Functional heterogeneity of the four voltage sensors of a human L-type calcium channel.

abstract：:Musical training is known to modify cortical organization. Here, we show that such modifications extend to subcortical sensory structures and generalize to processing of speech. Musicians had earlier and larger brainstem responses than nonmusician controls to both speech and music stimuli presented in auditory and aud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Musacchia G,Sams M,Skoe E,Kraus N

更新日期：2007-10-02 00:00:00

abstract：:A quantum computer (QC) can operate in parallel on all its possible inputs at once, but the amount of information that can be extracted from the result is limited by the phenomenon of wave function collapse. We present a new computational model, which differs from a QC only in that the result of a measurement is the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cory DG,Fahmy AF,Havel TF

更新日期：1997-03-04 00:00:00

abstract：:Double-stranded RNA (dsRNA) recently has been shown to give rise to genetic interference in Caenorhabditis elegans and also is likely to be the basis for phenotypic cosuppression in plants in certain instances. While constructing a plasmid vector for transfection of trypanosome cells, we serendipitously discovered tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ngô H,Tschudi C,Gull K,Ullu E

更新日期：1998-12-08 00:00:00

abstract：:Life-long protection from disease through immunization can be accomplished through individual or community protection. Individual protection is the goal for vaccination against diseases that have inanimate or animal reservoirs or that pose risks for certain populations. Community protection is the goal for vaccination...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dowdle WR,Orenstein WA

更新日期：1994-03-29 00:00:00

abstract：:Overexpression of membrane proteins in Escherichia coli frequently leads to the formation of aggregates or inclusion bodies, which is undesirable for most studies. Ideally, one would like to optimize the expression conditions by monitoring simultaneously and rapidly both the amounts of properly folded and aggregated m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geertsma ER,Groeneveld M,Slotboom DJ,Poolman B

更新日期：2008-04-15 00:00:00

abstract：:The interaction of activated Ras with Raf initiates signaling cascades that contribute to a significant percentage of human tumors, suggesting that agents that specifically disrupt this interaction might have desirable chemotherapeutic properties. We used a subtractive forward two-hybrid approach to identify small mol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kato-Stankiewicz J,Hakimi I,Zhi G,Zhang J,Serebriiskii I,Guo L,Edamatsu H,Koide H,Menon S,Eckl R,Sakamuri S,Lu Y,Chen QZ,Agarwal S,Baumbach WR,Golemis EA,Tamanoi F,Khazak V

更新日期：2002-10-29 00:00:00

abstract：:Escherichia coli cells treated with toluene replicate DNA when they are provided with deoxyribonucleoside 5'-triphosphates, ATP, Mg(++), and K(+). However, when deoxycytidine 5'-triphosphate is replaced by hydroxymethyl deoxycytidine 5'-triphosphate, incorporation of nucleotides into acid-precipitable material by tolu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fleischman RA,Richardson CC

更新日期：1971-10-01 00:00:00

abstract：:Recent studies have indicated that mammalian cells contain a cytosolic protein disaggregation machinery comprised of Hsc70, DnaJ homologs, and Hsp110 proteins, the last of which acts to accelerate a rate-limiting step of nucleotide exchange of Hsc70. We tested the ability of transgenic overexpression of a Thy1 promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagy M,Fenton WA,Li D,Furtak K,Horwich AL

更新日期：2016-05-10 00:00:00

abstract：:The photoaffinity labeling agent 5-azidoindole-3-acetic acid, an analog of the endogenous plant hormone indole-3-acetic acid (an auxin), was used to identify indole-3-acetic acid-binding proteins in maize. Two peptides with subunit molecular masses of 24 and 22 kilodaltons are specifically labeled in a saturable manne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones AM,Venis MA

更新日期：1989-08-01 00:00:00

abstract：:Colon carcinoma is one of the leading causes of death from cancer and is characterized by a heterogenic pool of cells with distinct differentiation patterns. Recently, it was reported that a population of undifferentiated cells from a primary tumor, so-called cancer stem cells (CSC), can reconstitute the original tumo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vermeulen L,Todaro M,de Sousa Mello F,Sprick MR,Kemper K,Perez Alea M,Richel DJ,Stassi G,Medema JP

更新日期：2008-09-09 00:00:00

abstract：:In all three domains of life, DNA replication begins at specialized loci termed replication origins. In bacteria, replication initiates from a single, clearly defined site. In contrast, eukaryotic organisms exploit a multitude of replication origins, dividing their genomes into an array of short contiguous units. Rece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson NP,Bell SD

更新日期：2007-04-03 00:00:00

abstract：:The cellular alterations associated with skeletal muscle differentiation share a high degree of similarity with key phenotypic changes usually ascribed to apoptosis. For example, actin fiber disassembly/reorganization is a conserved feature of both apoptosis and differentiating myoblasts and the conserved muscle contr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernando P,Kelly JF,Balazsi K,Slack RS,Megeney LA

更新日期：2002-08-20 00:00:00

abstract：:Microorganisms have mechanisms to sense their environment and rapidly adapt to survive changes in conditions. In Streptomyces albus, various transcriptional repressors mediate the induction of heat shock genes. The RheA repressor regulates the synthesis of HSP18, a small heat shock protein, which plays a role in therm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Servant P,Grandvalet C,Mazodier P

更新日期：2000-03-28 00:00:00

abstract：:Cholinergic pathways serve important functions in learning and memory processes, and deficits in cholinergic transmission occur in Alzheimer disease (AD). A subset of muscarinic cholinergic receptors are linked to G-proteins that activate phospholipase C, resulting in the liberation of inositol trisphosphate and Ca2+ ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly JF,Furukawa K,Barger SW,Rengen MR,Mark RJ,Blanc EM,Roth GS,Mattson MP

更新日期：1996-06-25 00:00:00

abstract：:The liver provides for long-term energy needs of the body by converting excess carbohydrate into fat for storage. Insulin is one factor that promotes hepatic lipogenesis, but there is increasing evidence that glucose also contributes to the coordinated regulation of carbohydrate and fat metabolism in liver by mechanis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iizuka K,Bruick RK,Liang G,Horton JD,Uyeda K

更新日期：2004-05-11 00:00:00

abstract：:A theory is proposed to study the sensitivity of cylindrical explosives. Using the equations governing the conservation of mass, energy, and momentum, the equation of state, and Newtonian mechanics, we have derived the expression D = D(o)e(-a2/d), in which the apparent length of the reaction zone, a, takes into accoun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eyring H,Walker FE,Ma SM,Coon N

更新日期：1980-05-01 00:00:00

abstract：:Elucidation of mechanisms that regulate hematopoietic stem cell self-renewal and differentiation would be facilitated by the identification of defined culture conditions that allow these cells to be amplified. We now demonstrate a significant net increase (3-fold, P < 0.001) in vitro of cells that are individually abl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller CL,Eaves CJ

更新日期：1997-12-09 00:00:00

abstract：:Small proteins can fold remarkably rapidly, even in μs. What limits their rate of folding? The Engrailed homeodomain is a particularly well-characterized example, which folds ultrafast via an intermediate, I, of solved structure. It is a puzzle that the helix2-turn-helix3 motif of the 3-helix bundle forms in approxima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neuweiler H,Banachewicz W,Fersht AR

更新日期：2010-12-21 00:00:00

abstract：:Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are associated with dysbiosis of the gut microbiome. Emerging evidence suggests that small-molecule metabolites derived from bacterial breakdown of a variety of dietary nutrients confer a wide array of host benefits, including amelio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scott SA,Fu J,Chang PV

更新日期：2020-08-11 00:00:00

abstract：:Protein-protein interactions are essential for life. Yet, our understanding of the general principles governing binding is not complete. In the present study, we show that the interface between proteins is built in a modular fashion; each module is comprised of a number of closely interacting residues, with few intera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reichmann D,Rahat O,Albeck S,Meged R,Dym O,Schreiber G

更新日期：2005-01-04 00:00:00

abstract：:Ultraviolet photosensitivity of the single-stranded forms of poly(A) and poly(dA) is compared. In contrast to poly(A), poly(dA) is rather sensitive to ultraviolet irradiation. Relatively low doses of ultraviolet light lead to characteristic changes of the ultraviolet and circular dichroism spectra of poly(dA), suggest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pörschke D

更新日期：1973-09-01 00:00:00

abstract：:Many pathological conditions of the central nervous system involve damage to and removal of myelin membrane. Very little is known about initiation of this membrane damage and the mechanisms of disposal of the damaged tissue. We are interested in the interaction between complement (the components of complement are desi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vanguri P,Koski CL,Silverman B,Shin ML

更新日期：1982-05-01 00:00:00

abstract：:We have shown that the long-term inhibition of IgE synthesis associated with perinatal inoculation of syngeneic IgE is accompanied by the synthesis of autoantibodies to IgE. Synthesis of IgE can also be inhibited by passive transfer of syngeneic anti-IgE antibodies. In the present investigation we made use of adoptive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haba S,Nisonoff A

更新日期：1994-01-18 00:00:00

abstract：:Albumin Redhill is an electrophoretically slow genetic variant of human serum albumin that does not bind 63Ni2+ and has a molecular mass 2.5 kDa higher than normal albumin. Its inability to bind Ni2+ was explained by the finding of an additional residue of Arg at position -1. This did not explain the molecular basis o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brennan SO,Myles T,Peach RJ,Donaldson D,George PM

更新日期：1990-01-01 00:00:00

abstract：:Astrocyte-elevated gene-1 (AEG-1) expression is increased in multiple cancers and plays a central role in Ha-ras-mediated oncogenesis through the phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway. Additionally, overexpression of AEG-1 protects primary and transformed human and rat cells from serum starvation-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Emdad L,Lee SG,Su ZZ,Jeon HY,Boukerche H,Sarkar D,Fisher PB

更新日期：2009-12-15 00:00:00

abstract：:The Hsp90 chaperone buffers development against a wide range of morphological changes in many organisms and in Drosophila masks the effects of hidden genetic variation. Theory predicts that genetic and nongenetic buffering will share common mechanisms. For example, it is argued that Hsp90 genetic buffering evolved sol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milton CC,Huynh B,Batterham P,Rutherford SL,Hoffmann AA

更新日期：2003-11-11 00:00:00

abstract：:Mice prefer to mate with individuals expressing different MHC genes from their own. Volatile components presenting MHC-dependent odor types are present in urine and can be detected by mice, as shown by extensive behavioral studies. Similar odor types are suspected to influence human behavior as well. Although a recent...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montag S,Frank M,Ulmer H,Wernet D,Göpel W,Rammensee HG

更新日期：2001-07-31 00:00:00

abstract：:By immunoaffinity column chromatography, we have purified two RNA polymerase complexes, the transcriptase and replicase, from vesicular stomatitis virus-infected baby hamster kidney cells. The transcriptase is a multiprotein complex, containing the virus-encoded RNA polymerase L and P proteins, and two cellular protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qanungo KR,Shaji D,Mathur M,Banerjee AK

更新日期：2004-04-20 00:00:00

abstract：:During latent infection of humans with Mycobacterium tuberculosis, bacteria persist in the asymptomatic host within granulomas, organized collections of differentiated macrophages, and other immune cells. The mechanisms for persistence remain poorly understood, as is the metabolic and replicative state of the microbes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan K,Knaak T,Satkamp L,Humbert O,Falkow S,Ramakrishnan L

更新日期：2002-03-19 00:00:00

abstract：:Gamma-band synchronization adjusts the timing of excitatory and inhibitory inputs to a neuron. Neurons in the visual cortex are selective for stimulus orientation because of dynamic interactions between excitatory and inhibitory inputs. We hypothesized that these interactions and hence also orientation selectivity var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Womelsdorf T,Lima B,Vinck M,Oostenveld R,Singer W,Neuenschwander S,Fries P

更新日期：2012-03-13 00:00:00