Abstract:
:Successful treatment in allergic, autoimmune, and infectious diseases often requires altering the nature of a detrimental immune response mediated by a particular CD4+ T helper (Th) cell subset. While several factors contribute to the development of CD4+ Th1 and Th2 cells, the requirements for switching an established response are not understood. Here we use infection with Leishmania major as a model to investigate those requirements. We report that treatment with interleukin 12 (IL-12), in combination with the antimony-based leishmanicidal drug Pentostam, induces healing in L. major-infected mice and that healing is associated with a switch from a Th2 to a Th1 response. The data suggest that decreasing antigen levels may be required for IL-12 to inhibit a Th2 response and enhance a Th1 response. These observations are important for treatment of nonhealing forms of human leishmaniasis and also demonstrate that in a chronic infectious disease an inappropriate Th2 response can be switched to an effective Th1 response.
journal_name
Proc Natl Acad Sci U S Aauthors
Nabors GS,Afonso LC,Farrell JP,Scott Pdoi
10.1073/pnas.92.8.3142subject
Has Abstractpub_date
1995-04-11 00:00:00pages
3142-6issue
8eissn
0027-8424issn
1091-6490journal_volume
92pub_type
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