Avian and mammalian receptors for 1,25-dihydroxyvitamin D3: in vitro translation to characterize size and hormone-dependent regulation.

abstract：:A generic modeling framework to infer the failure-spreading process based on failure times of individual nodes is proposed and tested in four simulation studies: one for cascading failures in interdependent power and transportation networks, one for influenza epidemics, one benchmark test case for congestion cascade i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guan X,Chen C

更新日期：2018-08-28 00:00:00

abstract：:The three-dimensional structures of RNA enzymes form catalytic centers that include specific substrate binding sites. High-resolution determination of these and other RNA structures is essential for a detailed understanding of the function of RNA in biological systems. The crystal structures of only a few RNA molecule...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doudna JA,Grosshans C,Gooding A,Kundrot CE

更新日期：1993-08-15 00:00:00

abstract：:Many neurotransmitters are known to regulate neuronal cell function by means of activation of cAMP-dependent protein kinase (PKA) and phosphorylation of neuronal substrate proteins, including transcription factors and ion channels. Here, we have characterized the gene expression of two isoforms of a protein kinase inh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seasholtz AF,Gamm DM,Ballestero RP,Scarpetta MA,Uhler MD

更新日期：1995-02-28 00:00:00

abstract：:Long-term plasticity can differ from short-term in recruiting the growth of new synaptic connections, a process that requires the participation of both the presynaptic and postsynaptic components of the synapse. How does information about synaptic plasticity spread from its site of origin to recruit the other componen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin I,Puthanveettil S,Udo H,Karl K,Kandel ER,Hawkins RD

更新日期：2012-06-05 00:00:00

abstract：:Rising sea levels and increased storminess are expected to accelerate the erosion of soft-cliff coastlines, threatening coastal infrastructure and livelihoods. To develop predictive models of future coastal change we need fundamentally to know how rapidly coasts have been eroding in the past, and to understand the dri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurst MD,Rood DH,Ellis MA,Anderson RS,Dornbusch U

更新日期：2016-11-22 00:00:00

abstract：:Phytochrome A (phyA) is the only plant photoreceptor that perceives far-red light and then mediates various responses to this signal. Phosphorylation and dephosphorylation of oat phyA have been extensively studied, and it was shown that phosphorylation of a serine residue in the hinge region of oat phyA could regulate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Y,Yang L,Duan J,Cheng J,Shen Y,Wang X,Han R,Li H,Li Z,Wang L,Terzaghi W,Zhu D,Chen H,Deng XW,Li J

更新日期：2018-12-11 00:00:00

abstract：:I reject the Darwinian assumption that larvae and their adults evolved from a single common ancestor. Rather I posit that, in animals that metamorphose, the basic types of larvae originated as adults of different lineages, i.e., larvae were transferred when, through hybridization, their genomes were acquired by distan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williamson DI

更新日期：2009-11-24 00:00:00

abstract：:We construct a class of global exact solutions of the Einstein equations that extend the Oppeheimer-Snyder model to the case of nonzero pressure, inside the black hole, by incorporating a shock wave at the leading edge of the expansion of the galaxies, arbitrarily far beyond the Hubble length in the Friedmann-Robertso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smoller J,Temple B

更新日期：2003-09-30 00:00:00

abstract：:One of sleep's putative functions is mediation of adaptation to waking experiences. Chronic stress is a common waking experience; however, which specific aspect of sleep is most responsive, and how sleep changes relate to behavioral disturbances and molecular correlates remain unknown. We quantified sleep, physical, e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nollet M,Hicks H,McCarthy AP,Wu H,Möller-Levet CS,Laing EE,Malki K,Lawless N,Wafford KA,Dijk DJ,Winsky-Sommerer R

更新日期：2019-02-12 00:00:00

abstract：:We have examined whether dissociation of the histone octamer is required for elongation of RNA transcripts through arrays of nucleosome cores in vitro. Control or dimethyl suberimidate-crosslinked histone octamers were reconstituted onto supercoiled, closed circular pT207-18 DNA, which contains tandemly repeated 207-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill TE,Smith JG,Bradbury EM

更新日期：1993-07-01 00:00:00

abstract：:In this study we sought to better understand the role of the glycoprotein quality control machinery in the assembly of MHC class I molecules with high-affinity peptides. The lectin-like chaperone calreticulin (CRT) and the thiol oxidoreductase ERp57 participate in the final step of this process as part of the peptide-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wearsch PA,Peaper DR,Cresswell P

更新日期：2011-03-22 00:00:00

abstract：:Spontaneous liposome formation is predicted in binary mixtures of fluid phase phospholipids and poly(n)ethylene oxide (PEO)-bearing lipids by using single chain mean field theory. The range of stability of the spontaneous liposomes is determined as a function of percentage of PEO-conjugated lipids and polymer molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szleifer I,Gerasimov OV,Thompson DH

更新日期：1998-02-03 00:00:00

abstract：:We test the conjecture that becoming unemployed erodes the extent to which a person acknowledges earned entitlement. We use behavioral experiments to generate incentive-compatible measures of individuals' tendencies to acknowledge earned entitlement and incorporate these experiments in a two-stage study. In the first ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barr A,Miller L,Ubeda P

更新日期：2016-04-26 00:00:00

abstract：:It had been shown previously that the heat-stable polypeptide of the ATP-dependent proteolytic system of reticulocytes, designated APF-1, forms covalent conjugates with protein substrates in an ATP-requiring process. We now describe an enzyme that carries out the activation by ATP of the polypeptide with pyrophosphate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ciechanover A,Heller H,Katz-Etzion R,Hershko A

更新日期：1981-02-01 00:00:00

abstract：:Double-stranded RNA (dsRNA) recently has been shown to give rise to genetic interference in Caenorhabditis elegans and also is likely to be the basis for phenotypic cosuppression in plants in certain instances. While constructing a plasmid vector for transfection of trypanosome cells, we serendipitously discovered tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ngô H,Tschudi C,Gull K,Ullu E

更新日期：1998-12-08 00:00:00

abstract：:The structure of the adeno-associated virus (AAV-2) has been determined to 3-A resolution by x-ray crystallography. AAV is being developed as a vector for gene therapy to treat diseases including hemophilia, cancer, and cystic fibrosis. As in the distantly related autonomous parvoviruses, the capsid protein has a beta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie Q,Bu W,Bhatia S,Hare J,Somasundaram T,Azzi A,Chapman MS

更新日期：2002-08-06 00:00:00

abstract：:Affinity-fractionated porcine heparin was randomly scissioned by chemical techniques to give hexasaccharides, octasaccharides, decasaccharides, and mucopolysaccharide fragments of approximately 14 residues and approximately 16 residues that were able to complex with the protease inhibitor. Direct measurements of the k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oosta GM,Gardner WT,Beeler DL,Rosenberg RD

更新日期：1981-02-01 00:00:00

abstract：:Purified cellular retinol-binding protein (CRBP), a potential mediator of vitamin A action, was found to enable retinol to bind in a specific manner to isolated nuclei from livers of vitamin A deficient rats. Binding was followed after complexing [3H]retinol with CRBP. The binding was specific, saturable, and temperat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takase S,Ong DE,Chytil F

更新日期：1979-05-01 00:00:00

abstract：:We provide here evidence that supports the occurrence of a biologically dormant form of selectin ligand carbohydrate, the sialyl 6-sulfo Lewis X containing modified sialic acid, in human leukocytes. The modification of sialic acid involves first de-N-acetylation of sialic acid moiety through ubiquitous de-N-acetylatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitsuoka C,Ohmori K,Kimura N,Kanamori A,Komba S,Ishida H,Kiso M,Kannagi R

更新日期：1999-02-16 00:00:00

abstract：:Epilepsy, a disease characterized by abnormal brain activity, is a disabling and potentially life-threatening condition for nearly 1% of the world population. Unfortunately, modulation of brain excitability using available antiepileptic drugs can have serious side effects, especially in the developing brain, and some ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraban SC,Southwell DG,Estrada RC,Jones DL,Sebe JY,Alfaro-Cervello C,García-Verdugo JM,Rubenstein JL,Alvarez-Buylla A

更新日期：2009-09-08 00:00:00

abstract：:Collective animal behavior studies have led the way in developing models that account for a large number of individuals, but mostly have considered situations in which alignment and attraction play a key role, such as in schooling and flocking. By quantifying how animals react to one another's presence, when interacti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giuggioli L,Potts JR,Rubenstein DI,Levin SA

更新日期：2013-10-15 00:00:00

abstract：:Absolute pitch (AP) is the rare ability to identify the pitch of a tone without the aid of a reference tone. Understanding both the nature and genesis of AP can provide insights into neuroplasticity in the auditory system. We explored factors that may influence the accuracy of pitch perception in AP subjects both duri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Athos EA,Levinson B,Kistler A,Zemansky J,Bostrom A,Freimer N,Gitschier J

更新日期：2007-09-11 00:00:00

abstract：:A recently described organ culture system for human thymocytes is shown to support the generation of a diverse T-cell receptor repertoire in vitro: thymocytes of the alpha beta lineage, including representatives of the V beta families 5.2/5.3, 6.7, and 8, accounted for the majority of T-cell receptor-positive cells th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merkenschlager M,Fisher AG

更新日期：1992-05-15 00:00:00

abstract：:The phosphatase and tensin homolog (PTEN) is a tumor suppressor that is inactivated in many human cancers. PTEN loss has been associated with resistance to inhibitors of the epidermal growth factor receptor (EGFR), but the molecular basis of this resistance is unclear. It is believed that unopposed phosphatidylinosito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vivanco I,Rohle D,Versele M,Iwanami A,Kuga D,Oldrini B,Tanaka K,Dang J,Kubek S,Palaskas N,Hsueh T,Evans M,Mulholland D,Wolle D,Rajasekaran S,Rajasekaran A,Liau LM,Cloughesy TF,Dikic I,Brennan C,Wu H,Mischel PS,

更新日期：2010-04-06 00:00:00

abstract：:Nitric oxide (NO) is an antiviral effector of the innate immune system. Viruses that can interfere with NO synthesis may be able to replicate more rapidly than viruses that cannot limit NO synthesis. We show that the adenovirus E1A protein inhibits NO production by decreasing expression of the inducible NO synthase (N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao W,Bao C,Lowenstein CJ

更新日期：2003-06-24 00:00:00

abstract：:Somatic fungal hyphae are generally assumed to elongate at steady linear rates when grown under constant environmental conditions with ample nutrients. However, patterns of pulsed hyphal elongation were detected during apparent steady growth of hyphal tips in fungi from several major taxonomic groups (Oomycetes, Pythi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： López-Franco R,Bartnicki-Garcia S,Bracker CE

更新日期：1994-12-06 00:00:00

abstract：:Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) has been implicated in Parkinson's disease (PD) and is present in neurofibrillary tangles or Lewy bodies. However, the molecular basis for UCH-L1s involvement in proteinacious fibril formation is still elusive, especially in regard to the pathogenicity of the I93M muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koharudin LM,Liu H,Di Maio R,Kodali RB,Graham SH,Gronenborn AM

更新日期：2010-04-13 00:00:00

abstract：:We report substantially improved performance of high-power quantum cascade lasers (QCLs) by using epitaxial-side-down mounting that provides superior heat dissipation properties. We used aluminum nitride as the heatsink material and gold-tin eutectic solder. We have obtained continuous wave power output of 450 mW at 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsekoun A,Go R,Pushkarsky M,Razeghi M,Patel CK

更新日期：2006-03-28 00:00:00

abstract：:Cholera vibrios produce a single polymeric protein that (i) causes hemagglutination; (ii) appears to participate in their attachment to gut epithelium; (iii) may mediate their detachment from gut epithelium; and (iv) is a protease that hydrolyzes fibronectin and mucin, cleaves lactoferrin, and nicks the A subunit of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finkelstein RA,Boesman-Finkelstein M,Holt P

更新日期：1983-02-01 00:00:00

abstract：:Complex phenotypes can be modeled as networks of component traits connected by genetic, developmental, or functional interactions. Aposematism, which has evolved multiple times in poison frogs (Dendrobatidae), links a warning signal to a chemical defense against predators. Other traits are involved in this complex phe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santos JC,Cannatella DC

更新日期：2011-04-12 00:00:00