MYB30 links ROS signaling, root cell elongation, and plant immune responses.

abstract：:The rate of change of climate codetermines the global warming impacts on natural and socioeconomic systems and their capabilities to adapt. Establishing past rates of climate change from temperature proxy data remains difficult given their limited spatiotemporal resolution. In contrast, past greenhouse gas radiative f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Joos F,Spahni R

更新日期：2008-02-05 00:00:00

abstract：:During cardiac trabeculation, cardiomyocytes delaminate from the outermost (compact) layer to form complex muscular structures known as trabeculae. As these cardiomyocytes delaminate, the remodeling of adhesion junctions must be tightly coordinated so cells can extrude from the compact layer while remaining in tight c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherian AV,Fukuda R,Augustine SM,Maischein HM,Stainier DY

更新日期：2016-07-05 00:00:00

abstract：:The interaction between mutations in the tumor-suppressor genes Apc and p53 was studied in congenic mouse strains to minimize the influence of polymorphic modifiers. The multiplicity and invasiveness of intestinal adenomas of Apc(Min/+) (Min) mice was enhanced by deficiency for p53. In addition, the occurrence of desm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halberg RB,Katzung DS,Hoff PD,Moser AR,Cole CE,Lubet RA,Donehower LA,Jacoby RF,Dove WF

更新日期：2000-03-28 00:00:00

abstract：:Folding mechanisms of proteins incorporated within supramolecular assemblies, including viruses, are little understood and may differ fundamentally from folding mechanisms of small globular proteins. We describe a novel Raman dynamic probe of hydrogen-isotope exchange to investigate directly these protein folding/asse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tuma R,Prevelige PE Jr,Thomas GJ Jr

更新日期：1998-08-18 00:00:00

abstract：:Neuropeptide B (NPB) and neuropeptide W (NPW) have been recently identified as ligands for the G protein-coupled receptor (GPR) 7 and GPR8. The precise in vivo role of this neuropeptide-receptor pathway has not been fully demonstrated. In this paper, we report that NPB-deficient mice manifest a mild adult-onset obesit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly MA,Beuckmann CT,Williams SC,Sinton CM,Motoike T,Richardson JA,Hammer RE,Garry MG,Yanagisawa M

更新日期：2005-07-12 00:00:00

abstract：:Cell type in Saccharomyces yeasts is regulated by two transposable blocks of DNA, the a and alpha cassettes. There are three loci where either cassette can exist. At the HML and HMR loci the cassettes are not expressed. The cassette at the MAT locus is expressed and controls the cell type. Changes of cell type involve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strathern JN,Spatola E,McGill C,Hicks JB

更新日期：1980-05-01 00:00:00

abstract：:The kinetics for hydrogen exchange at individual base pairs in self-complementary deoxydodecanucleotide duplexes have been estimated from NMR saturation recovery measurements on the resolved imino protons as a function of temperature. The imino protons of dA . dT base pairs in the center of the fully alternating d(C-G...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Patel DJ,Ikuta S,Kozlowski S,Itakura K

更新日期：1983-04-01 00:00:00

abstract：:We have used wild-type and variants of the T-lymphoma cell line S49 to explore internalization and down-regulation of adenylate cyclase-linked beta-adrenergic receptors. Internalization was defined by the loss in "surface receptors" detected at 4 degrees C on intact cells by the antagonists [3H]CGP-12177 or [125I]iodo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahan LC,Koachman AM,Insel PA

更新日期：1985-01-01 00:00:00

abstract：:The degradation of the plant cell wall by glycoside hydrolases is central to environmentally sustainable industries. The major polysaccharides of the plant cell wall are cellulose and xylan, a highly decorated β-1,4-xylopyranose polymer. Glycoside hydrolases displaying multiple catalytic functions may simplify the enz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McKee LS,Peña MJ,Rogowski A,Jackson A,Lewis RJ,York WS,Krogh KB,Viksø-Nielsen A,Skjøt M,Gilbert HJ,Marles-Wright J

更新日期：2012-04-24 00:00:00

abstract：:P-glycoprotein is an ATP-binding cassette multidrug transporter that actively transports chemically diverse substrates across the lipid bilayer. The precise molecular mechanism underlying transport is not fully understood. Here, we present crystal structures of a eukaryotic P-glycoprotein homolog, CmABCB1 from Cyanidi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kodan A,Yamaguchi T,Nakatsu T,Sakiyama K,Hipolito CJ,Fujioka A,Hirokane R,Ikeguchi K,Watanabe B,Hiratake J,Kimura Y,Suga H,Ueda K,Kato H

更新日期：2014-03-18 00:00:00

abstract：:Interleukin (IL)-15 and its specific receptor chain, IL-15Rα, support the development of various effector cells, including NK and CD8 T cells via a mechanism called trans-presentation. Whereas the dynamic of trans-presentation has been shown to involve the recycling of IL-15Rα by presenting cells, the way responding c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamzalit F,Barbieux I,Plet A,Heim J,Nedellec S,Morisseau S,Jacques Y,Mortier E

更新日期：2014-06-10 00:00:00

abstract：:An argument is presented in favor of the hypothesis that, bovine carboxypeptidases A and B fit by and large, the concept of homology on the levels of both amino acid sequence and three-dimensional structure. Two peptide sequences from carboxypeptidases A and B, comprising 46 amino acid residues, display structural hom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bradshaw RA,Neurath H,Walsh KA

更新日期：1969-06-01 00:00:00

abstract：:In a previous study, we found that human neural stem cells (HNSCs) exposed to high concentrations of secreted amyloid-precursor protein (sAPP) in vitro differentiated into mainly astrocytes, suggesting that pathological alterations in APP processing during neurodegenerative conditions such as Alzheimer's disease (AD) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marutle A,Ohmitsu M,Nilbratt M,Greig NH,Nordberg A,Sugaya K

更新日期：2007-07-24 00:00:00

abstract：:We show that the stimulation of human immunodeficiency virus (HIV) brought about by tumor necrosis factor alpha and phorbol 12-myristate 13-acetate can be inhibited by adding N-acetyl-L-cysteine (NAC). NAC, which replenishes intracellular glutathione, effectively inhibits the tumor necrosis factor alpha- or phorbol es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roederer M,Staal FJ,Raju PA,Ela SW,Herzenberg LA,Herzenberg LA

更新日期：1990-06-01 00:00:00

abstract：:HIV-1 envelope glycoprotein is the primary target for HIV-1-specific antibodies. The native HIV-1 envelope spike on the virion surface is a trimer, but trimeric gp140 and monomeric gp120 currently are believed to induce comparable immune responses. Indeed, most studies on the immunogenicity of HIV-1 envelope oligomers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovacs JM,Nkolola JP,Peng H,Cheung A,Perry J,Miller CA,Seaman MS,Barouch DH,Chen B

更新日期：2012-07-24 00:00:00

abstract：:For many intraoperative decisions surgeons depend on frozen section pathology, a technique developed over 150 y ago. Technical innovations that permit rapid molecular characterization of tissue samples at the time of surgery are needed. Here, using desorption electrospray ionization (DESI) MS, we rapidly detect the tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Santagata S,Eberlin LS,Norton I,Calligaris D,Feldman DR,Ide JL,Liu X,Wiley JS,Vestal ML,Ramkissoon SH,Orringer DA,Gill KK,Dunn IF,Dias-Santagata D,Ligon KL,Jolesz FA,Golby AJ,Cooks RG,Agar NY

更新日期：2014-07-29 00:00:00

abstract：:Recent theory suggests that animals should switch facultatively among canonical movement modes as a complex function of internal state, landscape characteristics, motion capacity, and navigational capacity. We tested the generality of this paradigm for free-ranging elk (Cervus elaphus) over 5 orders of magnitude in ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fryxell JM,Hazell M,Börger L,Dalziel BD,Haydon DT,Morales JM,McIntosh T,Rosatte RC

更新日期：2008-12-09 00:00:00

abstract：:The heterodimeric Elongin BC complex has been shown to interact in vitro and in cells with a conserved BC-box motif found in an increasing number of proteins including RNA polymerase II elongation factor Elongin A, suppressor of cytokine signaling (SOCS)-box proteins, and the von Hippel-Lindau tumor suppressor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brower CS,Sato S,Tomomori-Sato C,Kamura T,Pause A,Stearman R,Klausner RD,Malik S,Lane WS,Sorokina I,Roeder RG,Conaway JW,Conaway RC

更新日期：2002-08-06 00:00:00

abstract：:p300 acetylates and activates the tumor suppressor p53 after DNA damage. Here, we show that MDM2, a negative-feedback regulator of p53, inhibited p300-mediated p53 acetylation by complexing with these two proteins. First, we purified a p300-MDM2-p53 protein complex from HeLa nuclear extracts, which was inactive in p53...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobet E,Zeng X,Zhu Y,Keller D,Lu H

更新日期：2000-11-07 00:00:00

abstract：:Aspergillus fumigatus is commonly associated with allergic bronchopulmonary aspergillosis in patients with severe asthma in which chronic airway neutrophilia predicts a poor outcome. We were able to recapitulate fungus-induced neutrophilic airway inflammation in a mouse model in our efforts to understand the underlyin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fei M,Bhatia S,Oriss TB,Yarlagadda M,Khare A,Akira S,Saijo S,Iwakura Y,Fallert Junecko BA,Reinhart TA,Foreman O,Ray P,Kolls J,Ray A

更新日期：2011-03-29 00:00:00

abstract：:Efforts to understand the dramatic declines in mortality over the past century have focused on life expectancy. However, understanding changes in disparity in age of death is important to understanding mechanisms of mortality improvement and devising policy to promote health equity. We derive a novel decomposition of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seligman B,Greenberg G,Tuljapurkar S

更新日期：2016-07-26 00:00:00

abstract：:To enter host cells, vaccinia virus, a prototype poxvirus, can induce transient macropinocytosis followed by endocytic internalization and penetration through the limiting membrane of pinosomes by membrane fusion. Although mature virions (MVs) of the Western reserve (WR) strain do this in HeLa cells by activating tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mercer J,Knébel S,Schmidt FI,Crouse J,Burkard C,Helenius A

更新日期：2010-05-18 00:00:00

abstract：:Sialic acid-containing glycosphingolipids, i.e., gangliosides, constitute a major component of neuronal cells and are thought to be essential for brain function. UDP-glucose:ceramide glucosyltransferase (Ugcg) catalyzes the initial step of glycosphingolipid (GSL) biosynthesis. To gain insight into the role of GSLs in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jennemann R,Sandhoff R,Wang S,Kiss E,Gretz N,Zuliani C,Martin-Villalba A,Jäger R,Schorle H,Kenzelmann M,Bonrouhi M,Wiegandt H,Gröne HJ

更新日期：2005-08-30 00:00:00

abstract：:The apparatus of photosynthetic energy conversion in chloroplasts is quite well characterized with respect to structure and function. Light-driven electron transport in the thylakoid membrane is coupled to synthesis of ATP, used to drive energy-dependent metabolic processes in the stroma and the outer surface of the t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spetea C,Hundal T,Lundin B,Heddad M,Adamska I,Andersson B

更新日期：2004-02-03 00:00:00

abstract：:Stimulation of resting CD4(+) T lymphocytes leads to rapid proliferation and differentiation into effector (Teff) or inducible regulatory (Treg) subsets with specific functions to promote or suppress immunity. Importantly, Teff and Treg use distinct metabolic programs to support subset specification, survival, and fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michalek RD,Gerriets VA,Nichols AG,Inoue M,Kazmin D,Chang CY,Dwyer MA,Nelson ER,Pollizzi KN,Ilkayeva O,Giguere V,Zuercher WJ,Powell JD,Shinohara ML,McDonnell DP,Rathmell JC

更新日期：2011-11-08 00:00:00

abstract：:People who are more avoidant of pathogens are more politically conservative, as are nations with greater parasite stress. In the current research, we test two prominent hypotheses that have been proposed as explanations for these relationships. The first, which is an intragroup account, holds that these relationships ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tybur JM,Inbar Y,Aarøe L,Barclay P,Barlow FK,de Barra M,Becker DV,Borovoi L,Choi I,Choi JA,Consedine NS,Conway A,Conway JR,Conway P,Adoric VC,Demirci DE,Fernández AM,Ferreira DC,Ishii K,Jakšić I,Ji T,van Leeuwen

更新日期：2016-11-01 00:00:00

abstract：:Many pathological conditions of the central nervous system involve damage to and removal of myelin membrane. Very little is known about initiation of this membrane damage and the mechanisms of disposal of the damaged tissue. We are interested in the interaction between complement (the components of complement are desi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vanguri P,Koski CL,Silverman B,Shin ML

更新日期：1982-05-01 00:00:00

abstract：:The cDNA of the gene pds from tomato, encoding the carotenoid biosynthesis enzyme phytoene desaturase, was cloned, and its nucleotide sequence was determined. Cells of Escherichia coli that expressed the tomato pds gene could convert phytoene to zeta-carotene. This result suggests that one polypeptide, the product of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pecker I,Chamovitz D,Linden H,Sandmann G,Hirschberg J

更新日期：1992-06-01 00:00:00

abstract：:The recent isolation and identification of alpha-N-acetyl forms of the C-Fragment of lipotropin (beta-endorphin, residues 61-91) and the C'-Fragment (residues 61-87) [Smyth, D.G., Massey, D.E., Zakarian, S. & Finnie, M. (1979) Nature (London) 279, 252-254] has led to a study of their distribution in the pituitary and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zakarian S,Smyth D

更新日期：1979-11-01 00:00:00

abstract：:Humans choose actions based on both habit and planning. Habitual control is computationally frugal but adapts slowly to novel circumstances, whereas planning is computationally expensive but can adapt swiftly. Current research emphasizes the competition between habits and plans for behavioral control, yet many complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cushman F,Morris A

更新日期：2015-11-10 00:00:00