Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice.

abstract：:The ability to instantly create a state of immunity as achieved in the passive transfer of hyperimmune globulin has had a tremendous impact on public health. Unlike passive immunization, active immunization, which is the foundation of vaccinology, is an anticipatory strategy with inherent limitations. Here we show tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Popkov M,Gonzalez B,Sinha SC,Barbas CF 3rd

更新日期：2009-03-17 00:00:00

abstract：:During vertebrate brain development, the onset of neuronal differentiation is under strict temporal control. In the mammalian thalamus and other brain regions, neurogenesis is regulated also in a spatially progressive manner referred to as a neurogenetic gradient, the underlying mechanism of which is unknown. Here we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scholpp S,Delogu A,Gilthorpe J,Peukert D,Schindler S,Lumsden A

更新日期：2009-11-24 00:00:00

abstract：:Growing knowledge of the key molecular components involved in biological processes such as endocytosis, exocytosis, and motility has enabled direct testing of proposed mechanistic models by reconstitution. However, current techniques for building increasingly complex cellular structures and functions from purified com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richmond DL,Schmid EM,Martens S,Stachowiak JC,Liska N,Fletcher DA

更新日期：2011-06-07 00:00:00

abstract：:The location of phosphate residues involved in specific centers for binding of metal ions in M1 RNA, the catalytic RNA subunit of RNase P from Escherichia coli, was determined by analysis of induction of cleavage of RNA by metal ions. At pH 9.5, Mg2+ catalyzes cleavage of M1 RNA at five principal sites. Under certain ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kazakov S,Altman S

更新日期：1991-10-15 00:00:00

abstract：:Loss of heterozygosity affecting chromosome 17p has been detected at high frequencies in a variety of human tumors, including cancers of the colon, breast, lung, and brain. One presumed target of these losses is p53, a tumor suppressor gene located on 17p. To our knowledge, loss of heterozygosity has not yet been repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meltzer SJ,Yin J,Huang Y,McDaniel TK,Newkirk C,Iseri O,Vogelstein B,Resau JH

更新日期：1991-06-01 00:00:00

abstract：:Several hypolipidemic drugs and certain industrial plasticizers induce proliferation of peroxisomes, enhance the activity of peroxisome-associated beta-oxidation of fatty acids, and produce hepatocellular carcinomas in the livers of rodents. Because these chemicals themselves are not mutagens and do not covalently mod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fahl WE,Lalwani ND,Watanabe T,Goel SK,Reddy JK

更新日期：1984-12-01 00:00:00

abstract：:Purified preparations of rabbit skeletal white, red, and cardiac muscle myosin (WM, RM, and CM) were subjected to sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Significant differences in both the molecular weights and number of light chains in these myosins were found. WM has three distinct light-chain co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar S,Sreter FA,Gergely J

更新日期：1971-05-01 00:00:00

abstract：:The nucleotide sequence of intracellular 26S mRNA of Sindbis virus has been determined by direct sequence analysis of the cDNA made to this RNA with reverse transcriptase. From this, the amino acid sequences of the encoded virus structural proteins, which include a basic capsid protein and two integral membrane glycop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice CM,Strauss JH

更新日期：1981-04-01 00:00:00

abstract：:Curved DNA molecules and unusually small circles have been obtained by ligation of synthetic 21-base precursors: (sequence in text). The ligation resulted in the formation of double-stranded oligo-(precursor)s possessing a strong 10.5-base-pair (bp) periodicity of the runs of adenines. Two-dimensional polyacrylamide g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulanovsky L,Bodner M,Trifonov EN,Choder M

更新日期：1986-02-01 00:00:00

abstract：:We introduce and analyze a general model of a population evolving over a network of selectively neutral genotypes. We show that the population's limit distribution on the neutral network is solely determined by the network topology and given by the principal eigenvector of the network's adjacency matrix. Moreover, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Nimwegen E,Crutchfield JP,Huynen M

更新日期：1999-08-17 00:00:00

abstract：:Rhomboid domain-containing protein 3 (Rhbdd3), which belongs to a family of proteins with rhomboid domain, is widely expressed in immune cells; however, the roles of the Rhbdd members, including Rhbdd3, in immunity remain unknown. Natural killer (NK) cells are critical for host immune defense and also can mediate infl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Liu S,Xia M,Xu S,Wang C,Bao Y,Jiang M,Wu Y,Xu T,Cao X

更新日期：2013-05-07 00:00:00

abstract：:A method for estimating intrafamilial correlations under variable family sizes involving weightings of paired data points is introduced. Classical methods of intrafamilial correlation estimation and those in current use are outlined and critically analyzed. Extensions of the proposed estimation method to more general ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karlin S,Cameron EC,Williams PT

更新日期：1981-05-01 00:00:00

abstract：:Marine ecosystems are in decline. New transformational changes in governance are urgently required to cope with overfishing, pollution, global changes, and other drivers of degradation. Here we explore social, political, and ecological aspects of a transformation in governance of Chile's coastal marine resources, from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gelcich S,Hughes TP,Olsson P,Folke C,Defeo O,Fernández M,Foale S,Gunderson LH,Rodríguez-Sickert C,Scheffer M,Steneck RS,Castilla JC

更新日期：2010-09-28 00:00:00

abstract：:To maintain genome stability, cells with damaged DNA must arrest to allow repair of mutations before replication. Although several key components required to elicit this arrest have been discovered, much of the pathway remains elusive. Here we report that pRB acts as a central mediator of the proliferative block induc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrington EA,Bruce JL,Harlow E,Dyson N

更新日期：1998-09-29 00:00:00

abstract：:H-2M3 encodes HMT, the major histocompatibility complex (MHC) class I heavy chain of the maternally transmitted antigen (Mta). Like classical MHC class I genes, the expression of M3 can be stimulated by gamma-interferon and its message can be detected from mid-gestational embryos (day 8) through adulthood. HMTb, a non...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang CR,Lindahl KF

更新日期：1993-04-01 00:00:00

abstract：:Poliovirus mRNA and mRNA transcribed from vesicular stomatitis virus and reovirus genomes efficiently direct protein synthesis in vivo under experimental conditions where the initiation of host protein synthesis is selectively blocked. The selective blockage of host peptide chain initiation after exposure to hypertoni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nuss DL,Oppermann H,Koch G

更新日期：1975-04-01 00:00:00

abstract：:The alternative splicing of mRNA is a critical process in higher eukaryotes that generates substantial proteomic diversity. Many of the proteins that are essential to this process contain arginine/serine-rich (RS) domains. ZRANB2 is a widely-expressed and highly-conserved RS-domain protein that can regulate alternativ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loughlin FE,Mansfield RE,Vaz PM,McGrath AP,Setiyaputra S,Gamsjaeger R,Chen ES,Morris BJ,Guss JM,Mackay JP

更新日期：2009-04-07 00:00:00

abstract：:Peripheral blood leukocytes, obtained from volunteers after vaccination or natural illness with influenza, were assayed for cytotoxicity against influenza virus-infected cells. Approximately 7 days after vaccination or the onset of respiratory illness, peak cytotoxicity was demonstrated in a chromium-release assay. Se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greenberg SB,Six HR,Drake S,Couch RB

更新日期：1979-09-01 00:00:00

abstract：:We have constructed a phylogenic tree for green plants by comparing 5S rRNA sequences. The tree suggests that the emergence of most of the uni- and multicellular green algae such as Chlamydomonas, Spirogyra, Ulva, and Chlorella occurred in the early stage of green plant evolution. The branching point of Nitella is a l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hori H,Lim BL,Osawa S

更新日期：1985-02-01 00:00:00

abstract：:The three-dimensional crystal structure of variant-3 toxin from the scorpion Centruroides sculpturatus Ewing has been determined at 3 A resolution. Phases were obtained by use of K2PtCl4 and K2IrCl6 derivatives. The most prominent secondary structural features are two and a half turns of alpha-helix and a three-strand...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fontecilla-Camps JC,Almassy RJ,Suddath FL,Watt DD,Bugg CE

更新日期：1980-11-01 00:00:00

abstract：:The translocation from chromosome 8 to chromosome 21, t(8;21), associated with acute myeloid leukemia results in production of an AML1/MTG8(ETO) fusion transcript. The product of the AML1 gene contains an evolutionarily conserved 128-amino acid region referred to as the "Runt domain," which is necessary for binding to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakakura C,Yamaguchi-Iwai Y,Satake M,Bae SC,Takahashi A,Ogawa E,Hagiwara A,Takahashi T,Murakami A,Makino K

更新日期：1994-11-22 00:00:00

abstract：:Influenza is a lipid-enveloped, pleomorphic virus. We combine electron cryotomography and analysis of images of frozen-hydrated virions to determine the structural organization of filamentous influenza A virus. Influenza A/Udorn/72 virions are capsule-shaped or filamentous particles of highly uniform diameter. We show...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calder LJ,Wasilewski S,Berriman JA,Rosenthal PB

更新日期：2010-06-08 00:00:00

abstract：:Two series of peptides that specifically bind to the extracellular domain of the alpha chain of the human interleukin-5 receptor (IL-5Ralpha), but share no primary sequence homology to IL-5, were identified from libraries of random recombinant peptides. Affinity maturation procedures generated a 19-aa peptide that bin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： England BP,Balasubramanian P,Uings I,Bethell S,Chen MJ,Schatz PJ,Yin Q,Chen YF,Whitehorn EA,Tsavaler A,Martens CL,Barrett RW,McKinnon M

更新日期：2000-06-06 00:00:00

abstract：:Tropical deforestation for the establishment of tree cash crop plantations causes significant alterations to soil organic carbon (SOC) dynamics. Despite this recognition, the current Intergovernmental Panel on Climate Change (IPCC) tier 1 method has a SOC change factor of 1 (no SOC loss) for conversion of forests to p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Straaten O,Corre MD,Wolf K,Tchienkoua M,Cuellar E,Matthews RB,Veldkamp E

更新日期：2015-08-11 00:00:00

abstract：:A study of the near-infrared absorption spectra of three oxygen compounds of membrane-bound cytochrome oxidase (ferrocytochrome c:oxygen oxidoreductase; EC 1.9.3.1) shows that the formation of compound A (oxycytochrome oxidase) causes no significant infrared absorbance changes at -103 degrees. At -64 degrees, the form...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chance B,Leigh JS Jr

更新日期：1977-11-01 00:00:00

abstract：:Biological membranes contain an extraordinary diversity of lipids. Phospholipids function as major structural elements of cellular membranes, and analysis of changes in the highly heterogeneous mixtures of lipids found in eukaryotic cells is central to understanding the complex functions in which lipids participate. P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivanova PT,Cerda BA,Horn DM,Cohen JS,McLafferty FW,Brown HA

更新日期：2001-06-19 00:00:00

abstract：:During sporulation of the Gram-positive bacterium Bacillus subtilis, transcription of genes encoding spore coat proteins in the mother-cell compartment of the sporangium is controlled by RNA polymerase containing the sigma subunit called sigma K. Based on comparison of the N-terminal amino acid sequence of sigma K wit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu S,Halberg R,Kroos L

更新日期：1990-12-01 00:00:00

abstract：:NIH 3T3 mouse cells were transfected with plasmids that induce efficient expression of either (i) the Rous sarcoma virus v-src gene, (ii) the chicken c-src gene, or (iii) a recombinant gene combining the 5' portion of c-src with the 3' end of v-src. Focus formation in tissue culture and formation of large colonies in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shalloway D,Coussens PM,Yaciuk P

更新日期：1984-11-01 00:00:00

abstract：:An expression in the exterior algebra of a Peano space yielding Pappus' theorem was originally given by Doubilet, Rota, and Stein [Doubilet, P., Rota, G.-C. & Stein, J. (1974) Stud. Appl. Math. 8, 185-216]. Motivated by an identity of Rota, I give an identity in a Grassmann-Cayley algebra of step 3, involving joins an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hawrylycz M

更新日期：1994-04-12 00:00:00

abstract：:In his Philosophical Investigations, Wittgenstein famously noted that the formation of semantic representations requires more than a simple combination of verbal and nonverbal features to generate conceptually based similarities and differences. Classical and contemporary neuroscience has tended to focus upon how diff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lambon Ralph MA,Sage K,Jones RW,Mayberry EJ

更新日期：2010-02-09 00:00:00