Abstract:
:In normal messenger RNA for the human beta-globin chain, nucleotide sequences have been identified which can be matched to the amino-acid sequence of the abnormally long segment of the beta-chain of hemoglobin Cranston. The finding of these sequences strengthens the hypothesis that the betaCranston chain arose by a frameshift mutation allowing the "readthrough" of the normal termination codon and translation of usually untranslated portions of the messenger RNA for the beta-globin chain. The oligonucleotides which match the amino-acid sequence of hemoglobin Cranston provide a sequence of 36 nucleotides which follows the normal beta-chain termination codon UAA.
journal_name
Proc Natl Acad Sci U S Aauthors
Forget BG,Marotta CA,Weissman SM,Cohen-Solal Mdoi
10.1073/pnas.72.9.3614keywords:
subject
Has Abstractpub_date
1975-09-01 00:00:00pages
3614-8issue
9eissn
0027-8424issn
1091-6490journal_volume
72pub_type
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