Abstract:
:Nitric oxide (NO) is an antiviral effector of the innate immune system. Viruses that can interfere with NO synthesis may be able to replicate more rapidly than viruses that cannot limit NO synthesis. We show that the adenovirus E1A protein inhibits NO production by decreasing expression of the inducible NO synthase (NOS2). The amino-terminal portion of E1A decreases transactivation of the NOS2 5'-flanking region, limiting the DNA binding activity of NF-kappaB and inhibiting NOS2 expression. E1A is thus able to deactivate a critical component of the host defense against viral infection. Viral inhibition of NO production is a mechanism that may enable certain viruses to evade the host innate immune system.
journal_name
Proc Natl Acad Sci U S Aauthors
Cao W,Bao C,Lowenstein CJdoi
10.1073/pnas.1337185100keywords:
subject
Has Abstractpub_date
2003-06-24 00:00:00pages
7773-8issue
13eissn
0027-8424issn
1091-6490pii
1337185100journal_volume
100pub_type
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