A peptide of a type I toxin-antitoxin system induces Helicobacter pylori morphological transformation from spiral shape to coccoids.

abstract：:In everyday life, a macroscopic valve is a device with a movable control element that regulates the flow of gases or liquids by blocking and opening passageways. Construction of such a device on the nanoscale level requires (i) suitably proportioned movable control elements, (ii) a method for operating them on demand,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen TD,Tseng HR,Celestre PC,Flood AH,Liu Y,Stoddart JF,Zink JI

更新日期：2005-07-19 00:00:00

abstract：:Human activities increasingly take place in online environments, providing novel opportunities for relating individual behaviors to population-level outcomes. In this paper, we introduce a simple generative model for the collective behavior of millions of social networking site users who are deciding between different...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gleeson JP,Cellai D,Onnela JP,Porter MA,Reed-Tsochas F

更新日期：2014-07-22 00:00:00

abstract：:We have cloned a mutS homolog from Drosophila melanogaster called spellchecker1 (spel1) and have constructed spel1 mutant flies. MutS proteins promote the correction of DNA mismatches and serve important roles in DNA replication, recombination, and repair. The spel1 gene belongs to a subfamily of mutS first characteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores C,Engels W

更新日期：1999-03-16 00:00:00

abstract：:Unprecedented population declines and extinctions because of human activities, combined with a growing recognition that such losses affect the stability of ecosystems, underscore the need to better understand how populations persist naturally. We provide field experimental evidence that high biodiversity-in particular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carr MH,Anderson TW,Hixon MA

更新日期：2002-08-20 00:00:00

abstract：:Inactivation of the transcription factor p53 is central to carcinogenesis. Yet only approximately one-half of cancers have p53 loss-of-function mutations. Here, we demonstrate a mechanism for p53 inactivation by apoptosis repressor with caspase recruitment domain (ARC), a protein induced in multiple cancer cells. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foo RS,Nam YJ,Ostreicher MJ,Metzl MD,Whelan RS,Peng CF,Ashton AW,Fu W,Mani K,Chin SF,Provenzano E,Ellis I,Figg N,Pinder S,Bennett MR,Caldas C,Kitsis RN

更新日期：2007-12-26 00:00:00

abstract：:The E6 protein of the high-risk human papillomaviruses inactivates the tumor suppressor protein p53 by stimulating its ubiquitinylation and subsequent degradation. Ubiquitinylation is a multistep process involving a ubiquitin-activating enzyme, one of many distinct ubiquitin-conjugating enzymes, and in certain cases, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rolfe M,Beer-Romero P,Glass S,Eckstein J,Berdo I,Theodoras A,Pagano M,Draetta G

更新日期：1995-04-11 00:00:00

abstract：:In normal messenger RNA for the human beta-globin chain, nucleotide sequences have been identified which can be matched to the amino-acid sequence of the abnormally long segment of the beta-chain of hemoglobin Cranston. The finding of these sequences strengthens the hypothesis that the betaCranston chain arose by a fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forget BG,Marotta CA,Weissman SM,Cohen-Solal M

更新日期：1975-09-01 00:00:00

abstract：:Bovine pyruvate dehydrogenase phosphatase (PDP) is a Mg2+-dependent and Ca2+-stimulated heterodimer that is a member of the protein phosphatase 2C family and is localized to mitochondria. Insight into the function of the regulatory subunit of PDP (PDPr) has been gained. It decreases the sensitivity of the catalytic su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan J,Lawson JE,Reed LJ

更新日期：1996-05-14 00:00:00

abstract：:Targeting neuroendocrine tumors expressing somatostatin receptor subtypes (sst) with radiolabeled somatostatin agonists is an established diagnostic and therapeutic approach in oncology. While agonists readily internalize into tumor cells, permitting accumulation of radioactivity, radiolabeled antagonists do not, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ginj M,Zhang H,Waser B,Cescato R,Wild D,Wang X,Erchegyi J,Rivier J,Mäcke HR,Reubi JC

更新日期：2006-10-31 00:00:00

abstract：:To some extent, the genetic theory of adaptive evolution in bacteria is a simple extension of that developed for sexually reproducing eukaryotes. In other, fundamental ways, the process of adaptive evolution in bacteria is quantitatively and qualitatively different from that of organisms for which recombination is an ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin BR,Bergstrom CT

更新日期：2000-06-20 00:00:00

abstract：:The bottom-up design of protein-based signaling networks is a key goal of synthetic biology; yet, it remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Here, we report a generic approach for the construction of protein-base...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein V,Alexandrov K

更新日期：2014-11-11 00:00:00

abstract：:Dendritic cells (DCs) play a central role in determining the induction of T cell responses. IL-27 production by DCs favors induction of IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell responses. The regulatory mechanisms in DCs that control these two cells types are not u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murugaiyan G,Mittal A,Weiner HL

更新日期：2010-06-22 00:00:00

abstract：:Escherichia coli fMet-tRNAfMet alters the pattern of promoter selection of E. coli RNA polymerase (RNA nucleotidyltransferase, nucleosidetriphosphate:RNA nucleotidyltransferase; EC 2.7.7.6), affecting RNA synthesis from the rRNA, suIII+tRNA, and lac promoters in different ways. The in vitro synthesis of the stable RNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Debenham PG,Pongs O,Travers AA

更新日期：1980-02-01 00:00:00

abstract：:A three-step purification procedure for the isolation of heart muscle chalones is described. The method uses ultrafiltration followed by concanavalin A-Sepharose affinity chromatography and subsequent sucrose density gradient centrifugation. Analytical ultracentrifugation of the highly purified chalone fraction indica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kriek JA,van der Walt BJ,Bester AJ

更新日期：1981-07-01 00:00:00

abstract：:Previous studies have shown that the effect of language on categorical perception of color is stronger when stimuli are presented in the right visual field than in the left. To examine whether this lateralized effect occurs preattentively at an early stage of processing, we monitored the visual mismatch negativity, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mo L,Xu G,Kay P,Tan LH

更新日期：2011-08-23 00:00:00

abstract：:Sympatric speciation has been controversial since it was first proposed as a mode of speciation. Subterranean blind mole rats (Spalacidae) are considered to speciate allopatrically or peripatrically. Here, we report a possible incipient sympatric adaptive ecological speciation in Spalax galili (2n = 52). The study mic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hadid Y,Tzur S,Pavlícek T,Šumbera R,Šklíba J,Lövy M,Fragman-Sapir O,Beiles A,Arieli R,Raz S,Nevo E

更新日期：2013-02-12 00:00:00

abstract：:A key barrier to the realization of personalized medicine for cancer is the identification of biomarkers. Here we describe a two-stage strategy for the discovery of serum biomarker signatures corresponding to specific cancer-causing mutations and its application to prostate cancer (PCa) in the context of the commonly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cima I,Schiess R,Wild P,Kaelin M,Schüffler P,Lange V,Picotti P,Ossola R,Templeton A,Schubert O,Fuchs T,Leippold T,Wyler S,Zehetner J,Jochum W,Buhmann J,Cerny T,Moch H,Gillessen S,Aebersold R,Krek W

更新日期：2011-02-22 00:00:00

abstract：:Skeletal muscle adapts to different patterns of motor nerve activity by alterations in gene expression that match specialized properties of contraction, metabolism, and muscle mass to changing work demands (muscle plasticity). Calcineurin, a calcium/calmodulin-dependent, serine-threonine protein phosphatase, has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenberg P,Hawkins A,Stiber J,Shelton JM,Hutcheson K,Bassel-Duby R,Shin DM,Yan Z,Williams RS

更新日期：2004-06-22 00:00:00

abstract：:Direct reciprocity and conditional cooperation are important mechanisms to prevent free riding in social dilemmas. However, in large groups, these mechanisms may become ineffective because they require single individuals to have a substantial influence on their peers. However, the recent discovery of zero-determinant ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hilbe C,Wu B,Traulsen A,Nowak MA

更新日期：2014-11-18 00:00:00

abstract：:Effects of the anti-T-cell monoclonal antibodies OKT3, OKT5, and OKT8 on T-cell surface properties and cell functions were evaluated. Incubation of mononuclear cells isolated from peripheral blood for 48 hr with each monoclonal antibody in the absence of complement resulted in modulation of their respective surface an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antel J,Oger JJ,Jackevicius S,Kuo HH,Arnason BG

更新日期：1982-05-01 00:00:00

abstract：:Pulmonary pathologies including adult respiratory distress syndrome are characterized by disruption of pulmonary integrity and edema compromising respiratory function. Sphingosine 1-phosphate (S1P) is a lipid mediator synthesized and/or stored in mast cells, platelets, and epithelial cells, with production up-regulate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gon Y,Wood MR,Kiosses WB,Jo E,Sanna MG,Chun J,Rosen H

更新日期：2005-06-28 00:00:00

abstract：:We performed label-free observation of molecular dynamics in apoptotic cells by Raman microscopy. Dynamic changes in cytochrome c distribution at the Raman band of 750 cm(-1) were observed after adding an apoptosis inducer to the cells. The comparison of mitochondria fluorescence images and Raman images of cytochrome ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada M,Smith NI,Palonpon AF,Endo H,Kawata S,Sodeoka M,Fujita K

更新日期：2012-01-03 00:00:00

abstract：:Satellite tobacco necrosis virus (STNV) is one of the smallest viruses known. Its genome encodes only its coat protein (CP) subunit, relying on the polymerase of its helper virus TNV for replication. The genome has been shown to contain a cryptic set of dispersed assembly signals in the form of stem-loops that each pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel N,Wroblewski E,Leonov G,Phillips SEV,Tuma R,Twarock R,Stockley PG

更新日期：2017-11-14 00:00:00

abstract：:The solar system formed from interstellar dust and gas in a molecular cloud. Astronomical observations show that typical interstellar dust consists of amorphous (a-) silicate and organic carbon. Bona fide physical samples for laboratory studies would yield unprecedented insight about solar system formation, but they w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishii HA,Bradley JP,Bechtel HA,Brownlee DE,Bustillo KC,Ciston J,Cuzzi JN,Floss C,Joswiak DJ

更新日期：2018-06-26 00:00:00

abstract：:Aminoacyl-tRNAs are generally formed by direct attachment of an amino acid to tRNAs by aminoacyl-tRNA synthetases, but Gln-tRNA is an exception to this rule. Gln-tRNA(Gln) is formed by this direct pathway in the eukaryotic cytosol and in protists or fungi mitochondria but is formed by an indirect transamidation pathwa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pujol C,Bailly M,Kern D,Maréchal-Drouard L,Becker H,Duchêne AM

更新日期：2008-04-29 00:00:00

abstract：:The remarkable capacity of the adult olfactory epithelium (OE) to regenerate fully both neurosensory and nonneuronal cell types after severe epithelial injury depends on life-long persistence of two stem cell populations: the horizontal basal cells (HBCs), which are quiescent and held in reserve, and mitotically activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herrick DB,Lin B,Peterson J,Schnittke N,Schwob JE

更新日期：2017-07-11 00:00:00

abstract：:X chromosome-linked severe combined immunodeficiency disease (SCIDX1) is characterized by the absence of T-cell and natural killer cell development and results from molecular mutations of the interleukin 2 receptor (IL-2R) gamma chain. The IL-2R gamma chain is a common component of the IL-2, IL-4, and IL-7 receptor sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DiSanto JP,Rieux-Laucat F,Dautry-Varsat A,Fischer A,de Saint Basile G

更新日期：1994-09-27 00:00:00

abstract：:Meningococcal meningitis remains a substantial cause of mortality and morbidity worldwide. Until recently, countries in the African meningitis belt were susceptible to devastating outbreaks, largely attributed to serogroup A Neisseria meningitidis (MenA). Vaccination with glycoconjugates of MenA capsular polysaccharid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henriques P,Dello Iacono L,Gimeno A,Biolchi A,Romano MR,Arda A,Bernardes GJL,Jimenez-Barbero J,Berti F,Rappuoli R,Adamo R

更新日期：2020-11-24 00:00:00

abstract：:High ambient ozone (O3) concentrations are a widespread and persistent problem globally. Although studies have documented the role of forests in removing O3 and one of its precursors, nitrogen dioxide (NO2), the cost effectiveness of using peri-urban reforestation for O3 abatement purposes has not been examined. We de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroeger T,Escobedo FJ,Hernandez JL,Varela S,Delphin S,Fisher JR,Waldron J

更新日期：2014-10-07 00:00:00

abstract：:Optical waveguides simultaneously transport light at different colors, forming the basis of fiber-optic telecommunication networks that shuttle data in dozens of spectrally separated channels. Here, we reimagine this wavelength division multiplexing (WDM) paradigm in a novel context--the differentiated detection and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozcelik D,Parks JW,Wall TA,Stott MA,Cai H,Parks JW,Hawkins AR,Schmidt H

更新日期：2015-10-20 00:00:00