A Fas-associated protein factor, FAF1, potentiates Fas-mediated apoptosis.

abstract：:Commonly considered strategies for reducing the environmental impact of light-duty transportation include using alternative fuels and improving vehicle fuel economy. We evaluate the air quality-related human health impacts of 10 such options, including the use of liquid biofuels, diesel, and compressed natural gas (CN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tessum CW,Hill JD,Marshall JD

更新日期：2014-12-30 00:00:00

abstract：:Active center fractions have been prepared from Rhodopseudomonas spheroides strain Y. (de Klerk) using the cationic detergent cetyltrimethyl ammonium bromide and light particles from bacteria grown in two media differing in iron content. Spectral properties and composition of the fractions are presented. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jolchine G,Reiss-Husson F,Kamen MD

更新日期：1969-10-01 00:00:00

abstract：:To test the hypothesis that the nonrandom organization of the contents of interphase nuclei represents a compartmentalization of function, we examined the relative, spatial relationship of small nuclear ribonucleoproteins (snRNPs) and of DNase I hypersensitive chromatin (DHC) in rat pheochromocytoma cells. In controls...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park PC,De Boni U

更新日期：1996-10-15 00:00:00

abstract：:Cloned 3.18 kilobase fragments of Xenopus laevis DNA containing genes for tRNAMet1 and for at least one other 4S RNA species are transcribed rapidly after their injection into the nucleus of X. laevis oocytes. The newly synthesized RNA can be resolved by gel electrophoresis into a few predominant 4S RNA species and a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kressmann A,Clarkson SG,Pirrotta V,Birnstiel ML

更新日期：1978-03-01 00:00:00

abstract：:Although the Austronesian expansion had a major impact on the languages of Island Southeast Asia, controversy still exists over the genetic impact of this expansion. The coexistence of both Asian and Papuan genetic ancestry in Eastern Indonesia provides a unique opportunity to address this issue. Here, we estimate rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu S,Pugach I,Stoneking M,Kayser M,Jin L,HUGO Pan-Asian SNP Consortium.

更新日期：2012-03-20 00:00:00

abstract：:T-cell anergy is a state of T cells that is hyporesponsive to stimulation via the T-cell receptor and costimulatory molecules and is thought to be important for self-tolerance. How T-cell anergy is regulated is still poorly understood. We report here that tuberous sclerosis (TSC)1 is critical for T-cell anergy. Defici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie DL,Wu J,Lou YL,Zhong XP

更新日期：2012-08-28 00:00:00

abstract：:The avian neuroretina (NR) is part of the central nervous system and is composed of photoreceptors, neuronal cells, and Müller (glial) cells. These cells are derived from proliferating neuroectodermal precursors that differentiate after terminal mitosis and become organized in cell strata. Genes that are specifically ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guermah M,Crisanti P,Laugier D,Dezelee P,Bidou L,Pessac B,Calothy G

更新日期：1991-05-15 00:00:00

abstract：:Mycobacterium marinum, a natural pathogen of fish and frogs and an occasional pathogen of humans, is capable of inducing actin tail formation within the cytoplasm of macrophages, leading to actin-based motility and intercellular spread. Actin tail formation by M. marinum is markedly reduced in macrophages deficient in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stamm LM,Pak MA,Morisaki JH,Snapper SB,Rottner K,Lommel S,Brown EJ

更新日期：2005-10-11 00:00:00

abstract：:Hyperapobetalipoproteinemia is defined as the combination of a normal low density lipoprotein (LDL) cholesterol in the face of an increased LDL apolipoprotein B (apoB) protein. To examine the physical basis for the apparent disproportion between LDL cholesterol and apoB characteristic of this syndrome, we used density...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng B,Thompson GR,Sniderman AD,Forte TM,Krauss RM,Kwiterovich PO Jr

更新日期：1983-11-01 00:00:00

abstract：:During the development of a macronucleus from a micronucleus after cell mating in hypotrichs all the genes (approximately 20,000) are excised from micronuclear chromosomes as individual small DNA molecules. Telomeres are added to the ends of each gene-sized molecule and each is amplified, mostly by approximately 1000-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greslin AF,Prescott DM,Oka Y,Loukin SH,Chappell JC

更新日期：1989-08-01 00:00:00

abstract：:The activity of reconstituted cytochrome-c oxidase (EC 1.9.3.1) from bovine heart is stimulated by intraliposomal ADP but not by NaCl of the same ionic strength. A monoclonal antibody which reacts with subunits VIa-H (heart-type) and VIc, due to the evolutionary relationship between these subunits, also stimulates the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anthony G,Reimann A,Kadenbach B

更新日期：1993-03-01 00:00:00

abstract：:Cardiolipin is important for bacterial and mitochondrial stability and function. The final step in cardiolipin biosynthesis is catalyzed by cardiolipin synthase and differs mechanistically between prokaryotes and eukaryotes. To study the importance of cardiolipin synthesis for mitochondrial integrity, membrane protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serricchio M,Bütikofer P

更新日期：2012-04-17 00:00:00

abstract：:Earlier studies have shown that the DNA of herpes simplex virus 1 consists of two covalently linked components, L and S, each flanked by inverted repeats. The two components can invert, and viral DNA extracted from infected cells or virions consists of equimolar concentrations of four populations differing solely in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poffenberger KL,Tabares E,Roizman B

更新日期：1983-05-01 00:00:00

abstract：:Axonal degeneration is an initial key step in traumatic and neurodegenerative CNS disorders. We established a unique in vivo epifluorescence imaging paradigm to characterize very early events in axonal degeneration in the rat optic nerve. Single retinal ganglion cell axons were visualized by AAV-mediated expression of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knöferle J,Koch JC,Ostendorf T,Michel U,Planchamp V,Vutova P,Tönges L,Stadelmann C,Brück W,Bähr M,Lingor P

更新日期：2010-03-30 00:00:00

abstract：:Conflicts of interest between the community and its members are at the core of human social dilemmas. If observed selfishness has future costs, individuals may hide selfish acts but display altruistic ones, and peers aim at identifying the most selfish persons to avoid them as future social partners. An interaction in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rockenbach B,Milinski M

更新日期：2011-11-08 00:00:00

abstract：:Genetically obese (ob/ob) mice, mice that became obese after treatment with gold thioglucose, and lean animals were studied in the euthyroid state, after induction of hypothyroidism, and after treatment with triiodothyronine. The activity of glycerol 3-phosphate dehydrogenase (sn-glycerol-3-phosphate:(acceptor) oxidor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： York DA,Bray GA,Yukimura Y

更新日期：1978-01-01 00:00:00

abstract：:At the synapse, presynaptic membranes specialized for vesicular traffic are linked to postsynaptic membranes specialized for signal transduction. The mechanisms that connect pre- and postsynaptic membranes into synaptic junctions are unknown. Neuroligins and beta-neurexins are neuronal cell-surface proteins that bind ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song JY,Ichtchenko K,Südhof TC,Brose N

更新日期：1999-02-02 00:00:00

abstract：:Increases in cytoplasmic free calcium ([Ca2+]i) can be induced in resting B cells either by a low molecular weight (12-kDa) B-cell growth factor (LMW-BCGF) or by crosslinking the B-cell antigen CD19 with monoclonal antibody (mAb). LMW-BCGF causes a slow [Ca2+]i increase in peripheral blood and tonsillar B cells but ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ledbetter JA,Rabinovitch PS,June CH,Song CW,Clark EA,Uckun FM

更新日期：1988-03-01 00:00:00

abstract：:The carbon budget and dynamics of the Earth's interior, including the core, are currently very poorly understood. Diamond-bearing, mantle-derived rocks show a very well defined peak at δ(13)C ≈ -5 ± 3‰ with a very broad distribution to lower values (∼-40‰). The processes that have produced the wide δ(13)C distribution...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horita J,Polyakov VB

更新日期：2015-01-06 00:00:00

abstract：:Cytochrome c maturation in Escherichia coli requires the ccm operon, which encodes eight membrane proteins (CcmABCDEFGH). CcmE is a periplasmic heme chaperone that binds heme covalently and transfers it onto apocytochrome c in the presence of CcmF, CcmG, and CcmH. In this work we addressed the functions of the ccmABCD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz H,Fabianek RA,Pellicioli EC,Hennecke H,Thöny-Meyer L

更新日期：1999-05-25 00:00:00

abstract：:An elegant expression is obtained for the product of the inverse Weierstrass-Laguerre transforms of two functions in terms of their convolution. It is also shown how the main result can be extended to hold for the product of the inverse Weierstrass-Laguerre transforms of several functions. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava HM

更新日期：1971-03-01 00:00:00

abstract：:Expression of the homeobox protein CDX1 is lost or reduced in a significant proportion of colorectal carcinomas (CRCs) but the underlying mechanism for this is unclear. We have demonstrated absence of CDX1 mRNA expression in 7 of 37 CRC cell lines and shown that all 7 cell lines have a methylated CDX1 promoter. Twenty...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wong NA,Britton MP,Choi GS,Stanton TK,Bicknell DC,Wilding JL,Bodmer WF

更新日期：2004-01-13 00:00:00

abstract：:A definitive assay for microbiological and biochemical research on the biodegradation of lignin was developed using radioactive synthetic lignins specifically labeled in the side chains, aromatic rings or in the methoxyl groups. The [14C]lignins were prepared by oxidative polymerization with peroxidase and H2O2 Of spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirk TK,Connors WJ,Bleam RD,Hackett WF,Zeikus JG

更新日期：1975-07-01 00:00:00

abstract：:The intermediates and the rate-limiting step in the crystallization of deoxygenated sickle hemoglobin have been determined by a kinetic study with the use of electron microscopy. In slowly stirred solutions of deoxygenated hemoglobin S [Pumphrey, J. & Steinhardt, J. (1977) J. Mol. Biol. 112, 359--375], the sequential ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilson SM,Makinen MW

更新日期：1980-02-01 00:00:00

abstract：:Proteasomes are the multi-subunit protease thought to play a key role in the generation of peptides presented by major histocompatibility complex (MHC) class I molecules. When cells are stimulated with interferon gamma, two MHC-encoded subunits, low molecular mass polypeptide (LMP) 2 and LMP7, and the MECL1 subunit en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kasahara M,Hayashi M,Tanaka K,Inoko H,Sugaya K,Ikemura T,Ishibashi T

更新日期：1996-08-20 00:00:00

abstract：:Pneumococcal peptidoglycan amidase (N-acetylmuramoyl-L-alanine amidase, EC 3.5.1.28) and phage CPL1 lysozyme degrade a common substrate (choline-containing pneumococcal cell walls); the former hydrolyzes the bond between muramic acid and alanine, whereas the latter breaks down the linkage between muramic acid and gluc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Díaz E,López R,García JL

更新日期：1990-10-01 00:00:00

abstract：:Some monoclonal antibodies (mAbs) against interleukin (IL) 1 alpha have been found to activate antigen-presenting cells (APC, human peripheral blood monocytes and B lymphocytes), so that unstimulated T lymphocytes cultured with them are induced to proliferate and secrete IL-2. Control mAbs of the same isotypes and mAb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eugui EM,Almquist SJ

更新日期：1990-02-01 00:00:00

abstract：:The lateral mobility of individual murine polyoma virus-like particles (VLPs) bound to live cells and artificial lipid bilayers was studied by single fluorescent particle tracking using total internal reflection fluorescence microscopy. The particle trajectories were analyzed in terms of diffusion rates and modes of m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ewers H,Smith AE,Sbalzarini IF,Lilie H,Koumoutsakos P,Helenius A

更新日期：2005-10-18 00:00:00

abstract：:A murine monoclonal antibody (OKT9) raised against human leukemic cells binds to a wide variety of leukemia and tumor cell lines and to a minority of leukemia cells taken directly from patients. Fetal thymus and liver are strongly reactive as are some normal, immature hemopoietic cells and activated lymphocytes. React...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sutherland R,Delia D,Schneider C,Newman R,Kemshead J,Greaves M

更新日期：1981-07-01 00:00:00

abstract：:The synthesis of the covalently-closed, circular DNA form of colicinogenic factor E(1) (ColE(1)) continues in Escherichia coli cells after the addition of chloramphenicol. A large portion of the purified supercoiled ColE(1) DNA molecules made in the presence of chloramphenicol are converted to the open circular DNA fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blair DG,Sherratt DJ,Clewell DB,Helinski DR

更新日期：1972-09-01 00:00:00