Stimulation of DNA and protein synthesis in fetal-rat liver cells by serum from partially hepatectomized rats.

abstract：:Trisomy is a genetic abnormality of considerable medical importance. The most familiar example is trisomy 21, which causes Down Syndrome [Cummings, M. R. (1988) Human Heredity: Principles and Issues (West Publishing Company, New York)]. In a classic paper, Axelrod and Hamilton [Axelrod, R. & Hamilton, W. D. (1981) Sci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Day T,Taylor PD

更新日期：1998-03-03 00:00:00

abstract：:The S100A8/S100A9 heterodimer calprotectin (CP) functions in the host response to pathogens through a mechanism termed "nutritional immunity." CP binds Mn(2+) and Zn(2+) with high affinity and starves bacteria of these essential nutrients. Combining biophysical, structural, and microbiological analysis, we identified ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damo SM,Kehl-Fie TE,Sugitani N,Holt ME,Rathi S,Murphy WJ,Zhang Y,Betz C,Hench L,Fritz G,Skaar EP,Chazin WJ

更新日期：2013-03-05 00:00:00

abstract：:We are interested in using recombinant adeno-associated viral vectors in the treatment of hemophilia A. Because of the size constraints of recombinant adeno-associated viral vectors, we delivered the heavy and light chains of the human factor 8 (hFVIII) cDNA independently by using two separate vectors. Recombinant AAV...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burton M,Nakai H,Colosi P,Cunningham J,Mitchell R,Couto L

更新日期：1999-10-26 00:00:00

abstract：:High magnetic fields have revealed a surprisingly small Fermi surface in underdoped cuprates, possibly resulting from Fermi-surface reconstruction due to an order parameter that breaks translational symmetry of the crystal lattice. A crucial issue concerns the doping extent of such a state and its relationship to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan MK,McDonald RD,Ramshaw BJ,Betts JB,Shekhter A,Bauer ED,Harrison N

更新日期：2020-05-05 00:00:00

abstract：:Excitatory synaptic transmission in the mammalian central nervous system is mediated predominantly by glutamate receptor (GluR) channels of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate/kainate (AMPA/KA) receptor type. A major improvement in our understanding of glutamatergic synaptic transmission has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keller BU,Blaschke M,Rivosecchi R,Hollmann M,Heinemann SF,Konnerth A

更新日期：1993-01-15 00:00:00

abstract：:The covalent joining of topoisomerases to DNA is normally a transient step in the reaction cycle of these important enzymes. However, under a variety of circumstances, the covalent complex is converted to a long-lived or dead-end product that can result in chromosome breakage and cell death. We have discovered and par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SW,Burgin AB Jr,Huizenga BN,Robertson CA,Yao KC,Nash HA

更新日期：1996-10-15 00:00:00

abstract：:Biological resurfacing of entire articular surfaces represents an important but challenging strategy for treatment of cartilage degeneration that occurs in osteoarthritis. Not only does this approach require anatomically sized and functional engineered cartilage, but the inflammatory environment within an arthritic jo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moutos FT,Glass KA,Compton SA,Ross AK,Gersbach CA,Guilak F,Estes BT

更新日期：2016-08-02 00:00:00

abstract：:Cloned 3.18 kilobase fragments of Xenopus laevis DNA containing genes for tRNAMet1 and for at least one other 4S RNA species are transcribed rapidly after their injection into the nucleus of X. laevis oocytes. The newly synthesized RNA can be resolved by gel electrophoresis into a few predominant 4S RNA species and a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kressmann A,Clarkson SG,Pirrotta V,Birnstiel ML

更新日期：1978-03-01 00:00:00

abstract：:Genetic polymorphism in the H-2:Qa:Tla region of chromosome 17 is associated with constitutive variation of bodily odor phenotypes which permit individual olfactory recognition among mice. To determine whether known genes in the H-2:Qa:Tla complex are concerned in the constitution of odor phenotypes, mice were tested ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamazaki K,Beauchamp GK,Egorov IK,Bard J,Thomas L,Boyse EA

更新日期：1983-09-01 00:00:00

abstract：:The increasing frequency of antibiotic resistance in hospital-acquired infections is a major public health concern that has both biological and economic causes. Here we develop conceptual mathematical models that couple the economic incentives and population biology of hospital infection control (HIC). We show that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DL,Levin SA,Laxminarayan R

更新日期：2005-02-22 00:00:00

abstract：:Chronic, low grade, sterile inflammation frequently accompanies aging and age-related diseases. Cellular senescence is associated with the production of proinflammatory chemokines, cytokines, and extracellular matrix (ECM) remodeling proteases, which comprise the senescence-associated secretory phenotype (SASP). We fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu M,Tchkonia T,Ding H,Ogrodnik M,Lubbers ER,Pirtskhalava T,White TA,Johnson KO,Stout MB,Mezera V,Giorgadze N,Jensen MD,LeBrasseur NK,Kirkland JL

更新日期：2015-11-17 00:00:00

abstract：:Tissue cultures of Actinidia kolomikta can be maintained as callus through repeated passages on a nutrient medium devoid of cytokinin but containing inorganic nutrients, sucrose, and other basal organics plus auxin. Under these conditions, actively growing callus contained 2 and 0.5 nmol of the cytokinins zeatin [io(6...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Einset JW

更新日期：1986-02-01 00:00:00

abstract：:In illuminated rod outer segment membranes, GTP and guanosine 5'-[beta, gamma-imido]triphosphate (p[NH]ppG) have reciprocal effects on cGMP phosphodiesterase (PDEase; 3':5'-cyclic-nucleotide 5'-nucleotidohydrolase, EC 3.1.4.17) activity and cGMP binding to noncatalytic sites on that enzyme. Two micromolar p[NH]ppG inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamazaki A,Bartucca F,Ting A,Bitensky MW

更新日期：1982-06-01 00:00:00

abstract：:Renal medullary cells contain high concentrations of myo-inositol, sorbitol, betaine, and glycerophosphocholine, whose levels vary with urinary osmolality. Accumulation of these "compatible" organic osmolytes is believed to help the cells osmoregulate in response to the high extracellular osmolality that occurs as par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakanishi T,Turner RJ,Burg MB

更新日期：1989-08-01 00:00:00

abstract：:In mantle cell lymphoma (MCL), the translocation t(11;14) is considered the cytogenetic hallmark of the disease. Recently, however, deletion of the chromosomal region 11q22-q23 has been identified as a frequent event in this type of cancer, indicating the existence of a pathogenically relevant tumor suppressor gene in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schaffner C,Idler I,Stilgenbauer S,Döhner H,Lichter P

更新日期：2000-03-14 00:00:00

abstract：:A series of hairpin pyrrole-imidazole polyamide-fluorescein conjugates were synthesized and assayed for cellular localization. Thirteen cell lines, representing 11 human cancers, one human transformed kidney cell line, and one murine leukemia cell line, were treated with 5 microM polyamide-fluorescein conjugates for 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Best TP,Edelson BS,Nickols NG,Dervan PB

更新日期：2003-10-14 00:00:00

abstract：:If excision repair-proficient human cells are allowed time for repair before onset of S phase, the premutagenic lesions formed by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy- 7,8,9,10-tetrahydrobenzo[a]pyrene (benzo[a]pyrene diol epoxide, BPDE) are lost from the transcribed strand of the hypoxanthine (guanin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen RH,Maher VM,Brouwer J,van de Putte P,McCormick JJ

更新日期：1992-06-15 00:00:00

abstract：:The lymphoma-inducing potential of Ig heavy-chain enhancer- and promoter-regulated Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) was evaluated in three transgenic FVB mouse lineages. EBNA1 was expressed at a higher level in transgenic B220(+) splenocytes than in EBV-infected lymphoblastoid cell lines. EBNA1 was a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kang MS,Lu H,Yasui T,Sharpe A,Warren H,Cahir-McFarland E,Bronson R,Hung SC,Kieff E

更新日期：2005-01-18 00:00:00

abstract：:The challenging problem of ultra-high-energy-density, high-efficiency, and small-scale portable power generation is addressed here using a distinctive thermophotovoltaic energy conversion mechanism and chip-based system design, which we name the microthermophotovoltaic (μTPV) generator. The approach is predicted to be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan WR,Bermel P,Pilawa-Podgurski RC,Marton CH,Jensen KF,Senkevich JJ,Joannopoulos JD,Soljacic M,Celanovic I

更新日期：2013-04-02 00:00:00

abstract：:In the realm of protein-protein interactions, the assembly process of homooligomers plays a fundamental role because the majority of proteins fall into this category. A comprehensive understanding of this multistep process requires the characterization of the driving molecular interactions and the transient intermedia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barducci A,Bonomi M,Prakash MK,Parrinello M

更新日期：2013-12-03 00:00:00

abstract：:Human gene MAGE-1 encodes tumor-specific antigens that are recognized on melanoma cells by autologous cytolytic T lymphocytes. This gene is expressed in a significant proportion of tumors of various histological types, but not in normal tissues except male germ-line cells. We reported previously that reporter genes dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Smet C,De Backer O,Faraoni I,Lurquin C,Brasseur F,Boon T

更新日期：1996-07-09 00:00:00

abstract：:Neurofibrillary tangles are one of two lesions found in the brain of Alzheimer disease victims. With synthetic peptide fragments of human neurofilament NF-M17 (Glu-Glu-Lys-Gly-Lys-Ser-Pro- Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly, phosphorylated and unphosphorylated), CD studies were done to examine the effect of sodiu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fasman GD,Moore CD

更新日期：1994-11-08 00:00:00

abstract：:The replication initiator protein of plasmid R6K preferentially repressed transcription initiated in vitro from the promoter of the initiator protein cistron. DNase I protection experiments revealed that the sequences in the region of the promoter recognized by the initiator protein partially overlapped the sequences ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelley W,Bastia D

更新日期：1985-05-01 00:00:00

abstract：:The Alu element has been a major source of new exons during primate evolution. Thousands of human genes contain spliced exons derived from Alu elements. However, identifying Alu exons that have acquired genuine biological functions remains a major challenge. We investigated the creation and establishment of Alu exons ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen S,Lin L,Cai JJ,Jiang P,Kenkel EJ,Stroik MR,Sato S,Davidson BL,Xing Y

更新日期：2011-02-15 00:00:00

abstract：:Efficiently regenerated single colonies from mixed multiply auxotrophic Bacillus subtilis protoplasts, fused with polyethylene glycol, reveal colonies carrying each of the parent types (biparentals) and recombinant colonies. The latter appear in high yields (up to 1% of certain recombinant classes); the yield of bipar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hotchkiss RD,Gabor MH

更新日期：1980-06-01 00:00:00

abstract：:Inactivating mutations in chromodomain helicase DNA binding protein 7 (CHD7) cause CHARGE syndrome, a severe multiorgan system disorder of which Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is a minor feature. Recent reports have described predominantly missense CHD7 alleles in IGD patients, but it ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balasubramanian R,Choi JH,Francescatto L,Willer J,Horton ER,Asimacopoulos EP,Stankovic KM,Plummer L,Buck CL,Quinton R,Nebesio TD,Mericq V,Merino PM,Meyer BF,Monies D,Gusella JF,Al Tassan N,Katsanis N,Crowley WF Jr

更新日期：2014-12-16 00:00:00

abstract：:In 1989, populations of North American gypsy moth, Lymantria dispar, in seven contiguous northeastern states were severely reduced by a fungal pathogen. Based on morphology, development, and pathology, this organism appeared to be Entomophaga maimaiga. We have now used allozyme and restriction fragment length polymorp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hajek AE,Humber RA,Elkinton JS,May B,Walsh SR,Silver JC

更新日期：1990-09-01 00:00:00

abstract：:The activated form of the third complement protein, C3b, forms a stable complex with components of plasma membranes and particulate entities such as zymosan. The complex resists the action of detergents and protein denaturants as well as extremes of temperature, salt concentration, and pH. It can, however, be broken b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Law SK,Levine RP

更新日期：1977-07-01 00:00:00

abstract：:Type IV pili are thin filaments that extend from the poles of a diverse group of bacteria, enabling them to move at speeds of a few tenths of a micrometer per second. They are required for twitching motility, e.g., in Pseudomonas aeruginosa and Neisseria gonorrhoeae, and for social gliding motility in Myxococcus xanth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skerker JM,Berg HC

更新日期：2001-06-05 00:00:00

abstract：:Recent studies on proteins whose N and C termini are in close proximity have demonstrated that folding of polypeptide chains and assembly of oligomers can be accomplished with circularly permuted chains. As yet no methodical study has been conducted to determine how extensively new termini can be introduced and where ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graf R,Schachman HK

更新日期：1996-10-15 00:00:00