Scientists' incentives and attitudes toward public communication.

abstract：:A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse large B-cell lymphoma (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hailfinger S,Lenz G,Ngo V,Posvitz-Fejfar A,Rebeaud F,Guzzardi M,Penas EM,Dierlamm J,Chan WC,Staudt LM,Thome M

更新日期：2009-11-24 00:00:00

abstract：:MinD is a widely conserved ATPase that has been demonstrated to play a pivotal role in selection of the division site in eubacteria and chloroplasts. It is a member of the large ParA superfamily of ATPases that are characterized by a deviant Walker-type ATP-binding motif. MinD localizes to the cytoplasmic face of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Szeto TH,Rowland SL,Rothfield LI,King GF

更新日期：2002-11-26 00:00:00

abstract：:This paper studies the cathodic corrosion of a spherical single crystal of platinum in an aqueous alkaline electrolyte, to map out the detailed facet dependence of the corrosion structures forming during this still largely unexplored electrochemical phenomenon. We find that anisotropic corrosion of the platinum electr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arulmozhi N,Hersbach TJP,Koper MTM

更新日期：2020-12-22 00:00:00

abstract：:RNA from noninfectious virions produced by two established clonal lines of sarcoma positive-leukemia negative (S+L-)-transformed 3T3 cells has been characterized. RNA from virions or nucleoids of S+L--(C243) cells consisted of three to four sizes: +/-44 S (6%), 28 S (17%), 18 S (38%), and <18 S (39%). 28S virion RNA c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips LA,Hollis VW Jr,Bassin RH,Fischinger PJ

更新日期：1973-10-01 00:00:00

abstract：:When Sertoli cells of the seminiferous epithelium in the testis were cultured on Matrigel (a reconstituted basement membrane), laminin, or one of the biologically active laminin-derived peptides (YIGSR, SIKVAV, or RGD), they exhibited dramatic changes in morphology accompanied by changes in protein secretion and gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papadopoulos V,Dym M

更新日期：1994-07-19 00:00:00

abstract：:Real-time visualization of intracellular calcium concentration ([Ca2+]i) changes in mammalian Purkinje cells in vitro, utilizing the dye Fura-2, indicates that calcium action potentials are generated in the dendritic tree and follow a particular activation sequence. During spontaneous oscillations or after direct curr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugimori M,Llinás RR

更新日期：1990-07-01 00:00:00

abstract：:mRNA for the large subunit (LS) of ribulose-1,5-bisphosphate carboxylase [3-phospho-D-glycerate carboxylase (dimerizing), EC 4.1.1.39] of Zea mays is complementary to an uninterrupted 1600-base-pair-long chloroplast DNA sequence that has been mapped precisely within the 4350-base-pair-long chloroplast DNA fragment Bam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Link G,Bogorad L

更新日期：1980-04-01 00:00:00

abstract：:In many eukaryotic systems during immune responses, mitogen-activated protein kinases (MAPKs) link cytoplasmic signaling to chromatin events by targeting transcription factors, chromatin remodeling complexes, and the RNA polymerase machinery. So far, knowledge on these events is scarce in plants and no attempts have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rayapuram N,Jarad M,Alhoraibi HM,Bigeard J,Abulfaraj AA,Völz R,Mariappan KG,Almeida-Trapp M,Schlöffel M,Lastrucci E,Bonhomme L,Gust AA,Mithöfer A,Arold ST,Pflieger D,Hirt H

更新日期：2021-01-19 00:00:00

abstract：:Infection during the neonatal period commonly induces apnea episodes, and the proinflammatory cytokine IL-1beta may serve as a critical mediator between these events. To determine the mechanism by which IL-1beta depresses respiration, we examined a prostaglandin E(2) (PGE(2))-dependent pathway in newborn mice and huma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hofstetter AO,Saha S,Siljehav V,Jakobsson PJ,Herlenius E

更新日期：2007-06-05 00:00:00

abstract：:A robust body of evidence supports the concept that phosphodiesterase 10A (PDE10A) activity in the basal ganglia orchestrates the control of coordinated movement in human subjects. Although human mutations in the PDE10A gene manifest in hyperkinetic movement disorders that phenocopy many features of early Huntington's...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tejeda GS,Whiteley EL,Deeb TZ,Bürli RW,Moss SJ,Sheridan E,Brandon NJ,Baillie GS

更新日期：2020-01-07 00:00:00

abstract：:Since the demonstration that the sequence of a protein encodes its structure, the prediction of structure from sequence remains an outstanding problem that impacts numerous scientific disciplines, including many genome projects. By iteratively fixing secondary structure assignments of residues during Monte Carlo simul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeBartolo J,Colubri A,Jha AK,Fitzgerald JE,Freed KF,Sosnick TR

更新日期：2009-03-10 00:00:00

abstract：:Hypoxia-inducible factor-1 (HIF-1) plays an essential role in tumor development and progression by regulating genes that are vital for proliferation, glycolysis, angiogenesis, and metastasis. To identify strategies of targeting the HIF-1 pathway, we screened a siRNA library against the entire druggable genome and a sm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin X,David CA,Donnelly JB,Michaelides M,Chandel NS,Huang X,Warrior U,Weinberg F,Tormos KV,Fesik SW,Shen Y

更新日期：2008-01-08 00:00:00

abstract：:To elucidate the means by which metabolic inhibition depolarizes cardiac cells, spontaneously beating chicken embryonic myocardial cell aggregates were voltage clamped during superfusion with 2,4-dinitrophenol and iodoacetic acid. In aggregates continuously clamped in the pacemaker potential range, abrupt exposure to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clusin WT

更新日期：1983-06-01 00:00:00

abstract：:Multituberculates were the longest-lived order of the Class Mammalia and, during the Mesozoic and early Cenozoic, were among the most diverse and abundant representatives of the class. However, until the recent discovery of two Cretaceous teeth, one from South America and one from Africa, they were known only from nor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krause DW,Bonaparte JF

更新日期：1993-10-15 00:00:00

abstract：:Like many physiological ligands, several viruses and toxins enter mammalian cells through receptor-mediated endocytosis. Once internalized, the nucleic acids of several viruses and the toxic subunit of diphtheria toxin gain access to the cytosol of the host cell through an acidic intracellular compartment. In this rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merion M,Schlesinger P,Brooks RM,Moehring JM,Moehring TJ,Sly WS

更新日期：1983-09-01 00:00:00

abstract：:It is suggested that differentiated embryonic cells have a high specificity of molecular constitution as regards the surface layers surrounding their cellular membranes. Correspondingly, specific interface energies may characterize the early contacts between different cell types. The question is raised whether the mor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jehle H

更新日期：1970-09-01 00:00:00

abstract：:Evidence based on a study of alanine-resistant (Alar), constitutive mutants of CHO-K1 cells and the conditions that favor stimulation of the A system of amino acid activity supports the model that the A system of amino acid transport in these cells is repressible and under negative control of regulatory gene R1. In th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moffett J,Périer F,Jones M,Englesberg E

更新日期：1987-11-01 00:00:00

abstract：:Animals treated with potent gamma-glutamyl transpeptidase inhibitors and a patient with severe gamma-glutamyl transpeptidase deficiency excrete much larger than normal amounts of glutathione, gamma-glutamylcysteine, and cysteine in their urine; these compounds were found in disulfide forms. The findings indicate that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffith OW,Meister A

更新日期：1980-06-01 00:00:00

abstract：:Misfolded proteins are an emerging hallmark of cardiac diseases. Although some misfolded proteins, such as desmin, are associated with mutations in the genes encoding these disease-associated proteins, little is known regarding more general mechanisms that contribute to the generation of misfolded proteins in the hear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Satz JS,Vo MN,Nangle LA,Schimmel P,Ackerman SL

更新日期：2014-12-09 00:00:00

abstract：:Normal myeloid precursors and MGI(+)D(+) myeloid leukemic cells can be induced to differentiate to mature cells by the normal protein inducer MGI. The sequence of differentiation is the induction of C3 and Fc rosettes, C3 and Fc immune phagocytosis (IP), synthesis and secretion of lysozyme, and formation of mature mac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lotem J,Sachs L

更新日期：1977-12-01 00:00:00

abstract：:Optical spectra of biological polymers contain important information about their structure and function in living organisms. This information can be accessed by extracting an optical interaction of monomers, i.e., their exciton coupling, from experimental data. This coupling is sensitive to molecular structure, geomet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burin AL,Armbruster ME,Hariharan M,Lewis FD

更新日期：2009-01-27 00:00:00

abstract：:In Caenorhabditis elegans, the small nuclear ribonucleoprotein (snRNP)-associated proteins U1A and U2B'' are approximately 50% identical to each other, and neither bears signature characteristics of mammalian U1A or U2B'' or the single Drosophila homolog, SNF. We show here that the genes that encode these proteins (rn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saldi T,Wilusz C,MacMorris M,Blumenthal T

更新日期：2007-06-05 00:00:00

abstract：:We demonstrate ordered orientation of the hydration water at the surface of phospholipid bilayers by use of coherent anti-Stokes Raman scattering (CARS) microscopy, a highly sensitive vibrational imaging method recently developed. We investigated negatively charged POPS (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-ser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng JX,Pautot S,Weitz DA,Xie XS

更新日期：2003-08-19 00:00:00

abstract：:Phosphatidylcholine (PC) is the major glycerophospholipid in eukaryotic cells and is an essential component in all cellular membranes. The biochemistry of de novo PC synthesis by the Kennedy pathway is well established, but less is known about the physiological functions of PC. We identified two unrelated patients wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Payne F,Lim K,Girousse A,Brown RJ,Kory N,Robbins A,Xue Y,Sleigh A,Cochran E,Adams C,Dev Borman A,Russel-Jones D,Gorden P,Semple RK,Saudek V,O'Rahilly S,Walther TC,Barroso I,Savage DB

更新日期：2014-06-17 00:00:00

abstract：:The 2.1-A resolution crystal structure of wild-type green fluorescent protein and comparison of it with the recently determined structure of the Ser-65 --> Thr (S65T) mutant explains the dual wavelength absorption and photoisomerization properties of the wild-type protein. The two absorption maxima are caused by a cha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brejc K,Sixma TK,Kitts PA,Kain SR,Tsien RY,Ormö M,Remington SJ

更新日期：1997-03-18 00:00:00

abstract：:Earlier Monte Carlo studies on a single-helix model of the GTP cap at the end of a microtubule are extended here to a more realistic five-start helix model of the microtubule end. As in the earlier work, phase changes occur at the microtubule end: the end is either capped with GTP and growing slowly or uncapped and sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD,Hill TL

更新日期：1985-02-01 00:00:00

abstract：:Thiazides and related diuretics inhibit NaCl reabsorption in the distal tubule through an unknown mechanism. We report here that [3H]metolazone, a diuretic with a thiazide-like mechanism of action, labels a site in rat kidney membranes that has characteristics of the thiazide-sensitive ion transporter. [3H]Metolazone ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beaumont K,Vaughn DA,Fanestil DD

更新日期：1988-04-01 00:00:00

abstract：:Recent studies have shown that the genes of the gibberellin (GA) biosynthesis pathway in the fungus Gibberella fujikuroi are organized in a cluster of at least seven genes. P450-1 is one of four cytochrome P450 monooxygenase genes in this cluster. Disruption of the P450-1 gene in the GA-producing wild-type strain IMI ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rojas MC,Hedden P,Gaskin P,Tudzynski B

更新日期：2001-05-08 00:00:00

abstract：:The phagocyte NADPH oxidase, dormant in resting cells, is activated during phagocytosis to produce superoxide, a precursor of microbicidal oxidants. The activated oxidase is a complex of membrane-integrated cytochrome b558, composed of 91-kDa (gp91phox) and 22-kDa (p22phox) subunits, and two cytosolic factors (p47phox...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sumimoto H,Kage Y,Nunoi H,Sasaki H,Nose T,Fukumaki Y,Ohno M,Minakami S,Takeshige K

更新日期：1994-06-07 00:00:00

abstract：:We resolve the 3D trajectory and the orientation of individual cells for extended times, using a digital tracking technique combined with 3D reconstructions. We have used this technique to study the motility of the uniflagellated bacterium Caulobacter crescentus and have found that each cell displays two distinct mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu B,Gulino M,Morse M,Tang JX,Powers TR,Breuer KS

更新日期：2014-08-05 00:00:00