Does canvassing increase voter turnout? A field experiment.

abstract：:We describe the preparation and structural analysis of ordered tubular arrays of the actin-DNase I complex. These structures consist of helically stacked rings; each ring is 73 A thick, has a 240 A outer and a 120 A inner diameter, and has 7-fold rotational symmetry. The actin-DNase I complex forms tubes under conditi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler WE,Buhle EL,Aebi U

更新日期：1984-03-01 00:00:00

abstract：:We report the molecular cloning of the first beta-1,3 glucanase from animal tissue. Three peptide sequences were obtained from beta-1,3 glucanase that had been purified from eggs of the sea urchin Strongylocentrotus purpuratus and the gene was cloned by PCR using oligonucleotides deduced from the peptide sequences. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bachman ES,McClay DR

更新日期：1996-06-25 00:00:00

abstract：:In maturing T lineage cells, the helix-loop-helix protein E47 has been shown to enforce a critical proliferation and developmental checkpoint commonly referred to as beta selection. To examine how E47 regulates cellular expansion and developmental progression, we have used an E2A-deficient lymphoma cell line and DNA m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz R,Engel I,Fallahi-Sichani M,Petrie HT,Murre C

更新日期：2006-06-27 00:00:00

abstract：:Ferulic, caffeic, chlorogenic, and ellagic acids, four naturally occurring plant phenols, inhibit the mutagenicity and cytotoxicity of (+/-)-7beta,8alpha-dihydroxy-9alpha, 10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]P 7,8-diol-9,10-epoxide-2), the only known ultimate carcinogenic metabolite of benzo[a]pyrene....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood AW,Huang MT,Chang RL,Newmark HL,Lehr RE,Yagi H,Sayer JM,Jerina DM,Conney AH

更新日期：1982-09-01 00:00:00

abstract：:Allostatic load (AL) is a measure of overall physiological wear-and-tear over the life course, which could partially be the consequence of early life exposures. AL could allow a better understanding of the potential biological pathways playing a role in the construction of the social gradient in adult health. To explo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barboza Solís C,Kelly-Irving M,Fantin R,Darnaudéry M,Torrisani J,Lang T,Delpierre C

更新日期：2015-02-17 00:00:00

abstract：:Decision-making in a natural environment depends on a hierarchy of interacting decision processes. A high-level strategy guides ongoing choices, and the outcomes of those choices determine whether or not the strategy should change. When the right decision strategy is uncertain, as in most natural settings, feedback be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purcell BA,Kiani R

更新日期：2016-08-02 00:00:00

abstract：:Gamma-Glutamyl transpeptidase, which consists of two nonidentical subunits, is rapidly inactivated with respect to its transpeptidase and hydrolase activities by the gamma-glutamyl analogs 6-diazo-5-oxo-L-norleucine and L-azaserine. Inactivation, which is prevented by gamma-glutamyl substrates (but not by acceptor sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tate SS,Meister A

更新日期：1977-03-01 00:00:00

abstract：:Cathepsin B (CTSB) is overexpressed in tumors of the lung, prostate, colon, breast, and stomach. However, evidence of primary genomic alterations in the CTSB gene during tumor initiation or progression has been lacking. We have found a novel amplicon at 8p22-23 that results in CTSB overexpression in esophageal adenoca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hughes SJ,Glover TW,Zhu XX,Kuick R,Thoraval D,Orringer MB,Beer DG,Hanash S

更新日期：1998-10-13 00:00:00

abstract：:We report on the location of the chain part of the retinylidene chromophore in the projected density of bacteriorhodopsin as determined by neutron diffraction from the two-dimensional purple membrane lattice. For this purpose, partially deuterated retinal was synthesized containing 10 deuterons at positions C-8, C-10,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seiff F,Wallat I,Ermann P,Heyn MP

更新日期：1985-05-01 00:00:00

abstract：:Tikal has long been viewed as one of the leading polities of the ancient Maya realm, yet how the city was able to maintain its substantial population in the midst of a tropical forest environment has been a topic of unresolved debate among researchers for decades. We present ecological, paleoethnobotanical, hydraulic,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lentz DL,Dunning NP,Scarborough VL,Magee KS,Thompson KM,Weaver E,Carr C,Terry RE,Islebe G,Tankersley KB,Grazioso Sierra L,Jones JG,Buttles P,Valdez F,Ramos Hernandez CE

更新日期：2014-12-30 00:00:00

abstract：:Inorganic polyphosphate (polyP) is composed of linear chains of phosphate groups linked by high-energy phosphoanhydride bonds. However, this simple, ubiquitous molecule remains poorly understood. The use of nonstandardized analytical methods has contributed to this lack of clarity. By using improved polyacrylamide gel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livermore TM,Chubb JR,Saiardi A

更新日期：2016-01-26 00:00:00

abstract：:Junctional Adhesion Molecule-A (JAM-A) is a transmembrane adhesive protein expressed at endothelial junctions and in leukocytes. Here we report that JAM-A is required for the correct infiltration of polymorphonuclear leukocytes (PMN) into an inflamed peritoneum or in the heart upon ischemia-reperfusion injury. The def...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corada M,Chimenti S,Cera MR,Vinci M,Salio M,Fiordaliso F,De Angelis N,Villa A,Bossi M,Staszewsky LI,Vecchi A,Parazzoli D,Motoike T,Latini R,Dejana E

更新日期：2005-07-26 00:00:00

abstract：:Swarming and mass migration are spectacular and sometimes devastating features of the biology of various animal species. These phenomena are typically associated with actual or anticipated depletion of food resources after an increase in population density, but the mechanisms driving such collective movements are poor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simpson SJ,Sword GA,Lorch PD,Couzin ID

更新日期：2006-03-14 00:00:00

abstract：:An unsaturated fatty acid-requiring mutant derived from Chinese hamster ovary (CHO) cells has been isolated and characterized. This mutant grows normally when oleate or other unsaturated fatty acids are supplemented in the growth medium. Unlike the wild-type CHO cells, growth stops when medium is deprived of unsaturat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang TY,Vagelos PR

更新日期：1976-01-01 00:00:00

abstract：:Toxin-antitoxin systems are found in many bacterial chromosomes and plasmids with roles ranging from plasmid stabilization to biofilm formation and persistence. In these systems, the expression/activity of the toxin is counteracted by an antitoxin, which, in type I systems, is an antisense RNA. While the regulatory me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El Mortaji L,Tejada-Arranz A,Rifflet A,Boneca IG,Pehau-Arnaudet G,Radicella JP,Marsin S,De Reuse H

更新日期：2020-12-08 00:00:00

abstract：:Single-molecule manipulation techniques reveal that stretching unravels individually folded domains in the muscle protein titin and the extracellular matrix protein tenascin. These elastic proteins contain tandem repeats of folded domains with beta-sandwich architecture. Herein, we propose by stretching two model sequ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klimov DK,Thirumalai D

更新日期：2000-06-20 00:00:00

abstract：:The Mediator complex forms the bridge between transcriptional activators and RNA polymerase II. Mediator subunit Med1/TRAP220 is a key component of Mediator originally found to associate with nuclear hormone receptors. Med1 deficiency causes lethality at embryonic day 11.5 because of defects in heart and placenta deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stumpf M,Waskow C,Krötschel M,van Essen D,Rodriguez P,Zhang X,Guyot B,Roeder RG,Borggrefe T

更新日期：2006-12-05 00:00:00

abstract：:Transforming growth factor beta (TGF-beta)-mediated G(1) arrest previously has been shown to specifically target inactivation of cyclin D:cyclin-dependent kinase (Cdk) 4/6 complexes. We report here that TGF-beta-treated human HepG2 hepatocellular carcinoma cells arrest in G(1), but retain continued cyclin D:Cdk4/6 act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagahara H,Ezhevsky SA,Vocero-Akbani AM,Kaldis P,Solomon MJ,Dowdy SF

更新日期：1999-12-21 00:00:00

abstract：:Mouse interferon preparations inhibited the multiplication of mouse leukemia L 1210 cells cultivated under steady-state conditions in a chemostat. The use of this sensitive and controlled system led to the detection of a rapid inhibition in the incorporation of (3-H)thymidine into cellular acid-precipitable material 2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tovey M,Brouty-Boyé D,Gresser I

更新日期：1975-06-01 00:00:00

abstract：:Cancer therapies using genes and other macromolecules might realize their full clinical potential if they could be delivered to tumor tissue in optimal quantities. Unfortunately, the compromised circulation within tumors poses a formidable resistance to adequate and uniform penetration of these agents. Previously, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Netti PA,Hamberg LM,Babich JW,Kierstead D,Graham W,Hunter GJ,Wolf GL,Fischman A,Boucher Y,Jain RK

更新日期：1999-03-16 00:00:00

abstract：:Two genes encoding steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor: oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10], a cytochrome P-450 enzyme, have been located within the HLA major histocompatibility complex. Congenital adrenal hyperplasia due to 21-OHase deficiency is a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： White PC,Grossberger D,Onufer BJ,Chaplin DD,New MI,Dupont B,Strominger JL

更新日期：1985-02-01 00:00:00

abstract：:To achieve the mission of personalized medicine, centering on delivering the right drug to the right patient at the right dose, therapeutic drug monitoring solutions are necessary. In that regard, wearable biosensing technologies, capable of tracking drug pharmacokinetics in noninvasively retrievable biofluids (e.g., ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin S,Yu W,Wang B,Zhao Y,En K,Zhu J,Cheng X,Zhou C,Lin H,Wang Z,Hojaiji H,Yeung C,Milla C,Davis RW,Emaminejad S

更新日期：2020-08-11 00:00:00

abstract：:Astrocytes regulate synaptic transmission through controlling neurotransmitter concentrations around synapses. Little is known, however, about their roles in neural circuit development. Here we report that Bergmann glia (BG), specialized cerebellar astrocytes that thoroughly enwrap Purkinje cells (PCs), are essential ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyazaki T,Yamasaki M,Hashimoto K,Kohda K,Yuzaki M,Shimamoto K,Tanaka K,Kano M,Watanabe M

更新日期：2017-07-11 00:00:00

abstract：:Historical collapse of ancient states or civilizations has raised new awareness about its possible relevance to current issues of sustainability, in the context of global change. This Special Feature examines 12 case studies of societies under stress, of which seven suffered severe transformation. Outcomes were comple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butzer KW,Endfield GH

更新日期：2012-03-06 00:00:00

abstract：:Galectin-3 is a glycan-binding protein (GBP) that binds β-galactoside glycan structures to orchestrate a variety of important biological events, including the activation of hepatic stellate cells and regulation of immune responses. While the requisite glycan epitopes needed to bind galectin-3 have long been elucidated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joeh E,O'Leary T,Li W,Hawkins R,Hung JR,Parker CG,Huang ML

更新日期：2020-11-03 00:00:00

abstract：:The rat insulin-like growth factor II gene, encoding a fetal somatomedin, expresses a multitranscript family in embryonic/fetal tissues and in the adult brain and spinal cord. By performing in situ hybridization on tissue sections of adult brain and spinal cord, we have found that these transcripts are not expressed i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stylianopoulou F,Herbert J,Soares MB,Efstratiadis A

更新日期：1988-01-01 00:00:00

abstract：:A three-dimensional model of the protein arrangement in the Escherichia coli 30S ribosome was constructed by using computerized multidimensional scaling of immunoelectron microscope data. This enabled data comparison between the new electron microscope technique and other methods such as crosslinking, chemical protect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaffney PT,Craven G

更新日期：1978-07-01 00:00:00

abstract：:Vanilloid receptor subunit 1 (VR1) appears to play a critical role in the transduction of noxious chemical and thermal stimuli by sensory nerve endings in peripheral tissues. Thus, VR1 antagonists are useful compounds to unravel the contribution of this receptor to pain perception, as well as to induce analgesia. We h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García-Martinez C,Humet M,Planells-Cases R,Gomis A,Caprini M,Viana F,De La Pena E,Sanchez-Baeza F,Carbonell T,De Felipe C,Pérez-Paya E,Belmonte C,Messeguer A,Ferrer-Montiel A

更新日期：2002-02-19 00:00:00

abstract：:In the filamentous fungus Neurospora crassa, several events in the process of conidiation are influenced by light. Two genes, con-6 and con-10, which were previously shown to be transcriptionally activated during conidiation and by exposure to light, were found to be unexpressed in mycelium maintained in constant dark...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lauter FR,Yanofsky C

更新日期：1993-09-01 00:00:00

abstract：:The medial preoptic area has been shown to be intricately involved in many behaviors, including locomotion, sexual behavior, maternal care, and aggression. The gene encoding estrogen receptor-α (ERα) protein is expressed in preoptic area neurons, and a very dense immunoreactive field of ERα is found in the preoptic re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ribeiro AC,Musatov S,Shteyler A,Simanduyev S,Arrieta-Cruz I,Ogawa S,Pfaff DW

更新日期：2012-10-02 00:00:00