Sertoli cell differentiation on basement membrane is mediated by the c-fos protooncogene.

abstract：:The subcellular localization of Ocrl, the inositol polyphosphate 5-phosphatase that is mutated in Lowe syndrome, was investigated by fluorescence microscopy. Ocrl was localized to endosomes and Golgi membranes along with clathrin, giantin, the mannose 6-phosphate receptor, transferrin, and the early endosomal antigen ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ungewickell A,Ward ME,Ungewickell E,Majerus PW

更新日期：2004-09-14 00:00:00

abstract：:Palmitoylation is a common lipid modification known to regulate the functional properties of various proteins and is a vital step in the biosynthesis of voltage-activated sodium (Nav) channels. We discovered a mutation in an intracellular loop of rNav1.2a (G1079C), which results in a higher apparent affinity for exter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bosmans F,Milescu M,Swartz KJ

更新日期：2011-12-13 00:00:00

abstract：:Nanometer-scale pores have demonstrated potential for the electrical detection, quantification, and characterization of molecules for biomedical applications and the chemical analysis of polymers. Despite extensive research in the nanopore sensing field, there is a paucity of theoretical models that incorporate the in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reiner JE,Kasianowicz JJ,Nablo BJ,Robertson JW

更新日期：2010-07-06 00:00:00

abstract：:microRNAs comprise a few percent of animal genes and have been recognized as important regulators of a diverse range of biological processes. Understanding the biological functions of miRNAs requires effective means to identify their targets. Combined efforts from computational prediction, miRNA over-expression or dep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong X,Hammell M,Ambros V,Cohen SM

更新日期：2009-09-01 00:00:00

abstract：:The objective of this study has been to determine which Na,K-ATPase isoforms are expressed in red blood cells and whether kinetic differences in the uncoupled sodium efflux mode between the human red blood cell Na,K-ATPase and other preparations can be explained by differences in the underlying subunit composition. To...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stengelin MK,Hoffman JF

更新日期：1997-05-27 00:00:00

abstract：:The pattern of neurodegeneration in Alzheimer's disease (AD) is very distinctive: neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau selectively affect pyramidal neurons of the aging association cortex that interconnect extensively through glutamate synapses on dendritic spines. In contrast, primary se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carlyle BC,Nairn AC,Wang M,Yang Y,Jin LE,Simen AA,Ramos BP,Bordner KA,Craft GE,Davies P,Pletikos M,Šestan N,Arnsten AF,Paspalas CD

更新日期：2014-04-01 00:00:00

abstract：:Tissue- and cell-specific deletion of the Aqp4 gene is required to differentiate between the numerous pools of aquaporin-4 (AQP4) water channels. A glial-conditional Aqp4 knockout mouse line was generated to resolve whether astroglial AQP4 controls water exchange across the blood-brain interface. The conditional knock...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haj-Yasein NN,Vindedal GF,Eilert-Olsen M,Gundersen GA,Skare Ø,Laake P,Klungland A,Thorén AE,Burkhardt JM,Ottersen OP,Nagelhus EA

更新日期：2011-10-25 00:00:00

abstract：:The recent intensification of agriculture, and the prospects of future intensification, will have major detrimental impacts on the nonagricultural terrestrial and aquatic ecosystems of the world. The doubling of agricultural food production during the past 35 years was associated with a 6.87-fold increase in nitrogen ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilman D

更新日期：1999-05-25 00:00:00

abstract：:Sufficient conditions are found for a biinvariant operator on a compact Lie group to be bounded on L(p), 1 < p < infinity. The proof uses properties of g-functions on such a group, and an analog to the familiar relationship between differentiation and multiplication under the Fourier transform. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss NJ

更新日期：1971-05-01 00:00:00

abstract：:Metal-catalyzed oxidation results in loss of function and structural alteration of proteins. The oxidative process affects a variety of side amino acid groups, some of which are converted to carbonyl compounds. Spectrophotometric measurement of these moieties, after their reaction with 2,4-dinitrophenylhydrazine, is a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Requena JR,Chao CC,Levine RL,Stadtman ER

更新日期：2001-01-02 00:00:00

abstract：:Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional elongation, chromatin conformation, as well as the regulation of specific histone H3 methylations. Herein, we report a strategy for the site-specific chemical attachment of ubiquitin to preassembled nucleosomes. This allowed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holt MT,David Y,Pollock S,Tang Z,Jeon J,Kim J,Roeder RG,Muir TW

更新日期：2015-08-18 00:00:00

abstract：:Huntington's disease (HD) is a fatal, genetic, neurological disorder resulting from a trinucleotide repeat expansion in the gene that encodes for the protein huntingtin. These excessive repeats confer a toxic gain of function on huntingtin, which leads to the degeneration of striatal and cortical neurons and a devasta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McBride JL,Ramaswamy S,Gasmi M,Bartus RT,Herzog CD,Brandon EP,Zhou L,Pitzer MR,Berry-Kravis EM,Kordower JH

更新日期：2006-06-13 00:00:00

abstract：:A yeast genetic system was developed to study how the basic regions of basic-helix-loop-helix (bHLH) proteins distinguish between related consensus bHLH binding sites, with nucleotide sequence CANNTG. The yeast bHLH protein CBF1 binds to the sequence CAC(A/G)TG found in the yeast centromere element CDE1 and in promote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang CV,Dolde C,Gillison ML,Kato GJ

更新日期：1992-01-15 00:00:00

abstract：:We present a model describing how Mg(2+) binds and stabilizes specific RNA structures. In this model, RNA stabilization arises from two energetically distinct modes of Mg(2+) binding: diffuse- and site-binding. Diffusely bound Mg(2+) are electrostatically attracted to the strong anionic field around the RNA and are ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Misra VK,Draper DE

更新日期：2001-10-23 00:00:00

abstract：:Cyclic AMP (cAMP) and calcium are ubiquitous, interdependent second messengers that regulate a wide range of cellular processes. During development of neuronal networks they are critical for the first step of circuit formation, transducing signals required for axon pathfinding. Surprisingly, the spatial and temporal c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicol X,Hong KP,Spitzer NC

更新日期：2011-08-16 00:00:00

abstract：:The central limit theorem is applied to group foraging to show an automatic and universal benefit to group living. This may explain the paradoxical inverse correlation between group size and per capita brood production in primitively eusocial insects and why only one of the five major lineages of social insects contai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wenzel JW,Pickering J

更新日期：1991-01-01 00:00:00

abstract：:A hierarchy of residue density assessments and packing properties in protein structures are contrasted, including a regular density, a variety of charge densities, a hydrophobic density, a polar density, and an aromatic density. These densities are investigated by alternative distance measures and also at the interfac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baud F,Karlin S

更新日期：1999-10-26 00:00:00

abstract：:Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the direct characterization of amyloid polymorphism in hydrated and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cendrowska U,Silva PJ,Ait-Bouziad N,Müller M,Guven ZP,Vieweg S,Chiki A,Radamaker L,Kumar ST,Fändrich M,Tavanti F,Menziani MC,Alexander-Katz A,Stellacci F,Lashuel HA

更新日期：2020-03-24 00:00:00

abstract：:Expression of the Arabidopsis TRANSPARENT TESTA 2 (TT2) MYB family transcription factor leads to massive accumulation of proanthocyanidins (PAs) in hairy roots of Medicago truncatula. Microarray analysis showed that TT2 induces genes for flavonoid/PA biosynthesis, transcription factors, and a large number of genes of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pang Y,Peel GJ,Sharma SB,Tang Y,Dixon RA

更新日期：2008-09-16 00:00:00

abstract：:Mitochondrial carriers are believed widely to be homodimers both in the inner membrane of the organelle and in detergents. The dimensions and molecular masses of the detergent and protein-detergent micelles were measured for yeast ADP/ATP carriers in a range of different detergents. The radius of the carrier at the mi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bamber L,Harding M,Butler PJ,Kunji ER

更新日期：2006-10-31 00:00:00

abstract：:The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sonoda E,Takata M,Yamashita YM,Morrison C,Takeda S

更新日期：2001-07-17 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C) recently has been described to be a relatively specific growth factor for the lymphatic vascular system. Here we report that ectopic application of recombinant VEGF-C also has potent angiogenic effects in vivo. VEGF-C is sufficiently potent to stimulate neovascularization ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao Y,Linden P,Farnebo J,Cao R,Eriksson A,Kumar V,Qi JH,Claesson-Welsh L,Alitalo K

更新日期：1998-11-24 00:00:00

abstract：:One of the most fundamental functions of the brain is to predict upcoming events on the basis of the recent past. A closely related function is to signal when a prediction has been violated. The identity of the brain regions that mediate these functions is not known. We set out to determine whether they are implemente...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer T,Olson CR

更新日期：2011-11-29 00:00:00

abstract：:Development of the nervous system in the amphibian embryo is initiated during gastrulation by an inductive interaction between chordamesoderm and dorsal ectoderm. The induced ectoderm forms the neural plate while uninduced ectoderm generates epidermis. We screened for genes activated during gastrulation and expressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter K,Grunz H,Dawid IB

更新日期：1988-11-01 00:00:00

abstract：:Different polyubiquitin chain linkages direct substrates toward distinct cellular pathways. K63-linked ubiquitylation is known to regulate proteasome-independent events such as signal transduction, but its function in the context of heterogeneous ubiquitin chains remains unclear. Here, we report that K63 ubiquitylatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohtake F,Tsuchiya H,Saeki Y,Tanaka K

更新日期：2018-02-13 00:00:00

abstract：:Ski8p is implicated in degradation of non-poly(A) and double-stranded RNA, and in meiotic DNA recombination. We have identified the Sordaria macrospora SKI8 gene. Ski8p is cytoplasmically localized in all vegetative and sexual cycle cells, and is nuclear localized, specifically in early-mid-meiotic prophase, in tempor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tessé S,Storlazzi A,Kleckner N,Gargano S,Zickler D

更新日期：2003-10-28 00:00:00

abstract：:KRAS interacts with the inner leaflet of the plasma membrane (PM) using a hybrid anchor that comprises a lysine-rich polybasic domain (PBD) and a C-terminal farnesyl chain. Electrostatic interactions have been envisaged as the primary determinant of interactions between KRAS and membranes. Here, we integrated molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Y,Prakash PS,Liang H,Gorfe AA,Hancock JF

更新日期：2021-02-09 00:00:00

abstract：:Tripeptidyl peptidase II (TPPII) is a eukaryotic protease acting downstream of the 26S proteasome; it removes tripeptides from the degradation products released by the proteasome. Structural studies in vitro have revealed the basic architecture of TPPII, a two-stranded linear polymer that assembles to form a spindle-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukuda Y,Beck F,Plitzko JM,Baumeister W

更新日期：2017-04-25 00:00:00

abstract：:Swimming Escherichia coli responds to changes in temperature by modifying its motor behavior. Previous studies using populations of cells have shown that E. coli accumulate in spatial thermal gradients, but these experiments did not cleanly separate thermal responses from chemotactic responses. Here we have isolated t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paster E,Ryu WS

更新日期：2008-04-08 00:00:00

abstract：:Conventional markets can underprovide ecosystem services. Deliberate creation of a market for ecosystem services [e.g., a payments for ecosystem services (PES) scheme] can close the gap. The new ecosystem service market alters behaviors and quantities of ecosystem service provided and reveals prices for the ecosystems...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adamowicz W,Calderon-Etter L,Entem A,Fenichel EP,Hall JS,Lloyd-Smith P,Ogden FL,Regina JA,Rouhi Rad M,Stallard RF

更新日期：2019-03-19 00:00:00