Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation.

abstract：:Most poxviruses, including variola, the causative agent of smallpox, express a secreted protein of 35 kDa, vCCI, which binds CC-chemokines with high affinity. This viral protein competes with the host cellular CC-chemokine receptors (CCRs), reducing inflammation and interfering with the host immune response. Such prot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carfí A,Smith CA,Smolak PJ,McGrew J,Wiley DC

更新日期：1999-10-26 00:00:00

abstract：:Biomass burning drives changes in greenhouse gases, climate-forcing aerosols, and global atmospheric chemistry. There is controversy about the magnitude and timing of changes in biomass burning emissions on millennial time scales from preindustrial to present and about the relative importance of climate change and hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicewonger MR,Aydin M,Prather MJ,Saltzman ES

更新日期：2018-12-04 00:00:00

abstract：:Although the occurrence of epistasis and pleiotropy is widely accepted at the molecular level, its effect on the adaptive value of fitness-related genes is rarely investigated in plants. Knowledge of these features of a gene is critical to understand the molecular basis of adaptive evolution. Here we investigate the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scarcelli N,Cheverud JM,Schaal BA,Kover PX

更新日期：2007-10-23 00:00:00

abstract：:Preincubation of quiescent BALB/C3T3 cells with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) in conditioned medium resulted in a time- and concentration-dependent stimulation of uptake of 2-deoxyglucose, uridine, and alpha-aminoisobutyric acid over that seen in conditioned medium alone. The apparent Km values ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Natraj CV,Datta P

更新日期：1978-08-01 00:00:00

abstract：:DNA delivery of IL-12 has shown promise in reducing the toxic side effects associated with administration of recombinant human (h)IL-12 protein while maintaining the ability to inhibit tumor growth and abolish tumor metastases in animal models. We have developed a more potent version of IL-12 by using DNA shuffling an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leong SR,Chang JC,Ong R,Dawes G,Stemmer WP,Punnonen J

更新日期：2003-02-04 00:00:00

abstract：:The rate of change of climate codetermines the global warming impacts on natural and socioeconomic systems and their capabilities to adapt. Establishing past rates of climate change from temperature proxy data remains difficult given their limited spatiotemporal resolution. In contrast, past greenhouse gas radiative f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joos F,Spahni R

更新日期：2008-02-05 00:00:00

abstract：:Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma, tissue eosinophilia, overproduction of cysteinyl leukotrienes (cysLTs), and respiratory reactions to nonselective cyclooxygenase (COX) inhibitors. Ex vivo studies suggest that functional abnormalities of the COX-2/microsomal prostaglandin (PG)E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu T,Laidlaw TM,Katz HR,Boyce JA

更新日期：2013-10-15 00:00:00

abstract：:The Drosophila splicing factor RBP1 participates together with TRA and TRA-2 in the regulation of alternative splicing of doublesex (dsx) pre-mRNA. It does so by recognizing RBP1 RNA target sequences in the dsx pre-mRNA. RBP1 belongs to the Ser-Arg-rich (SR) protein family of splicing factors, which have in common a N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heinrichs V,Baker BS

更新日期：1997-01-07 00:00:00

abstract：:Incubation of rat calvaria for short times in the presence of a labeled amino acid revealed the existence of a collagen fraction (procollagen) that functions as a biosynthetic precursor of collagen. Procollagen contains an alpha1-like chain (pre-alpha1) that elutes earlier from CM-cellulose than does rat-bone alpha1 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bellamy G,Bornstein P

更新日期：1971-06-01 00:00:00

abstract：:The mechanisms that regulate the ubiquitin (Ub)-proteasome system's own components, although critically important, are largely unknown. Ub, a principal component of the system, must be maintained at adequate levels to support cellular homeostasis under basal and stressed conditions. It was suggested that Ub is degrade...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shabek N,Herman-Bachinsky Y,Ciechanover A

更新日期：2009-07-21 00:00:00

abstract：:The 5-hydroxytryptamine-3 (5-HT3) receptor mediates the fast excitatory neurotransmission of serotonin and is known to mediate the nausea/emesis induced by radio/chemotherapy and anesthetics. A polymorphism encoding the variation Y129S in the 5-HT3B subunit exists in high frequency in the general population and has be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krzywkowski K,Davies PA,Feinberg-Zadek PL,Bräuner-Osborne H,Jensen AA

更新日期：2008-01-15 00:00:00

abstract：:The human genome is made up of long DNA segments, the isochores, which are compositionally homogeneous and can be subdivided into a small number of families characterized by different G+C levels. Chromosome in situ suppression hybridization (in which excess unlabeled human DNA is added to suppress hybridization of rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saccone S,De Sario A,Wiegant J,Raap AK,Della Valle G,Bernardi G

更新日期：1993-12-15 00:00:00

abstract：:n-Type Si electrodes in MeOH solvent with 0.2 M (1-hydroxyethyl)ferrocene, 0.5 mM (1-hydroxyethyl)ferricenium, and 1.0 M LiClO(4) exhibit air mass 2 conversion efficiencies of 10.1% for optical energy into electricity. We observe open-circuit voltages of 0.53 V and short-circuit quantum efficiencies for electron flow ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gronet CM,Lewis NS,Cogan G,Gibbons J

更新日期：1983-02-01 00:00:00

abstract：:We have constructed and cloned, in bacteria, recombinant plasmids containing DNA complementary to mRNA coding for a pancreatic pre-prosomatostatin, a product of the cell-free translation of pancreatic islet mRNAs shown previously by immunoprecipitation to be a precursor of somatostatin. A clone containing a nearly ful...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodman RH,Jacobs JW,Chin WW,Lund PK,Dee PC,Habener JF

更新日期：1980-10-01 00:00:00

abstract：:Visual development is thought to be completed at an early age. We suggest that the maturation of the visual brain is not homogeneous: functions with greater need for early availability, such as visuomotor control, mature earlier, and the development of other visual functions may extend well into childhood. We found si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovács I,Kozma P,Fehér A,Benedek G

更新日期：1999-10-12 00:00:00

abstract：:Kruppel-like factor 4 (KLF4) is involved in self-renewal of embryonic stem cells and reprogramming of somatic cells to pluripotency. However, its role in lineage-committed stem cells remains largely unknown. Here, we show that KLF4 is expressed in neural stem cells (NSCs) and is down-regulated during neuronal differen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin S,Liu M,Niu W,Zhang CL

更新日期：2011-12-27 00:00:00

abstract：:The relative importance of the roles of adaptation and chance in determining genetic diversity and evolution has received attention in the last 50 years, but our understanding is still incomplete. All statements about the relative effects of evolutionary factors, especially drift, need confirmation by strong demograph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiaroni J,Underhill PA,Cavalli-Sforza LL

更新日期：2009-12-01 00:00:00

abstract：:Beta subunits of voltage-gated Ca2+ channels are encoded in four genes and display additional molecular diversity because of alternative splicing. At the functional level, all forms are very similar except for beta2a, which differs in that it does not support prepulse facilitation of alpha1C Ca2+ channels, inhibits vo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin N,Platano D,Olcese R,Costantin JL,Stefani E,Birnbaumer L

更新日期：1998-04-14 00:00:00

abstract：:Neurotrophins (NTs) have recently been found to regulate synaptic transmission in the hippocampus. Whole-cell and single-channel recordings from cultured hippocampal neurons revealed a mechanism responsible for enhanced synaptic strength. Specifically, brain-derived neurotrophic factor augmented glutamate-evoked, but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine ES,Crozier RA,Black IB,Plummer MR

更新日期：1998-08-18 00:00:00

abstract：:Rad51 is a highly conserved eukaryotic homolog of the prokaryotic recombination protein RecA, which has been shown to function in both recombinational repair of DNA damage and meiotic recombination in yeast. In primary murine B cells cultured with lipopolysaccharide (LPS) to stimulate heavy chain class switch recombin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li MJ,Peakman MC,Golub EI,Reddy G,Ward DC,Radding CM,Maizels N

更新日期：1996-09-17 00:00:00

abstract：:Representations of the (infinite) canonical anticommutation relations and the associated operator algebra, the fermion algebra, are studied. A "coupling constant" (in (0,1]) is defined for primary states of "finite type" of that algebra. Primary, faithful states of finite type with arbitrary coupling are constructed a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kadison RV

更新日期：1998-11-10 00:00:00

abstract：:AK032317 is the GenBank accession no. of a full-length RIKEN mouse cDNA. It encodes a putative variant of the C3-type TRPC (transient receptor potential channel) that differs from the previously cloned murine TRPC3 cDNA in that it has a 5' extension stemming from inclusion of an additional exon (exon 0). The extended ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yildirim E,Kawasaki BT,Birnbaumer L

更新日期：2005-03-01 00:00:00

abstract：:Groundwater arsenic (As) is elevated in the shallow Holocene aquifers of Bangladesh. In the dry season, the shallow groundwater discharges to major rivers. This process may influence the chemistry of the river and the hyporheic zone sediment. To assess the fate of As during discharge, surface (0-5 cm) and subsurface (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Datta S,Mailloux B,Jung HB,Hoque MA,Stute M,Ahmed KM,Zheng Y

更新日期：2009-10-06 00:00:00

abstract：:Exposure of cholera toxin to membrane particles prepared from sarcoma 180 cells gives rise to a variety of fragments which are capable of activating adenylate cyclase [ATP:pyrophosphate-lyase (cyclizing), EC 4.6.1.1]. A major component of these fragments has an apparent molecular weight in the 8,000-10,000 range. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matuo Y,Wheeler MA,Bitensky MW

更新日期：1976-08-01 00:00:00

abstract：:A metabolic mechanism for oxalic acid biosynthesis in the wood-rotting basidiomycete Fomitopsis palustris has been proposed on the basis of biochemical analyses of glucose metabolism. There was a strong correlation between glucose consumption and oxalate production. Oxalic acid was found to accumulate in the culture f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Munir E,Yoon JJ,Tokimatsu T,Hattori T,Shimada M

更新日期：2001-09-25 00:00:00

abstract：:In higher eukaryotic cells, mitochondria are essential subcellular organelles for energy production, cell signaling, and the biosynthesis of biomolecules. The mitochondrial DNA (mtDNA) genome is indispensable for mitochondrial function because it encodes protein subunits of the electron transport chain and a full set ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu W,Boyd RM,Tree MO,Samkari F,Zhao L

更新日期：2019-09-03 00:00:00

abstract：:Jun is a transcription factor belonging to the activator protein 1 family. A mutated version of Jun (v-Jun) transduced by the avian retrovirus ASV17 induces oncogenic transformation in avian cell cultures and sarcomas in young galliform birds. The oncogenicity of Jun probably results from transcriptional deregulation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu Sl,Bottoli I,Goller M,Vogt PK

更新日期：1999-05-11 00:00:00

abstract：:Microstructural, δ(13)C isotope and C/N ratio investigations were conducted on excavated material from the black Younger Dryas boundary in Lommel, Belgium, aiming for a characterisation of the carbon content and structures. Cubic diamond nanoparticles are found in large numbers. The larger ones with diameters around o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian H,Schryvers D,Claeys P

更新日期：2011-01-04 00:00:00

abstract：:We have determined the general constraints that govern sequence divergence in proteins that retain entirely, or very largely, the same structure and function. To do this we collected data from three different groups of orthologous sequences: those found in humans and mice, in humans and chickens, and in Escherichia co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasidharan R,Chothia C

更新日期：2007-06-12 00:00:00

abstract：:Various proteins with different biological activities have been observed to be translocated from the nucleus to the cytoplasm in an energy- and signal-dependent manner in eukaryotic cells. This nuclear export is directed by nuclear export signals (NESs), typically characterized by hydrophobic, primarily leucine, amino...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elfgang C,Rosorius O,Hofer L,Jaksche H,Hauber J,Bevec D

更新日期：1999-05-25 00:00:00