Brain-derived neurotrophic factor modulates hippocampal synaptic transmission by increasing N-methyl-D-aspartic acid receptor activity.

abstract：:We have used a semiselective Hahn spin-echo sequence of the form (1331)-tau-(2662)-tau-AQ, delivered by a surface coil to obtain high-resolution 1H NMR spectra from the brains of intact dead rats. This sequence gave suppression of the tissue water resonance by a factor of 80,000 when tau = 68 ms. Delivery of a frequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hetherington HP,Avison MJ,Shulman RG

更新日期：1985-05-01 00:00:00

abstract：:We have isolated cold-sensitive mutations in two genes of the yeast Saccharomyces cerevisiae, BIN2 and BIN3, that cause aberrant chromosome segregation in vivo. BIN2 and BIN3 encode essential proteins that are similar to each other and to TCP-1. TCP-1 and TCP-1-like proteins are components of the eukaryotic cytoplasmi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen X,Sullivan DS,Huffaker TC

更新日期：1994-09-13 00:00:00

abstract：:Erythropoietin regulates the proliferation and differentiation of erythroid precursor cells. Its effect is mediated by the erythropoietin receptor (EPOR), a member of a large family of cytokine receptors. The EPOR gene has recently been cloned, sequenced, and characterized. As shown experimentally, its intracellular C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de la Chapelle A,Träskelin AL,Juvonen E

更新日期：1993-05-15 00:00:00

abstract：:The reactivities of N-iodosuccinimide and iodine with various goitrogenic compounds were studied with dimethylsulfoxide through which nitrogen had been bubbled as a solvent. Although iodine does not react with all of the compounds, N-iodosuccinimide does react with all of them. N-Iodosuccinimide may, therefore, serve ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jirousek L,Soodak M

更新日期：1973-05-01 00:00:00

abstract：:The number of x-irradiated mammalian cells surviving is markedly increased when the cells are incubated with an uncoupler of oxidative phosphorylation prior to or immediately after irradiation. This increase is greater in plateau-phase cells than in exponentially growing cells. The increase in survival is related to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laval F

更新日期：1980-05-01 00:00:00

abstract：:B-G antigens are cell-surface molecules encoded by a highly polymorphic multigene family located in the chicken major histocompatibility complex (MHC). Rabbit antisera to B-G molecules immunoprecipitate 3-6 bands from iodinated erythrocytes by sodium dodecyl sulfate (SDS) gels under reducing conditions. These are all ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman J,Salomonsen J,Skjødt K,Thorpe D

更新日期：1990-11-01 00:00:00

abstract：:A unique neuronal system was detected in the rat central nervous system by immunohistochemistry and radioimmunoassay with antibodies to salmon melanin-concentrating hormone (MCH). MCH-like immunoreactive (MCH-LI) cell bodies were confined to the hypothalamus. MCH-LI fibers were found throughout the brain but were most...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir N,Skofitsch G,Bannon MJ,Jacobowitz DM

更新日期：1986-03-01 00:00:00

abstract：:It is believed that neural representations of recent experiences become reactivated during sleep, and that this process serves to stabilize associated memories in long-term memory. Here, we initiated this reactivation process for specific memories during slow-wave sleep. Participants studied 50 object-location associa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Dongen EV,Takashima A,Barth M,Zapp J,Schad LR,Paller KA,Fernández G

更新日期：2012-06-26 00:00:00

abstract：:E. coli cells treated with the bifunctional crosslinking reagents dimethyl malonimidate, succinimidate, adipimidate, suberimidate, and sebacinimidate served for the isolation of rod-shaped "ghosts." These ghosts proved to be crosslinked over their entire surface; i.e., a macromolecule (resistant to boiling 1% Na dodec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haller I,Henning U

更新日期：1974-05-01 00:00:00

abstract：:Retroviral entry into cells depends on envelope glycoproteins, whereby receptor binding to the surface-exposed subunit triggers membrane fusion by the transmembrane protein (TM) subunit. We determined the crystal structure at 2.5-A resolution of the ectodomain of gp21, the TM from human T cell leukemia virus type 1. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kobe B,Center RJ,Kemp BE,Poumbourios P

更新日期：1999-04-13 00:00:00

abstract：:A discrepancy of about 20% exists between the molecular weight of the alpha subunit of Torpedo californica electroplax acetylcholine receptor as determined by gel electrophoresis of the mature protein (Mr 40,000 +/- 2000) and by nucleotide sequence analysis of cDNA (Mr approximately equal to 50,000). We demonstrate by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conti-Tronconi BM,Hunkapiller MW,Raftery MA

更新日期：1984-05-01 00:00:00

abstract：:A preparative two-dimensional polyacrylamide gel system was used to separate and purify the major Coomassie blue-stained proteins from the isolated rat liver nuclear matrix. Approximately 12 major proteins were consistently found. Of these, 5 proteins represented identified proteins, including nuclear lamins A, B, and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayasu H,Berezney R

更新日期：1991-11-15 00:00:00

abstract：:The C-terminal 179-aa region of yeast (Saccharomyces cerevisiae) TATA-binding protein (TBP), phylogenetically conserved and sufficient for many functions, formed crystals diffracting to 1.7-A resolution. The structure of the protein, determined by molecular replacement with coordinates from Arabidopsis TBP and refined...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chasman DI,Flaherty KM,Sharp PA,Kornberg RD

更新日期：1993-09-01 00:00:00

abstract：:Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation. We analyzed melanoma cells with acquired resistance to the CDK4/6 inhibitor palbociclib an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： AbuHammad S,Cullinane C,Martin C,Bacolas Z,Ward T,Chen H,Slater A,Ardley K,Kirby L,Chan KT,Brajanovski N,Smith LK,Rao AD,Lelliott EJ,Kleinschmidt M,Vergara IA,Papenfuss AT,Lau P,Ghosh P,Haupt S,Haupt Y,Sanij E,

更新日期：2019-09-03 00:00:00

abstract：:In virtually every real-life situation humans are confronted with complex and cluttered visual environments that contain a multitude of objects. Because of the limited capacity of the visual system, objects compete for neural representation and cognitive processing resources. Previous work has shown that such attentio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaiser D,Stein T,Peelen MV

更新日期：2014-07-29 00:00:00

abstract：:A method is presented for variational calculation of the energy and the spin densities derived from a single-determinant wavefunction. Sum and difference coordinates [unk]R = (1/2)([unk]r(1) + [unk]r(1)) and [unk]r = [unk]r(1) - [unk]r(1) are introduced, and the density matrix P([unk]r(1),[unk]r(1)) is expanded in par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Payne PW

更新日期：1980-11-01 00:00:00

abstract：:To better understand the roles of Sm proteins in forming the cores of many RNA-processing ribonucleoproteins, we determined the crystal structure of an atypical Sm-like archaeal protein (SmAP3) in which the conserved Sm domain is augmented by a previously uncharacterized, mixed alpha/beta C-terminal domain. The struct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mura C,Phillips M,Kozhukhovsky A,Eisenberg D

更新日期：2003-04-15 00:00:00

abstract：:Exposure of human monocyte-macrophages to as little as 50 microliters of cultured medium from lymphocytes stimulated by concanavalin A (Con A) resulted in a dramatic decrease in the activities of the low density lipoprotein (LDL) receptor pathway, the LDL-dextran sulfate pathway, and the scavenger receptor pathway. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fogelman AM,Seager J,Haberland ME,Hokom M,Tanaka R,Edwards PA

更新日期：1982-02-01 00:00:00

abstract：:The domestication of cultivated barley has been used as a model system for studying the origins and early spread of agrarian culture. Our previous results indicated that the Tibetan Plateau and its vicinity is one of the centers of domestication of cultivated barley. Here we reveal multiple origins of domesticated bar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dai F,Chen ZH,Wang X,Li Z,Jin G,Wu D,Cai S,Wang N,Wu F,Nevo E,Zhang G

更新日期：2014-09-16 00:00:00

abstract：:Positive allosteric modulation of the mu-opioid receptor (MOPr), the site of action of all clinically used opioids, represents a potential approach for the management of pain. We recently reported on positive allosteric modulators of MOPr (mu-PAMs), a class A G protein coupled receptor (GPCR). This study was designed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Livingston KE,Traynor JR

更新日期：2014-12-23 00:00:00

abstract：:RNA interference (RNAi) is a widely used method for analysis of gene function in tissue culture cells. However, to date there has been no reliable method for testing the specificity of any particular RNAi experiment. The ideal experiment is to rescue the phenotype by expression of the target gene in a form refractory ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kittler R,Pelletier L,Ma C,Poser I,Fischer S,Hyman AA,Buchholz F

更新日期：2005-02-15 00:00:00

abstract：:Exposure of 3T3/A31 cells to serum-free medium, one type of apoptotic stimulus, causes a rapid increase in the sphingosine (Sph) level, which initiates a series of processes: (i) activation of caspase 3 through an enhanced "cascade" of caspases, (ii) release of the C-terminal-half kinase domain of PKCdelta (PKCdelta K...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki E,Handa K,Toledo MS,Hakomori S

更新日期：2004-10-12 00:00:00

abstract：:Two endocytic receptors, the low density lipoprotein (LDL) receptor (LDLR) and the LDLR-related protein (LRP), are thought to act in concert in the hepatic uptake of partially metabolized dietary lipoproteins, the chylomicron remnants. We have evaluated the role of these two receptors in the hepatic metabolism of chyl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Herz J,Qiu SQ,Oesterle A,DeSilva HV,Shafi S,Havel RJ

更新日期：1995-05-09 00:00:00

abstract：:The exemplary search capabilities of flying insects have established them as one of the most diverse taxa on Earth. However, we still lack the fundamental ability to quantify, represent, and predict trajectories under natural contexts to understand search and its applications. For example, flying insects have evolved ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaushik PK,Renz M,Olsson SB

更新日期：2020-06-02 00:00:00

abstract：:High-pressure methods are increasingly used to produce new dense materials with unusual properties. Increasing efforts to understand the reaction mechanisms at the microscopic level, to set up and optimize synthetic approaches, are currently directed at carbon-based solids. A fundamental, but still unsolved, question ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Citroni M,Bini R,Foggi P,Schettino V

更新日期：2008-06-03 00:00:00

abstract：:The mid-winter development of refractoriness to melatonin (Mel) triggers recrudescence of the atrophied reproductive apparatus of rodents. As a consequence, over-wintering animals become reproductively competent just before the onset of spring conditions favorable for breeding. The neural target tissues that cease to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman DA,Zucker I

更新日期：2001-05-22 00:00:00

abstract：:Plant morphogenesis requires coordinated cytoplasmic growth, oriented cell wall extension, and cell cycle progression, but it is debated which of these processes are primary drivers for tissue growth and directly targeted by developmental genes. Here, we used ChIP high-throughput sequencing combined with transcriptome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schiessl K,Muiño JM,Sablowski R

更新日期：2014-02-18 00:00:00

abstract：:DNA double-strand breaks (DSBs) are serious genomic insults that can lead to chromosomal rearrangements if repaired incorrectly. To gain insight into the nuclear mechanisms contributing to these rearrangements, we developed an assay in yeast to measure cis (same site) vs. trans (different site) repair for the majority...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sunder S,Wilson TE

更新日期：2019-05-07 00:00:00

abstract：:As the Copenhagen Accord indicates, most of the international community agrees that global mean temperature should not be allowed to rise more than two degrees Celsius above preindustrial levels to avoid unacceptable damages from climate change. The scientific evidence distilled in the Fourth Assessment Report of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heitzig J,Lessmann K,Zou Y

更新日期：2011-09-20 00:00:00

abstract：:Glioblastoma is the most common primary malignant brain tumor of adults and one of the most lethal of all cancers. Patients with this disease have a median survival of 15 months from the time of diagnosis despite surgery, radiation, and chemotherapy. New treatment approaches are needed. Recent works suggest that gliob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horvath S,Zhang B,Carlson M,Lu KV,Zhu S,Felciano RM,Laurance MF,Zhao W,Qi S,Chen Z,Lee Y,Scheck AC,Liau LM,Wu H,Geschwind DH,Febbo PG,Kornblum HI,Cloughesy TF,Nelson SF,Mischel PS

更新日期：2006-11-14 00:00:00