Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery.

abstract：:With global heavy metal contamination increasing, plants that can process heavy metals might provide efficient and ecologically sound approaches to sequestration and removal. Mercuric ion reductase, MerA, converts toxic Hg2+ to the less toxic, relatively inert metallic mercury (Hg0) The bacterial merA sequence is rich...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rugh CL,Wilde HD,Stack NM,Thompson DM,Summers AO,Meagher RB

更新日期：1996-04-16 00:00:00

abstract：:A metabolic mechanism for oxalic acid biosynthesis in the wood-rotting basidiomycete Fomitopsis palustris has been proposed on the basis of biochemical analyses of glucose metabolism. There was a strong correlation between glucose consumption and oxalate production. Oxalic acid was found to accumulate in the culture f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Munir E,Yoon JJ,Tokimatsu T,Hattori T,Shimada M

更新日期：2001-09-25 00:00:00

abstract：:Macrophage foam cells are integral in the development of atherosclerotic lesions. Gene expression analysis of lesional macrophage foam cells is complicated by the cellular heterogeneity of atherosclerotic plaque and the presence of lesions of various degrees of severity. To overcome these limitations, we tested the ab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trogan E,Choudhury RP,Dansky HM,Rong JX,Breslow JL,Fisher EA

更新日期：2002-02-19 00:00:00

abstract：:Listeria monocytogenes is an intracellular parasite that can readily infect the macrophage-like cell line J774 and the kidney epithelial cell PtK2. After being ingested, the organism escapes from the phagolysosome into the host-cell cytoplasm. N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)-phallacidin, a specific stain for act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dabiri GA,Sanger JM,Portnoy DA,Southwick FS

更新日期：1990-08-01 00:00:00

abstract：:G9a is an epigenetic regulator that methylates H3K9, generally causing repression of gene expression, and participates in diverse cellular functions. G9a is genetically deregulated in a variety of tumor types and can silence tumor suppressor genes and, therefore, is important for carcinogenesis. Although hypoxia is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casciello F,Al-Ejeh F,Kelly G,Brennan DJ,Ngiow SF,Young A,Stoll T,Windloch K,Hill MM,Smyth MJ,Gannon F,Lee JS

更新日期：2017-07-03 00:00:00

abstract：:dAn.dTn sequences, otherwise known as A tracts, are hotspots for cis-syn thymine dimer formation and deletion mutations induced by UV light. Such A tracts are also known to bend DNA, suggesting that some biological effects of UV light might be related to the distinctive structure and properties of cis-syn dimer-contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang CI,Taylor JS

更新日期：1991-10-15 00:00:00

abstract：:There are at least three short-range gap repressors in the precellular Drosophila embryo: Krüppel, Knirps, and Giant. Krüppel and Knirps contain related repression motifs, PxDLSxH and PxDLSxK, respectively, which mediate interactions with the dCtBP corepressor protein. Here, we present evidence that Giant might also i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nibu Y,Levine MS

更新日期：2001-05-22 00:00:00

abstract：:We show in climate model experiments that large-scale afforestation in northern mid-latitudes warms the Northern Hemisphere and alters global circulation patterns. An expansion of dark forests increases the absorption of solar energy and increases surface temperature, particularly in regions where the land surface is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swann AL,Fung IY,Chiang JC

更新日期：2012-01-17 00:00:00

abstract：:A purified rabbit liver membrane protein that binds desialylated glycoproteins has been shown to be a mitogen for human peripheral lymphocytes. The mitogenic activity is specific for desialylated thymus-derived (T)-cells. The loss of mitogenicity upon exposure of the binding protein to neuraminidase and the inhibitory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novogrodsky A,Ashwell G

更新日期：1977-02-01 00:00:00

abstract：:Many ecosystems, from vegetation to biofilms, are composed of territorial populations that compete for both nutrients and physical space. What are the implications of such spatial organization for biodiversity? To address this question, we developed and analyzed a model of territorial resource competition. In the mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiner BG,Posfai A,Wingreen NS

更新日期：2019-09-03 00:00:00

abstract：:In the United States, blood donors are being screened for infection with human T cell lymphotropic viruses I and II (HTLV-I/II) by serologic means, which detect antibodies to the structural proteins of these viruses. Because patients with mycosis fungoides (MF) usually do not have such antibodies even though their cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zucker-Franklin D,Pancake BA,Marmor M,Legler PM

更新日期：1997-06-10 00:00:00

abstract：:After pollen grains germinate on the stigma, pollen tubes traverse the extracellular matrix of the style on their way to the ovules. We previously characterized two pollen-specific, receptor-like kinases, LePRK1 and LePRK2, from tomato (Lycopersicon esculentum). Their structure and immunolocalization pattern and the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wengier D,Valsecchi I,Cabanas ML,Tang WH,McCormick S,Muschietti J

更新日期：2003-05-27 00:00:00

abstract：:Plasmonics now delivers sensors capable of detecting single molecules. The emission enhancements and nanometer-scale optical confinement achieved by these metallic nanostructures vastly increase spectroscopic sensitivity, enabling real-time tracking. However, the interaction of light with such nanostructures typically...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horton MJ,Ojambati OS,Chikkaraddy R,Deacon WM,Kongsuwan N,Demetriadou A,Hess O,Baumberg JJ

更新日期：2020-02-04 00:00:00

abstract：:A chromosomal locus required for copper resistance and competitive fitness was cloned from a strain of Pseudomonas fluorescens isolated from copper-contaminated agricultural soil. Sequence analysis of this locus revealed six open reading frames with homology to genes involved in cytochrome c biogenesis in other bacter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang CH,Azad HR,Cooksey DA

更新日期：1996-07-09 00:00:00

abstract：:Merkel cell polyomavirus (MCV) contributes to approximately 80% of all Merkel cell carcinomas (MCCs), a highly aggressive neuroendocrine carcinoma of the skin. MCV-positive MCC expresses small T antigen (ST) and a truncated form of large T antigen (LT) and usually contains wild-type p53 (TP53) and RB (RB1). In contras...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park DE,Cheng J,Berrios C,Montero J,Cortés-Cros M,Ferretti S,Arora R,Tillgren ML,Gokhale PC,DeCaprio JA

更新日期：2019-01-15 00:00:00

abstract：:In this paper we demonstrate that near infrared Fourier transform Raman spectroscopy provides unprecedented biochemical information about the extent of atherosclerosis in human aorta. In particular, elastin, collagen, cholesterol, cholesterol esters, lipids, carotenoids, and calcium apatite deposits all can be discern...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraga JJ,Feld MS,Rava RP

更新日期：1992-04-15 00:00:00

abstract：:We have cloned a mutS homolog from Drosophila melanogaster called spellchecker1 (spel1) and have constructed spel1 mutant flies. MutS proteins promote the correction of DNA mismatches and serve important roles in DNA replication, recombination, and repair. The spel1 gene belongs to a subfamily of mutS first characteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores C,Engels W

更新日期：1999-03-16 00:00:00

abstract：:It was proved that the protoplasts prepared from mesophyll of Nicotiana tabacum are infected by tobacco mosaic virus. The infection occurred when purified tobacco mosaic virus particles were added to a protoplast suspension in the presence of poly-L-ornithine. The virus multiplied in these protoplasts to a level of 10...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takebe I,Otsuki Y

更新日期：1969-11-01 00:00:00

abstract：:The outer membrane (OM) of Gram-negative bacteria forms a robust permeability barrier that blocks entry of toxins and antibiotics. Most OM proteins (OMPs) assume a β-barrel fold, and some form aqueous channels for nutrient uptake and efflux of intracellular toxins. The Bam machine catalyzes rapid folding and assembly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Konovalova A,Grabowicz M,Balibar CJ,Malinverni JC,Painter RE,Riley D,Mann PA,Wang H,Garlisi CG,Sherborne B,Rigel NW,Ricci DP,Black TA,Roemer T,Silhavy TJ,Walker SS

更新日期：2018-07-10 00:00:00

abstract：:Mounting effective T cell responses is critical for eliciting long-lasting immunity following viral infection and vaccination. A multitude of inhibitory and stimulatory factors are induced following infection, and it is the compilation of these signals that quantitatively and qualitatively program the ensuing effector...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks DG,Walsh KB,Elsaesser H,Oldstone MB

更新日期：2010-02-16 00:00:00

abstract：:Pathogen exit is a key stage in the spread and propagation of infectious disease, with the fecal-oral route being a common mode of disease transmission. However, it is poorly understood which molecular pathways provide the major modes for intracellular pathogen exit and fecal-oral transmission in vivo. Here, we use th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szumowski SC,Botts MR,Popovich JJ,Smelkinson MG,Troemel ER

更新日期：2014-06-03 00:00:00

abstract：:Most human tumors are clonal in origin, although the cells may be diverse in their properties. Since the tumors evolve through progressive stages over decades of time, it is possible that the conditions that induced the tumor transform many cells, but that selective overgrowth of the fastest growing lead to a clonal p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao A,Rubin H

更新日期：1993-11-15 00:00:00

abstract：:Humans have altered natural patterns of fire for millennia, but the impact of human-set fires is thought to have been slight in wet closed-canopy forests. In the South Island of New Zealand, Polynesians (Māori), who arrived 700-800 calibrated years (cal y) ago, and then Europeans, who settled ∼150 cal y ago, used fire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McWethy DB,Whitlock C,Wilmshurst JM,McGlone MS,Fromont M,Li X,Dieffenbacher-Krall A,Hobbs WO,Fritz SC,Cook ER

更新日期：2010-12-14 00:00:00

abstract：:The Escherichia coli RuvA and RuvB protein complex promotes branch migration of Holliday junctions during recombinational repair and homologous recombination and at stalled replication forks. The RuvB protein belongs to the AAA(+) (ATPase associated with various cellular activities) ATPase family and forms a hexameric...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hishida T,Han YW,Fujimoto S,Iwasaki H,Shinagawa H

更新日期：2004-06-29 00:00:00

abstract：:We have used electron microscopy to examine freshly isolated Salmonella typhimurium and Escherichia coli basal flagellar fragments, purified without resort to extremes of pH or ionic strength. Such fragments contain the large bell-like basal structures visualized recently in freeze-substituted or fixed preparations. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khan IH,Reese TS,Khan S

更新日期：1992-07-01 00:00:00

abstract：:Changes in the expression of Hox genes have been widely linked to the evolution of animal body plans, but functional demonstrations of this relationship have been impeded by the lack of suitable model organisms. A classic case study involves the repeated evolution of specialized feeding appendages, called maxillipeds,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pavlopoulos A,Kontarakis Z,Liubicich DM,Serano JM,Akam M,Patel NH,Averof M

更新日期：2009-08-18 00:00:00

abstract：:The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteria through the autotransporter pathway. We previously classified SPATE proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2). Here, we show that Pic, a class 2 SPATE protein produced b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Perez F,Wahid R,Faherty CS,Kolappaswamy K,Rodriguez L,Santiago A,Murphy E,Cross A,Sztein MB,Nataro JP

更新日期：2011-08-02 00:00:00

abstract：:Previously we reported that proteasome inhibitors were able to overcome Bcl-2-mediated protection from apoptosis. Here we show that inhibition of the proteasome activity in Bcl-2-overexpressing cells accumulates the proapoptotic Bax protein to mitochondria/cytoplasm, where it interacts to Bcl-2 protein. This event was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li B,Dou QP

更新日期：2000-04-11 00:00:00

abstract：:Interleukin 10 (IL-10) inhibits interferon gamma-induced macrophage activation for cytotoxicity against larvae of the human parasite Schistosoma mansoni by suppressing production of the toxic effector molecule nitric oxide (NO). In this study, the mechanism of IL-10 action was identified as inhibition of endogenous tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oswald IP,Wynn TA,Sher A,James SL

更新日期：1992-09-15 00:00:00

abstract：:A human peripheral T-cell cDNA library was screened with two labeled synthetic oligonucleotides encoding regions of a human placenta protein-tyrosine-phosphatase (protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48). One positive clone was isolated and the nucleotide sequence was determined. It contained 1305 bas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cool DE,Tonks NK,Charbonneau H,Walsh KA,Fischer EH,Krebs EG

更新日期：1989-07-01 00:00:00