Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner.

abstract：:Cells obtained from normal human skin synthesize predominantly type I collogen in culture. Cells obtained from the skin of an infant with a severe form of osteogenesis imperfecta were found to synthesize as much type III as type I collagen. Decreased synthesis of type I collagen could explain the tissue fragility obse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Penttinen RP,Lichtenstein JR,Martin GR,McKusick VA

更新日期：1975-02-01 00:00:00

abstract：:Phage phi 29 DNA cannot be phosphorylated with polynucleotide kinase and [gamma-32P]ATP because of the presence of a viral protein covalently linked to the 5' termini. The 5' ends can, however, be made susceptible to phosphorylation by treatment with alkali and alkaline phosphatase. Restriction fragments Hpa II C and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Escarmís C,Salas M

更新日期：1981-03-01 00:00:00

abstract：:Exposing primary cultures of cerebellar granule neurons to 100 nM phorbol 12-myristate 13-acetate (PMA) for 24 hr decreases the Ca2+/phosphatidylserine/diolein-dependent protein kinase C (PKC; ATP:protein phosphotransferase, EC 2.7.1.37) by approximately 90% in the 100,000 x g supernatant and pellet fractions of neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Favaron M,Manev H,Siman R,Bertolino M,Szekely AM,DeErausquin G,Guidotti A,Costa E

更新日期：1990-03-01 00:00:00

abstract：:There are defined medullary, mesencephalic, hypothalamic, and thalamic functions in regulation of respiration, but knowledge of cortical control and the elements subserving the consciousness of breathlessness and air hunger is limited. In nine young adults, air hunger was produced acutely by CO(2) inhalation. Comparis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brannan S,Liotti M,Egan G,Shade R,Madden L,Robillard R,Abplanalp B,Stofer K,Denton D,Fox PT

更新日期：2001-02-13 00:00:00

abstract：:The molecular nature of the cell surface-cytoskeleton interaction in microvilli isolated from ascites 13762 rat mammary adenocarcinoma sublines with immobile (MAT-C1) and mobile (MAT-B1) receptors was investigated by extraction and fractionation studies on the microvillar membranes. Extraction of membranes from MAT-C1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carraway CA,Jung G,Carraway KL

更新日期：1983-01-01 00:00:00

abstract：:Sex differences in parenting are common in species where both males and females provide care. Although there is a considerable body of game and optimality theory for why the sexes should differ in parental care, genetics can also play a role, and no study has examined how genetic influences might influence differences...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walling CA,Stamper CE,Smiseth PT,Moore AJ

更新日期：2008-11-25 00:00:00

abstract：:Inside-out erythrocyte membranes attached to polycationic beads manifested glutathione disulfide (GSSG)-stimulated ATPase activity. A Lineweaver-Burk plot of the ATPase activity as a function of GSSG concentration was biphasic and gave apparent Km values of 0.13 mM and 2.0 mM. These kinetics are similar to those repor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo T,Kawakami Y,Taniguchi N,Beutler E

更新日期：1987-11-01 00:00:00

abstract：:The genomic basis of primate phenotypic uniqueness remains obscure, despite increasing genome and transcriptome sequence data availability. Although factors such as segmental duplications and positive selection have received much attention as potential drivers of primate phenotypes, single-copy primate-specific genes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tay SK,Blythe J,Lipovich L

更新日期：2009-07-21 00:00:00

abstract：:Nogo isoforms (Nogo-A and -B) have been implicated in regulating neural and cardiovascular functions, such as cell spreading and chemotaxis. Unlike the loop domain (Nogo-66) found in all Nogo isoforms that can interact with a neural-specific Nogo-66 receptor, the receptor for the amino terminus of Nogo-B that mediates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miao RQ,Gao Y,Harrison KD,Prendergast J,Acevedo LM,Yu J,Hu F,Strittmatter SM,Sessa WC

更新日期：2006-07-18 00:00:00

abstract：:In order to assess whether DNA rearrangement occurs with equal frequency at each of the several J (joining region) elements in the mouse kappa light chain locus, we set out to determine the relative frequency of usage of J kappa segments in populations of B lymphocytes unperturbed by antigenic selection or cloning. To...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood DL,Coleclough C

更新日期：1984-08-01 00:00:00

abstract：:Breast tumors lacking expression of human epidermal growth factor receptor 2 (HER2) and the estrogen and the progesterone receptors (triple negative; TNBC) are more aggressive than other disease subtypes, and no molecular targeted agents are currently available for their treatment. Because TNBC commonly displays EGF r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferraro DA,Gaborit N,Maron R,Cohen-Dvashi H,Porat Z,Pareja F,Lavi S,Lindzen M,Ben-Chetrit N,Sela M,Yarden Y

更新日期：2013-01-29 00:00:00

abstract：:Neuroinflammation is an important contributor to neuronal pathology and death in neurodegenerative diseases and neuronal injury. Therapeutic interventions blocking the activity of the inflammatory kinase IKKβ, a key regulator of neuroinflammatory pathways, is protective in several animal models of neurodegenerative di...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ochaba J,Fote G,Kachemov M,Thein S,Yeung SY,Lau AL,Hernandez S,Lim RG,Casale M,Neel MJ,Monuki ES,Reidling J,Housman DE,Thompson LM,Steffan JS

更新日期：2019-05-28 00:00:00

abstract：:Communication about prescription drugs ought to be a paragon of public science communication. Unfortunately, it is not. Consumers see $4 billion of direct-to-consumer advertising annually, which typically fails to present data about how well drugs work. The professional label--the Food and Drug Administration's (FDA) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz LM,Woloshin S

更新日期：2013-08-20 00:00:00

abstract：:Animals are associated with a microbiome that can affect their reproductive success. It is, therefore, important to understand how a host and its microbiome coevolve. According to the hologenome concept, hosts and their microbiome form an integrated evolutionary entity, a holobiont, on which selection can potentially ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Vliet S,Doebeli M

更新日期：2019-10-08 00:00:00

abstract：:Bovine adrenal medullary cells, cultured on quartz plates, were superfused with buffer to which pulses of stimulant were added. Cytosolic Ca2+ was measured by the fura-2 fluorescence method and the simultaneously released catecholamine was measured electrochemically. When stimulant concentrations were adjusted to give...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim KT,Westhead EW

更新日期：1989-12-01 00:00:00

abstract：:CD83 is commonly known as a specific marker for mature dendritic cells. It has been shown to be important for CD4(+) T-cell development in the thymus. However, its function in the peripheral immune system remains enigmatic. Here, we show that CD83 inhibits proliferation and production of IL-2 and IFN-γ by T cells, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen L,Zhu Y,Zhang G,Gao C,Zhong W,Zhang X

更新日期：2011-11-15 00:00:00

abstract：:Characterization and functional annotation of the large number of proteins predicted from genome sequencing projects poses a major scientific challenge. Whereas several proteomics techniques have been developed to quantify the abundance of proteins, these methods provide little information regarding protein function. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okerberg ES,Wu J,Zhang B,Samii B,Blackford K,Winn DT,Shreder KR,Burbaum JJ,Patricelli MP

更新日期：2005-04-05 00:00:00

abstract：:Mouse teratocarcinoma cells induced to differentiate in vitro undergo a massive (30%) demethylation of DNA. A similar undermethylation is also observed in the mouse extraembryonic membranes, the yolk sac and placenta. In both cases, the decrease in methyl moieties occurs at a large number of CpG sites spread out over ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razin A,Webb C,Szyf M,Yisraeli J,Rosenthal A,Naveh-Many T,Sciaky-Gallili N,Cedar H

更新日期：1984-04-01 00:00:00

abstract：:GT-2 is a plant transcriptional activator that contains two separate, but similar, trihelix DNA-binding domains. GT-1 is similar to GT-2, although it contains only one of such domains. cDNAs that encode GT-2 were isolated from rice (OS-GT2) and Arabidopsis (AT-GT2). Evidence is presented for the existence of an Arabid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smalle J,Kurepa J,Haegman M,Gielen J,Van Montagu M,Van Der Straeten D

更新日期：1998-03-17 00:00:00

abstract：:Messenger RNA from rat liver was partially purified by chromatography on cellulose on the basis of its poly(A) content. Microgram amounts of this RNA stimulate protein synthesis manyfold in a heterologous cell-free system, derived from Krebs ascites cells supplemented with reticulocyte initiation factors. The messenge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schutz G,Beato M,Feigelson P

更新日期：1973-04-01 00:00:00

abstract：:The baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV, which is representative of the MNPV subtype in which the virions may contain many nucleocapsids within a single viral envelope) encodes a protein, v-ubi, that has 76% identity with the eukaryotic protein ubiquitin. Transcriptional mapping indic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guarino LA

更新日期：1990-01-01 00:00:00

abstract：:The conservation of developmental functions exerted by Antp-class homeoproteins in protostomes and deuterostomes suggested that homologs with related functions are present in diploblastic animals. Our phylogenetic analyses showed that Antp-class homeodomains belong either to non-Hox or to Hox/paraHox families. Among t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gauchat D,Mazet F,Berney C,Schummer M,Kreger S,Pawlowski J,Galliot B

更新日期：2000-04-25 00:00:00

abstract：:An mRNA fraction coding for hexon polypeptide, the major virion structural protein, was purified by gel electrophoresis from extracts of adenovirus 2-infected cells late in the lytic cycle. The mRNA sequences in this fraction were mapped between 51.7 and 61.3 units on the genome by visualizing RNA-DNA hybrids in the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berget SM,Moore C,Sharp PA

更新日期：1977-08-01 00:00:00

abstract：:Microbial fatty acid derivatives are emerging as promising alternatives to fossil fuel derived transportation fuels. Among bacterial fatty acid synthases (FAS), the Escherichia coli FAS is perhaps the most well studied, but little is known about its steady-state kinetic behavior. Here we describe the reconstitution of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu X,Liu T,Zhu F,Khosla C

更新日期：2011-11-15 00:00:00

abstract：:Arsenate is an abundant oxyanion that, because of its ability to mimic the phosphate group, is toxic to cells. Arsenate reductase (EC; encoded by the arsC gene in bacteria) participates to achieve arsenate resistance in both prokaryotes and yeast by reducing arsenate to arsenite; the arsenite is then exported by a spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett MS,Guan Z,Laurberg M,Su XD

更新日期：2001-11-20 00:00:00

abstract：:Activated RAS transforming genes that encode proteins (p21s) with amino acid substitutions at positions 12, 13, or 61 have been detected in 10-20% of human neoplasms. This report describes a monoclonal antibody (DWP) raised against a synthetic peptide corresponding to amino acids 5-16 of a mutated RAS gene encoding Va...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carney WP,Petit D,Hamer P,Der CJ,Finkel T,Cooper GM,Lefebvre M,Mobtaker H,Delellis R,Tischler AS

更新日期：1986-10-01 00:00:00

abstract：:Mice with a targeted deletion of beta3 integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of beta3+/+ mice by 14 days. In contrast, only 4% of beta3-/- mice developed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bakewell SJ,Nestor P,Prasad S,Tomasson MH,Dowland N,Mehrotra M,Scarborough R,Kanter J,Abe K,Phillips D,Weilbaecher KN

更新日期：2003-11-25 00:00:00

abstract：:IFN-alpha/beta plays an essential role in innate immunity against viral and bacterial infection. Among the proteins induced by IFN-alpha/beta are the ubiquitin-like ISG15 protein and its E1- (Ube1L) and E2- (UbcH8) conjugating enzymes, leading to the conjugation of ISG15 to cellular proteins. It is likely that ISG15 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao C,Denison C,Huibregtse JM,Gygi S,Krug RM

更新日期：2005-07-19 00:00:00

abstract：:Fas, a member of the tumor necrosis factor receptor family, can induce apoptosis when activated by Fas ligand binding or anti-Fas antibody crosslinking. Genetic studies have shown that a defect in Fas-mediated apoptosis resulted in abnormal development and function of the immune system in mice. A point mutation in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu K,Niu X,Williams LT

更新日期：1995-12-05 00:00:00

abstract：:Imaging reporter gene expression in living subjects is a rapidly evolving area of molecular imaging research. Studies have validated the use of reporter genes with positron emission tomography (PET), single photon emission computed tomography (SPECT), MRI, fluorescence with wild-type and mutants of green fluorescent p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhaumik S,Gambhir SS

更新日期：2002-01-08 00:00:00