Inducible nitric oxide synthase expression inhibition by adenovirus E1A.

Abstract:

:Nitric oxide (NO) is an antiviral effector of the innate immune system. Viruses that can interfere with NO synthesis may be able to replicate more rapidly than viruses that cannot limit NO synthesis. We show that the adenovirus E1A protein inhibits NO production by decreasing expression of the inducible NO synthase (NOS2). The amino-terminal portion of E1A decreases transactivation of the NOS2 5'-flanking region, limiting the DNA binding activity of NF-kappaB and inhibiting NOS2 expression. E1A is thus able to deactivate a critical component of the host defense against viral infection. Viral inhibition of NO production is a mechanism that may enable certain viruses to evade the host innate immune system.

authors

Cao W,Bao C,Lowenstein CJ

doi

10.1073/pnas.1337185100

keywords:

subject

Has Abstract

pub_date

2003-06-24 00:00:00

pages

7773-8

issue

13

eissn

0027-8424

issn

1091-6490

pii

1337185100

journal_volume

100

pub_type

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