Homeobox genes in the ribbonworm Lineus sanguineus: evolutionary implications.

abstract：:The ability to analyze and isolate cells based on the expression of specific surface markers has increased our understanding of cell biology and produced numerous applications for biomedicine. However, established cell-sorting platforms rely on labels that are limited in number due to biophysical constraints, such as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahotre SN,Chang YM,Wieland A,Stammen SR,Kwong GA

更新日期：2018-04-24 00:00:00

abstract：:Mitogen-activated protein (MAP) kinases are central components of signal transduction pathways for cell proliferation, stress responses, and differentiation. Signaling efficiency and specificity are modulated in large part by docking interactions between individual MAP kinase and the kinase interaction motif (KIM), (R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Sun JP,Zhou B,Zhang ZY

更新日期：2006-04-04 00:00:00

abstract：:The relative stabilities and structural properties of a representative set of 20 ALS-mutant Cu,Zn-superoxide dismutase apoproteins were examined by using differential scanning calorimetry and hydrogen-deuterium (H/D) exchange followed by MS. Contrary to recent reports from other laboratories, we found that ALS-mutant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez JA,Shaw BF,Durazo A,Sohn SH,Doucette PA,Nersissian AM,Faull KF,Eggers DK,Tiwari A,Hayward LJ,Valentine JS

更新日期：2005-07-26 00:00:00

abstract：:The hepatic pigment accumulated in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated rats, which has been reported to inhibit ferrochelatase, has been isolated and purified. The pigment has been resolved into one major, one minor, and two trace components, all of which appear to be isomeric porphyrins. The major fract...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ortiz de Montellano PR,Beilan HS,Kunze KL

更新日期：1981-03-01 00:00:00

abstract：:Children whose parents divorce tend to have worse educational outcomes than children whose parents stay married. However, not all children respond identically to their parents divorcing. We focus on how the impact of parental divorce on children's education varies by how likely or unlikely divorce was for those parent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brand JE,Moore R,Song X,Xie Y

更新日期：2019-04-09 00:00:00

abstract：:Transgenic pigs were generated that produced human protein C in their milk at up to 1 g/liter. The gene construct was a fusion gene consisting of the cDNA for human protein C inserted into the first exon of the mouse whey acidic protein gene. These results demonstrate that the mouse whey acidic protein gene contains r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Velander WH,Johnson JL,Page RL,Russell CG,Subramanian A,Wilkins TD,Gwazdauskas FC,Pittius C,Drohan WN

更新日期：1992-12-15 00:00:00

abstract：:Hox genes are located in highly conserved clusters. The significance of this organization is unclear, but one possibility is that regulatory regions for individual genes are dispersed throughout the cluster and shared with other Hox genes. This hypothesis is supported by studies on several Hox genes in which even larg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bradshaw MS,Shashikant CS,Belting HG,Bollekens JA,Ruddle FH

更新日期：1996-03-19 00:00:00

abstract：:The nuclear receptor Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII) is an important coordinator of glucose homeostasis through its function in different organs such as the endocrine pancreas, adipose tissue, skeletal muscle, and liver. Recently we have demonstrated that COUP-TFII expression in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sabra-Makke L,Maritan M,Planchais J,Boutant M,Pégorier JP,Even PC,Vasseur-Cognet M,Bossard P

更新日期：2013-03-12 00:00:00

abstract：:Phenotypic capacitance refers to the ability of a genome to accumulate mutations that are conditionally hidden and only reveal phenotype-altering effects after certain environmental or genetic changes. Capacitance has important implications for the evolution of novel forms and functions, but experimentally studied mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hayden EJ,Bendixsen DP,Wagner A

更新日期：2015-10-06 00:00:00

abstract：:Uncoupling protein 1 (UCP1) catalyzes fatty acid-activated, purine nucleotide-sensitive proton leak across the mitochondrial inner membrane of brown adipose tissue to produce heat, and could help combat obesity and metabolic disease in humans. Studies over the last 30 years conclude that the protein is a dimer, bindin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee Y,Willers C,Kunji ER,Crichton PG

更新日期：2015-06-02 00:00:00

abstract：:Glucocorticoids rapidly and completely inhibit intracellular plasminogen activator activity in rat hepatoma cells, as assayed by the solubilization of 125I-labeled fibrin. Experiments in which extracts of dexamethasone-treated cells are mixed with extracts of control cells demonstrate an inhibitor of protease activity...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seifert SC,Gelehrter TD

更新日期：1978-12-01 00:00:00

abstract：:The DEMETER (DME) DNA glycosylase initiates active DNA demethylation via the base-excision repair pathway and is vital for reproduction in Arabidopsis thaliana DME-mediated DNA demethylation is preferentially targeted to small, AT-rich, and nucleosome-depleted euchromatic transposable elements, influencing expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park JS,Frost JM,Park K,Ohr H,Park GT,Kim S,Eom H,Lee I,Brooks JS,Fischer RL,Choi Y

更新日期：2017-02-21 00:00:00

abstract：:Sixteen hybridomas have been identified that secrete antibodies specific to horizontal cells in the carp retina. The hybridomas have been classified into three groups based on their antibody staining patterns: group I, staining associated with all horizontal cells; group II, staining associated with the most abundant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young LH,Dowling JE

更新日期：1984-10-01 00:00:00

abstract：:Dendritic spines receive most synaptic inputs in the forebrain. Their morphology, with a spine head isolated from the dendrite by a slender neck, indicates a potential role in isolating inputs. Indeed, biochemical compartmentalization occurs at spine heads because of the diffusional bottleneck created by the spine nec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araya R,Jiang J,Eisenthal KB,Yuste R

更新日期：2006-11-21 00:00:00

abstract：:Rickettsiae are responsible for some of the most devastating human infections. A high infectivity and severe illness after inhalation make some rickettsiae bioterrorism threats. We report that deletion of the exchange protein directly activated by cAMP (Epac) gene, Epac1, in mice protects them from an ordinarily letha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gong B,Shelite T,Mei FC,Ha T,Hu Y,Xu G,Chang Q,Wakamiya M,Ksiazek TG,Boor PJ,Bouyer DH,Popov VL,Chen J,Walker DH,Cheng X

更新日期：2013-11-26 00:00:00

abstract：:We developed a method for rapidly generating thermostable enzyme variants. Our strategy is to introduce the gene coding for a given enzyme from a mesophilic organism into a thermophile, Bacillus stearothermophilus. Variants that retain the enzymatic activity at the higher growth temperatures of the thermophile are the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liao H,McKenzie T,Hageman R

更新日期：1986-02-01 00:00:00

abstract：:L-2-hydroxyglutarate (L-2HG) has emerged as a putative oncometabolite that is capable of inhibiting enzymes involved in metabolism, chromatin modification, and cell differentiation. However, despite the ability of L-2HG to interfere with a broad range of cellular processes, this molecule is often characterized as a me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Chawla G,Hurlburt AJ,Sterrett MC,Zaslaver O,Cox J,Karty JA,Rosebrock AP,Caudy AA,Tennessen JM

更新日期：2017-02-07 00:00:00

abstract：:To test the hypothesis that periodic signals and chemotaxis direct later morphogenesis in Dictyostelium discoideum, we investigated cell behavior and cell movement in slugs. Trails of neutral red-stained prestalk and anterior-like cells were recorded by high-resolution digital image processing. Neutral red-stained ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siegert F,Weijer CJ

更新日期：1992-07-15 00:00:00

abstract：:The in situ stimulation of Fe(III) oxide reduction by Geobacter bacteria leads to the concomitant precipitation of hexavalent uranium [U(VI)] from groundwater. Despite its promise for the bioremediation of uranium contaminants, the biological mechanism behind this reaction remains elusive. Because Fe(III) oxide reduct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cologgi DL,Lampa-Pastirk S,Speers AM,Kelly SD,Reguera G

更新日期：2011-09-13 00:00:00

abstract：:Amplitude-modulated phosphorescence/microwave double-resonance (AM-PMDR) spectra are reported for complexes of methylmercury(II) cation, designated CH3Hg(II), with tryptophan and glyceraldehyde-3-phosphate dehydrogenase (GPDHase; from rabbit muscle). Wavelength shifts are observed in the AM-PMDR spectra of CH3Hg(II)-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis JM,Maki AH

更新日期：1982-07-01 00:00:00

abstract：:Molecular imaging probes have potential for in vivo identification of apoptosis and other intracellular processes. TcapQ, a cell-penetrating, near-infrared fluorescent peptide probe designed to be optically silent through intramolecular fluorescence quenching and activated by effector caspases, has been previously des...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnett EM,Zhang X,Maxwell D,Chang Q,Piwnica-Worms D

更新日期：2009-06-09 00:00:00

abstract：:Understanding the molecular determinants of specificity in protein-protein interaction is an outstanding challenge of postgenome biology. The availability of large protein databases generated from sequences of hundreds of bacterial genomes enables various statistical approaches to this problem. In this context covaria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weigt M,White RA,Szurmant H,Hoch JA,Hwa T

更新日期：2009-01-06 00:00:00

abstract：:The rate of Cl- secretion by human airway epithelium is determined, in part, by apical cell membrane Cl- conductance. In cystic fibrosis airway epithelia, defective regulation of Cl- conductance decreases the capability to secrete Cl-. Here we report that extracytosolic ATP in the luminal bath of cultured human airway...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stutts MJ,Chinet TC,Mason SJ,Fullton JM,Clarke LL,Boucher RC

更新日期：1992-03-01 00:00:00

abstract：:The mechanisms underlying analgesia related to social touch are not clear. While recent research highlights the role of the empathy of the observer to pain relief in the target, the contribution of social interaction to analgesia is unknown. The current study examines brain-to-brain coupling during pain with interpers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein P,Weissman-Fogel I,Dumas G,Shamay-Tsoory SG

更新日期：2018-03-13 00:00:00

abstract：:Micrometeorites with diameter approximately 100-200 microm dominate the flux of extraterrestrial matter on Earth. The vast majority of micrometeorites are chemically, mineralogically, and isotopically related to carbonaceous chondrites, which amount to only 2.5% of meteorite falls. Here, we report the discovery of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gounelle M,Chaussidon M,Morbidelli A,Barrat JA,Engrand C,Zolensky ME,McKeegan KD

更新日期：2009-04-28 00:00:00

abstract：:Recent evidence indicates there is a role for small membrane vesicles, including exosomes, as vehicles for intercellular communication. Exosomes secreted by most cell types can mediate transfer of proteins, mRNAs, and microRNAs, but their role in the transmission of infectious agents is less established. Recent studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnaiah V,Thumann C,Fofana I,Habersetzer F,Pan Q,de Ruiter PE,Willemsen R,Demmers JA,Stalin Raj V,Jenster G,Kwekkeboom J,Tilanus HW,Haagmans BL,Baumert TF,van der Laan LJ

更新日期：2013-08-06 00:00:00

abstract：:Evidence is presented for the simultaneous release of platelet-activating factor (PAF-acether) and of its deacetylated derivative (lyso-PAF-acether) from hog leukocytes. On the basis of spectroscopy and chemical reactions, the structure of O-deacetyl-PAF is shown to be 1-O-alkylglyceryl 3-phosphorylcholine, an alkyl e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polonsky J,Tencé M,Varenne P,Das BC,Lunel J,Benveniste J

更新日期：1980-12-01 00:00:00

abstract：:In an investigation to determine how proteins are localized within the nucleus of a cell, we demonstrate that the restriction endonuclease EcoRI is able to enter and function within the nucleus of Saccharomyces cerevisiae when this prokaryotic protein is synthesized in vivo. The EcoRI endonuclease was produced in yeas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnes G,Rine J

更新日期：1985-03-01 00:00:00

abstract：:Rat serine dehydratase cDNA clones were isolated from a lambda gt11 cDNA library on the basis of their reactivity with monospecific immunoglobulin to the purified enzyme. Using the cDNA insert from a clone that encoded the serine dehydratase subunit as a probe, additional clones were isolated from the same library by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogawa H,Miller DA,Dunn T,Su Y,Burcham JM,Peraino C,Fujioka M,Babcock K,Pitot HC

更新日期：1988-08-01 00:00:00

abstract：:The core protein of a small chondroitin/dermatan sulfate proteoglycan expressed by human fibroblasts and present in extracellular matrices in association with collagen has been cloned from a lambda gt11 fibroblast cDNA library. cDNA clones were isolated by use of antibodies specific for the intact proteoglycan and ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krusius T,Ruoslahti E

更新日期：1986-10-01 00:00:00