Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.

abstract：:Plasma norepinephrine and dopamine beta-hydroxylase (EC 1.14.17.1) activity were measured in rats. Adrenergic neuron blockade with bretylium for 4 hr and ganglion blockade with chlorisondamine for 72 hr lowered plasma norepinephrine. Neither treatment altered plasma dopamine beta-hydroxylase activity. Phenoxybenzamine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid JL,Kopin IJ

更新日期：1974-11-01 00:00:00

abstract：:Health care is a crucial factor in US economic growth, because growing health care costs have made US corporations less competitive than their counterparts in countries where central governments assume most of those costs. In this paper we illustrate a second, possibly more powerful, effect of health care expenditures...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manton KG,Gu XL,Ullian A,Tolley HD,Headen AE Jr,Lowrimore G

更新日期：2009-12-15 00:00:00

abstract：:Transporters in the Golgi apparatus membrane translocate nucleotide sugars from the cytosol into the Golgi lumen before these can be substrates for the glycosylation of proteins, lipids, and proteoglycans. We have cloned the mammalian Golgi membrane transporter for uridine diphosphate-N-acetylglucosamine by phenotypic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guillen E,Abeijon C,Hirschberg CB

更新日期：1998-07-07 00:00:00

abstract：:Acquisition of acetylcholine receptors during differentiation of a clonal myoblast cell line was monitored with a neurotoxin isolated from venom of the Indian Cobra Naja naja. Toxin bound specifically and reversibly to acetylcholine receptors of the differentiated cells. Specificity of the binding reaction was assayed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patrick J,Heinemann SF,Lindstrom J,Schubert D,Steinbach JH

更新日期：1972-10-01 00:00:00

abstract：:After decades of robust growth, the rise in US life expectancy stalled after 2010. Explanations for the stall have focused on rising drug-related deaths. Here we show that a stagnating decline in cardiovascular disease (CVD) mortality was the main culprit, outpacing and overshadowing the effects of all other causes of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehta NK,Abrams LR,Myrskylä M

更新日期：2020-03-31 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent of a large group of related proteinopathies for which there is currently no cure. Here, we used Drosophila to explore a strategy to block Aβ42 neurotoxicity through engineering of the Heat shock protein 70 (Hsp70), a chaperone that has demonstrated neuroprotective activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez-Funez P,Sanchez-Garcia J,de Mena L,Zhang Y,Levites Y,Khare S,Golde TE,Rincon-Limas DE

更新日期：2016-08-30 00:00:00

abstract：:The body-wall muscle cells of the nematode Caenorhabditis elegans produce thick filaments during embryonic, larval, and adult stages. These thick filaments contain two myosin isoforms, A and B, which assemble into different zones along the 10-microns lengths. Paramyosin, a protein homologous to myosin rods, forms a su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honda S,Epstein HF

更新日期：1990-02-01 00:00:00

abstract：:We have investigated the pharmacologic and neurotoxic properties of 2,4,5-trihydroxyphenylalanine [topa; the 6-hydroxylated derivative of 3,4-dihydroxyphenylalanine (dopa)] in central neurons. Application of solutions of topa to the chicken eyecup preparation results in glutamatergic responses mediated predominantly b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenberg PA,Loring R,Xie Y,Zaleskas V,Aizenman E

更新日期：1991-06-01 00:00:00

abstract：:Transcriptional interference between genes and the regulatory elements of simple eukaryotes such as Saccharomyces cerevisiae is an unavoidable consequence of their compressed genetic arrangement. We have shown previously that with the tandem arranged genes GAL10 and GAL7, inefficient transcriptional termination of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prescott EM,Proudfoot NJ

更新日期：2002-06-25 00:00:00

abstract：:Treatment of small resting B cells with soluble F(ab')2 fragments of anti-IgM, an analogue of T-independent type 2 antigens, induced activation characterized by proliferation and the expression of surface CD5. In contrast, B cells induced to proliferate in response to thymus-dependent inductive signals provided by eit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wortis HH,Teutsch M,Higer M,Zheng J,Parker DC

更新日期：1995-04-11 00:00:00

abstract：:Although infection by primary HIV type 1 (HIV-1) isolates normally requires the functional interaction of the viral envelope protein with both CD4 and the CCR-5 coreceptor, a subset of such isolates also are able to use the distinct CCR-3 receptor. By analyzing the ability of a series of wild-type and chimeric HIV-1 e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross TM,Cullen BR

更新日期：1998-06-23 00:00:00

abstract：:n-Type Si electrodes in MeOH solvent with 0.2 M (1-hydroxyethyl)ferrocene, 0.5 mM (1-hydroxyethyl)ferricenium, and 1.0 M LiClO(4) exhibit air mass 2 conversion efficiencies of 10.1% for optical energy into electricity. We observe open-circuit voltages of 0.53 V and short-circuit quantum efficiencies for electron flow ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gronet CM,Lewis NS,Cogan G,Gibbons J

更新日期：1983-02-01 00:00:00

abstract：:Covariance analysis of protein sequence alignments uses coevolving pairs of sequence positions to predict features of protein structure and function. However, current methods ignore the phylogenetic relationships between sequences, potentially corrupting the identification of covarying positions. Here, we use random m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin C,Colwell LJ

更新日期：2018-01-23 00:00:00

abstract：:We have previously identified two species of the low-affinity human Fc receptor for IgE, Fc epsilon RIIa and Fc epsilon RIIb, which differ only in a short stretch of amino acids at the N-terminal cytoplasmic end. Their differential expressions on B cells and monocytes suggest that Fc epsilon RIIa and Fc epsilon RIIb a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yokota A,Yukawa K,Yamamoto A,Sugiyama K,Suemura M,Tashiro Y,Kishimoto T,Kikutani H

更新日期：1992-06-01 00:00:00

abstract：:Although neurotrophins are primarily associated with long-term effects on neuronal survival and differentiation, recent studies have shown that acute changes in synaptic transmission can also be produced. In the hippocampus, an area critically involved in learning and memory, we have found that brain-derived neurotrop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine ES,Dreyfus CF,Black IB,Plummer MR

更新日期：1995-08-15 00:00:00

abstract：:Glucose, one of the most important nutrients for animals, acts as a regulatory signal that controls the secretion of hormones, such as insulin, by endocrine tissues. However, how organisms respond to extracellular glucose and how glucose controls nutrient homeostasis remain unknown. Here, we show that a putative Droso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kohyama-Koganeya A,Kim YJ,Miura M,Hirabayashi Y

更新日期：2008-10-07 00:00:00

abstract：:Without a fully developed initial segment, the most proximal region of the epididymis, male infertility results. Therefore, it is important to understand the development and regulation of this crucial region. In addition to distinctively high activity levels of the components of the ERK pathway, which are essential fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu B,Washington AM,Hinton BT

更新日期：2014-12-30 00:00:00

abstract：:Negative cooperativity has been observed in CTP synthetase, an allosteric enzyme which contains a regulatory site. Thus, the same enzyme exhibits negative cooperativity for GTP (an effector) and glutamine (a substrate) and positive cooperativity for ATP and UTP (both substrates). In the process of the delineation of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levitzki A,Koshland DE Jr

更新日期：1969-04-01 00:00:00

abstract：:During mammalian aging, cellular proteins become increasingly damaged: for example, by carbonylation and formation of advanced glycation end products (AGEs). The means to ensure that offspring are born without such damage are unknown. Unexpectedly, we found that undifferentiated mouse ES cells contain high levels of b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hernebring M,Brolén G,Aguilaniu H,Semb H,Nyström T

更新日期：2006-05-16 00:00:00

abstract：:Bone morphogenetic protein 4 (BMP-4) induces ventral mesoderm but represses dorsal mesoderm formation in Xenopus embryos. We show that BMP-4 inhibits two signaling pathways regulating dorsal mesoderm formation, the induction of dorsal mesoderm (Spemann organizer) and the dorsalization of ventral mesoderm. Ectopic expr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Re'em-Kalma Y,Lamb T,Frank D

更新日期：1995-12-19 00:00:00

abstract：:Accumulation of misfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR), an intracellular signaling pathway that adjusts the protein folding capacity of the ER according to need. If homeostasis in the ER protein folding environment cannot be reestablished, cells commit to apop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Korennykh AV,Behrman SL,Walter P

更新日期：2010-09-14 00:00:00

abstract：:Mounting effective T cell responses is critical for eliciting long-lasting immunity following viral infection and vaccination. A multitude of inhibitory and stimulatory factors are induced following infection, and it is the compilation of these signals that quantitatively and qualitatively program the ensuing effector...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks DG,Walsh KB,Elsaesser H,Oldstone MB

更新日期：2010-02-16 00:00:00

abstract：:p-Coumaric acid is the precursor of phenylpropanoids, which are plant secondary metabolites that are beneficial to human health. Tyrosine ammonia lyase catalyzes the production of p-coumaric acid from tyrosine. Because of their photosynthetic ability and biosynthetic versatility, cyanobacteria are promising candidates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xue Y,Zhang Y,Cheng D,Daddy S,He Q

更新日期：2014-07-01 00:00:00

abstract：:Protein kinase P (PK-P) activated by histones or certain other basic compounds has been purified previously from yeast [Yanagita, Y., Abdel-Ghany, M., Raden, D., Nelson, N. & Racker, E. (1987) Proc. Natl. Acad. Sci. USA 84, 925-929]. It is shown here that PK-P is present in solubilized membranes of A-431 carcinoma cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abdel-Ghany M,Kole HK,Racker E

更新日期：1987-12-01 00:00:00

abstract：:Debate over the influence of postwildfire management on future fire severity is occurring in the absence of empirical studies. We used satellite data, government agency records, and aerial photography to examine a forest landscape in southwest Oregon that burned in 1987 and then was subject, in part, to salvage-loggin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson JR,Spies TA,Ganio LM

更新日期：2007-06-19 00:00:00

abstract：:Array technologies have made it straightforward to monitor simultaneously the expression pattern of thousands of genes. The challenge now is to interpret such massive data sets. The first step is to extract the fundamental patterns of gene expression inherent in the data. This paper describes the application of self-o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamayo P,Slonim D,Mesirov J,Zhu Q,Kitareewan S,Dmitrovsky E,Lander ES,Golub TR

更新日期：1999-03-16 00:00:00

abstract：:A method for estimating intrafamilial correlations under variable family sizes involving weightings of paired data points is introduced. Classical methods of intrafamilial correlation estimation and those in current use are outlined and critically analyzed. Extensions of the proposed estimation method to more general ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karlin S,Cameron EC,Williams PT

更新日期：1981-05-01 00:00:00

abstract：:In genotypic mutation analysis DNA sequence changes are determined without the in vivo or in vitro selection of phenotypically altered cells. We have studied the induction of base-pair changes by N-ethyl-N-nitrosourea in Taq I endonuclease recognition site 2508-2511 (TCGA) of the c-H-ras1 gene in human fibroblasts by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiocca SM,Sandy MS,Cerutti PA

更新日期：1992-06-15 00:00:00

abstract：:Estimation of evolutionary distances has always been a major issue in the study of molecular evolution because evolutionary distances are required for estimating the rate of evolution in a gene, the divergence dates between genes or organisms, and the relationships among genes or organisms. Other closely related issue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gu X,Li WH

更新日期：1998-05-26 00:00:00

abstract：:p38 mitogen-activated protein kinase (MAPK) regulates cytokines in arthritis and is, in turn, regulated by MAPK kinase (MKK) 3 and MKK6. To modulate p38 function but potentially minimize toxicity, we evaluated the utility of targeting MKK3 by using MKK3(-/-) mice. These studies showed that TNF-alpha increased phosphor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue T,Boyle DL,Corr M,Hammaker D,Davis RJ,Flavell RA,Firestein GS

更新日期：2006-04-04 00:00:00