Human disturbance increases trophic niche overlap in terrestrial carnivore communities.

abstract：:Social and emotional skills are tightly interlinked in human development, and both are negatively impacted by disrupted social development. The same interplay between social and emotional skills, including expressions of empathy, has received scant attention in other primates however, despite the growing interest in c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clay Z,de Waal FB

更新日期：2013-11-05 00:00:00

abstract：:Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute to the inflammatory response associated with autoimmune diseases. Transforming growth factor beta 1 (TGF-beta 1) counteracts many effects of these cytokines and has various immunosuppressive properties. In the present study, it is shown tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuruvilla AP,Shah R,Hochwald GM,Liggitt HD,Palladino MA,Thorbecke GJ

更新日期：1991-04-01 00:00:00

abstract：:Preferential phosphorylation of specific proteins by cAMP-dependent protein kinase (PKA) may be mediated in part by the anchoring of PKA to a family of A-kinase anchor proteins (AKAPs) positioned in close proximity to target proteins. This interaction is thought to depend on binding of the type II regulatory (RII) sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burton KA,Johnson BD,Hausken ZE,Westenbroek RE,Idzerda RL,Scheuer T,Scott JD,Catterall WA,McKnight GS

更新日期：1997-09-30 00:00:00

abstract：:We describe preliminary studies of the pharmacokinetics, biodistribution, and excretion of an oligodeoxy-nucleotide phosphorothioate ([S]oligonucleotide) in mice. After either intravenous or intraperitoneal administration of a single dose (30 mg/kg of body weight), [S]oligonucleotide (35S-labeled at each internucleoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal S,Temsamani J,Tang JY

更新日期：1991-09-01 00:00:00

abstract：:A scientist may publish tens or hundreds of papers over a career, but these contributions are not evenly spaced in time. Sixty years of studies on career productivity patterns in a variety of fields suggest an intuitive and universal pattern: Productivity tends to rise rapidly to an early peak and then gradually decli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Way SF,Morgan AC,Clauset A,Larremore DB

更新日期：2017-10-31 00:00:00

abstract：:Online education is rapidly expanding in response to rising demand for higher and continuing education, but many online students struggle to achieve their educational goals. Several behavioral science interventions have shown promise in raising student persistence and completion rates in a handful of courses, but evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kizilcec RF,Reich J,Yeomans M,Dann C,Brunskill E,Lopez G,Turkay S,Williams JJ,Tingley D

更新日期：2020-06-30 00:00:00

abstract：:Aliphatic hydrocarbons such as fatty alcohols and petroleum-derived alkanes have numerous applications in the chemical industry. In recent years, the renewable synthesis of aliphatic hydrocarbons has been made possible by engineering microbes to overaccumulate fatty acids. However, to generate end products with the de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akhtar MK,Turner NJ,Jones PR

更新日期：2013-01-02 00:00:00

abstract：:An established line of mouse fibroblasts, C3H/10T1/2 cells, was used for the assessment in vitro of oncogenic transformations caused by single and split doses of x-rays. The shape of the dose-response relationship was determined over the range from 0.1 to 10 Gy. It was found that splitting the x-ray dose into two equa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller RC,Hall EJ,Rossi HH

更新日期：1979-11-01 00:00:00

abstract：:The ability to integrate visual information over space is a fundamental component of human pattern vision. Regardless of whether it is for detecting luminance contrast or for recognizing objects in a cluttered scene, the position of the target in the visual field governs the size of a window within which visual inform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon M,Liu R

更新日期：2019-02-26 00:00:00

abstract：:Aberrant glycosylation and the overexpression of certain carbohydrate moieties is a consistent feature of cancers, and tumor-associated oligosaccharides are actively investigated as targets for immunotherapy. One of the most common aberrations in glycosylation patterns is the presentation of a single O-linked N-acetyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks CL,Schietinger A,Borisova SN,Kufer P,Okon M,Hirama T,Mackenzie CR,Wang LX,Schreiber H,Evans SV

更新日期：2010-06-01 00:00:00

abstract：:Fibroblasts cultured from the skin of a patient with metachromatic leukodystrophy have been found to manifest the biochemical defect of this inborn error of metabolism, a deficiency of arylsulfatase A. Diseased cells had less than five per cent of normal arylsulfatase-A activity, while activities of other lysosomal en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter MT,Fluharty AL,Kihara H

更新日期：1969-03-01 00:00:00

abstract：:The location of phosphate residues involved in specific centers for binding of metal ions in M1 RNA, the catalytic RNA subunit of RNase P from Escherichia coli, was determined by analysis of induction of cleavage of RNA by metal ions. At pH 9.5, Mg2+ catalyzes cleavage of M1 RNA at five principal sites. Under certain ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kazakov S,Altman S

更新日期：1991-10-15 00:00:00

abstract：:The 5' end of a eukaryotic mRNA transcript generally has a 7-methylguanosine (m7G) cap that protects mRNA from degradation and mediates almost all other aspects of gene expression. Some RNAs in Escherichia coli, yeast, and mammals were recently found to contain an NAD+ cap. Here, we report the development of the metho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Zhong H,Zhang S,Shao X,Ni M,Cai Z,Chen X,Xia Y

更新日期：2019-06-11 00:00:00

abstract：:Glutamate release activates multiple receptors that interact with each other and thus determine the response of the cell. Exploring these interactions is critical to developing an understanding of the functional consequences of synaptic transmission. Activation of metabotropic glutamate receptors (mGluRs) inhibits N-m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colwell CS,Altemus KL,Cepeda C,Levine MS

更新日期：1996-02-06 00:00:00

abstract：:Biologists regularly search databases of DNA or protein sequences for evolutionary or functional relationships to a given query sequence. We describe a ranking algorithm that exploits the entire network structure of similarity relationships among proteins in a sequence database by performing a diffusion operation on a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weston J,Elisseeff A,Zhou D,Leslie CS,Noble WS

更新日期：2004-04-27 00:00:00

abstract：:The idea that the first living systems on earth were based on self-replicating RNA molecules has recently become popular as a result of the discovery of ribozymes. However, there are several major problems associated with the prebiotic synthesis of ribonucleotides. In addition, there is the newly recognized problem of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joyce GF,Schwartz AW,Miller SL,Orgel LE

更新日期：1987-07-01 00:00:00

abstract：:A single anterior-animal blastomere, which includes the presumptive neural region in the eight-cell embryo of the Halocynthia, a protochordate, when dissociated, cleavage-arrested with cytochalasin B, and cultured in isolation, differentiated exclusively to epidermal type judging from membrane excitability and immunor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okado H,Takahashi K

更新日期：1988-08-01 00:00:00

abstract：:For the polypentapeptide of elastin, (L-Val-L-Pro-Gly-L-Val-Gly)n, and appropriate analogs when suitably cross-linked, it has been previously demonstrated that development of elastomeric force at fixed length and length changes at fixed load occur as the result of an inverse temperature transition, with the temperatur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urry DW,Haynes B,Zhang H,Harris RD,Prasad KU

更新日期：1988-05-01 00:00:00

abstract：:Temporal patterning of biological variables, in the form of oscillations and rhythms on many time scales, is ubiquitous. Altering the temporal pattern of an input variable greatly affects the output of many biological processes. We develop here a conceptual framework for a quantitative understanding of such pattern de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brezina V,Orekhova IV,Weiss KR

更新日期：1997-09-16 00:00:00

abstract：:Vasopressin's action in renal cells to regulate water transport depends on protein phosphorylation. Here we used mass spectrometry-based quantitative phosphoproteomics to identify signaling pathways involved in the short-term V2-receptor-mediated response in cultured collecting duct cells (mpkCCD) from mouse. Using St...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rinschen MM,Yu MJ,Wang G,Boja ES,Hoffert JD,Pisitkun T,Knepper MA

更新日期：2010-02-23 00:00:00

abstract：:Previously we reported that pretreatment of rats with the substance P (SP) antagonist CP-96,345 inhibits the enterotoxic responses following administration of toxin A from Clostridium difficile into ileal loops, indicating that SP participates in the intestinal responses to this toxin. We now report that injection of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castagliuolo I,Keates AC,Qiu B,Kelly CP,Nikulasson S,Leeman SE,Pothoulakis C

更新日期：1997-04-29 00:00:00

abstract：:Coatomer, the coat protein of coat protein complex (COP)I-vesicles, is a soluble protein complex made up of seven subunits, alpha-, beta-, beta'-, gamma-, delta-, epsilon-, and zeta-COP. Higher eukaryotes have two paralogous versions of the gamma- and zeta- subunits, termed gamma1- and gamma2-COP and zeta1- and zeta2-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moelleken J,Malsam J,Betts MJ,Movafeghi A,Reckmann I,Meissner I,Hellwig A,Russell RB,Söllner T,Brügger B,Wieland FT

更新日期：2007-03-13 00:00:00

abstract：:The pattern of antibody specificities in sera from patients with myasthenia gravis (MG) was determined by the ability of monoclonal antibodies against defined determinants on the acetylcholine receptor molecule to inhibit binding of the serum antibodies to receptor from human muscle. We found that MG patients produce ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzartos SJ,Seybold ME,Lindstrom JM

更新日期：1982-01-01 00:00:00

abstract：:The eukaryotic proteasome mediates degradation of polyubiquitinated proteins. Here we report the single-particle cryoelectron microscopy (cryo-EM) structures of the endogenous 26S proteasome from Saccharomyces cerevisiae at 4.6- to 6.3-Å resolution. The fine features of the cryo-EM maps allow modeling of 18 subunits i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luan B,Huang X,Wu J,Mei Z,Wang Y,Xue X,Yan C,Wang J,Finley DJ,Shi Y,Wang F

更新日期：2016-03-08 00:00:00

abstract：:A library of amphiphilic Janus dendrimers including two that are fluorescent and one glycodendrimer presenting lactose were used to construct giant dendrimersomes and glycodendrimersomes. Coassembly with the components of bacterial membrane vesicles by a dehydration-rehydration process generated giant cell-like hybrid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao Q,Yadavalli SS,Zhang S,Sherman SE,Fiorin E,da Silva L,Wilson DA,Hammer DA,André S,Gabius HJ,Klein ML,Goulian M,Percec V

更新日期：2016-03-01 00:00:00

abstract：:Coacervation is a common phenomenon in natural polymers and has been applied to synthetic materials systems for coatings, adhesives, and encapsulants. Single-component coacervates are formed when block polyampholytes exhibit self-coacervation, phase separating into a dense liquid coacervate phase rich in the polyampho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Danielsen SPO,McCarty J,Shea JE,Delaney KT,Fredrickson GH

更新日期：2019-04-23 00:00:00

abstract：:The 4D organization of the interphase nucleus, or the 4D Nucleome (4DN), reflects a dynamical interaction between 3D genome structure and function and its relationship to phenotype. We present initial analyses of the human 4DN, capturing genome-wide structure using chromosome conformation capture and 3D imaging, and f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen H,Chen J,Muir LA,Ronquist S,Meixner W,Ljungman M,Ried T,Smale S,Rajapakse I

更新日期：2015-06-30 00:00:00

abstract：:Immediately after focal retinal lesions, receptive fields (RFs) in primary visual cortex expand considerably, even when the retinal damage is limited to the photoreceptor layer. The time course of these changes suggests that mere lack of stimulation in the vicinity of the RF accompanied by stimulation in the surroundi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pettet MW,Gilbert CD

更新日期：1992-09-01 00:00:00

abstract：:Two functional domains in the primary structure of basic fibroblast growth factor (FGF) have been identified on the basis of their ability to interact with the FGF receptor, bind radiolabeled heparin, and modulate the cellular response to FGF. Peptides derived from these two functional domains can act as partial agoni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird A,Schubert D,Ling N,Guillemin R

更新日期：1988-04-01 00:00:00

abstract：:The specificity of human skin collagenase and of an enzyme from an invasive tumor were studied by using types I, II, III, IV, and V (AB) collagen as substrates. Human skin collagenase degraded types I, II, and III collagen, producing the characteristic 3/4 and 1/4 cleavage products, but failed to degrade type IV or V ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liotta LA,Abe S,Robey PG,Martin GR

更新日期：1979-05-01 00:00:00