Hippocampal, but not amygdala, activity at encoding correlates with long-term, free recall of nonemotional information.

abstract：:Accurately estimating human mobility and gauging its relationship with virus transmission is critical for the control of COVID-19 spreading. Using mobile device location data of over 100 million monthly active samples, we compute origin-destination travel demand and aggregate mobility inflow at each US county from Mar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiong C,Hu S,Yang M,Luo W,Zhang L

更新日期：2020-11-03 00:00:00

abstract：:Poly([14C]adenosine diphosphate ribose) was synthesized from [14C]NAD+ with calf thymus nuclei. The fraction containing poly(adenosine diphosphate ribose) eluted with 0.22--0.40 M phosphate buffer (pH 6.8) from a hydroxylapatite column, was completely hydrolyzed with venom phosphodiesterase, and was separated by DEAE-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miwa M,Saikawa N,Yamaizumi Z,Nishimura S,Sugimura T

更新日期：1979-02-01 00:00:00

abstract：:Papain solubilized H-2a histocompatibility antigens (H-2Kk plus H-2Dd) have been purified by a large-scale procedure that can routinely provide 2-3 mg of heavy chain from 1 kg of mouse liver. The heavy chains were homogeneous by sodium dodecyl sulfate electrophoresis. Disc gel electrophoresis resolved two protein band...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henriksen O,Robinson EA,Appella E

更新日期：1978-07-01 00:00:00

abstract：:Although NMDA receptor (NMDAR)-dependent long-term potentiation (LTP) and long-term depression (LTD) of glutamatergic transmission are candidate mechanisms for long-term spatial memory, the precise contributions of LTP and LTD remain poorly understood. Here, we report that LTP and LTD in the hippocampal CA1 region of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge Y,Dong Z,Bagot RC,Howland JG,Phillips AG,Wong TP,Wang YT

更新日期：2010-09-21 00:00:00

abstract：:Glc3Man9GlcNAc2 is the preferred substrate of the oligosaccharyltransferase of N-linked glycosylation of proteins, but nonglucosylated oligosaccharides can be transferred to proteins in Saccharomyces cerevisiae. Mutations affecting the addition of the three terminal glucose residues lead to accumulation of Man9GlcNAc2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stagljar I,te Heesen S,Aebi M

更新日期：1994-06-21 00:00:00

abstract：:Although much evidence suggests that the plasma membrane of eukaryotic cells is not homogenous, the precise architecture of this important structure has not been clear. Here we use transmission electron microscopy of plasma membrane sheets and specific probes to show that most or all plasma membrane-associated protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lillemeier BF,Pfeiffer JR,Surviladze Z,Wilson BS,Davis MM

更新日期：2006-12-12 00:00:00

abstract：:Many neurotransmitters are known to regulate neuronal cell function by means of activation of cAMP-dependent protein kinase (PKA) and phosphorylation of neuronal substrate proteins, including transcription factors and ion channels. Here, we have characterized the gene expression of two isoforms of a protein kinase inh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seasholtz AF,Gamm DM,Ballestero RP,Scarpetta MA,Uhler MD

更新日期：1995-02-28 00:00:00

abstract：:Recent studies have shown that orthotopic (transurethral) transplantation of human bladder cancer cell lines into nude mice permits tumor growth that accurately reflects their clinical malignant status in the original host. Thus, such a system allows a unique opportunity to analyze the genetic events involved in the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Theodorescu D,Cornil I,Fernandez BJ,Kerbel RS

更新日期：1990-11-01 00:00:00

abstract：:From our current understanding of the genetic basis of development and pattern formation in Drosophila and vertebrates it is commonly thought that clusters of Hox genes sculpt the morphology of animals in specific body regions. Based on Hox gene conservation throughout the animal kingdom it is proposed that these gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kmita-Cunisse M,Loosli F,Bièrne J,Gehring WJ

更新日期：1998-03-17 00:00:00

abstract：:CooA, the CO-sensing heme protein from Rhodospirillum rubrum, regulates the expression of genes that encode a CO-oxidation system, allowing R. rubrum to use CO as a sole energy source. To better understand the gas-sensing regulation mechanism used by R. rubrum CooA and its homologs in other organisms, we characterized...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark RW,Lanz ND,Lee AJ,Kerby RL,Roberts GP,Burstyn JN

更新日期：2006-01-24 00:00:00

abstract：:Midbrain dopamine neurons play central roles in reward processing. It is widely assumed that all dopamine neurons encode the same information. Some evidence, however, suggests functional differences between subgroups of dopamine neurons, particularly with respect to processing nonrewarding, aversive stimuli. To direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brischoux F,Chakraborty S,Brierley DI,Ungless MA

更新日期：2009-03-24 00:00:00

abstract：:Protein tyrosine phosphatase (PTP)σ (PTPRS) was shown previously to be associated with susceptibility to inflammatory bowel disease (IBD). PTPσ(-/-) mice exhibit an IBD-like phenotype in the intestine and show increased susceptibility to acute models of murine colitis. However, the function of PTPσ in the intestine is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murchie R,Guo CH,Persaud A,Muise A,Rotin D

更新日期：2014-01-14 00:00:00

abstract：:Most marine organisms disperse via ocean currents as larvae, so it is often assumed that larval-stage duration is the primary determinant of geographic range size. However, empirical tests of this relationship have yielded mixed results, and alternative hypotheses have rarely been considered. Here we assess the relati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luiz OJ,Allen AP,Robertson DR,Floeter SR,Kulbicki M,Vigliola L,Becheler R,Madin JS

更新日期：2013-10-08 00:00:00

abstract：:It has been found that the mutator phenotype of the recA441 and recA730 strains that express the SOS response constitutively is suppressed by pIP1, a high-copy plasmid carrying the dnaQ gene encoding the 3'----5' exonuclease subunit (epsilon) of DNA polymerase III. We have constructed plasmid pIP11, in which the dnaQ ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jonczyk P,Fijalkowska I,Ciesla Z

更新日期：1988-12-01 00:00:00

abstract：:The requirement for protein synthesis in the mechanism of a circadian pacemaker was investigated by using inhibitors of protein synthesis. Continuous treatment of the ocular circadian pacemaker of the mollusc Bulla gouldiana with anisomycin or cycloheximide substantially lengthened (up to 39 and 52 hr, respectively) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khalsa SB,Whitmore D,Block GD

更新日期：1992-11-15 00:00:00

abstract：:Plants have intercellular channels, plasmodesmata (PD), that span the cell wall to enable cell-to-cell transport of micro- and macromolecules. We identified an Arabidopsis thaliana embryo lethal mutant increased size exclusion limit 1 (ise1) that results in increased PD-mediated transport of fluorescent tracers. The i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stonebloom S,Burch-Smith T,Kim I,Meinke D,Mindrinos M,Zambryski P

更新日期：2009-10-06 00:00:00

abstract：:More than a thousand proteins are thought to contribute to mammalian chromatin and its regulation, but our understanding of the genomic occupancy and function of most of these proteins is limited. Here we describe an approach, which we call "chromatin proteomic profiling," to identify proteins associated with genomic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ji X,Dadon DB,Abraham BJ,Lee TI,Jaenisch R,Bradner JE,Young RA

更新日期：2015-03-24 00:00:00

abstract：:High-valent iron-oxo species are thought to be intermediates in the catalytic cycles of oxygenases and peroxidases. An attractive route to these iron-oxo intermediates involves laser flash-quench oxidation of ferric hemes, as demonstrated by our work on the ferryl (compound II) and ferryl porphyrin radical cation (com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ener ME,Lee YT,Winkler JR,Gray HB,Cheruzel L

更新日期：2010-11-02 00:00:00

abstract：:Uropathogenic Escherichia coli invade bladder epithelial cells (BECs) by direct entry into specialized cAMP regulated exocytic compartments. Remarkably, a significant number of these intracellular bacteria are subsequently expelled in a nonlytic and piecemeal fashion by infected BECs. Here, we report that expulsion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song J,Bishop BL,Li G,Grady R,Stapleton A,Abraham SN

更新日期：2009-09-01 00:00:00

abstract：:Serotonin (5-HT) plays a critical role in modulating synaptic plasticity in the marine mollusc Aplysia and in the mammalian nervous system. In Aplysia sensory neurons, 5-HT can activate several signal cascades, including PKA and PKC, presumably via distinct types of G protein-coupled receptors. However, the molecular ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee YS,Choi SL,Lee SH,Kim H,Park H,Lee N,Lee SH,Chae YS,Jang DJ,Kandel ER,Kaang BK

更新日期：2009-08-25 00:00:00

abstract：:The transmembrane precursor of tumor necrosis factor-alpha (TNF) exits the trans-Golgi network (TGN) in tubular carriers for subsequent trafficking and delivery to the cell surface; however, the molecular machinery responsible for Golgi export is unknown. We previously reported that members of the TGN golgin family ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lieu ZZ,Lock JG,Hammond LA,La Gruta NL,Stow JL,Gleeson PA

更新日期：2008-03-04 00:00:00

abstract：:Neutrinos represent a new "window" to the Universe, spanning a large range of energy. We discuss the science of neutrino astrophysics and focus on two energy regimes. At "lower" energies ( approximately 1 MeV), studies of neutrinos born inside the sun, or produced in interactions of cosmic rays with the atmosphere, ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Besson D,Cowen D,Selen M,Wiebusch C

更新日期：1999-12-07 00:00:00

abstract：:We have previously demonstrated in a series of searches for antithrombotic agents that diadenosine 5',5"'-P1,P4-tetraphosphate (AppppA) and its analogues are competitive inhibitors of ADP-induced platelet aggregation. Among various analogues, the P2,P3-monochloromethylene analog of AppppA (AppCHClppA) is superior to u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan SW,Gallo SJ,Kim BK,Guo MJ,Blackburn GM,Zamecnik PC

更新日期：1997-04-15 00:00:00

abstract：:The dominant insulin-stimulated ribosomal protein S6 kinase activity was purified to near homogeneity from insulin-treated 32P-labeled rat H4 hepatoma cells and found to copurify with a 70-kDa 32P-labeled polypeptide. The dominant S6 kinase purified from livers of cycloheximide-treated rats is also a 70-kDa polypeptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price DJ,Gunsalus JR,Avruch J

更新日期：1990-10-01 00:00:00

abstract：:The endodermis acts as a "second skin" in plant roots by providing the cellular control necessary for the selective entry of water and solutes into the vascular system. To enable such control, Casparian strips span the cell wall of adjacent endodermal cells to form a tight junction that blocks extracellular diffusion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hosmani PS,Kamiya T,Danku J,Naseer S,Geldner N,Guerinot ML,Salt DE

更新日期：2013-08-27 00:00:00

abstract：:Photoadaptation, the ability to attenuate a light response on prolonged light exposure while remaining sensitive to escalating changes in light intensity, is essential for organisms to decipher time information appropriately, yet the underlying molecular mechanisms are poorly understood. In Neurospora crassa, VIVID (V...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen CH,DeMay BS,Gladfelter AS,Dunlap JC,Loros JJ

更新日期：2010-09-21 00:00:00

abstract：:The 5'-phosphoinositol phosphatase SHIP negatively regulates signaling pathways triggered by antigen, cytokine and Fc receptors in both lymphocytes and myeloid cells. Mice with germ-line (null) deletion of SHIP develop a myeloproliferative-like syndrome that causes early lethality. Lymphocyte anomalies have been obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tarasenko T,Kole HK,Chi AW,Mentink-Kane MM,Wynn TA,Bolland S

更新日期：2007-07-03 00:00:00

abstract：:Since at least T. H. Marshall, scholars have recognized military service as a form of sacrifice that warrants compensation from the state. War-widow pensions, expansion of the franchise, and subsidized higher education are all examples of rights and benefits "bestowed" in return for wartime mobilization. Similarly, in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johnson T,Conley D

更新日期：2019-10-22 00:00:00

abstract：:Control over the fluorescence of supramolecular assemblies is crucial for the development of chemosensors and light-emitting materials. Consequently, the postsynthetic modification of supramolecular structures via host-guest interactions has emerged as an efficient strategy in recent years that allows the facile tunin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang M,Yin S,Zhang J,Zhou Z,Saha ML,Lu C,Stang PJ

更新日期：2017-03-21 00:00:00

abstract：:The effects of three anti-inflammatory drugs, which interfere with arachidonic acid transformation by three different enzymes, have been compared by using a simple model of tissue damage and foreign body rejection. In groups of control rats, subcutaneously implanted polyester sponges were rejected after a mean of 12 d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higgs GA,Mugridge KG,Moncada S,Vane JR

更新日期：1984-05-01 00:00:00