Milk and fat production in dairy cattle influenced by advanced subclinical bovine leukemia virus infection.

abstract：:Bacteriophage 434 encodes a repressor that, like bacteriophage lambda repressor, both activates and represses transcription. As in the lambda chromosome, a region of the 434 chromosome, called the right operator, contains three repressor binding sites (OR1, OR2, and OR3) that mediate these effects on two adjacent prom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bushman FD,Ptashne M

更新日期：1986-12-01 00:00:00

abstract：:Photochemical release (uncaging) of bioactive messengers with three-dimensional spatial resolution in light-scattering media would be greatly facilitated if the photolysis could be powered by pairs of IR photons rather than the customary single UV photons. The quadratic dependence on light intensity would confine the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furuta T,Wang SS,Dantzker JL,Dore TM,Bybee WJ,Callaway EM,Denk W,Tsien RY

更新日期：1999-02-16 00:00:00

abstract：:The kinetics of electrogenic events associated with the different steps of the light-induced proton pump of bacteriorhodopsin is well studied in a wide range of time scales by direct electric methods. However, the investigation of the fundamental primary charge translocation phenomena taking place in the functional en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groma GI,Hebling J,Kozma IZ,Váró G,Hauer J,Kuhl J,Riedle E

更新日期：2008-05-13 00:00:00

abstract：:The emergence of resistance to multiple unrelated chemotherapeutic drugs impedes the treatment of several cancers. Although the involvement of ATP-binding cassette transporters has long been known, there is no in situ method capable of tracking this transporter-related resistance at the single-cell level without inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuss S,Polcari D,Geissler M,Brassard D,Mauzeroll J

更新日期：2013-06-04 00:00:00

abstract：:This paper reports the results of a randomized field experiment involving registered voters in the city of New Haven. Nonpartisan get-out-the-vote messages were delivered through personal canvassing shortly before the November 1998 election. We find that personal canvassing increased voter turnout by approximately 6. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerber AS,Green DP

更新日期：1999-09-14 00:00:00

abstract：:The kinase Cdc2p is a central regulator of entry into and progression through nuclear division during mitosis and meiosis in eukaryotes. Cdc2p is activated at the onset of mitosis by dephosphorylation on tyrosine-15, the phosphorylation status of which is determined mainly by the kinase Wee1p and the phosphatase Cdc25...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami-Tonami Y,Yamada-Namikawa C,Tochigi A,Hasegawa N,Kojima H,Kunimatsu M,Nakanishi M,Murakami H

更新日期：2007-09-11 00:00:00

abstract：:The envelope spike of HIV is one of the most highly N-glycosylated structures found in nature. However, despite extensive research revealing essential functional roles in infection and immune evasion, the chemical structures of the glycans on the native viral envelope glycoprotein gp120--as opposed to recombinantly ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doores KJ,Bonomelli C,Harvey DJ,Vasiljevic S,Dwek RA,Burton DR,Crispin M,Scanlan CN

更新日期：2010-08-03 00:00:00

abstract：:The failure of the population of microjunctions forming the frictional interface between two solids is central to fields ranging from biomechanics to seismology. This failure is mediated by the propagation along the interface of various types of rupture fronts, covering a wide range of velocities. Among them are the s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trømborg JK,Sveinsson HA,Scheibert J,Thøgersen K,Amundsen DS,Malthe-Sørenssen A

更新日期：2014-06-17 00:00:00

abstract：:beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, beta-endorphin is 18 to 33 times more potent than morphine and its ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loh HH,Tseng LF,Wei E,Li CH

更新日期：1976-08-01 00:00:00

abstract：:The bacterial TATAAT -10 region sequence was the first promoter element to be identified, but how it functions is still not clear. Because the duplex element is melted during initiation, the effects of substitutions were studied in both single-and double-strand contexts. Band-shift results were particularly unexpected...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fenton MS,Gralla JD

更新日期：2001-07-31 00:00:00

abstract：:Wild barley (Hordeum spontaneum) represents a significant genetic resource for crop improvement in barley (Hordeum vulgare) and for the study of the evolution and domestication of plant populations. The Isa gene from barley has a putative role in plant defense. This gene encodes a bifunctional alpha-amylase/subtilisin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cronin JK,Bundock PC,Henry RJ,Nevo E

更新日期：2007-02-20 00:00:00

abstract：:The effect of 12-O-tetradecanoylphorbol 13-acetate (TPA), a potent tumor promoter, on the synthesis of proteins in BALB/c 3T3 mouse fibroblasts has been studied. When [35S]methionine-labeled proteins synthesized after the addition of TPA were analyzed by one- or two-dimensional polyacrylamide gel electrophoresis, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hiwasa T,Fujimura S,Sakiyama S

更新日期：1982-03-01 00:00:00

abstract：:Loquacious-PD (Loqs-PD) is required for biogenesis of many endogenous siRNAs in Drosophila In vitro, Loqs-PD enhances the rate of dsRNA cleavage by Dicer-2 and also enables processing of substrates normally refractory to cleavage. Using purified components, and Loqs-PD truncations, we provide a mechanistic basis for L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trettin KD,Sinha NK,Eckert DM,Apple SE,Bass BL

更新日期：2017-09-19 00:00:00

abstract：:A key barrier to the realization of personalized medicine for cancer is the identification of biomarkers. Here we describe a two-stage strategy for the discovery of serum biomarker signatures corresponding to specific cancer-causing mutations and its application to prostate cancer (PCa) in the context of the commonly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cima I,Schiess R,Wild P,Kaelin M,Schüffler P,Lange V,Picotti P,Ossola R,Templeton A,Schubert O,Fuchs T,Leippold T,Wyler S,Zehetner J,Jochum W,Buhmann J,Cerny T,Moch H,Gillessen S,Aebersold R,Krek W

更新日期：2011-02-22 00:00:00

abstract：:8-Oxoguanine (8OG) is efficiently bypassed by RNA polymerases in vitro and in bacterial cells in vivo, leading to mutant transcripts by directing incorporation of an incorrect nucleotide during transcription. Such transcriptional mutagenesis (TM) may produce a pool of mutant proteins. In contrast, transcription-couple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saxowsky TT,Meadows KL,Klungland A,Doetsch PW

更新日期：2008-12-02 00:00:00

abstract：:IL-17-producing CD4(+) T helper (Th17) cells have recently been defined as a unique subset of proinflammatory helper cells whose development depends on signaling initiated by IL-6 and TGF-beta, autocrine activity of IL-21, activation of STAT3, and induction of the orphan nuclear receptor RORgammat. The maintenance, ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voo KS,Wang YH,Santori FR,Boggiano C,Wang YH,Arima K,Bover L,Hanabuchi S,Khalili J,Marinova E,Zheng B,Littman DR,Liu YJ

更新日期：2009-03-24 00:00:00

abstract：:In an era of large-scale science-related challenges and rapid advancements in groundbreaking science with major societal implications, communicating about science is critical. The profile of science communication has increased over the last few decades, with multiple sectors calling for such activities. As scientists ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rose KM,Markowitz EM,Brossard D

更新日期：2020-01-21 00:00:00

abstract：:Clostridium difficile, a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The level of toxin production appears to be critical for determining the seve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mani N,Dupuy B

更新日期：2001-05-08 00:00:00

abstract：:Immune cells take residence in metabolic tissues, providing a framework for direct regulation of nutrient metabolism. Despite conservation of this anatomic relationship through evolution, the signals and mechanisms by which the immune system regulates nutrient homeostasis and insulin action remain poorly understood. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ricardo-Gonzalez RR,Red Eagle A,Odegaard JI,Jouihan H,Morel CR,Heredia JE,Mukundan L,Wu D,Locksley RM,Chawla A

更新日期：2010-12-28 00:00:00

abstract：:The fungus, Phycomyces blakesleeanus, shows many well-defined responses to a number of external stimuli. Genetic analysis shows that at least eight genes are involved in Phycomyces sensory transduction. As a first step toward the molecular analysis of these genes and their products, we have developed a transformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Revuelta JL,Jayaram M

更新日期：1986-10-01 00:00:00

abstract：:A Raleigh, NC, population of Drosophila melanogaster was sampled for the presence of enzyme null alleles at 25 loci. No nulls were found at any of five X-linked loci. Nulls were recovered at 13 of 20 autosomal loci; the weighted mean frequency for all 20 autosomal loci was estimated to be 0.0025. A consideration of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voelker RA,Langley CH,Brown AJ,Ohnishi S,Dickson B,Montgomery E,Smith SC

更新日期：1980-02-01 00:00:00

abstract：:In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pando B,Dawson SP,Mak DO,Pearson JE

更新日期：2006-04-04 00:00:00

abstract：:The Paramyxoviridae family of enveloped viruses enters cells through the concerted action of two viral glycoproteins. The receptor-binding protein, hemagglutinin-neuraminidase (HN), H, or G, binds its cellular receptor and activates the fusion protein, F, which, through an extensive refolding event, brings viral and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bose S,Zokarkar A,Welch BD,Leser GP,Jardetzky TS,Lamb RA

更新日期：2012-09-25 00:00:00

abstract：:Many neurotransmitters are known to regulate neuronal cell function by means of activation of cAMP-dependent protein kinase (PKA) and phosphorylation of neuronal substrate proteins, including transcription factors and ion channels. Here, we have characterized the gene expression of two isoforms of a protein kinase inh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seasholtz AF,Gamm DM,Ballestero RP,Scarpetta MA,Uhler MD

更新日期：1995-02-28 00:00:00

abstract：:Aging and some pathological conditions are associated with the accumulation of altered (inactive or less active) forms of enzymes. It was suggested that these age-related alterations reflect spontaneous changes in protein conformation and/or posttranslational modifications (e.g., oxidation). Because changes in protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chao CC,Ma YS,Stadtman ER

更新日期：1997-04-01 00:00:00

abstract：:Bioluminescence-based imaging of living cells has become an important tool in biological and medical research. However, many bioluminescence imaging applications are limited by the requirement of an externally provided luciferin substrate and the low bioluminescence signal which restricts the sensitivity and spatiotem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregor C,Pape JK,Gwosch KC,Gilat T,Sahl SJ,Hell SW

更新日期：2019-12-02 00:00:00

abstract：:A 38-base-pair region required for normal CYC1 mRNA 3' end formation in Saccharomyces cerevisiae was shown to be necessary for the termination of transcription in vivo by examining the stability of CEN3 plasmids. CEN3 plasmids were stably maintained during vegetative growth, unless a GAL1 transcript impinged on the CE...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russo P,Sherman F

更新日期：1989-11-01 00:00:00

abstract：:The structurally diverse peroxisome proliferators ciprofibrate, clofibrate, and bis(2-ethylhexyl) phthalate [(EtHx)2 greater than Pht] increase the activities of hepatic catalase and peroxisomal fatty acid beta-oxidation enzymes in conjunction with profound proliferation of peroxisomes in hepatocytes. In order to deli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddy JK,Goel SK,Nemali MR,Carrino JJ,Laffler TG,Reddy MK,Sperbeck SJ,Osumi T,Hashimoto T,Lalwani ND

更新日期：1986-03-01 00:00:00

abstract：:Autophagy is responsible for nonspecific, bulk degradation of cytoplasmic components. Recent work has revealed also that there is specific, autophagic degradation of polyubiquitinated protein aggregates, whose buildup occurs during neurodegenerative disease. Here, we report that simple mono-ubiquitination of normally ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim PK,Hailey DW,Mullen RT,Lippincott-Schwartz J

更新日期：2008-12-30 00:00:00

abstract：:Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite adhesins on the surface of IEs binding to human receptors on microvasc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Claessens A,Adams Y,Ghumra A,Lindergard G,Buchan CC,Andisi C,Bull PC,Mok S,Gupta AP,Wang CW,Turner L,Arman M,Raza A,Bozdech Z,Rowe JA

更新日期：2012-06-26 00:00:00