Primary structure of an extracellular matrix proteoglycan core protein deduced from cloned cDNA.

abstract：:The concept of gametic isolation has its origins in the 1937 edition of T. Dobzhansky's Genetics and the Origin of Species. Involving either positive assortative fertilization (as opposed to self-incompatibility) or negative assortative fertilization, it occurs after mating but prior to fertilization. Gametic isolatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markow TA

更新日期：1997-07-22 00:00:00

abstract：:Inositol polyphosphate 4-phosphatase (4-phosphatase) is an enzyme that catalyses the hydrolysis of the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P2]. In human platelets the formation of this phosphatidylinositol, by the actions of phosphatidylinositol 3-kinase (PI 3-kinase), correlate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Munday AD,Norris FA,Caldwell KK,Brown S,Majerus PW,Mitchell CA

更新日期：1999-03-30 00:00:00

abstract：:Eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) were isolated from lysates of human eosinophil granules by gel filtration and ion exchange chromatography on heparin-Sepharose. Radioimmunoassay, using monoclonal antibodies, of fractions from the heparin-Sepharose chromatography showed one peak...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gleich GJ,Loegering DA,Bell MP,Checkel JL,Ackerman SJ,McKean DJ

更新日期：1986-05-01 00:00:00

abstract：:A monomorphic anti-HLA-G monoclonal antibody (mAb) was obtained by immunization of HLA-B27/human beta 2-microglobulin double-transgenic mice with transfected murine L cells expressing both HLA-G and human beta 2-microglobulin. This mAb, designated BFL.1, specifically recognizes, by flow cytometry analysis, the immuniz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bensussan A,Mansur IG,Mallet V,Rodriguez AM,Girr M,Weiss EH,Brem G,Boumsell L,Gluckman E,Dausset J

更新日期：1995-10-24 00:00:00

abstract：:Clostridium difficile, a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The level of toxin production appears to be critical for determining the seve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mani N,Dupuy B

更新日期：2001-05-08 00:00:00

abstract：:The interaction of interleukin 8 (IL-8) with heparin was studied by using synthetic IL-8 analogs with C- and N-terminal truncations. Elimination of the N-terminal region preceding the first cysteine, which constitutes the IL-8 receptor binding site, did not affect the affinity to heparin-Sepharose. Affinity, however, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Webb LM,Ehrengruber MU,Clark-Lewis I,Baggiolini M,Rot A

更新日期：1993-08-01 00:00:00

abstract：:Hoxb13 is robustly transcribed in derivatives of posterior endoderm including the colon, rectum, and the prostate gland. Transcriptional activity in the prostate persists unabated under conditions of androgen deprivation and throughout the course of disease progression in a mouse prostate cancer model. To elucidate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMullin RP,Dobi A,Mutton LN,Orosz A,Maheshwari S,Shashikant CS,Bieberich CJ

更新日期：2010-01-05 00:00:00

abstract：:Efficient execution of perceptual-motor tasks requires rapid voluntary reconfiguration of cognitive task sets as circumstances unfold. Such acts of cognitive control, which are thought to rely on a network of cortical regions in prefrontal and posterior parietal cortex, include voluntary shifts of attention among perc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esterman M,Chiu YC,Tamber-Rosenau BJ,Yantis S

更新日期：2009-10-20 00:00:00

abstract：:A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li JZ,Bunney BG,Meng F,Hagenauer MH,Walsh DM,Vawter MP,Evans SJ,Choudary PV,Cartagena P,Barchas JD,Schatzberg AF,Jones EG,Myers RM,Watson SJ Jr,Akil H,Bunney WE

更新日期：2013-06-11 00:00:00

abstract：:In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the inability to detect dehydroepiandrosterone synthase, P45017alpha. In adult male rat hippocampal formation, significant localization was demonstrated for both cytochromes P45017alpha and P450 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hojo Y,Hattori TA,Enami T,Furukawa A,Suzuki K,Ishii HT,Mukai H,Morrison JH,Janssen WG,Kominami S,Harada N,Kimoto T,Kawato S

更新日期：2004-01-20 00:00:00

abstract：:Electron microscopy is arguably the most powerful tool for spatial imaging of structures. As such, 2D and 3D microscopies provide static structures with subnanometer and increasingly with angstrom-scale spatial resolution. Here we report the development of 4D ultrafast electron microscopy, whose capability imparts ano...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lobastov VA,Srinivasan R,Zewail AH

更新日期：2005-05-17 00:00:00

abstract：:Many native proteins occasionally form partially unfolded forms (PUFs), which can be detected by hydrogen/deuterium exchange and NMR spectroscopy. Knowledge about these metastable states is required to better understand the onset of folding-related diseases. So far, not much is known about where PUFs reside within the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bollen YJ,Kamphuis MB,van Mierlo CP

更新日期：2006-03-14 00:00:00

abstract：:Most organisms are evolutionary conservatives; they may subdivide their niches but tend to remain within them. Yet the fossil record shows many cases of breakthrough to a new mode of life. How may such evolutionary innovation be recognized at this time level? Three species of Drosophila have accomplished an innovation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carson HL

更新日期：1974-09-01 00:00:00

abstract：:It has been reported that expression of familial amyotrophic lateral sclerosis (FALS)-associated mutant Cu/Zn superoxide dismutase-1 (SOD) induces apoptosis of neuronal cells in culture associated with an increase in reactive oxygen species. SOD recently has been shown to prevent calcineurin inactivation, initiating t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JP,Palfrey HC,Bindokas VP,Ghadge GD,Ma L,Miller RJ,Roos RP

更新日期：1999-03-16 00:00:00

abstract：:Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation through the acetylation of cyclooxygenase II. These aspirin-triggered lipoxins (ATL) may mediate some of ASA's beneficial actions and therefore are of interest in the search...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clish CB,O'Brien JA,Gronert K,Stahl GL,Petasis NA,Serhan CN

更新日期：1999-07-06 00:00:00

abstract：:Facial expressions of emotion in humans are believed to be produced by contracting one's facial muscles, generally called action units. However, the surface of the face is also innervated with a large network of blood vessels. Blood flow variations in these vessels yield visible color changes on the face. Here, we stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benitez-Quiroz CF,Srinivasan R,Martinez AM

更新日期：2018-04-03 00:00:00

abstract：:Activation of JAK2 by chromosomal translocation or point mutation is a recurrent event in hematopoietic malignancies, including acute leukemias and myeloproliferative disorders. Although the effects of activated JAK2 signaling have been examined in cell lines and murine models, the functional consequences of deregulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kennedy JA,Barabé F,Patterson BJ,Bayani J,Squire JA,Barber DL,Dick JE

更新日期：2006-11-07 00:00:00

abstract：:The ovaries of the mosquito Aedes aegypti cultured in vitro secrete material that behaves like ecdysone in a radioimmunoassay. The material was identified as alpha-ecdysone by high-resolution liquid and gas-liquid chromatography. Secretion reached a maximum 16 hr after a blood meal as shown by bioassay and direct dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagedorn HH,O'Connor JD,Fuchs MS,Sage B,Schlaeger DA,Bohm MK

更新日期：1975-08-01 00:00:00

abstract：:Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition. We show here that Lewy bodies and Lewy neurites from Parkinson's disease and dementia with Lewy bodies are stai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spillantini MG,Crowther RA,Jakes R,Hasegawa M,Goedert M

更新日期：1998-05-26 00:00:00

abstract：:Inducer-mediated murine erythroleukemia cell (MELC) differentiation provides a model for examining factors determining terminal cell differentiation. The nuclear protein, p53, has been implicated as a potential determinant of cell cycle progression and cell differentiation. In this study p53 content and synthesis, dur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen DW,Real FX,DeLeo AB,Old LJ,Marks PA,Rifkind RA

更新日期：1983-10-01 00:00:00

abstract：:Human beings differ in their ability to master the sounds of their second language (L2). Phonetic training studies have proposed that differences in phonetic learning stem from differences in psychoacoustic abilities rather than speech-specific capabilities. We aimed at finding the origin of individual differences in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Díaz B,Baus C,Escera C,Costa A,Sebastián-Gallés N

更新日期：2008-10-21 00:00:00

abstract：:Successful treatment in allergic, autoimmune, and infectious diseases often requires altering the nature of a detrimental immune response mediated by a particular CD4+ T helper (Th) cell subset. While several factors contribute to the development of CD4+ Th1 and Th2 cells, the requirements for switching an established...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nabors GS,Afonso LC,Farrell JP,Scott P

更新日期：1995-04-11 00:00:00

abstract：:Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C, or D, leading to dysfunction of complex II of the electron transport chain. We evaluated the ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Janeway KA,Kim SY,Lodish M,Nosé V,Rustin P,Gaal J,Dahia PL,Liegl B,Ball ER,Raygada M,Lai AH,Kelly L,Hornick JL,NIH Pediatric and Wild-Type GIST Clinic.,O'Sullivan M,de Krijger RR,Dinjens WN,Demetri GD,Antonescu CR,F

更新日期：2011-01-04 00:00:00

abstract：:Little is known about stem cell biology or the specialized environments or niches believed to control stem cell renewal and differentiation in self-renewing tissues of the body. Functional assays for stem cells are available only for hematopoiesis and spermatogenesis, and the microenvironment, or niche, for hematopoie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinohara T,Orwig KE,Avarbock MR,Brinster RL

更新日期：2001-05-22 00:00:00

abstract：:XMAP215/Dis1 family proteins positively regulate microtubule growth. Repeats at their N termini, called TOG domains, are important for this function. While TOG domains directly bind tubulin dimers, it is unclear how this interaction translates to polymerase activity. Understanding the functional roles of TOG domains i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Widlund PO,Stear JH,Pozniakovsky A,Zanic M,Reber S,Brouhard GJ,Hyman AA,Howard J

更新日期：2011-02-15 00:00:00

abstract：:T cells expressing chimeric antigen receptors (CAR T cells) have shown impressive therapeutic efficacy against leukemias and lymphomas. However, they have not been as effective against solid tumors because they become hyporesponsive ("exhausted" or "dysfunctional") within the tumor microenvironment, with decreased cyt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seo H,Chen J,González-Avalos E,Samaniego-Castruita D,Das A,Wang YH,López-Moyado IF,Georges RO,Zhang W,Onodera A,Wu CJ,Lu LF,Hogan PG,Bhandoola A,Rao A

更新日期：2019-06-18 00:00:00

abstract：:The detection of biological molecules and their interactions is a significant component of modern biomedical research. In current biosensor technologies, simultaneous detection is limited to a small number of analytes by the spectral overlap of their signals. We have developed an NMR-based xenon biosensor that capital...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spence MM,Rubin SM,Dimitrov IE,Ruiz EJ,Wemmer DE,Pines A,Yao SQ,Tian F,Schultz PG

更新日期：2001-09-11 00:00:00

abstract：:The protease encoded by the human immunodeficiency virus (HIV) processes the viral gag and gag-pol protein precursor by posttranslational cleavage. In this study we have demonstrated by site-specific mutagenesis (Asp----Thr) and by pepstatin A inhibition that the recombinant HIV protease is an aspartic-type protease. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seelmeier S,Schmidt H,Turk V,von der Helm K

更新日期：1988-09-01 00:00:00

abstract：:Severe combined immunodeficient (SCID) mice display an increased sensitivity to ionizing radiation compared with the parental, C.B-17, strain due to a deficiency in DNA double-strand break repair. The catalytic subunit of DNA-dependent protein kinase (DNA-PKCS) has previously been identified as a strong candidate for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fried LM,Koumenis C,Peterson SR,Green SL,van Zijl P,Allalunis-Turner J,Chen DJ,Fishel R,Giaccia AJ,Brown JM,Kirchgessner CU

更新日期：1996-11-26 00:00:00

abstract：:Active center fractions have been prepared from Rhodopseudomonas spheroides strain Y. (de Klerk) using the cationic detergent cetyltrimethyl ammonium bromide and light particles from bacteria grown in two media differing in iron content. Spectral properties and composition of the fractions are presented. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jolchine G,Reiss-Husson F,Kamen MD

更新日期：1969-10-01 00:00:00