A putative Ca2+-binding protein: structure of the light subunit of porcine calpain elucidated by molecular cloning and protein sequence analysis.

abstract：:Lateral inhibition is the ubiquitous strategy used by visual neurons for spatial resolution throughout the animal kingdom. It has been a puzzle whether lateral inputs in retinal bipolar cells are mediated by the horizontal cell (HC)-cone feedback synapse, by the HC-bipolar cell feedforward synapse, or by both. By bloc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang XL,Wu SM

更新日期：1991-04-15 00:00:00

abstract：:Peace River is one of the few shocked members of the L-chondrites clan that contains both high-pressure polymorphs of olivine, ringwoodite and wadsleyite, in diverse textures and settings in fragments entrained in shock-melt veins. Among these settings are complete olivine porphyritic chondrules. We encountered few sq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyahara M,El Goresy A,Ohtani E,Nagase T,Nishijima M,Vashaei Z,Ferroir T,Gillet P,Dubrovinsky L,Simionovici A

更新日期：2008-06-24 00:00:00

abstract：:Mouse teratocarcinoma cells induced to differentiate in vitro undergo a massive (30%) demethylation of DNA. A similar undermethylation is also observed in the mouse extraembryonic membranes, the yolk sac and placenta. In both cases, the decrease in methyl moieties occurs at a large number of CpG sites spread out over ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razin A,Webb C,Szyf M,Yisraeli J,Rosenthal A,Naveh-Many T,Sciaky-Gallili N,Cedar H

更新日期：1984-04-01 00:00:00

abstract：:Historical collapse of ancient states or civilizations has raised new awareness about its possible relevance to current issues of sustainability, in the context of global change. This Special Feature examines 12 case studies of societies under stress, of which seven suffered severe transformation. Outcomes were comple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butzer KW,Endfield GH

更新日期：2012-03-06 00:00:00

abstract：:A 38-base-pair region required for normal CYC1 mRNA 3' end formation in Saccharomyces cerevisiae was shown to be necessary for the termination of transcription in vivo by examining the stability of CEN3 plasmids. CEN3 plasmids were stably maintained during vegetative growth, unless a GAL1 transcript impinged on the CE...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russo P,Sherman F

更新日期：1989-11-01 00:00:00

abstract：:Transcripts from mitochondrial (maxicircle) genes of kinetoplastid organisms undergo RNA editing characterized by a series of reactions that insert and delete uridine nucleotides within the sequence of the pre-mRNAs. Guide RNAs, which complement fully edited mRNAs, provide the information for the edited sequence by an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Göringer HU,Koslowsky DJ,Morales TH,Stuart K

更新日期：1994-03-01 00:00:00

abstract：:Rev-Erbβ is a nuclear receptor that couples circadian rhythm, metabolism, and inflammation. Heme binding to the protein modulates its function as a repressor, its stability, its ability to bind other proteins, and its activity in gas sensing. Rev-Erbβ binds Fe3+-heme more tightly than Fe2+-heme, suggesting its activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar A,Carter EL,Harland JB,Speelman AL,Lehnert N,Ragsdale SW

更新日期：2021-01-19 00:00:00

abstract：:The interactions between products of the 15-lipoxygenase cascade and human natural killer (NK) cell activity have been studied. Addition of human leukocyte-derived (14R,15S)-14,15-dihydroxy-5Z,8Z,10E,12E-ic osatetraenoic acid (14,15-DiHETE) to the NK cytotoxicity assay against K562 target cells resulted in inhibition ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramstedt U,Serhan CN,Lundberg U,Wigzell H,Samuelsson B

更新日期：1984-11-01 00:00:00

abstract：:The family of WD40-repeat (WDR) proteins is one of the largest in eukaryotes, but little is known about their function in brain development. Among 26 WDR genes assessed, we found 7 displaying a major impact in neuronal morphology when inactivated in mice. Remarkably, all seven genes showed corpus callosum defects, inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kannan M,Bayam E,Wagner C,Rinaldi B,Kretz PF,Tilly P,Roos M,McGillewie L,Bär S,Minocha S,Chevalier C,Po C,Sanger Mouse Genetics Project.,Chelly J,Mandel JL,Borgatti R,Piton A,Kinnear C,Loos B,Adams DJ,Hérault Y,

更新日期：2017-10-31 00:00:00

abstract：:Many substances in the plant kingdom and in man's diet occur as glycosides. Recent studies have indicated that many glycosides that are not mutagenic in tests such as the Salmonella test become mutagenic upon hydrolysis of the glycosidic linkages. The Salmonella test utilizes a liver homogenate to approximate mammalia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamura G,Gold C,Ferro-Luzzi A,Ames BN

更新日期：1980-08-01 00:00:00

abstract：:Prototrophic hybrids formed from an adenine-requiring Chinese hamster cell and human fibroblasts uniformly display new esterase activity that differs from that of either parental cell in electrophoretic mobility and substrate specificity. The hybrids that grew in the selective medium and possessed the new esterase act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kao FT,Puck TT

更新日期：1972-11-01 00:00:00

abstract：:Defining prospective pathways by which zoonoses evolve and emerge as human pathogens is critical for anticipating and controlling both natural and deliberate pandemics. However, predicting tenable pathways of animal-to-human movement has been hindered by challenges in identifying reservoir species, cultivating zoonoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Becker MM,Graham RL,Donaldson EF,Rockx B,Sims AC,Sheahan T,Pickles RJ,Corti D,Johnston RE,Baric RS,Denison MR

更新日期：2008-12-16 00:00:00

abstract：:One of the enduring problems in the study of social evolution has been to understand how cooperation can be maintained in the presence of freeloaders, individuals that take advantage of the more cooperative members of groups they are eager to join. The freeloader problem has been particularly troublesome when groups c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Avilés L

更新日期：2002-10-29 00:00:00

abstract：:The chromosomal locations of cellular sequences flanking integrated papillomavirus DNA in four cervical carcinoma cell lines and a primary cervical carcinoma have been determined. The two human papillomavirus (HPV) 16 flanking sequences derived from the tumor were localized to chromosome regions 20pter----20q13 and 3p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dürst M,Croce CM,Gissmann L,Schwarz E,Huebner K

更新日期：1987-02-01 00:00:00

abstract：:Extracellular matrix (ECM) profoundly influences the growth and differentiation of the mammary gland epithelium, both in culture and in vivo. Utilizing a clonal population of mouse mammary epithelial cells that absolutely requires an exogenous ECM for function, we developed a rapid assay to study signal transduction b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roskelley CD,Desprez PY,Bissell MJ

更新日期：1994-12-20 00:00:00

abstract：:Secretion of inflammatory mediators by rat mast cells (line RBL-2H3) was earlier shown to be inhibited upon clustering a membrane glycoprotein by monoclonal antibody G63. This glycoprotein, named mast cell function-associated antigen (MAFA), was also shown to interfere with the coupling cascade of the type 1 Fc epsilo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guthmann MD,Tal M,Pecht I

更新日期：1995-09-26 00:00:00

abstract：:The pathways that allow quiescent disseminated cancer cells to survive during prolonged dormancy periods are unknown. Here, we identify the transcription factor ATF6alpha as a pivotal survival factor for quiescent but not proliferative squamous carcinoma cells. ATF6alpha is essential for the adaptation of dormant cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schewe DM,Aguirre-Ghiso JA

更新日期：2008-07-29 00:00:00

abstract：:Elucidation of the genetic control of rice architecture is crucial due to the global demand for high crop yields. Rice architecture is a complex trait affected by plant height, tillering, and panicle morphology. In this study, principal component analysis (PCA) on 8 typical traits related to plant architecture reveale...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yano K,Morinaka Y,Wang F,Huang P,Takehara S,Hirai T,Ito A,Koketsu E,Kawamura M,Kotake K,Yoshida S,Endo M,Tamiya G,Kitano H,Ueguchi-Tanaka M,Hirano K,Matsuoka M

更新日期：2019-10-15 00:00:00

abstract：:Nodules harboring nitrogen-fixing rhizobia are a well-known trait of legumes, but nodules also occur in other plant lineages, with rhizobia or the actinomycete Frankia as microsymbiont. It is generally assumed that nodulation evolved independently multiple times. However, molecular-genetic support for this hypothesis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Velzen R,Holmer R,Bu F,Rutten L,van Zeijl A,Liu W,Santuari L,Cao Q,Sharma T,Shen D,Roswanjaya Y,Wardhani TAK,Kalhor MS,Jansen J,van den Hoogen J,Güngör B,Hartog M,Hontelez J,Verver J,Yang WC,Schijlen E,Repin

更新日期：2018-05-15 00:00:00

abstract：:The principal axes of inertia are eigenvectors that can be calculated for any rigid body. We report studies of the position of the principal axes in crystallographically solved protein molecules. We find with high frequency that at least one principal axis penetrates the surface of the respective protein in a region u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foote J,Raman A

更新日期：2000-02-01 00:00:00

abstract：:Molecules of keystone significance are relatively rare, yet mediate a variety of interactions between organisms. They influence the distribution and abundance of species, the transfer of energy across multiple trophic levels, and thus they play significant roles in structuring ecosystems. Despite their potential impor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kicklighter CE,Kamio M,Nguyen L,Germann MW,Derby CD

更新日期：2011-07-12 00:00:00

abstract：:A careful review of the literature in political science and neighboring social science disciplines shows that prevailing assumptions in the international development policy community about improved governance as a principal mechanism to reduce poverty in Africa rests more on faith than science. Conventional policy mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hyden G

更新日期：2007-10-23 00:00:00

abstract：:Cell cycle checkpoints are evolutionarily conserved surveillance systems that protect genomic stability and prevent oncogenesis in mammals. One important target of checkpoint control is ribonucleotide reductase (RNR), which catalyzes the rate-limiting step in dNTP and DNA synthesis. In both yeast and humans, RNR is tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao X,Rothstein R

更新日期：2002-03-19 00:00:00

abstract：:A procedure for combined sequential affinity adsorption-electrophoresis has been devised. Its use for the rapid purification of a calcium-dependent cyclic nucleotide phosphodiesterase from bovine brain in high yield is described. In this procedure, proteins bound to a solid phase of calcium-dependent regulatory protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kincaid RL,Vaughan M

更新日期：1979-10-01 00:00:00

abstract：:We use age distributions of sea otters (Enhydra lutris) found dead on beaches of western Prince William Sound, Alaska, between 1976 and 1998 in conjunction with time-varying demographic models to test for lingering effects from the 1989 Exxon Valdez oil spill. Our results show that sea otters in this area had decrease...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monson DH,Doak DF,Ballachey BE,Johnson A,Bodkin JL

更新日期：2000-06-06 00:00:00

abstract：:Methods for the construction of ordered nanoscale arrays have been implicated in fields ranging from separation technologies to microelectronics. Yet, despite the plethora of nanoscale structures assembled in nature that use a templating strategy, chemists have been unable to replicate this success. A technology is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willis B,Eubanks LM,Wood MR,Janda KD,Dickerson TJ,Lerner RA

更新日期：2008-02-05 00:00:00

abstract：:Changes in tree growth rates can affect tree mortality and forest feedbacks to the global carbon cycle. As air temperature increases, evaporative demand also increases, increasing effective drought in forest ecosystems. Using a spatially comprehensive network of Douglas fir (Pseudotsuga menziesii) chronologies from 12...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Restaino CM,Peterson DL,Littell J

更新日期：2016-08-23 00:00:00

abstract：:The central nervous system both influences and is influenced by the gastrointestinal system. Most research on this gut-brain connection has focused on how ascending signals from the gut and its microbiome alter brain function. Less attention has focused on how descending signals from the central nervous system alter g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levinthal DJ,Strick PL

更新日期：2020-06-09 00:00:00

abstract：:An Epstein-Barr virus (EBV) deletion mutant, HR-1, cannot immortalize lymphocytes. HR-1 was derived from a virus strain, Jijoye, that is immortalization competent. Using human antiserum from certain patients with chronic active EBV infection, we have identified in Jijoye cells a protein of apparent mass of 78-80 kDa t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rowe D,Heston L,Metlay J,Miller G

更新日期：1985-11-01 00:00:00

abstract：:The cis-acting regulatory sequence of transcription from long terminal repeats (LTRs) of human T-cell leukemia virus type I and type II (HTLV-I and HTLV-II), which is essential for action of the virally encoded trans-acting transcriptional factor(s) designated pX(s), in HTLV-I and -II was identified. Deletion of most ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimotohno K,Takano M,Teruuchi T,Miwa M

更新日期：1986-11-01 00:00:00