Unique regulatory properties of the type 2a Ca2+ channel beta subunit caused by palmitoylation.

abstract：:As the Copenhagen Accord indicates, most of the international community agrees that global mean temperature should not be allowed to rise more than two degrees Celsius above preindustrial levels to avoid unacceptable damages from climate change. The scientific evidence distilled in the Fourth Assessment Report of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heitzig J,Lessmann K,Zou Y

更新日期：2011-09-20 00:00:00

abstract：:Tubular membrane structures are widespread in eukaryotic cells, but the mechanisms underlying their formation and stability are not well understood. Previous work has focused on tube extrusion from cells and model membranes under the application of external forces. Here, we present novel membrane/polymer systems, wher...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Lipowsky R,Dimova R

更新日期：2011-03-22 00:00:00

abstract：:We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI in vivo. There is a large clinical need for a noninvasive tool to assess atherosclerosis from a molecular and cellular standpoint. Macrophages play a central role in atherosclerosis and are assoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amirbekian V,Lipinski MJ,Briley-Saebo KC,Amirbekian S,Aguinaldo JG,Weinreb DB,Vucic E,Frias JC,Hyafil F,Mani V,Fisher EA,Fayad ZA

更新日期：2007-01-16 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV), etiologically associated with Kaposi's sarcoma, uses integrins (α3β1, αVβ3, and αVβ5) and associated signaling to enter human dermal microvascular endothelial cells (HMVEC-d), an in vivo target of infection. KSHV infection activated c-Cbl, which induced the selective tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakraborty S,Veettil MV,Bottero V,Chandran B

更新日期：2012-05-08 00:00:00

abstract：:"Evolution behaves like a tinkerer" (François Jacob, Science, 1977). Software systems provide a singular opportunity to understand biological processes using concepts from network theory. The Debian GNU/Linux operating system allows us to explore the evolution of a complex network in a unique way. The modular design d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fortuna MA,Bonachela JA,Levin SA

更新日期：2011-12-13 00:00:00

abstract：:Bordetella pertussis secretes a calmodulin-activated adenylate cyclase toxin, CyaA, that is able to deliver its N-terminal catalytic domain (400-aa residues) into the cytosol of eukaryotic target cells, directly through the cytoplasmic membrane. We have previously shown that CyaA can be used as a vehicle to deliver T ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karimova G,Fayolle C,Gmira S,Ullmann A,Leclerc C,Ladant D

更新日期：1998-10-13 00:00:00

abstract：:Reactive oxygen species (ROS) are known to be important signal molecules that are involved in biotic and abiotic stress responses as well as in growth regulation. However, the molecular mechanisms by which ROS act as a growth regulator, as well as how ROS-dependent growth regulation relates to its roles in stress resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mabuchi K,Maki H,Itaya T,Suzuki T,Nomoto M,Sakaoka S,Morikami A,Higashiyama T,Tada Y,Busch W,Tsukagoshi H

更新日期：2018-05-15 00:00:00

abstract：:Human-caused environmental changes are creating regional combinations of environmental conditions that, within the next 50 to 100 years, may fall outside the envelope within which many of the terrestrial plants of a region evolved. These environmental modifications might become a greater cause of global species extinc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilman D,Lehman C

更新日期：2001-05-08 00:00:00

abstract：:In the central nervous system, glycogen-derived bioenergetic resources in astrocytes help promote tissue survival in response to focal neuronal stress. However, our understanding of the extent to which these resources are mobilized and utilized during neurodegeneration, especially in nearby regions that are not active...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper ML,Pasini S,Lambert WS,D'Alessandro KB,Yao V,Risner ML,Calkins DJ

更新日期：2020-08-04 00:00:00

abstract：:The functional architecture of mammalian visual cortex has been elucidated in impressive detail by experimental work of the past 20-25 years. The origin of many of the salient features of this architecture, however, has remained unexplained. This paper is the first of three (the others will appear in subsequent issues...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Linsker R

更新日期：1986-10-01 00:00:00

abstract：:The formation of a fracture network is a key process for many geophysical and industrial practices from energy resource recovery to induced seismic management. We focus on the initial stage of a fracture network formation using experiments on the symmetric coalescence of two equal coplanar, fluid-driven, penny-shaped ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Keeffe NJ,Zheng Z,Huppert HE,Linden PF

更新日期：2018-10-09 00:00:00

abstract：:A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li JZ,Bunney BG,Meng F,Hagenauer MH,Walsh DM,Vawter MP,Evans SJ,Choudary PV,Cartagena P,Barchas JD,Schatzberg AF,Jones EG,Myers RM,Watson SJ Jr,Akil H,Bunney WE

更新日期：2013-06-11 00:00:00

abstract：:Staphylococcus aureus forms biofilms on indwelling medical devices using a variety of cell-surface proteins. There is growing evidence that specific homophilic interactions between these proteins represent an important mechanism of cell accumulation during biofilm formation, but the underlying molecular mechanisms are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feuillie C,Formosa-Dague C,Hays LM,Vervaeck O,Derclaye S,Brennan MP,Foster TJ,Geoghegan JA,Dufrêne YF

更新日期：2017-04-04 00:00:00

abstract：:Excessive poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) activation kills cells via a cell-death process designated "parthanatos" in which PAR induces the mitochondrial release and nuclear translocation of apoptosis-inducing factor to initiate chromatinolysis and cell death. Accompanying the formation of PAR are the red...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andrabi SA,Umanah GK,Chang C,Stevens DA,Karuppagounder SS,Gagné JP,Poirier GG,Dawson VL,Dawson TM

更新日期：2014-07-15 00:00:00

abstract：:Dendritic cells (DCs) play a central role in determining the induction of T cell responses. IL-27 production by DCs favors induction of IL-10-producing regulatory T cells, whereas osteopontin (OPN) promotes pathogenic IL-17 T cell responses. The regulatory mechanisms in DCs that control these two cells types are not u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murugaiyan G,Mittal A,Weiner HL

更新日期：2010-06-22 00:00:00

abstract：:Ionizing radiation (IR) induces a variety of DNA lesions among which DNA double-strand breaks (DSBs) are the biologically most significant. It is currently unclear if DSB repair is equally efficient after low and high doses. Here, we use gamma-H2AX, phospho-ATM (pATM), and 53BP1 foci analysis to monitor DSB repair. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grudzenski S,Raths A,Conrad S,Rübe CE,Löbrich M

更新日期：2010-08-10 00:00:00

abstract：:The photoaffinity herbicide azidoatrazine (2-azido-4-ethylamino-6-isopropylamino-s-triazine) selectively labels the L subunit of the reaction center of the photosynthetic bacterium Rhodopseudomonas sphaeroides. Herbicide-resistant mutants retain the L subunit and have altered binding properties for methylthio- and chl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown AE,Gilbert CW,Guy R,Arntzen CJ

更新日期：1984-10-01 00:00:00

abstract：:The U1 small nuclear ribonucleoprotein particle U1C protein has a zinc finger-like structure (C2H2 motif) at its N terminus, which is conserved from yeast to humans. Mutations of amino acid L13 within this domain rescue the essential function of the helicase protein Prp28p. Prp28p has been implicated in unwinding the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du H,Tardiff DF,Moore MJ,Rosbash M

更新日期：2004-10-12 00:00:00

abstract：:Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains unknown, but the need for a long-term reduction in caloric intake to achieve these benefits has been assumed. We report that w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anson RM,Guo Z,de Cabo R,Iyun T,Rios M,Hagepanos A,Ingram DK,Lane MA,Mattson MP

更新日期：2003-05-13 00:00:00

abstract：:The activity-regulated cytoskeleton-associated protein (Arc) gene is a neural immediate early gene that is involved in synaptic downscaling and is robustly induced by prolonged wakefulness in rodent brains. Converging evidence has led to the hypothesis that wakefulness potentiates, and sleep reduces, synaptic strength...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki A,Yanagisawa M,Greene RW

更新日期：2020-05-12 00:00:00

abstract：:Infection of the mouse trigeminal ganglia (TG) is the most commonly used model for the study of herpes simplex virus type 1 (HSV-1) latency. Its popularity is caused, at least in part, by the perception that latent infection can be studied in this system in the absence of spontaneous viral reactivation. However, this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldman LT,Ellison AR,Voytek CC,Yang L,Krause P,Margolis TP

更新日期：2002-01-22 00:00:00

abstract：:Clostridium perfringens iota-toxin (Ia) mono-ADP ribosylates Arg177 of actin, leading to cytoskeletal disorganization and cell death. To fully understand the reaction mechanism of arginine-specific mono-ADP ribosyl transferase, the structure of the toxin-substrate protein complex must be characterized. Recently, we so...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsurumura T,Tsumori Y,Qiu H,Oda M,Sakurai J,Nagahama M,Tsuge H

更新日期：2013-03-12 00:00:00

abstract：:Asymmetric cell division is of fundamental importance in biology as it allows for the establishment of separate cell lineages during the development of multicellular organisms. Although microbial systems, including the yeast Saccharomyces cerevisiae, are excellent models of asymmetric cell division, this phenotype occ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thorpe PH,Bruno J,Rothstein R

更新日期：2009-04-21 00:00:00

abstract：:Rat, but not human, erythrocytes undergo fusion promoted by the membrane-mobility agent 2-(2-methoxyethoxy)-ethyl cis-8-(2-octylcyclopropyl)octanoate (A2C). The difference in behavior is correlated with rat erythrocyte membrane protein degradation caused by Ca2+-activated proteases. The human erythrocyte is deficient ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kosower NS,Glaser T,Kosower EM

更新日期：1983-12-01 00:00:00

abstract：:Single-stranded DNA oligonucleotides can achieve targeted base-pair substitution with modest efficiency but high precision. We show that "oligo targeting" can be used effectively to study missense mutations in DNA mismatch repair (MMR) genes. Inherited inactivating mutations in DNA MMR genes are causative for the canc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Houlleberghs H,Dekker M,Lantermans H,Kleinendorst R,Dubbink HJ,Hofstra RM,Verhoef S,Te Riele H

更新日期：2016-04-12 00:00:00

abstract：:Human settlement of Oceania marked the culmination of a global colonization process that began when humans first left Africa at least 90,000 years ago. The precise origins and dispersal routes of the Austronesian peoples and the associated Lapita culture remain contentious, and numerous disparate models of dispersal (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larson G,Cucchi T,Fujita M,Matisoo-Smith E,Robins J,Anderson A,Rolett B,Spriggs M,Dolman G,Kim TH,Thuy NT,Randi E,Doherty M,Due RA,Bollt R,Djubiantono T,Griffin B,Intoh M,Keane E,Kirch P,Li KT,Morwood M,Pedriñ

更新日期：2007-03-20 00:00:00

abstract：:Conflicts of interest between the community and its members are at the core of human social dilemmas. If observed selfishness has future costs, individuals may hide selfish acts but display altruistic ones, and peers aim at identifying the most selfish persons to avoid them as future social partners. An interaction in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rockenbach B,Milinski M

更新日期：2011-11-08 00:00:00

abstract：:Plant cuticles are composed of wax and cutin and evolved in the land plants as a hydrophobic boundary that reduces water loss from the plant epidermis. The expanding maize adult leaf displays a dynamic, proximodistal gradient of cuticle development, from the leaf base to the tip. Laser microdissection RNA Sequencing (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiao P,Bourgault R,Mohammadi M,Matschi S,Philippe G,Smith LG,Gore MA,Molina I,Scanlon MJ

更新日期：2020-06-02 00:00:00

abstract：:DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA resynthesis. Dominant MMR models posit that after mismatch recognition, ATP converts MutS to a hydrolysis-independent, diffusive mobile clamp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao P,LeBlanc SJ,Case BC,Elston TC,Hingorani MM,Erie DA,Weninger KR

更新日期：2020-07-28 00:00:00

abstract：:Suppressor T cells have been shown to be much more radiosensitive than other lymphoïd cells, and we have tried to reduce tumor growth by low-dose irradiation. Syngeneic DBA/2 mice received whole-body irradiation (150 rads; 1 rad = 0.01 J/kg) 6 days after P815 tumor inoculation. Tumor growth is significantly reduced in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilkin AF,Schaaf-Lafontaine N,Van Acker A,Boccadoro M,Urbain J

更新日期：1981-03-01 00:00:00