Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.

abstract：:Mechanoelectrical transduction in the inner ear is a biophysical process underlying the senses of hearing and balance. The key players involved in this process are mechanosensitive ion channels. They are located in the stereocilia of hair cells and opened by the tension in specialized molecular springs, the tip links,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gianoli F,Risler T,Kozlov AS

更新日期：2017-12-19 00:00:00

abstract：:A detailed phenomenology of low energy excitations is a crucial starting point for microscopic understanding of complex materials, such as the cuprate high-temperature superconductors. Because of its unique momentum-space discrimination, angle-resolved photoemission spectroscopy (ARPES) is ideally suited for this task...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vishik IM,Hashimoto M,He RH,Lee WS,Schmitt F,Lu D,Moore RG,Zhang C,Meevasana W,Sasagawa T,Uchida S,Fujita K,Ishida S,Ishikado M,Yoshida Y,Eisaki H,Hussain Z,Devereaux TP,Shen ZX

更新日期：2012-11-06 00:00:00

abstract：:The type of cytokines produced during T cell responses determines susceptibility or resistance to many pathogens and influences the development of autoimmunity and allergy. To define the role of individual accessory molecules in cytokine production during primary immune responses, Drosophila cell lines expressing muri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luksch CR,Winqvist O,Ozaki ME,Karlsson L,Jackson MR,Peterson PA,Webb SR

更新日期：1999-03-16 00:00:00

abstract：:Previous work has established stargazin and its related family of transmembrane AMPA receptor regulatory proteins (TARPs) as auxiliary subunits of AMPA receptors (AMPARs) that control synaptic strength both by targeting AMPARs to synapses through an intracellular PDZ-binding motif and by modulating their gating throug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milstein AD,Nicoll RA

更新日期：2009-07-07 00:00:00

abstract：:Experimentally, protein engineering and phi-value analysis is the method of choice to characterize the structure in folding transition state ensemble (TSE) of any protein. Combining experimental phi values and computer simulations has led to a deeper understanding of how proteins fold. In this report, we construct the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Shakhnovich EI

更新日期：2001-11-06 00:00:00

abstract：:There are well-recognized sex differences in many pituitary endocrine axes, usually thought to be generated by gonadal steroid imprinting of the neuroendocrine hypothalamus. However, the recognition that growth hormone (GH) cells are arranged in functionally organized networks raises the possibility that the responses...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanchez-Cardenas C,Fontanaud P,He Z,Lafont C,Meunier AC,Schaeffer M,Carmignac D,Molino F,Coutry N,Bonnefont X,Gouty-Colomer LA,Gavois E,Hodson DJ,Le Tissier P,Robinson IC,Mollard P

更新日期：2010-12-14 00:00:00

abstract：:We recently have shown that mice deficient for the 86-kDa component (Ku80) of the DNA-dependent protein kinase exhibit growth retardation and a profound deficiency in V(D)J (variable, diversity, and joining) recombination. These defects may be related to abnormalities in DNA metabolism that arise from the inability of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nussenzweig A,Sokol K,Burgman P,Li L,Li GC

更新日期：1997-12-09 00:00:00

abstract：:Although rigorous measures of similarity for sequence and structure are now well established, the problem of defining functional relationships has been particularly daunting. Here, we present several manifold embedding techniques to compute distances between Gene Ontology (GO) functional annotations and consequently e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerman G,Shakhnovich BE

更新日期：2007-07-03 00:00:00

abstract：:Synthesis of the 31-amino acid, inner membrane protein MgtS (formerly denoted YneM) is induced by very low Mg2+ in a PhoPQ-dependent manner in Escherichia coli Here we report that MgtS acts to increase intracellular Mg2+ levels and maintain cell integrity upon Mg2+ depletion. Upon development of a functional tagged de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang H,Yin X,Wu Orr M,Dambach M,Curtis R,Storz G

更新日期：2017-05-30 00:00:00

abstract：:Amino-terminal sequence determinations are reported of the subunits of biliproteins of prokaryotic unicellular and filamentous cyanobacteria and of eukaryotic unicellular red algae. The biliproteins examined, allophycocyanin, C-phycocyanin, R-phycocyanin, b-phycoerythrin, and phycoerythrocyanin, vary with respect to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glazer AN,Apell GS,Hixson CS,Bryant DA,Rimon S,Brown DM

更新日期：1976-02-01 00:00:00

abstract：:cDNA array technology has proven to be a powerful way to monitor global changes in gene expression patterns. Here, we present an approach that extends the current utility of cDNA arrays to allow the evaluation of the relative roles of transcription and mRNA turnover in governing gene expression on a global basis, comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan J,Yang X,Wang W,Wood WH 3rd,Becker KG,Gorospe M

更新日期：2002-08-06 00:00:00

abstract：:In most cervical carcinoma cells the E6 and E7 genes of specific human papillomaviruses are transcribed from viral sequences integrated into host cell chromosomes. Glucocorticoids activate the promoter elements of various human papillomaviruses in transient-expression assays. We have analyzed the effect of dexamethaso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Knebel Doeberitz M,Bauknecht T,Bartsch D,zur Hausen H

更新日期：1991-02-15 00:00:00

abstract：:Fluorescence spectroscopy was used to characterize blue light responses from chloroplasts of adaxial guard cells from Pima cotton (Gossypium barbadense) and coleoptile tips from corn (Zea mays). The chloroplast response to blue light was quantified by measurements of the blue light-induced enhancement of a red light-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quiñones MA,Lu Z,Zeiger E

更新日期：1996-03-05 00:00:00

abstract：:A molecular recognition code has been hypothesized to exist in which ligands and their binding sites are encoded on complementary segments of genomic DNA. We have tested this hypothesis by generating a rabbit antibody to a synthetic decapeptide (complementary peptide) encoded by an RNA complementary to the mRNA for lu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mulchahey JJ,Neill JD,Dion LD,Bost KL,Blalock JE

更新日期：1986-12-01 00:00:00

abstract：:Solar photovoltaic (PV) electricity generation is expanding rapidly in China, with total capacity projected to be 400 GW by 2030. However, severe aerosol pollution over China reduces solar radiation reaching the surface. We estimate the aerosol impact on solar PV electricity generation at the provincial and regional g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Wagner F,Peng W,Yang J,Mauzerall DL

更新日期：2017-11-07 00:00:00

abstract：:The antiangiogenic agent fumagillin (Fg) and its analog TNP-470 bind to intracellular metalloprotease methionine aminopeptidase-2 (MetAP-2) and inhibit endothelial cell growth in a p53-dependent manner. To confirm the role of MetAP-2 in endothelial cell proliferation and to validate it as a physiological target for th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh JJ,Ju R,Brdlik CM,Zhang W,Zhang Y,Matyskiela ME,Shotwell JD,Crews CM

更新日期：2006-07-05 00:00:00

abstract：:The marine cyanobacterium Trichodesmium is ubiquitous in tropical and subtropical seas and is an important contributor to global N and C cycling. We sought to characterize metabolic uptake patterns in individual Trichodesmium IMS-101 cells by quantitatively imaging (13)C and (15)N uptake with high-resolution secondary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finzi-Hart JA,Pett-Ridge J,Weber PK,Popa R,Fallon SJ,Gunderson T,Hutcheon ID,Nealson KH,Capone DG

更新日期：2009-04-14 00:00:00

abstract：:We have investigated whether glycosylation of membrane glycoproteins is a determinant of the site of maturation of enveloped viruses in Madin-Darby canine kidney (MDCK) cells. In MDCK cell monolayers, vesicular stomatitis virus buds exclusively from the basal or lateral plasma membranes and contains a sialylated glyco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth MG,Fitzpatrick JP,Compans RW

更新日期：1979-12-01 00:00:00

abstract：:The thyroid hormone and retinoid X receptors form a heterodimer with each other and mediate thyroid hormone (T3)-dependent transcription. Retinoid X receptor, in addition, forms a homodimer and mediates 9-cis-retinoic acid-dependent transcription. Here, recombinant thyroid hormone receptor and recombinant retinoid X r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee IJ,Driggers PH,Medin JA,Nikodem VM,Ozato K

更新日期：1994-03-01 00:00:00

abstract：:Setting aside high-quality large areas of habitat to protect threatened populations is becoming increasingly difficult as humans fragment and degrade the environment. Biologists and managers therefore must determine the best way to shepherd small populations through the dual challenges of reductions in both the number...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hufbauer RA,Szűcs M,Kasyon E,Youngberg C,Koontz MJ,Richards C,Tuff T,Melbourne BA

更新日期：2015-08-18 00:00:00

abstract：:We determined the complete mtDNA sequence of the centipede Lithobius forficatus and found that only one of the 22 inferred tRNA genes encodes a fully paired aminoacyl acceptor stem. The other 21 genes encode tRNAs with up to five mismatches in these stems, and some of these overlap extensively with the downstream gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavrov DV,Brown WM,Boore JL

更新日期：2000-12-05 00:00:00

abstract：:Two clusters of configurations of the main proteolytic subunit β5 were identified by principal component analysis of crystal structures of the yeast proteasome core particle (yCP). The apo-cluster encompasses unliganded species and complexes with nonpeptidic ligands, and the pep-cluster comprises complexes with peptid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arciniega M,Beck P,Lange OF,Groll M,Huber R

更新日期：2014-07-01 00:00:00

abstract：:Infection during the neonatal period commonly induces apnea episodes, and the proinflammatory cytokine IL-1beta may serve as a critical mediator between these events. To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and huma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hofstetter AO,Saha S,Siljehav V,Jakobsson PJ,Herlenius E

更新日期：2007-06-05 00:00:00

abstract：:Immunoreactive intact cholecystokinin and its COOH-terminal octapeptide are found in brain as well as in extracts of gut of the monkey, dog, and pig, by using an antiserum with equivalent sensitivities for detecting the octapeptide in free form or incorporated in the intact molecule. The failure to detect intact chole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Straus E,Yalow RS

更新日期：1978-01-01 00:00:00

abstract：:The caspases are cysteine proteases that have been implicated in the execution of programmed cell death in organisms ranging from nematodes to humans. Many members of the Bcl-2 family, including Bcl-XL, are potent inhibitors of programmed cell death and inhibit activation of caspases in cells. Here, we report a direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clem RJ,Cheng EH,Karp CL,Kirsch DG,Ueno K,Takahashi A,Kastan MB,Griffin DE,Earnshaw WC,Veliuona MA,Hardwick JM

更新日期：1998-01-20 00:00:00

abstract：:Mesenchymal stromal stem cells (MSCs) isolated from adult tissues offer tangible potential for regenerative medicine, given their feasibility for autologous transplantation. MSC research shows encouraging results in experimental stroke, amyotrophic lateral sclerosis, and neurotrauma models. However, further translatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ropper AE,Thakor DK,Han I,Yu D,Zeng X,Anderson JE,Aljuboori Z,Kim SW,Wang H,Sidman RL,Zafonte RD,Teng YD

更新日期：2017-01-31 00:00:00

abstract：:The human major histocompatibility complex encodes three classical class I antigens, HLA-A, -B, and -C. Of these HLA-A and -B act as strong transplantation antigens and as restriction molecules for recognition of foreign antigen by cytotoxic T lymphocytes. In contrast, little is known about HLA-C and it is not clear w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dill O,Kievits F,Koch S,Ivanyi P,Hämmerling GJ

更新日期：1988-08-01 00:00:00

abstract：:The chemokine CXC ligand 8 (CXCL8)/IL-8 and related agonists recruit and activate polymorphonuclear cells by binding the CXC chemokine receptor 1 (CXCR1) and CXCR2. Here we characterize the unique mode of action of a small-molecule inhibitor (Repertaxin) of CXCR1 and CXCR2. Structural and biochemical data are consiste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bertini R,Allegretti M,Bizzarri C,Moriconi A,Locati M,Zampella G,Cervellera MN,Di Cioccio V,Cesta MC,Galliera E,Martinez FO,Di Bitondo R,Troiani G,Sabbatini V,D'Anniballe G,Anacardio R,Cutrin JC,Cavalieri B,Mainiero F

更新日期：2004-08-10 00:00:00

abstract：:We report that oxytocin (Oxt) receptors (Oxtrs), on stimulation by the ligand Oxt, translocate into the nucleus of osteoblasts, implicating this process in the action of Oxt on osteoblast maturation. Sequential immunocytochemistry of intact cells or isolated nucleoplasts stripped of the outer nuclear membrane showed p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Benedetto A,Sun L,Zambonin CG,Tamma R,Nico B,Calvano CD,Colaianni G,Ji Y,Mori G,Grano M,Lu P,Colucci S,Yuen T,New MI,Zallone A,Zaidi M

更新日期：2014-11-18 00:00:00

abstract：:Cellular metabolism alters patterns of gene expression through a variety of mechanisms, including alterations in histone modifications and transcription factor activity. Nicotinamide adenine dinucleotide (NAD)-dependent proteins such as poly(ADP ribose) polymerases (PARPs) and sirtuin deacetylases play important roles...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang J,Zhang B,Heath H,Galjart N,Wang X,Milbrandt J

更新日期：2010-12-14 00:00:00