Genetic consequences of sequential founder events by an island-colonizing bird.

abstract：:The rates of spontaneous mutation to 6-thioguanine resistance were determined in fibroblasts derived from normal and two Bloom syndrome individuals (GM 2548 and GM 1492). Two methods were utilized to determine the rates. Method I obtained the spontaneous mutation rate from the increase in the mutation frequency of a c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren ST,Schultz RA,Chang CC,Wade MH,Trosko JE

更新日期：1981-05-01 00:00:00

abstract：:Specific Ca2+ binding and Ca2+ activation of ATPase activity in scallop myosin require a regulatory light chain (RLC) from regulated (molluscan or vertebrate smooth) myosin; hybrids containing vertebrate skeletal RLCs do not bind Ca2+ and their ATPase activity is inhibited. Chimeras between scallop and chicken skeleta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jancso A,Szent-Györgyi AG

更新日期：1994-09-13 00:00:00

abstract：:In the absence of adaptive immunity displayed by animals, plants respond locally to biotic challenge via inducible basal defense networks activated through recognition and response to conserved pathogen-associated molecular patterns. In addition, immunity can be induced in tissues remote from infection sites by system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Truman W,Bennett MH,Kubigsteltig I,Turnbull C,Grant M

更新日期：2007-01-16 00:00:00

abstract：:Cells of the craniofacial skeleton are derived from a common mesenchymal progenitor. The regulatory factors that control their differentiation into various cell lineages are unknown. To investigate the biological function of dentin matrix protein 1 (DMP1), an extracellular matrix gene involved in calcified tissue form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Narayanan K,Srinivas R,Ramachandran A,Hao J,Quinn B,George A

更新日期：2001-04-10 00:00:00

abstract：:Staphylococcal protein A (SpA) is anchored to the cell wall envelope of Staphylococcus aureus by sortase A, which links the threonyl (T) of its C-terminal LPXTG motif to peptidoglycan cross-bridges (i.e., Gly5). SpA binds the Fcγ domains of IgG and protects staphylococci from opsonophagocytic clearance. Moreover, SpA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker S,Frankel MB,Schneewind O,Missiakas D

更新日期：2014-01-28 00:00:00

abstract：:Drosophila melanogaster is a powerful model organism for dissecting the neurogenetic basis of appetitive and aversive behaviors. However, some methods used to assay food preference require or cause starvation. This can be problematic for fly ethanol research because it can be difficult to dissociate caloric preference...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park A,Tran T,Atkinson NS

更新日期：2018-09-04 00:00:00

abstract：:Somatic fungal hyphae are generally assumed to elongate at steady linear rates when grown under constant environmental conditions with ample nutrients. However, patterns of pulsed hyphal elongation were detected during apparent steady growth of hyphal tips in fungi from several major taxonomic groups (Oomycetes, Pythi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： López-Franco R,Bartnicki-Garcia S,Bracker CE

更新日期：1994-12-06 00:00:00

abstract：:Activation of the CB2 receptor is apparently an endogenous protective mechanism. Thus, it restrains inflammation and protects the skeleton against age-related bone loss. However, the endogenous cannabinoids, as well as Δ(9)-tetrahydrocannabinol, the main plant psychoactive constituent, activate both cannabinoid recept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smoum R,Baraghithy S,Chourasia M,Breuer A,Mussai N,Attar-Namdar M,Kogan NM,Raphael B,Bolognini D,Cascio MG,Marini P,Pertwee RG,Shurki A,Mechoulam R,Bab I

更新日期：2015-07-14 00:00:00

abstract：:Selection of mammalian cells in progressively increasing concentrations of methotrexate results in selective amplification of DNA sequences coding for dihydrofolate reductase (tetrahydrofolate dehydrogenase, 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase, EC 1.5.1.3). In some cell variants the amplified genes are stabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman RJ,Brown PC,Schimke RT

更新日期：1979-11-01 00:00:00

abstract：:As an electron transfer-driven proton pump, cytochrome c oxidase (ferrocytochrome-c:oxygen oxidoreductase, EC 1.9.3.1) must alternate between two conformations in each valence state of the redox element associated with ion translocation. Using second derivative absorption spectroscopy, the conformation of the cytochro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Copeland RA

更新日期：1991-08-15 00:00:00

abstract：:Conflict between groups of individuals is a prevalent feature in human societies. A common theoretical explanation for intergroup conflict is that it provides benefits to individuals within groups in the form of reproduction-enhancing resources, such as food, territory, or mates. However, it is not always the case tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henriques GJB,Simon B,Ispolatov Y,Doebeli M

更新日期：2019-07-09 00:00:00

abstract：:We present a mandible recovered in 2003 from the Aurora Stratum of the TD6 level of the Gran Dolina site (Sierra de Atapuerca, northern Spain). The specimen, catalogued as ATD6-96, adds to the hominin sample recovered from this site in 1994-1996, and assigned to Homo antecessor. ATD6-96 is the left half of a gracile m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carbonell E,Bermúdez de Castro JM,Arsuaga JL,Allue E,Bastir M,Benito A,Cáceres I,Canals T,Díez JC,van der Made J,Mosquera M,Ollé A,Pérez-González A,Rodríguez J,Rodríguez XP,Rosas A,Rosell J,Sala R,Vallverdú J,Vergés

更新日期：2005-04-19 00:00:00

abstract：:There is currently an unmet need for versatile techniques to monitor the assembly and dynamics of ternary complexes in live cells. Here we describe bioluminescence resonance energy transfer with fluorescence enhancement by combined transfer (BRETFect), a high-throughput technique that enables robust spectrometric dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cotnoir-White D,El Ezzy M,Boulay PL,Rozendaal M,Bouvier M,Gagnon E,Mader S

更新日期：2018-03-13 00:00:00

abstract：:Karrikins are a class of seed germination stimulants identified in smoke from wildfires. Microarray analysis of imbibed Arabidopsis thaliana seeds was performed to identify transcriptional responses to KAR(1) before germination. A small set of genes that are regulated by KAR(1), even when germination is prevented by t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nelson DC,Flematti GR,Riseborough JA,Ghisalberti EL,Dixon KW,Smith SM

更新日期：2010-04-13 00:00:00

abstract：:Tibetans have adapted to the chronic hypoxia of high altitude and display a distinctive suite of physiologic adaptations, including augmented hypoxic ventilatory response and resistance to pulmonary hypertension. Genome-wide studies have consistently identified compelling genetic signatures of natural selection in two...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song D,Navalsky BE,Guan W,Ingersoll C,Wang T,Loro E,Eeles L,Matchett KB,Percy MJ,Walsby-Tickle J,McCullagh JSO,Medina RJ,Khurana TS,Bigham AW,Lappin TR,Lee FS

更新日期：2020-06-02 00:00:00

abstract：:The four-helical bundle soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor (SNARE) complex that mediates intracellular membrane fusion events contains a highly conserved ionic layer at the center of an otherwise hydrophobic core. This layer has an undetermined function; it consists of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scales SJ,Yoo BY,Scheller RH

更新日期：2001-12-04 00:00:00

abstract：:Antiviral drugs targeting viral proteins often result in prompt selection for resistance. Moreover, the number of viral targets is limited. Novel antiviral targets are therefore needed. The unique characteristics of fusion between virion envelopes and cell membranes may provide such targets. Like all fusing bilayers, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： St Vincent MR,Colpitts CC,Ustinov AV,Muqadas M,Joyce MA,Barsby NL,Epand RF,Epand RM,Khramyshev SA,Valueva OA,Korshun VA,Tyrrell DL,Schang LM

更新日期：2010-10-05 00:00:00

abstract：:With continued debate over the functional significance of adult neurogenesis, identifying an in vivo correlate of neurogenesis has become an important goal. Here we rely on the coupling between neurogenesis and angiogenesis and test whether MRI measurements of cerebral blood volume (CBV) provide an imaging correlate o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pereira AC,Huddleston DE,Brickman AM,Sosunov AA,Hen R,McKhann GM,Sloan R,Gage FH,Brown TR,Small SA

更新日期：2007-03-27 00:00:00

abstract：:The formation of social attachments is a critical component of human relationships. Infants begin to bond to their caregivers from the moment of birth, and these social bonds continue to provide regulatory emotional functions throughout adulthood. It is difficult to examine the interactions between social experience a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wismer Fries AB,Ziegler TE,Kurian JR,Jacoris S,Pollak SD

更新日期：2005-11-22 00:00:00

abstract：:The INT6 gene has been implicated in human breast cancer formation, but its function is unknown. We isolated an Int6 homolog from fission yeast, Yin6, by its binding to a conserved protein in the Ras pathway, Moe1. Yin6 and Moe1 converge on the same protein complex to promote microtubule instability/disassembly. Yin6 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yen HC,Chang EC

更新日期：2000-12-19 00:00:00

abstract：:Natural killer-22 (NK-22) cells are a human NK cell subset situated in mucosal-associated lymphoid tissues that specialize in IL-22 secretion in response to IL-23. Here we investigated the cytokine requirements for NK-22 cell expansion. IL-7 maintained the survival of NK-22 cells and IL-22 production in response to IL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cella M,Otero K,Colonna M

更新日期：2010-06-15 00:00:00

abstract：:A transcription factor required for synthesis of accurately initiated run-off transcripts by RNA polymerase II has been purified and shown to have an associated DNA-dependent ATPase (dATPase) activity that is strongly stimulated by the TATA region of promoters. This transcription factor, designated delta, was purified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conaway RC,Conaway JW

更新日期：1989-10-01 00:00:00

abstract：:During the entry process, the human papillomavirus (HPV) capsid is trafficked to the trans-Golgi network (TGN), whereupon it enters the nucleus during mitosis. We previously demonstrated that the minor capsid protein L2 assumes a transmembranous conformation in the TGN. Here we provide evidence that the incoming viral...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiGiuseppe S,Luszczek W,Keiffer TR,Bienkowska-Haba M,Guion LG,Sapp MJ

更新日期：2016-05-31 00:00:00

abstract：:Receptor tyrosine kinases (RTKs) control a multitude of biological processes and are therefore subjected to multiple levels of regulation. Negative feedback is one of the mechanisms that provide an effective means to control RTK-mediated signaling. Sef has recently been identified as a specific antagonist of fibroblas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preger E,Ziv I,Shabtay A,Sher I,Tsang M,Dawid IB,Altuvia Y,Ron D

更新日期：2004-02-03 00:00:00

abstract：:The release of catecholamines from adrenal chromaffin cells is known to be blocked by dihydropyridines, such as nitrendipine, and enhanced by others, such as BAY K8644. On the other hand, release from sympathetic neurons is predominantly insensitive to these agents. Release of [3H]norepinephrine from undifferentiated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kongsamut S,Miller RJ

更新日期：1986-04-01 00:00:00

abstract：:Formulas are derived for the effect of size on a free-swimming microbe's ability to follow chemical, light, or temperature stimuli or to disperse in random directions. The four main assumptions are as follows: (i) the organisms can be modeled as spheres, (ii) the power available to the organism for swimming is proport...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dusenbery DB

更新日期：1997-09-30 00:00:00

abstract：:The motility of cilia and flagella is powered by dynein ATPases associated with outer doublet microtubules. However, a flagellar kinesin-like protein that may function as a motor associates with the central pair complex. We determined that Chlamydomonas reinhardtii central pair kinesin Klp1 is a phosphoprotein and, li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yokoyama R,O'toole E,Ghosh S,Mitchell DR

更新日期：2004-12-14 00:00:00

abstract：:Daphnia pulex de Geer and Daphnia magna Straus populations cannot be maintained in defined (sensu stricto) media containing less than 0.1 part per billion (ppb) of selenium. A concentration of 1 ppb is sufficient to satisfy minimal needs in otherwise sufficient media. In the first generation with no selenium added to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keating KI,Dagbusan BC

更新日期：1984-06-01 00:00:00

abstract：:Using a genome-wide approach, we asked how many transporter genes contribute to symbiotic phosphate uptake and analyzed their evolutionary conservation. Considering the sequenced rice genome at hand, only the Oryza sativa phosphate transporter (OsPT) gene OsPT11 was specifically induced during the arbuscular mycorrhiz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paszkowski U,Kroken S,Roux C,Briggs SP

更新日期：2002-10-01 00:00:00

abstract：:A retrovirus containing the entire human platelet-derived growth factor B-chain (PDGF-B) gene was constructed in order to investigate the in vivo biological activity of its encoded growth factor. When this virus was introduced into newborn mice, it reproducibly generated fibrosarcomas at the site of inoculation. Provi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pech M,Gazit A,Arnstein P,Aaronson SA

更新日期：1989-04-01 00:00:00