Abstract:
:The RAD52 epistasis group genes are involved in homologous DNA recombination, and their primary structures are conserved from yeast to humans. Although biochemical studies have suggested that the fundamental mechanism of homologous DNA recombination is conserved from yeast to mammals, recent studies of vertebrate cells deficient in genes of the RAD52 epistasis group reveal that the role of each protein is not necessarily the same as that of the corresponding yeast gene product. This review addresses the roles and mechanisms of homologous recombination-mediated repair with a special emphasis on differences between yeast and vertebrate cells.
journal_name
Proc Natl Acad Sci U S Aauthors
Sonoda E,Takata M,Yamashita YM,Morrison C,Takeda Sdoi
10.1073/pnas.111006398keywords:
subject
Has Abstractpub_date
2001-07-17 00:00:00pages
8388-94issue
15eissn
0027-8424issn
1091-6490pii
98/15/8388journal_volume
98pub_type
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