Abstract:
:Dietary restriction has been shown to have several health benefits including increased insulin sensitivity, stress resistance, reduced morbidity, and increased life span. The mechanism remains unknown, but the need for a long-term reduction in caloric intake to achieve these benefits has been assumed. We report that when C57BL6 mice are maintained on an intermittent fasting (alternate-day fasting) dietary-restriction regimen their overall food intake is not decreased and their body weight is maintained. Nevertheless, intermittent fasting resulted in beneficial effects that met or exceeded those of caloric restriction including reduced serum glucose and insulin levels and increased resistance of neurons in the brain to excitotoxic stress. Intermittent fasting therefore has beneficial effects on glucose regulation and neuronal resistance to injury in these mice that are independent of caloric intake.
journal_name
Proc Natl Acad Sci U S Aauthors
Anson RM,Guo Z,de Cabo R,Iyun T,Rios M,Hagepanos A,Ingram DK,Lane MA,Mattson MPdoi
10.1073/pnas.1035720100keywords:
subject
Has Abstractpub_date
2003-05-13 00:00:00pages
6216-20issue
10eissn
0027-8424issn
1091-6490pii
1035720100journal_volume
100pub_type
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更新日期:2013-08-27 00:00:00