Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

abstract：:Intracellular proteolytic processing of precursor polypeptides is an essential step in the maturation of many proteins, including plasma proteins, hormones, neuropeptides, and growth factors. Most frequently, propeptide cleavage occurs after paired basic amino acid residues. To date, no mammalian propeptide processing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise RJ,Barr PJ,Wong PA,Kiefer MC,Brake AJ,Kaufman RJ

更新日期：1990-12-01 00:00:00

abstract：:Influenza hemagglutinin (HA) glycoprotein is the primary surface antigen targeted by the host immune response and a focus for development of novel vaccines, broadly neutralizing antibodies (bnAbs), and therapeutics. HA enables viral entry into host cells via receptor binding and membrane fusion and is a validated targ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Kadam RU,Lee CD,Woehl JL,Wu NC,Zhu X,Kitamura S,Wilson IA,Wolan DW

更新日期：2020-08-04 00:00:00

abstract：:Paleogenetics is an emerging field that resurrects ancestral proteins from now-extinct organisms to test, in the laboratory, models of protein function based on natural history and Darwinian evolution. Here, we resurrect digestive alcohol dehydrogenases (ADH4) from our primate ancestors to explore the history of prima...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrigan MA,Uryasev O,Frye CB,Eckman BL,Myers CR,Hurley TD,Benner SA

更新日期：2015-01-13 00:00:00

abstract：:A virus is associated with a strain of transovarially-transmitted SR-spirochetes, NSR, of Drosophila. This virus, designated spv-1, is able to infect and to multiply in another strain of SR-spirochetes, WSR, thereby eliminating the SR condition from the host flies. Spv-1 contains DNA, has a buoyant density of 1.480 in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oishi K,Poulson DF

更新日期：1970-11-01 00:00:00

abstract：:Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of which are associated with neuroinflammation. Circadian rhythm dysfunction has been associated with inflammation in the periphery, but the role of the core clock in neuroinflammation remains poorly understood. Here we demonstrate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffin P,Dimitry JM,Sheehan PW,Lananna BV,Guo C,Robinette ML,Hayes ME,Cedeño MR,Nadarajah CJ,Ezerskiy LA,Colonna M,Zhang J,Bauer AQ,Burris TP,Musiek ES

更新日期：2019-03-12 00:00:00

abstract：:The high-pressure behavior of amorphous selenium has been investigated with time-resolved diamond anvil cell synchrotron x-ray diffraction and computed microtomography techniques. A two-step dynamic crystallization process is observed in which the monoclinic phase crystallized from the amorphous selenium and gradually...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu H,Wang L,Xiao X,De Carlo F,Feng J,Mao HK,Hemley RJ

更新日期：2008-09-09 00:00:00

abstract：:The multiwavelength anomalous diffraction (MAD) method for phase evaluation is now widely used in macromolecular crystallography. Successful MAD structure determinations have been carried out at the K or L absorption edges of a variety of elements. In this study, we investigate the anomalous scattering properties of u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Ogata CM,Hendrickson WA

更新日期：2001-09-11 00:00:00

abstract：:Thymin, a purified polypeptide isolated from bovine thymus, was shown to induce the expression of differentiation antigens characteristic of thymocytes [TL and Thy-1 (theta)] when incubated in vitro with mouse bone marrow or spleen cells. This induction occurred in 5-10% of the cells from bone marrow after a 2-hr incu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basch RS,Goldstein G

更新日期：1974-04-01 00:00:00

abstract：:In vitro translation of cellular poly(A)+ RNA coupled with immunoprecipitation was developed as a technique for characterizing 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] receptors and assessing receptor mRNA activity. Cell-free translation of poly(A)+ RNA isolated from chicken intestine revealed two immunoprecipitable fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangelsdorf DJ,Pike JW,Haussler MR

更新日期：1987-01-01 00:00:00

abstract：:Several authors have considered Markov processes defined by the motion of a particle on a fixed line with a random velocity(1, 6, 8, 10) or a random diffusivity.(5, 12) A "random evolution" is a natural but apparently new generalization of this notion. In this note we hope to show that this concept leads to simple and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griego RJ,Hersh R

更新日期：1969-02-01 00:00:00

abstract：:Through a process called "bioturbation," burrowing macrofauna have altered the seafloor habitat and modified global carbon cycling since the Cambrian. However, the impact of macrofauna on the community structure of microorganisms is poorly understood. Here, we show that microbial communities across bioturbated, but ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deng L,Bölsterli D,Kristensen E,Meile C,Su CC,Bernasconi SM,Seidenkrantz MS,Glombitza C,Lagostina L,Han X,Jørgensen BB,Røy H,Lever MA

更新日期：2020-07-07 00:00:00

abstract：:We have earlier reported conditions that support the axenic development in vitro of a complete asexual erythrocytic cycle of Plasmodium falciparum. Up to 30% of merozoites showed initial differentiation into trophic forms (rings) viable at 14 hr. However, only approximately 1% of the merozoites would develop further i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JH,Gill GS,Trager W

更新日期：1995-01-17 00:00:00

abstract：:It has been recognized since ancient times that malaria fever is highly periodic but the mechanism has been poorly understood. Malaria fever is related to the parasite growth cycle in erythrocytes. After a fixed period of replication, a mature parasite (schizont) causes the infected erythrocyte to rupture, releasing p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwiatkowski D,Nowak M

更新日期：1991-06-15 00:00:00

abstract：:The partial purification of mouse mammary gland stem cells (MaSCs) using combinatorial cell surface markers (Lin(-)CD24(+)CD29(h)CD49f(h)) has improved our understanding of their role in normal development and breast tumorigenesis. Despite the significant improvement in MaSC enrichment, there is presently no methodolo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： dos Santos CO,Rebbeck C,Rozhkova E,Valentine A,Samuels A,Kadiri LR,Osten P,Harris EY,Uren PJ,Smith AD,Hannon GJ

更新日期：2013-04-30 00:00:00

abstract：:Tumor hypoxia reduces the effectiveness of radiation therapy by limiting the biologically effective dose. An acute increase in tumor oxygenation before radiation treatment should therefore significantly improve the tumor cell kill after radiation. Efforts to increase oxygen delivery to the tumor have not shown positiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benej M,Hong X,Vibhute S,Scott S,Wu J,Graves E,Le QT,Koong AC,Giaccia AJ,Yu B,Chen CS,Papandreou I,Denko NC

更新日期：2018-10-16 00:00:00

abstract：:Dopamine (DA) promotes wakefulness, and DA transporter inhibitors such as dextroamphetamine and methylphenidate are effective for increasing arousal and inducing reanimation, or active emergence from general anesthesia. DA neurons in the ventral tegmental area (VTA) are involved in reward processing, motivation, emoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor NE,Van Dort CJ,Kenny JD,Pei J,Guidera JA,Vlasov KY,Lee JT,Boyden ES,Brown EN,Solt K

更新日期：2016-11-08 00:00:00

abstract：:Cultural processes occur in a wide variety of animal taxa, from insects to cetaceans. The songs of humpback whales are one of the most striking examples of the transmission of a cultural trait and social learning in any nonhuman animal. To understand how songs are learned, we investigate rare cases of song hybridizati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garland EC,Rendell L,Lamoni L,Poole MM,Noad MJ

更新日期：2017-07-25 00:00:00

abstract：:The magnetic microstructure of a natural, finely exsolved intergrowth of submicron magnetite blocks in an ulvöspinel matrix is characterized by using off-axis electron holography in the transmission electron microscope. Single-domain and vortex states in individual blocks, as well as magnetostatic interaction fields b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrison RJ,Dunin-Borkowski RE,Putnis A

更新日期：2002-12-24 00:00:00

abstract：:Genomic clones and cDNA plasmids were isolated for the intermediate filament protein vimentin from chicken. The identity of the various clones was determined both by mRNA selection [Paterson, B. M. & Roberts, B. E. (1981) in Gene Amplification and Analysis, Structural Analysis or Nucleic Acids, eds. Chirikjian, J. G. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zehner ZE,Paterson BM

更新日期：1983-02-01 00:00:00

abstract：:Significantly above-chance detection of stimuli presented within the field defect of patients with postgeniculate lesions is termed "blindsight." It has been proposed that those with blindsight are more likely to benefit from visual rehabilitation by repeated stimulation, leading to increased visual sensitivity within...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sahraie A,Trevethan CT,MacLeod MJ,Urquhart J,Weiskrantz L

更新日期：2013-11-05 00:00:00

abstract：:P-glycoprotein is an ATP-binding cassette multidrug transporter that actively transports chemically diverse substrates across the lipid bilayer. The precise molecular mechanism underlying transport is not fully understood. Here, we present crystal structures of a eukaryotic P-glycoprotein homolog, CmABCB1 from Cyanidi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kodan A,Yamaguchi T,Nakatsu T,Sakiyama K,Hipolito CJ,Fujioka A,Hirokane R,Ikeguchi K,Watanabe B,Hiratake J,Kimura Y,Suga H,Ueda K,Kato H

更新日期：2014-03-18 00:00:00

abstract：:A coarse-grained model for protein-folding dynamics is introduced based on a discretized representation of torsional modes. The model, based on the Ramachandran map of the local torsional potential surface and the class (hydrophobic/polar/neutral) of each residue, recognizes patterns of both torsional conformations an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Kostov K,Berry RS

更新日期：1999-11-09 00:00:00

abstract：:Hypertension increases the pressure load on the heart and is associated with a poorly understood chronic systemic inflammatory state. Interleukin 33 (IL-33) binds to membrane-bound ST2 (ST2L) and has antihypertrophic and antifibrotic effects in the myocardium. In contrast, soluble ST2 appears to act as a decoy recepto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen WY,Hong J,Gannon J,Kakkar R,Lee RT

更新日期：2015-06-09 00:00:00

abstract：:We induced an essential fatty acid deficiency (EFAD) in human umbilical vein endothelial cells by culture in medium with 20% (vol/vol) delipidated fetal calf serum. EFAD, reflected by decreased cellular linoleic acid (18:2 omega 6) and arachidonic acid (20:4 omega 6) and emergence of the oleic acid derivative 5,8,11-e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerner R,Lindström P,Berg A,Johansson E,Rosendahl K,Palmblad J

更新日期：1995-02-14 00:00:00

abstract：:Infection of Swiss mouse 3T3FL cells with a clonal isolate of Moloney leukemia virus (MLV-IC) resulted in virus progeny composed of at least three different murine helper oncornaviruses. Each entity was purified in appropriate cells by several sequential terminal dilution isolations and was grouwn to high titers. Besi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischinger PJ,Nomura S,Bolognesi DP

更新日期：1975-12-01 00:00:00

abstract：:The functional architecture of mammalian visual cortex has been elucidated in impressive detail by experimental work of the past 20-25 years. The origin of many of the salient features of this architecture, however, has remained unexplained. This paper is the first of three (the others will appear in subsequent issues...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Linsker R

更新日期：1986-10-01 00:00:00

abstract：:Myelodysplastic syndromes (MDS) are among the most frequent hematologic malignancies. Patients have a short survival and often progress to acute myeloid leukemia. The diagnosis of MDS can be difficult; there is a paucity of molecular markers, and the pathophysiology is largely unknown. Therefore, we conducted a multic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aivado M,Spentzos D,Germing U,Alterovitz G,Meng XY,Grall F,Giagounidis AA,Klement G,Steidl U,Otu HH,Czibere A,Prall WC,Iking-Konert C,Shayne M,Ramoni MF,Gattermann N,Haas R,Mitsiades CS,Fung ET,Libermann TA

更新日期：2007-01-23 00:00:00

abstract：:The p21(WAF1) (p21) cyclin-dependent kinase inhibitor plays a major role in regulating cell cycle arrest. It was recently reported that the p53-independent elevation of p21 protein levels is essential in mediating the G(1) arrest resulting from signal transduction events initiated by the crosslinking of membrane IgM o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marches R,Hsueh R,Uhr JW

更新日期：1999-07-20 00:00:00

abstract：:Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators. We report the solution structure of the cysteine/histidine-rich 1 (CH1) domain of p300 bound to the C-terminal transactivation domain of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freedman SJ,Sun ZY,Poy F,Kung AL,Livingston DM,Wagner G,Eck MJ

更新日期：2002-04-16 00:00:00

abstract：:Prediction of the native tertiary structure of a globular protein from the primary sequence will require a potential energy model that can discriminate all nonnative structures from the native structure(s). A successful model must distinguish not only alternate structures that are very nonnative but also alternate str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Zhang H,Li W,Scott RA

更新日期：1995-01-31 00:00:00