Neuroimaging of cerebral activations and deactivations associated with hypercapnia and hunger for air.

abstract：:A mutant factor IX, designated factor IXCambridge, was isolated from a patient with hemophilia B. This protein includes an 18-residue propeptide attached to the NH2 terminus of factor IX. A point mutation at residue -1, from an arginine to a serine, precludes cleavage of the propeptide by a processing protease and int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Diuguid DL,Rabiet MJ,Furie BC,Liebman HA,Furie B

更新日期：1986-08-01 00:00:00

abstract：:We have inserted the sequence 5'-AAG-GAGGU-3', which is complementary to the 3' terminus of Escherichia coli 16S rRNA, in a reading frame and analyzed its effect on the accuracy and overall rate of translation in vivo. Translation over the sequence yields a 50% ribosomal frameshift if the reading phase is A-AGG-AGG-U....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spanjaard RA,van Duin J

更新日期：1988-11-01 00:00:00

abstract：:One of the enduring problems in the study of social evolution has been to understand how cooperation can be maintained in the presence of freeloaders, individuals that take advantage of the more cooperative members of groups they are eager to join. The freeloader problem has been particularly troublesome when groups c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Avilés L

更新日期：2002-10-29 00:00:00

abstract：:Several studies have suggested that introgressed Neandertal DNA was subjected to negative selection in modern humans. A striking observation in support of this is an apparent monotonic decline in Neandertal ancestry observed in modern humans in Europe over the past 45,000 years. Here, we show that this decline is an a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petr M,Pääbo S,Kelso J,Vernot B

更新日期：2019-01-29 00:00:00

abstract：:Telomerase activity was identified in extracts from several different mouse cell lines. Addition of telomeric TTAGGG repeats was specific to telomeric oligonucleotide primers and sensitive to pretreatment with RNase A. In contrast to the hundreds of repeats synthesized by the human and Tetrahymena telomerase enzymes i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prowse KR,Avilion AA,Greider CW

更新日期：1993-02-15 00:00:00

abstract：:Steroidogenic acute regulatory protein (StAR) appears to mediate the rapid increase in pregnenolone synthesis stimulated by tropic hormones. cDNAs encoding StAR were isolated from a human adrenal cortex library. Human StAR, coexpressed in COS-1 cells with cytochrome P450scc and adrenodoxin, increased pregnenolone synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugawara T,Holt JA,Driscoll D,Strauss JF 3rd,Lin D,Miller WL,Patterson D,Clancy KP,Hart IM,Clark BJ

更新日期：1995-05-23 00:00:00

abstract：:Voltage-gated Na+ channels are the molecular targets of local anesthetics, class I antiarrhythmic drugs, and some anticonvulsants. These chemically diverse drugs inhibit Na+ channels with complex voltage- and frequency-dependent properties that reflect preferential drug binding to open and inactivated channel states. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ragsdale DS,McPhee JC,Scheuer T,Catterall WA

更新日期：1996-08-20 00:00:00

abstract：:The plant trans-Golgi network (TGN) is a central trafficking hub where secretory, vacuolar, recycling, and endocytic pathways merge. Among currently known molecular players involved in TGN transport, three different adaptor protein (AP) complexes promote vesicle generation at the TGN with different cargo specificity a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heinze L,Freimuth N,Rößling AK,Hahnke R,Riebschläger S,Fröhlich A,Sampathkumar A,McFarlane HE,Sauer M

更新日期：2020-10-13 00:00:00

abstract：:The mammalian protein ZnT3 resides on synaptic vesicle membranes of zinc-containing neurons, suggesting its possible role in vesicular zinc transport. We show here that histochemically reactive zinc, corresponding to the zinc found within synaptic vesicles, was undetectable in the brains of mice with targeted disrupti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole TB,Wenzel HJ,Kafer KE,Schwartzkroin PA,Palmiter RD

更新日期：1999-02-16 00:00:00

abstract：:Metallothioneins are small cysteine-rich proteins capable of binding heavy metal ions such as Zn2+ and Cd2+. They are ubiquitous tissue components in higher organisms, which tentatively have been attributed both unspecific protective functions against toxic metal ions and highly specific roles in fundamental zinc-regu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braun W,Vasák M,Robbins AH,Stout CD,Wagner G,Kägi JH,Wüthrich K

更新日期：1992-11-01 00:00:00

abstract：:Recent studies have shown that genes involved in oxidative phosphorylation (OXPHOS) exhibit reduced expression in skeletal muscle of diabetic and prediabetic humans. Moreover, these changes may be mediated by the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mootha VK,Handschin C,Arlow D,Xie X,St Pierre J,Sihag S,Yang W,Altshuler D,Puigserver P,Patterson N,Willy PJ,Schulman IG,Heyman RA,Lander ES,Spiegelman BM

更新日期：2004-04-27 00:00:00

abstract：:The heterodisaccharide lactose (1,4-O-beta-D-galactopyranosyl-D-glucose) induces cellulase formation in the ascomycete Hypocrea jecorina (= Trichoderma reesei). Lactose assimilation is slow, and the assimilation of its beta-D-galactose moiety depends mainly on the operation of a recently described reductive pathway an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fekete E,Seiboth B,Kubicek CP,Szentirmai A,Karaffa L

更新日期：2008-05-20 00:00:00

abstract：:A closed duplex DNA molecule relaxed and containing nucleosomes has a different linking number from the same molecule relaxed and without nucleosomes. What does this say about the structure of the nucleosome? A mathematical study of this question is made, representing the DNA molecule by a ribbon. It is shown that the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuller FB

更新日期：1978-08-01 00:00:00

abstract：:"Functional connectivity" techniques are commonplace tools for studying brain organization. A critical element of these analyses is to distinguish variance due to neurobiological signals from variance due to nonneurobiological signals. Multiecho fMRI techniques are a promising means for making such distinctions based ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Power JD,Plitt M,Gotts SJ,Kundu P,Voon V,Bandettini PA,Martin A

更新日期：2018-02-27 00:00:00

abstract：:Coagulation is an innate defense mechanism intended to limit blood loss and trap invading pathogens during infection. However, Staphylococcus aureus has the ability to hijack the coagulation cascade and generate clots via secretion of coagulases. Although many S. aureus have this characteristic, some do not. The popul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trivedi U,Madsen JS,Everett J,Fell C,Russel J,Haaber J,Crosby HA,Horswill AR,Burmølle M,Rumbaugh KP,Sørensen SJ

更新日期：2018-12-11 00:00:00

abstract：:Understanding the causes and consequences of wildfires in forests of the western United States requires integrated information about fire, climate changes, and human activity on multiple temporal scales. We use sedimentary charcoal accumulation rates to construct long-term variations in fire during the past 3,000 y in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marlon JR,Bartlein PJ,Gavin DG,Long CJ,Anderson RS,Briles CE,Brown KJ,Colombaroli D,Hallett DJ,Power MJ,Scharf EA,Walsh MK

更新日期：2012-02-28 00:00:00

abstract：:Some dinosaurs reached masses that were approximately 8 times those of the largest, ecologically equivalent terrestrial mammals. The factors most responsible for setting the maximal body size of vertebrates are resource quality and quantity, as modified by the mobility of the consumer, and the vertebrate's rate of ene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNab BK

更新日期：2009-07-21 00:00:00

abstract：:Cancer therapies using genes and other macromolecules might realize their full clinical potential if they could be delivered to tumor tissue in optimal quantities. Unfortunately, the compromised circulation within tumors poses a formidable resistance to adequate and uniform penetration of these agents. Previously, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Netti PA,Hamberg LM,Babich JW,Kierstead D,Graham W,Hunter GJ,Wolf GL,Fischman A,Boucher Y,Jain RK

更新日期：1999-03-16 00:00:00

abstract：:Integrin-dependent adhesions mediate reciprocal exchange of force and information between the cell and the extracellular matrix. These effects are attributed to the "focal adhesion clutch," in which moving actin filaments transmit force to integrins via dynamic protein interactions. To elucidate these processes, we me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Driscoll TP,Ahn SJ,Huang B,Kumar A,Schwartz MA

更新日期：2020-12-22 00:00:00

abstract：:A key feature of immune evasion for African trypanosomes is the functional specialization of their surface membrane in an invagination known as the flagellar pocket (FP), the cell's sole site of endocytosis and exocytosis. The FP membrane is biochemically distinct yet continuous with those of the cell body and the fla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gadelha C,Rothery S,Morphew M,McIntosh JR,Severs NJ,Gull K

更新日期：2009-10-13 00:00:00

abstract：:Two brefeldin A (BFA)-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors, 200-kDa BIG1 and 190-kDa BIG2, were copurified from bovine brain cytosol associated with >670-kDa macromolecular complexes. When observed by immunofluorescence in HeLa S3 and HepG2 cells, endogenous BIG1 and coexpressed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaji R,Adamik R,Takeda K,Togawa A,Pacheco-Rodriguez G,Ferrans VJ,Moss J,Vaughan M

更新日期：2000-03-14 00:00:00

abstract：:We have obtained long-term cultures of differentiated proliferating follicular cells from normal adult human thyroid glands. In vitro growth of such human cells has been sustained by a modified F-12 medium, supplemented with bovine hypothalamus and pituitary extracts and no added thyrotropin. Cultures have been expand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Curcio F,Ambesi-Impiombato FS,Perrella G,Coon HG

更新日期：1994-09-13 00:00:00

abstract：:High-pressure methods are increasingly used to produce new dense materials with unusual properties. Increasing efforts to understand the reaction mechanisms at the microscopic level, to set up and optimize synthetic approaches, are currently directed at carbon-based solids. A fundamental, but still unsolved, question ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Citroni M,Bini R,Foggi P,Schettino V

更新日期：2008-06-03 00:00:00

abstract：:The mode of action of "allogeneic supernatant" (the culture supernatant of a 24-hr mixedlymphocyte reaction), has been studied. This factor stimulates the response of spleen cell cultures depleted in thymus-derived lymphoid cells (T-cells) to antigens that elicit a thymus-dependent response. We used a limiting dilutio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunter P,Kettman JR

更新日期：1974-02-01 00:00:00

abstract：:The production of hybridomas between immunologically activated T cells and malignant T-cell lines offers a potentially unlimited source of soluble T-cell-derived products. Recently, human T-T hybrids have been described; however, their use has been hampered by slow growth and chromosomal instability due at least in pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foung SK,Sasaki DT,Grumet FC,Engleman EG

更新日期：1982-12-01 00:00:00

abstract：:Fall migratory monarch butterflies, tested for their directional responses to magnetic cues under three conditions, amagnetic, normal, and reversed magnetic fields, showed three distinct patterns. In the absence of a magnetic field, monarchs lacked directionality as a group. In the normal magnetic field, monarchs orie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etheredge JA,Perez SM,Taylor OR,Jander R

更新日期：1999-11-23 00:00:00

abstract：:Amyotrophic lateral sclerosis is a neurodegenerative syndrome associated with 114 mutations in the gene encoding the cytosolic homodimeric enzyme Cu/Zn superoxide dismutase (SOD). In this article, we report that amyotrophic lateral sclerosis-associated SOD mutations with distinctly different disease progression can be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindberg MJ,Byström R,Boknäs N,Andersen PM,Oliveberg M

更新日期：2005-07-12 00:00:00

abstract：:Fungal cell walls and fragments thereof (elicitors) induce the formation of low and high molecular weight defense compounds in plant cell suspension cultures. This induced synthesis requires a signal molecule transmitting the message between the elicitor plant cell wall receptor and gene activation. We demonstrate in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mueller MJ,Brodschelm W,Spannagl E,Zenk MH

更新日期：1993-08-15 00:00:00

abstract：:The adzuki bean beetle, Callosobruchus chinensis, is triple-infected with distinct lineages of Wolbachia endosymbiont, wBruCon, wBruOri, and wBruAus, which were identified by their wsp (Wolbachia surface protein) gene sequences. Whereas wBruCon and wBruOri caused cytoplasmic incompatibility of the host insect, wBruAus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo N,Nikoh N,Ijichi N,Shimada M,Fukatsu T

更新日期：2002-10-29 00:00:00

abstract：:This study describes the photochemical deposition of Co-based oxygen evolution catalysts on a semiconductor photoanode for use in solar oxygen evolution. In the photodeposition process, electron-hole pairs are generated in a semiconductor upon illumination and the photogenerated holes are used to oxidize Co(2+) ions t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steinmiller EM,Choi KS

更新日期：2009-12-08 00:00:00