当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells.

Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells.

Abstract：

:IL-17-producing CD27(-) γδ cells (γδ(27-) cells) are widely viewed as innate immune cells that make critical contributions to host protection and autoimmunity. However, factors that promote them over IFN-γ-producing γδ(27+) cells are poorly elucidated. Moreover, although human IL-17-producing γδ cells are commonly implicated in inflammation, such cells themselves have proved difficult to isolate and characterize. Here, murine γδ(27-) T cells and thymocytes are shown to be rapidly and substantially expanded by IL-7 in vitro and in vivo. This selectivity owes in substantial part to the capacity of IL-7 to activate STAT3 in such cells. Additionally, IL-7 promotes strong responses of IL-17-producing γδ cells to TCR agonists, thus reemphasizing the cells' adaptive and innate potentials. Moreover, human IL-17-producing γδ cells are also substantially expanded by IL-7 plus TCR agonists. Hence, IL-7 has a conserved potential to preferentially regulate IL-17-producing γδ cells, with both biological and clinical implications.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Michel ML,Pang DJ,Haque SF,Potocnik AJ,Pennington DJ,Hayday AC

doi

10.1073/pnas.1204327109

subject

Has Abstract

pub_date

2012-10-23 00:00:00

pages

17549-54

issue

43

eissn

0027-8424

issn

1091-6490

pii

1204327109

journal_volume

109

pub_type

杂志文章

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