Disruption of the Na+ ion binding site as a mechanism for positive allosteric modulation of the mu-opioid receptor.

abstract：:There is accumulating evidence that AKT signaling plays a role in the pathogenesis of schizophrenia. We asked whether Akt1 deficiency in mice results in structural and functional abnormalities in prefrontal cortex (PFC). Exploratory transcriptional profiling revealed concerted alterations in the expression of PFC gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai WS,Xu B,Westphal KG,Paterlini M,Olivier B,Pavlidis P,Karayiorgou M,Gogos JA

更新日期：2006-11-07 00:00:00

abstract：:Natural transformation (i.e., the uptake of DNA and its stable integration in the chromosome) is a major mechanism of horizontal gene transfer in bacteria. Although the vast majority of bacterial genomes carry the genes involved in natural transformation, close relatives of naturally transformable species often appear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Durieux I,Ginevra C,Attaiech L,Picq K,Juan PA,Jarraud S,Charpentier X

更新日期：2019-09-10 00:00:00

abstract：:Agrobacterium tumefaciens can transfer part of its Ti plasmid, the T-DNA, to plant cells where it integrates into the nuclear genome via illegitimate recombination. Integration of the T-DNA results in small deletions of the plant target DNA, and may lead to truncation of the T-DNA borders and the production of filler ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bundock P,Hooykaas PJ

更新日期：1996-12-24 00:00:00

abstract：:Coimmunoprecipitation of members of the phytochrome red/farred photoreceptor family from plant extracts has been used to analyze their heteromeric binding interactions. Phytochrome (phy)B or phyD apoproteins with six myc epitopes fused to their N termini are biologically active when expressed in Arabidopsis. Immunopre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharrock RA,Clack T

更新日期：2004-08-03 00:00:00

abstract：:Soluble extracts of adenovirus-infected HeLa cell nuclei support DNA replication on exogenous adenovirus DNA templates. Conditions of synthesis using both wild-type and temperature-sensitive extracts have been defined. Nuclear extracts prepared from cells permissively infected with the adenovirus mutant H5ts125 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan LM,Ariga H,Hurwitz J,Horwitz MS

更新日期：1979-11-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is strongly associated with obesity in most, but not all, ethnic groups, suggesting important ethnic differences in disease susceptibility. Although it is clear that insulin resistance plays a major role in the pathogenesis of T2DM and that insulin resistance is strongly associated with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petersen KF,Dufour S,Feng J,Befroy D,Dziura J,Dalla Man C,Cobelli C,Shulman GI

更新日期：2006-11-28 00:00:00

abstract：:This article emphasizes the role played by a remarkable pointwise inequality satisfied by fractionary derivatives in order to obtain maximum principles and Lp-decay of solutions of several interesting partial differential equations. In particular, there are applications to quasigeostrophic flows, in two space variable...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cordoba A,Cordoba D

更新日期：2003-12-23 00:00:00

abstract：:Reducible compounds that participate in crosslinking were analyzed in hydroxylysine-deficient collagens of patients with a heritable disorder of connective tissue. After treatment with [(3)H]sodium borohydride, new compounds, as well as a totally different pattern of tritiated compounds, were found in hydroxylysine-de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eyre DR,Glimcher MJ

更新日期：1972-09-01 00:00:00

abstract：:Complementary DNA (cDNA) clones encoding the adult human liver flavin-containing monooxygenase (FMO; dimethylaniline N-oxidase, EC 1.14.13.8) were isolated from lambda gt10 and lambda gt11 libraries. The cDNA libraries were screened with three synthetic 36-mer oligonucleotide probes derived from the nucleic acid seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lomri N,Gu Q,Cashman JR

更新日期：1992-03-01 00:00:00

abstract：:Sustained activation of N-methyl-d-aspartate (NMDA) -type glutamate receptors leads to excitotoxic neuronal death in stroke, brain trauma, and neurodegenerative disorders. Superoxide production by NADPH oxidase is a requisite event in the process leading from NMDA receptor activation to excitotoxic death. NADPH oxidas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lam TI,Brennan-Minnella AM,Won SJ,Shen Y,Hefner C,Shi Y,Sun D,Swanson RA

更新日期：2013-11-12 00:00:00

abstract：:In biological processes, such as fission, fusion and trafficking, it has been shown that lipids of different shapes are sorted into regions with different membrane curvatures. This lipid sorting has been hypothesized to be due to the coupling between the membrane curvature and the lipid's spontaneous curvature, which ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamal MM,Mills D,Grzybek M,Howard J

更新日期：2009-12-29 00:00:00

abstract：:We evaluate the impact of anthropogenic and natural NO(x) sources over the contiguous United States on tropospheric NO(x) and O(3) levels by using a global 3D chemical transport model. The effects of major U.S. surface NO(x) emission sources (including anthropogenic, biomass burning, and soil emissions) are compared w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,Tie X,Bond DW

更新日期：2003-02-18 00:00:00

abstract：:Long-term plasticity can differ from short-term in recruiting the growth of new synaptic connections, a process that requires the participation of both the presynaptic and postsynaptic components of the synapse. How does information about synaptic plasticity spread from its site of origin to recruit the other componen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin I,Puthanveettil S,Udo H,Karl K,Kandel ER,Hawkins RD

更新日期：2012-06-05 00:00:00

abstract：:Early members of the dinosaur-pterosaur clade Ornithodira are very rare in the fossil record, obscuring our understanding of the origins of this important group. Here, we describe an early ornithodiran (Kongonaphon kely gen. et sp. nov.) from the Mid-to-Upper Triassic of Madagascar that represents one of the smallest ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kammerer CF,Nesbitt SJ,Flynn JJ,Ranivoharimanana L,Wyss AR

更新日期：2020-07-28 00:00:00

abstract：:Phagocytosis is a primary defense program orchestrated by monocytes/macrophages. Unregulated phagocytosis can lead to pathological conditions. In the current study we have demonstrated that Wnt5a stimulates phagocytosis through PI3 kinase-Rac1 and lipid-raft-dependent processes. Wnt5a-mediated augmentation in phagocyt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maiti G,Naskar D,Sen M

更新日期：2012-10-09 00:00:00

abstract：:Thrombospondin, a 450-kDa multinodular glycoprotein with lectin-type activity, is found in human platelets, endothelial cells, fibroblasts, smooth muscle cells, monocytes, and granular pneumocytes. Thrombospondin interacts with heparin, fibrinogen, fibronectin, collagen, histidine-rich glycoprotein, and plasminogen. R...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Asch AS,Leung LL,Shapiro J,Nachman RL

更新日期：1986-05-01 00:00:00

abstract：:Proteins need to be tightly regulated as they control biological processes in most normal cellular functions. The precise mechanisms of regulation are rarely completely understood but can involve binding of endogenous ligands and/or partner proteins at specific locations on a protein that can modulate function. Often,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ludlow RF,Verdonk ML,Saini HK,Tickle IJ,Jhoti H

更新日期：2015-12-29 00:00:00

abstract：:Acquired immunity to Streptococcus pneumoniae (pneumococcus) has long been assumed to depend on the presence of anticapsular antibodies. We found, however, that colonization with live pneumococci of serotypes 6B, 7F, or 14 protected mice against recolonization by any of the serotypes and that protection from acquisiti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malley R,Trzcinski K,Srivastava A,Thompson CM,Anderson PW,Lipsitch M

更新日期：2005-03-29 00:00:00

abstract：:In this study, we used functional MRI (fMRI) at high field (3T) to track the time course of activation in the entire basal ganglia circuitry, as well as other motor-related structures, during the explicit learning of a sequence of finger movements over a month of training. Fourteen right-handed healthy volunteers had ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehéricy S,Benali H,Van de Moortele PF,Pélégrini-Issac M,Waechter T,Ugurbil K,Doyon J

更新日期：2005-08-30 00:00:00

abstract：:We have developed a high-throughput approach to the labor-intensive problems of DNA cyclization, which we use to characterize DNA curvature and mechanical properties. The method includes a combinatorial approach to make the DNA constructs needed and automated real-time measurement of the kinetics using fluorescence. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Crothers DM

更新日期：2003-03-18 00:00:00

abstract：:The environmental impact of using recombinant bovine somatotropin (rbST) in dairy production was examined on an individual cow, industry-scale adoption, and overall production system basis. An average 2006 U.S. milk yield of 28.9 kg per day was used, with a daily response to rbST supplementation of 4.5 kg per cow. Rat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Capper JL,Castañeda-Gutiérrez E,Cady RA,Bauman DE

更新日期：2008-07-15 00:00:00

abstract：:Accumulating evidence suggests that α-synuclein (α-syn) occurs physiologically as a helically folded tetramer that resists aggregation. However, the mechanisms underlying the regulation of formation of α-syn tetramers are still mostly unknown. Cellular membrane lipids are thought to play an important role in the regul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Yun SP,Lee S,Umanah GE,Bandaru VVR,Yin X,Rhee P,Karuppagounder SS,Kwon SH,Lee H,Mao X,Kim D,Pandey A,Lee G,Dawson VL,Dawson TM,Ko HS

更新日期：2018-01-23 00:00:00

abstract：:While the physical dimensions of climate change are now routinely assessed through multimodel intercomparisons, projected impacts on the global ocean ecosystem generally rely on individual models with a specific set of assumptions. To address these single-model limitations, we present standardized ensemble projections...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lotze HK,Tittensor DP,Bryndum-Buchholz A,Eddy TD,Cheung WWL,Galbraith ED,Barange M,Barrier N,Bianchi D,Blanchard JL,Bopp L,Büchner M,Bulman CM,Carozza DA,Christensen V,Coll M,Dunne JP,Fulton EA,Jennings S,Jones MC,

更新日期：2019-06-25 00:00:00

abstract：:Two-dimensional gel electrophoresis of immunoprecipitated human HLA-DR antigens from cells expressing the HLA-DR4 haplotype shows distinct clustering of beta-chain patterns. Six unique electrophoretic variants were observed among 17 HLA-DR4 homozygous cell lines (HCL) analyzed. These patterns correlate precisely with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nepom BS,Nepom GT,Mickelson E,Antonelli P,Hansen JA

更新日期：1983-11-01 00:00:00

abstract：:The actions of various opioids were examined on calcium action potentials in the cell somata of guinea pig myenteric neurones and on the release of acetylcholine at synapses onto these cells. The opioids morphine, normorphine, and [D-Ala2, MePhe4, Met5(O)]enkephalin-ol caused membrane hyperpolarizations resulting from...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cherubini E,North RA

更新日期：1985-03-01 00:00:00

abstract：:Genetic manipulation of the alpha(2A)-adrenergic receptor (alpha(2A)-AR) in mice has revealed the role of this subtype in numerous responses, including agonist-induced hypotension and sedation. Unexpectedly, alpha(2)-agonist treatment of mice heterozygous for the alpha(2A)-AR (alpha(2A)-AR(+/-)) lowers blood pressure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tan CM,Wilson MH,MacMillan LB,Kobilka BK,Limbird LE

更新日期：2002-09-17 00:00:00

abstract：:We have earlier reported conditions that support the axenic development in vitro of a complete asexual erythrocytic cycle of Plasmodium falciparum. Up to 30% of merozoites showed initial differentiation into trophic forms (rings) viable at 14 hr. However, only approximately 1% of the merozoites would develop further i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JH,Gill GS,Trager W

更新日期：1995-01-17 00:00:00

abstract：:Using defined oligomers of IgE, our group previously studied the quantitative relationship between the aggregation of the high affinity receptors for IgE (Fc epsilonRI) and the earliest signals initiated by such aggregation: the phosphorylation of tyrosines on the receptor. Notably, at certain doses of the oligomers s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torigoe C,Goldstein B,Wofsy C,Metzger H

更新日期：1997-02-18 00:00:00

abstract：:The T-box transcription factor TBX5 plays essential roles in cardiac and limb development. Various mutations in the TBX5 gene have been identified in patients with Holt-Oram syndrome, which is characterized by congenital defects in the heart and upper extremities. In this study, we identified a WW-domain-containing tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami M,Nakagawa M,Olson EN,Nakagawa O

更新日期：2005-12-13 00:00:00

abstract：:The MYC family of cellular oncogenes includes c-Myc, N-myc, and L-myc, which encode transcriptional regulators involved in the control of cell proliferation and death. Accordingly, these genes become aberrantly activated and expressed in specific types of cancers. For example, c-Myc translocations occur frequently in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gostissa M,Ranganath S,Bianco JM,Alt FW

更新日期：2009-02-17 00:00:00