase nuclei represents a compartmentalization of function, we examined the relative, spatial relationship of small nuclear ribonucleoproteins (snRNPs) and of DNase I hypersensitive chromatin (DHC) in rat pheochromocytoma cells. In controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park PC,De Boni U

更新日期：1996-10-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) is one of the most intractable of human cancers, principally because of the highly infiltrative nature of these neoplasms. Tracking and eradicating infiltrating GBM cells and tumor microsatellites is of utmost importance for the treatment of this devastating disease, yet effective strateg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang X,Fitch S,Wang C,Wilson C,Li J,Grant GA,Yang F

更新日期：2016-11-29 00:00:00

abstract：:The homotypic fusion of endoplasmic reticulum (ER) membranes is mediated by atlastin (ATL), which consists of an N-terminal cytosolic domain containing a GTPase module and a three-helix bundle followed by two transmembrane (TM) segments and a C-terminal tail (CT). Fusion depends on a GTP hydrolysis-induced conformatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu TY,Bian X,Sun S,Hu X,Klemm RW,Prinz WA,Rapoport TA,Hu J

更新日期：2012-08-07 00:00:00

abstract：:Cl- channels in the apical membranes of salt-secreting epithelia are activated by both cAMP and Ca2+ second-messenger systems, and dysfunctions in their hormonal regulation have been demonstrated in patients with cystic fibrosis. We have transfected the epithelial cell line T84 with an expression vector containing a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers KV,Goldman PS,Frizzell RA,McKnight GS

更新日期：1990-11-01 00:00:00

abstract：:A somatic mutation in the X linked PIGA gene is responsible for the deficiency of glycosyl phosphatidylinositol (GPI)-anchored proteins on blood cells from patients with paroxysmal nocturnal hemoglobinuria. No inherited form of GPI-anchor deficiency has been described. Because conventional Piga gene knockout is associ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keller P,Tremml G,Rosti V,Bessler M

更新日期：1999-06-22 00:00:00