Elimination of damaged proteins during differentiation of embryonic stem cells.

abstract：:The optical transitions of a chiral, three-substituted polythiophene with an amino acid function can be tuned by interactions with synthetic peptides. The addition of a positively charged peptide with a random-coil formation will force the polymer to adopt a nonplanar conformation, and the intensity of the emitted lig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nilsson KP,Rydberg J,Baltzer L,Inganäs O

更新日期：2003-09-02 00:00:00

abstract：:Plant steroid hormones, brassinosteroids (BRs), are of great importance for plant growth and development. BRs signal through a cell surface receptor kinase, BRI1, and a GSK3-like kinase, BIN2, to regulate the BES1/BZR1 family of transcription factors, which directly bind to target gene promoters to activate or repress...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu X,Li L,Li L,Guo M,Chory J,Yin Y

更新日期：2008-05-27 00:00:00

abstract：:Saccharomyces cerevisiae Hop2 and Mnd1 are abundant meiosisspecific chromosomal proteins, and mutations in the corresponding genes lead to defects in meiotic recombination and in homologous chromosome interactions during mid-prophase. Analysis of various double mutants suggests that HOP2, MND1, and DMC1 act in the sam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YK,Leng CH,Olivares H,Lee MH,Chang YC,Kung WM,Ti SC,Lo YH,Wang AH,Chang CS,Bishop DK,Hsueh YP,Wang TF

更新日期：2004-07-20 00:00:00

abstract：:Although biological cells are mostly transparent, they are phase objects that differ in shape and refractive index. Any image that is projected through layers of randomly oriented cells will normally be distorted by refraction, reflection, and scattering. Counterintuitively, the retina of the vertebrate eye is inverte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Franze K,Grosche J,Skatchkov SN,Schinkinger S,Foja C,Schild D,Uckermann O,Travis K,Reichenbach A,Guck J

更新日期：2007-05-15 00:00:00

abstract：:Most human tumors are clonal in origin, although the cells may be diverse in their properties. Since the tumors evolve through progressive stages over decades of time, it is possible that the conditions that induced the tumor transform many cells, but that selective overgrowth of the fastest growing lead to a clonal p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao A,Rubin H

更新日期：1993-11-15 00:00:00

abstract：:Perfusion of rat hearts with Krebs--Henseleit medium containing 10 mM L-leucine methyl ester leads to swelling of lysosomes and loss of lysosomal integrity within 30-60 min. No morphological changes can be detected in the nuclei, mitochondria, sarcoplasmic reticulum, or Golgi complex as a result of the treatment with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeves JP,Decker RS,Crie JS,Wildenthal K

更新日期：1981-07-01 00:00:00

abstract：:Changes in the amount, intensity, and timing of precipitation are increasing hydrologic variability in many regions, but we have little understanding of how these changes are affecting freshwater species. Stream-breeding amphibians-a diverse group in North America-may be particularly sensitive to hydrologic variabilit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lowe WH,Swartz LK,Addis BR,Likens GE

更新日期：2019-09-24 00:00:00

abstract：:The sophistication of the insect olfactory system is elegantly demonstrated by the reception of sex pheromone by the Japanese beetle. In this insect, two olfactory receptor neurons housed in antennal sensilla placodea are highly sensitive. One neuron specifically detects the sex pheromone produced by conspecific femal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida Y,Leal WS

更新日期：2008-07-01 00:00:00

abstract：:Genetic potentials (pedigree-estimated breeding value) for milk and for fat were compared in cows grouped according to subclinical stage of bovine leukemia virus infection. Genetic potential for milk production was significantly greater in seropositive cows with persistent lymphocytosis (622 +/- 72 kg) and in seroposi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu MC,Shanks RD,Lewin HA

更新日期：1989-02-01 00:00:00

abstract：:Sunlight exposure is strongly indicated as one of the important etiologic agents in human cutaneous malignant melanoma. However, because of the absence of good animal models, it has not been possible to estimate the wavelengths or wavelength regions involved. We have developed a useful animal model from crosses and ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Setlow RB,Woodhead AD,Grist E

更新日期：1989-11-01 00:00:00

abstract：:Impaired wound closure is a growing medical problem associated with metabolic diseases and aging. Immune cells play important roles in wound healing by following instructions from the microenvironment. Here, we developed a technology to bioengineer the wound microenvironment and enhance healing abilities of the immune...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vågesjö E,Öhnstedt E,Mortier A,Lofton H,Huss F,Proost P,Roos S,Phillipson M

更新日期：2018-02-20 00:00:00

abstract：:Recent advances in coherent x-ray diffractive imaging have paved the way to reliable and quantitative imaging of noncompact specimens at the nanometer scale. Introduced a year ago, an advanced implementation of ptychographic coherent diffractive imaging has removed much of the previous limitations regarding sample pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giewekemeyer K,Thibault P,Kalbfleisch S,Beerlink A,Kewish CM,Dierolf M,Pfeiffer F,Salditt T

更新日期：2010-01-12 00:00:00

abstract：:Rat liver glutamine synthetase (s(20,w) 15.0 S; MW about 352,000) resembles ovine brain glutamine synthetase in that it (a) has 8 subunits, (b) acts on both L- and D-glutamate and certain glutamate analogs (e.g., beta-glutamate, cis-cycloglutamate, and alpha-methyl-L-glutamate), and (c) is irreversibly inhibited by L-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate SS,Meister A

更新日期：1971-04-01 00:00:00

abstract：:Genetic polymorphism in the H-2:Qa:Tla region of chromosome 17 is associated with constitutive variation of bodily odor phenotypes which permit individual olfactory recognition among mice. To determine whether known genes in the H-2:Qa:Tla complex are concerned in the constitution of odor phenotypes, mice were tested ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamazaki K,Beauchamp GK,Egorov IK,Bard J,Thomas L,Boyse EA

更新日期：1983-09-01 00:00:00

abstract：:Prostate cancer development is associated with hyperactive androgen signaling. However, the molecular link between androgen receptor (AR) function and humoral factors remains elusive. A prostate cancer mouse model was generated by selectively mutating the AR threonine 877 into alanine in prostatic epithelial cells thr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi S,Watanabe T,Okada M,Inoue K,Ueda T,Takada I,Watabe T,Yamamoto Y,Fukuda T,Nakamura T,Akimoto C,Fujimura T,Hoshino M,Imai Y,Metzger D,Miyazono K,Minami Y,Chambon P,Kitamura T,Matsumoto T,Kato S

更新日期：2011-03-22 00:00:00

abstract：:Small molecules of biological origin continue to yield the most promising leads for drug design, but systematic approaches for exploring nature's cache of structural diversity are lacking. Here, we demonstrate the use of 2D NMR spectroscopy to screen a library of biorationally selected insect metabolite samples for pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deyrup ST,Eckman LE,McCarthy PH,Smedley SR,Meinwald J,Schroeder FC

更新日期：2011-06-14 00:00:00

abstract：:Small ubiquitin-like modifier (SUMO) modification is emerging as an important control in transcription regulation. Here, we show that CREB-binding protein (CBP), a versatile transcriptional coactivator for numerous transcription factors in response to diverse signaling events, can be modified by SUMO-1 at lysine resid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuo HY,Chang CC,Jeng JC,Hu HM,Lin DY,Maul GG,Kwok RP,Shih HM

更新日期：2005-11-22 00:00:00

abstract：:Zinc is an essential micronutrient for all living organisms. When facing a shortage in zinc supply, plants adapt by enhancing the zinc uptake capacity. The molecular regulators controlling this adaptation are not known. We present the identification of two closely related members of the Arabidopsis thaliana basic-regi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Assunção AG,Herrero E,Lin YF,Huettel B,Talukdar S,Smaczniak C,Immink RG,van Eldik M,Fiers M,Schat H,Aarts MG

更新日期：2010-06-01 00:00:00

abstract：:REPRESSOR OF SILENCING 1 (ROS1) is a DNA demethylation enzyme that was previously identified during a genetic screen for the silencing of both RD29A-LUC and 35S-NPTII transgenes on a T-DNA construct. Here we performed a genetic screen to identify additional mutants in which the 35S-NPTII transgene is silenced. We iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Qian W,Zhao Y,Wang C,Shen J,Zhu JK,Gong Z

更新日期：2012-07-10 00:00:00

abstract：:The stator ring of the bacterial flagellar motor is composed of the MotA and MotB proteins that act together to generate a turning force (torque) acting on the FliG ring of the rotor. The C-terminal domain of MotB (MotB-C) is believed to anchor the MotA/MotB complex to peptidoglycan (PG) of the cell wall. The first cr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roujeinikova A

更新日期：2008-07-29 00:00:00

abstract：:Whereas amyloid-β (Aβ) accumulates in the brain of normal animals dosed with low levels of copper (Cu), the mechanism is not completely known. Cu could contribute to Aβ accumulation by altering its clearance and/or its production. Because Cu homeostasis is altered in transgenic mice overexpressing Aβ precursor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singh I,Sagare AP,Coma M,Perlmutter D,Gelein R,Bell RD,Deane RJ,Zhong E,Parisi M,Ciszewski J,Kasper RT,Deane R

更新日期：2013-09-03 00:00:00

abstract：:Explaining the maintenance of tropical forest diversity under the countervailing forces of drift and competition poses a major challenge to ecological theory. Janzen-Connell effects, in which host-specific natural enemies restrict the recruitment of juveniles near conspecific adults, provide a potential mechanism. Jan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levi T,Barfield M,Barrantes S,Sullivan C,Holt RD,Terborgh J

更新日期：2019-01-08 00:00:00

abstract：:Bacteriophage lambda encodes a number of genes involved in the recombinational repair of DNA double-strand breaks. The product of one of these genes, rap, has been purified. Truncated Rap proteins that copurify with the full-length form are derived, at least in part, from a rho-dependent transcription terminator locat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharples GJ,Corbett LM,Graham IR

更新日期：1998-11-10 00:00:00

abstract：:Despite being engineered to avoid renal clearance, many cationic polymer (polycation)-based siRNA nanoparticles that are used for systemic delivery are rapidly eliminated from the circulation. Here, we show that a component of the renal filtration barrier--the glomerular basement membrane (GBM)--can disassemble cation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuckerman JE,Choi CH,Han H,Davis ME

更新日期：2012-02-21 00:00:00

abstract：:Anatoxin-a, a bicyclic amine isolated from blue-green alga, binds to the nicotinic acetylcholine receptor of Torpedo electric tissue, thereby inducing conformational changes in the postsynaptic receptor--ion channel complex as evidenced by alterations in the binding of radiolabeled ligands to the complex. Anatoxin-a b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aronstam RS,Witkop B

更新日期：1981-07-01 00:00:00

abstract：:Myocardin and the myocardin-related transcription factors (MRTFs) A and B act as coactivators for serum response factor, which plays a key role in cardiovascular development. To determine the functions of MRTF-B in vivo, we generated MRTF-B mutant mice by targeted inactivation of the MRTF-B gene. We show that mice hom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oh J,Richardson JA,Olson EN

更新日期：2005-10-18 00:00:00

abstract：:In animals and in man, diverse immunologic functions are mediated by specialized T-cell (thymus-derived lymphocyte) subsets that are distinguishable from one another on the basis of differences in cell surface determinants. Unfortunately, in humans, subset-specific antibodies have been difficult to generate. In this s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Engleman EG,Benike C,Osborne B,Goldsby R

更新日期：1980-03-01 00:00:00

abstract：:Dendritic spines receive most synaptic inputs in the forebrain. Their morphology, with a spine head isolated from the dendrite by a slender neck, indicates a potential role in isolating inputs. Indeed, biochemical compartmentalization occurs at spine heads because of the diffusional bottleneck created by the spine nec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Araya R,Jiang J,Eisenthal KB,Yuste R

更新日期：2006-11-21 00:00:00

abstract：:Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. Molecular mechanisms that underlie cisplatin resistance are poorly understood. Here we demonstrate that deletion of the yeast CTR1 gene, which enco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishida S,Lee J,Thiele DJ,Herskowitz I

更新日期：2002-10-29 00:00:00

abstract：:The caspases are cysteine proteases that have been implicated in the execution of programmed cell death in organisms ranging from nematodes to humans. Many members of the Bcl-2 family, including Bcl-XL, are potent inhibitors of programmed cell death and inhibit activation of caspases in cells. Here, we report a direct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clem RJ,Cheng EH,Karp CL,Kirsch DG,Ueno K,Takahashi A,Kastan MB,Griffin DE,Earnshaw WC,Veliuona MA,Hardwick JM

更新日期：1998-01-20 00:00:00