Immunological function of HLA-C antigens in HLA-Cw3 transgenic mice.

abstract：:Despite immense variability across languages, people can learn to understand any human language, spoken or signed. What neural mechanisms allow people to comprehend language across sensory modalities? When people listen to speech, electrophysiological oscillations in auditory cortex entrain to slow ([Formula: see text...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brookshire G,Lu J,Nusbaum HC,Goldin-Meadow S,Casasanto D

更新日期：2017-06-13 00:00:00

abstract：:We used positron emission tomography (PET) to examine the role of the hippocampal formation in implicit and explicit memory. Human volunteers studied a list of familiar words, and then they either provided the first word that came to mind in response to three-letter cues (implicit memory) or tried to recall studied wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schacter DL,Alpert NM,Savage CR,Rauch SL,Albert MS

更新日期：1996-01-09 00:00:00

abstract：:We tested the possibility that insulin-like growth factor I (IGF-I) acts as a neuromodulator in the adult cerebellar cortex since previous observations indicated that IGF-I is located in the olivo-cerebellar system encompassing the inferior olive and Purkinje cells. We found that conjoint administration of IGF-I and g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castro-Alamancos MA,Torres-Aleman I

更新日期：1993-08-01 00:00:00

abstract：:The mitochondrial genome of the S-type male-sterile cytoplasm of maize contains two linear episomes, S1 (6397 base pairs) and S2 (5453 base pairs). The S2 episome contains two large unidentified open reading frames, URF1 (3512 base pairs) and URF2 (1017 base pairs). We have demonstrated that a polypeptide with an appa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zabala G,O'brien-Vedder C,Walbot V

更新日期：1987-11-01 00:00:00

abstract：:The lymphocyte differentiation (Ly) antigen phenotype of cytotoxic effector T cells specific for H-2 mutant alloantigens was determined. Cytotoxic effectors generated in primary mixed lymphocyte culture and specific for H-2Kba and H-2Dda alloantigens are sensitive to both anti-Ly-1 and anti-Ly-2 serum plus complement....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wettstein PJ,Bailey DW,Mobraaten LE,Klein J,Frelinger JA

更新日期：1979-07-01 00:00:00

abstract：:This paper reviews food (especially cereal) production trends and prospects for the world and its main regions. Despite fears to the contrary, in recent years we have seen continued progress toward better methods of feeding humanity. Sub-Saharan Africa is the sole major exception. Looking to the future, this paper arg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dyson T

更新日期：1999-05-25 00:00:00

abstract：:Prions are infectious agents which cause rapidly lethal neurodegenerative diseases in humans and animals following long, clinically silent incubation periods. They are composed of multichain assemblies of misfolded cellular prion protein. While it has long been assumed that prions are themselves neurotoxic, recent dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benilova I,Reilly M,Terry C,Wenborn A,Schmidt C,Marinho AT,Risse E,Al-Doujaily H,Wiggins De Oliveira M,Sandberg MK,Wadsworth JDF,Jat PS,Collinge J

更新日期：2020-09-22 00:00:00

abstract：:Effects of the anti-T-cell monoclonal antibodies OKT3, OKT5, and OKT8 on T-cell surface properties and cell functions were evaluated. Incubation of mononuclear cells isolated from peripheral blood for 48 hr with each monoclonal antibody in the absence of complement resulted in modulation of their respective surface an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antel J,Oger JJ,Jackevicius S,Kuo HH,Arnason BG

更新日期：1982-05-01 00:00:00

abstract：:Deletion of 5 residues (Delta5) from the central cytoplasmic loop of the lactose permease of Escherichia coli has no significant effect on expression or activity, whereas Delta12 leads to increased rates of permease turnover after membrane insertion and decreased transport activity, and Delta20 abolishes insertion and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weinglass AB,Kaback HR

更新日期：2000-08-01 00:00:00

abstract：:The kidney develops through reciprocal interactions between two precursor tissues: the metanephric mesenchyme and the ureteric bud. We previously demonstrated that the zinc finger protein Sall1 is essential for ureteric bud attraction toward the mesenchyme. Here, we show that Kif26b, a kinesin family gene, is a downst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchiyama Y,Sakaguchi M,Terabayashi T,Inenaga T,Inoue S,Kobayashi C,Oshima N,Kiyonari H,Nakagata N,Sato Y,Sekiguchi K,Miki H,Araki E,Fujimura S,Tanaka SS,Nishinakamura R

更新日期：2010-05-18 00:00:00

abstract：:For more than a century we have understood that our brain's left hemisphere is the primary site for processing language, yet why this is so has remained more elusive. Using positron emission tomography, we report cerebral blood flow activity in profoundly deaf signers processing specific aspects of sign language in ke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petitto LA,Zatorre RJ,Gauna K,Nikelski EJ,Dostie D,Evans AC

更新日期：2000-12-05 00:00:00

abstract：:Biological processes such as circadian rhythms, cell division, metabolism, and development occur as ordered sequences of events. The synchronization of these coordinated events is essential for proper cell function, and hence the determination of critical time points in biological processes is an important component o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramakrishnan N,Tadepalli S,Watson LT,Helm RF,Antoniotti M,Mishra B

更新日期：2010-07-13 00:00:00

abstract：:Theory suggests evolutionary change can significantly influence and act in tandem with ecological forces via ecological-evolutionary feedbacks. This theory assumes that significant evolutionary change occurs over ecologically relevant timescales and that phenotypes have differential effects on the environment. Here we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bassar RD,Marshall MC,López-Sepulcre A,Zandonà E,Auer SK,Travis J,Pringle CM,Flecker AS,Thomas SA,Fraser DF,Reznick DN

更新日期：2010-02-23 00:00:00

abstract：:Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). The catalytic subunit of the specific phosphatase, protein phosphatase 2A (PP2A) that dephosphorylates α-synuclein, is hypomethylated in these ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Zhang J,Park HJ,Park ES,Oh S,Zheng H,Junn E,Voronkov M,Stock JB,Mouradian MM

更新日期：2018-12-18 00:00:00

abstract：:The brain disturbances that place a person at risk for developing depression are unknown. We imaged the brains of 131 individuals, ages 6 to 54 years, who were biological descendants (children or grandchildren) of individuals identified as having either moderate to severe, recurrent, and functionally debilitating depr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peterson BS,Warner V,Bansal R,Zhu H,Hao X,Liu J,Durkin K,Adams PB,Wickramaratne P,Weissman MM

更新日期：2009-04-14 00:00:00

abstract：:Transcription termination is a critical step in the control of gene expression. One of the major termination mechanisms is mediated by Rho factor that dissociates the complex mRNA-DNA-RNA polymerase upon binding with RNA polymerase. Rho promotes termination at the end of operons, but it can also terminate transcriptio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva IJ,Barahona S,Eyraud A,Lalaouna D,Figueroa-Bossi N,Massé E,Arraiano CM

更新日期：2019-02-19 00:00:00

abstract：:Activator of G protein signaling 3 (AGS3), originally identified in a functional screen for mammalian proteins that activate heterotrimeric G protein signaling, is known to be involved in drug-seeking behavior and is up-regulated during cocaine withdrawal in animal models. These observations indicate a potential role ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groves B,Gong Q,Xu Z,Huntsman C,Nguyen C,Li D,Ma D

更新日期：2007-11-13 00:00:00

abstract：:Entorhinal grid cells integrate sensory and self-motion inputs to provide a spatial metric of a characteristic scale. One function of this metric may be to help localize the firing fields of hippocampal place cells during formation and use of the hippocampal spatial representation ("cognitive map"). Of theoretical imp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casali G,Bush D,Jeffery K

更新日期：2019-03-05 00:00:00

abstract：:The fah1 mutant of Arabidopsis is defective in the accumulation of sinapic acid-derived metabolites, including the guaiacyl-syringyl lignin typical of angiosperms. Earlier results indicated that the FAH1 locus encodes ferulate-5-hydroxylase (F5H), a cytochrome P450-dependent monooxygenase (P450) of the general phenylp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer K,Cusumano JC,Somerville C,Chapple CC

更新日期：1996-07-09 00:00:00

abstract：:The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a genome scale. Toward this end, we have designed custom arrays that interrogate the expression of the vast majority of pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Su AI,Wiltshire T,Batalov S,Lapp H,Ching KA,Block D,Zhang J,Soden R,Hayakawa M,Kreiman G,Cooke MP,Walker JR,Hogenesch JB

更新日期：2004-04-20 00:00:00

abstract：:Serial passage of simian virus 40 (SV40) at high multiplicity of infection leads to the emergence of variants with deleted, substituted, and/or duplicated DNA. Individual variants have been cloned by selective complementation with temperature sensitive SV40 mutants, or nonselectively by coinfection of cells with wild-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brockman WW,Nathans D

更新日期：1974-03-01 00:00:00

abstract：:Gastrointestinal stromal tumor (GIST) has emerged as a clinically distinct type of sarcoma with frequent overexpression and mutation of the c-Kit oncogene and a favorable response to imatinib mesylate [also known as STI571 (Gleevec)] therapy. However, a significant diagnostic challenge remains in the differentiation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price ND,Trent J,El-Naggar AK,Cogdell D,Taylor E,Hunt KK,Pollock RE,Hood L,Shmulevich I,Zhang W

更新日期：2007-02-27 00:00:00

abstract：:We demonstrate theoretically and experimentally the spontaneous clustering of solitons in partially coherent wavefronts during the final stages of pattern formation initiated by modulation instability and noise. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Z,Sears SM,Martin H,Christodoulides DN,Segev M

更新日期：2002-04-16 00:00:00

abstract：:The noninvasive detection and quantification of CD8(+) T cells in vivo are important for both the detection and staging of CD8(+) lymphomas and for the monitoring of successful cancer immunotherapies, such as adoptive cell transfer and antibody-based immunotherapeutics. Here, antibody fragments are constructed to targ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tavaré R,McCracken MN,Zettlitz KA,Knowles SM,Salazar FB,Olafsen T,Witte ON,Wu AM

更新日期：2014-01-21 00:00:00

abstract：:We previously demonstrated that platelets express high levels of the tyrosine protein kinase pp60c-src. By a quantitative immunoblot assay, it is shown in this report that pp60c-src represents 0.2-0.4% of total platelet protein. The expression of high levels of pp60c-src in platelets correlated with high levels of tot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Golden A,Brugge JS

更新日期：1989-02-01 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C) recently has been described to be a relatively specific growth factor for the lymphatic vascular system. Here we report that ectopic application of recombinant VEGF-C also has potent angiogenic effects in vivo. VEGF-C is sufficiently potent to stimulate neovascularization ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao Y,Linden P,Farnebo J,Cao R,Eriksson A,Kumar V,Qi JH,Claesson-Welsh L,Alitalo K

更新日期：1998-11-24 00:00:00

abstract：:In previous papers of this series, emphasis has been placed on the steady-state phase transition and critical properties of large lattices of interacting, symmetrical, and identical enzyme molecules. The present paper is concerned with a number of examples of enzyme--enzyme interactions that do not belong to the class...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL

更新日期：1978-03-01 00:00:00

abstract：:We have analyzed the cell cycle regulation of human cyclin-dependent kinase 2 (CDK2), a protein closely related to the cell cycle-regulatory protein kinase CDC2. We find that CDK2 activity, like that of CDC2, oscillates during the cell cycle in cultured mammalian fibroblasts. Unlike CDC2 activity (which peaks during m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenblatt J,Gu Y,Morgan DO

更新日期：1992-04-01 00:00:00

abstract：:It has long been known that cholera outbreaks can be initiated when Vibrio cholerae, the bacterium that causes cholera, is present in drinking water in sufficient numbers to constitute an infective dose, if ingested by humans. Outbreaks associated with drinking or bathing in unpurified river or brackish water may dire...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lobitz B,Beck L,Huq A,Wood B,Fuchs G,Faruque AS,Colwell R

更新日期：2000-02-15 00:00:00

abstract：:Adenine-thymine (AT)-rich interactive domain 5a (Arid5a) is an RNA-binding protein found in the cytoplasm and nucleus of normally growing cells. Although Arid5a is known to play an important role in immune regulation, whether and how Arid5a subcellular localization impacts immune regulation has remained unclear. In th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higa M,Oka M,Fujihara Y,Masuda K,Yoneda Y,Kishimoto T

更新日期：2018-02-06 00:00:00