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Are the presynaptic membrane particles the calcium channels?

Abstract：

:The number of large intramembrane particles associated with sites of synaptic vesicle release at the squid giant synapse was determined and compared to the average maximal presynaptic calcium current in order to derive an estimate of the conductance each particle would have if it were a calcium channel. This value, 0.21 pS, compares favorably with conductances of calcium channels in other preparations, substantiating the idea that the large intramembrane particles, which are concentrated at "active zones," represent calcium channels.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Pumplin DW,Reese TS,Llinás R

doi

10.1073/pnas.78.11.7210

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

7210-3

issue

11

eissn

0027-8424

issn

1091-6490

journal_volume

78

pub_type

杂志文章

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