Stabilization of electron spin resonance probes for photosynthesis studies.

abstract：:Alzheimer's disease (AD) comprises multifactorial ailments for which current therapeutic strategies remain insufficient to broadly address the underlying pathophysiology. Epigenetic gene regulation relies upon multifactorial processes that regulate multiple gene and protein pathways, including those involved in AD. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volmar CH,Salah-Uddin H,Janczura KJ,Halley P,Lambert G,Wodrich A,Manoah S,Patel NH,Sartor GC,Mehta N,Miles NTH,Desse S,Dorcius D,Cameron MD,Brothers SP,Wahlestedt C

更新日期：2017-10-24 00:00:00

abstract：:Stroke patients with small central nervous system infarcts often demonstrate an acute dysexecutive syndrome characterized by difficulty with attention, concentration, and processing speed, independent of lesion size or location. We use magnetoencephalography (MEG) to show that disruption of network dynamics may be res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marsh EB,Brodbeck C,Llinas RH,Mallick D,Kulasingham JP,Simon JZ,Llinás RR

更新日期：2020-12-29 00:00:00

abstract：:Deuterium oxide, D(2)O, increases the temperature-tolerance of Drosophila pseudoobscura when it is administered to adult flies as a sucrose solution. The effect is very rapidly exerted; it is detected within 10 min after the flies have a brief (10 min) opportunity to drink. This increased resistance to heat-death sure...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pittendrigh CS,Cosbey ES

更新日期：1974-02-01 00:00:00

abstract：:Insertion of trocars, needles, and catheters into unintended tissues or tissue compartments results in hundreds of thousands of complications annually. Current methods for blood vessel cannulation or epidural, chest tube, and initial trocar placement often involve the blind pass of a needle through several layers of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bassett EK,Slocum AH,Masiakos PT,Pryor HI 2nd,Farokhzad OC,Karp JM

更新日期：2009-04-07 00:00:00

abstract：:Plants can recognize and resist invading pathogens by signaling the induction of rapid defense responses. Often these responses are mediated by single dominant resistance genes (R genes). The products of R genes have been postulated to recognize the pathogen and trigger rapid host defense responses. Here we describe i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dinesh-Kumar SP,Whitham S,Choi D,Hehl R,Corr C,Baker B

更新日期：1995-05-09 00:00:00

abstract：:The isolated beta subunit of hemoglobin Kansas has an oxygen affinity that is as low relative to the oxygen affinity of the beta(A) subunit as the affinity of hemoglobin Kansas is low relative to hemoglobin A. Thus the low affinity properties of hemoglobin Kansas are almost completely reflected in the properties of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Riggs A,Gibson QH

更新日期：1973-06-01 00:00:00

abstract：:Animal foraging and competition are defined by the partitioning of three primary niche axes: space, time, and resources. Human disturbance is rapidly altering the spatial and temporal niches of animals, but the impact of humans on resource consumption and partitioning-arguably the most important niche axis-is poorly u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manlick PJ,Pauli JN

更新日期：2020-10-27 00:00:00

abstract：:p70 S6 kinase (p70(S6k)) is a mitogen-activated protein kinase that plays a central role in the control of mRNA translation. It physiologically phosphorylates the S6 protein of the 40s ribosomal subunit in response to mitogenic stimuli and is a downstream component of the rapamycin-sensitive pathway, which includes th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burnett PE,Blackshaw S,Lai MM,Qureshi IA,Burnett AF,Sabatini DM,Snyder SH

更新日期：1998-07-07 00:00:00

abstract：:Purified preparations of rabbit skeletal white, red, and cardiac muscle myosin (WM, RM, and CM) were subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Significant differences in both the molecular weights and number of light chains in these myosins were found. WM has three distinct light-chain co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar S,Sreter FA,Gergely J

更新日期：1971-05-01 00:00:00

abstract：:Inadequate resolution is the principal limitation of radiocarbon dating. However, recent work has shown that exact-year precision is attainable if use can be made of past increases in atmospheric radiocarbon concentration or so-called Miyake events. Here, this nascent method is applied to an archaeological site of pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuitems M,Panin A,Scifo A,Arzhantseva I,Kononov Y,Doeve P,Neocleous A,Dee M

更新日期：2020-06-23 00:00:00

abstract：:S-Adenosylhomocysteine hydrolase (SAHH) is a key enzyme in transmethylation reactions that use S-adenosylmethionine as the methyl donor. Because of the importance of SAHH in a number of S-adenosylmethionine-dependent transmethylation reactions, particularly the 5' capping of mRNA during viral replication, SAHH has bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masuta C,Tanaka H,Uehara K,Kuwata S,Koiwai A,Noma M

更新日期：1995-06-20 00:00:00

abstract：:Fast lateral proton migration along membranes is of vital importance for cellular energy homeostasis and various proton-coupled transport processes. It can only occur if attractive forces keep the proton at the interface. How to reconcile this high affinity to the membrane surface with high proton mobility is unclear....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang C,Knyazev DG,Vereshaga YA,Ippoliti E,Nguyen TH,Carloni P,Pohl P

更新日期：2012-06-19 00:00:00

abstract：:When long polymers such as DNA are in a highly concentrated state they may become entangled, leading to restricted self-diffusion. Here, we investigate the effect of molecular topology on diffusion in concentrated DNA solutions and find surprisingly large effects, even with molecules of modest length and concentration...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robertson RM,Smith DE

更新日期：2007-03-20 00:00:00

abstract：:Brief incubation of partially purified preparations of hormone-sensitive lipase from rat epididymal fat pads with ATP, Mg(++), cyclic adenosine 3':5'-monophosphate and rabbit muscle protein kinase (phosphorylase b kinase kinase) resulted in enhancement of lipolytic activity (44-93%). Little or no activation was observ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huttunen JK,Steinberg D,Mayer SE

更新日期：1970-09-01 00:00:00

abstract：:The amount of extra-pair paternity in socially monogamous bird species varies from 0% to 76% extra-pair offspring. The causes of this remarkable interspecific variation are largely unknown, although intraspecific analyses suggest that females seek extra-pair matings to improve the genetic quality of their offspring. I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petrie M,Doums C,Moller AP

更新日期：1998-08-04 00:00:00

abstract：:ChIP-on-chip has emerged as a powerful tool to dissect the complex network of regulatory interactions between transcription factors and their targets. However, most ChIP-on-chip analysis methods use conservative approaches aimed at minimizing false-positive transcription factor targets. We present a model with improve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Margolin AA,Palomero T,Sumazin P,Califano A,Ferrando AA,Stolovitzky G

更新日期：2009-01-06 00:00:00

abstract：:We have synthesized 175-nucleotide-long probes for the DNA of human histocompatibility antigens HLA-DR alpha and beta by extending on poly(A)+ mRNA from B-cell lines with short synthetic deoxyribonucleotide primers complementary to the predicted nucleotide sequence of the NH2 terminus of both polypeptides. The synthes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das HK,Biro PA,Cohen SN,Erlich HA,von Gabain A,Lawrance SK,Lemaux PG,McDevitt HO,Peterlin BM,Schulz MF,Sood AK,Weissman SM

更新日期：1983-03-01 00:00:00

abstract：:We report an approach for the detection of magnetic resonance imaging without superconducting magnets and cryogenics: optical atomic magnetometry. This technique possesses a high sensitivity independent of the strength of the static magnetic field, extending the applicability of magnetic resonance imaging to low magne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu S,Yashchuk VV,Donaldson MH,Rochester SM,Budker D,Pines A

更新日期：2006-08-22 00:00:00

abstract：:Using an antiserum raised against a synthetic C-terminal peptide of porcine pancreastatin, we detected pancreastatin-like immunoreactivity (PLI) in human pancreatic islets, adrenal medulla, and endocrine tumors. From a carcinoid liver metastasis, human PLI was extracted and purified by HPLC. Two C-terminally amidated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schmidt WE,Siegel EG,Kratzin H,Creutzfeldt W

更新日期：1988-11-01 00:00:00

abstract：:Nuclear bodies are RNA and protein-rich, membraneless organelles that play important roles in gene regulation. The largest and most well-known nuclear body is the nucleolus, an organelle whose primary function in ribosome biogenesis makes it key for cell growth and size homeostasis. The nucleolus and other nuclear bod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berry J,Weber SC,Vaidya N,Haataja M,Brangwynne CP

更新日期：2015-09-22 00:00:00

abstract：:Prions are thought to consist mainly or entirely of misfolded PrP, a constitutively expressed host protein. Prions associated with the same PrP sequence may occur in the form of different strains; the strain phenotype is believed to be encoded by the conformation of the PrP. Some cell lines can be persistently infecte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahal SP,Baker CA,Demczyk CA,Smith EW,Julius C,Weissmann C

更新日期：2007-12-26 00:00:00

abstract：:A unique neuronal system was detected in the rat central nervous system by immunohistochemistry and radioimmunoassay with antibodies to salmon melanin-concentrating hormone (MCH). MCH-like immunoreactive (MCH-LI) cell bodies were confined to the hypothalamus. MCH-LI fibers were found throughout the brain but were most...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir N,Skofitsch G,Bannon MJ,Jacobowitz DM

更新日期：1986-03-01 00:00:00

abstract：:Mosquitoes transmit devastating human diseases because they need vertebrate blood for egg development. Metabolism in female mosquitoes is tightly coupled with blood meal-mediated reproduction, which requires an extremely high level of energy consumption. Functional analysis has shown that major genes encoding for enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Hou Y,Saha TT,Pei G,Raikhel AS,Zou Z

更新日期：2017-03-28 00:00:00

abstract：:Precipitation extreme changes are often assumed to scale with, or are constrained by, the change in atmospheric moisture content. Studies have generally confirmed the scaling based on moisture content for the midlatitudes but identified deviations for the tropics. In fact half of the twelve selected Intergovernmental ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugiyama M,Shiogama H,Emori S

更新日期：2010-01-12 00:00:00

abstract：:Recent studies investigating the relationship between crop genetic diversity and human cultural diversity patterns showed that seed exchanges are embedded in farmers' social organization. However, our understanding of the social processes involved remains limited. We investigated how farmers' membership in three major...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Labeyrie V,Thomas M,Muthamia ZK,Leclerc C

更新日期：2016-01-05 00:00:00

abstract：:To address the significance of human immunodeficiency virus (HIV) replication in peripheral blood mononuclear cells (PBMCs), we have used reverse transcriptase-initiated PCR to measure HIV-1 mRNA expression in PBMC specimens collected from a cohort of HIV-infected individuals during a long-term prospective study. We f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saksela K,Stevens C,Rubinstein P,Baltimore D

更新日期：1994-02-01 00:00:00

abstract：:In plants, the AUXIN RESPONSE FACTOR (ARF) transcription factor family regulates gene expression in response to auxin. In the absence of auxin, ARF transcription factors are repressed by interaction with AUXIN/INDOLE 3-ACETIC ACID (Aux/IAA) proteins. Although the C termini of ARF and Aux/IAA proteins facilitate their ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korasick DA,Westfall CS,Lee SG,Nanao MH,Dumas R,Hagen G,Guilfoyle TJ,Jez JM,Strader LC

更新日期：2014-04-08 00:00:00

abstract：:Antibodies specific for allelic determinants of the cell membrane alloantigen Ly-17 were found to react with genetically determined polymorphic sites on the murine IgG Fc receptor (Fc gamma R). Monoclonal antibodies specific for Ly-17.2 and the Fc gamma R detected identical populations of cells in thymus, spleen, lymp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes KL,Palfree RG,Hammerling U,Morse HC 3rd

更新日期：1985-11-01 00:00:00

abstract：:Proteins potentiated by epidermal growth factor (EGF) to induce a transformed phenotype in non-neoplastic rat kidney fibroblasts in cell culture have been isolated from many non-neoplastic tissues of the adult mouse, including submaxillary gland, kidney, liver, muscle, heart, and brain. They resemble previously descri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roberts AB,Anzano MA,Lamb LC,Smith JM,Sporn MB

更新日期：1981-09-01 00:00:00

abstract：:Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ludwig B,Ludwig S,Steffen A,Knauf Y,Zimerman B,Heinke S,Lehmann S,Schubert U,Schmid J,Bleyer M,Schönmann U,Colton CK,Bonifacio E,Solimena M,Reichel A,Schally AV,Rotem A,Barkai U,Grinberg-Rashi H,Kaup FJ,Avni Y,J

更新日期：2017-10-31 00:00:00