Molecular cloning of the flavin-containing monooxygenase (form II) cDNA from adult human liver.

abstract：:A site has been found that is required for repression of the Escherichia coli araBAD operon. This site was detected by the in vivo properties of deletion mutants. In vitro protection studies with DNase I and dimethylsulfate showed that araC protein can specifically bind in this area to nucleotides lying at position -2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunn TM,Hahn S,Ogden S,Schleif RF

更新日期：1984-08-01 00:00:00

abstract：:Fluoride activation of adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] is significantly enhanced (2 to 5 times) by a protein factor isolated from rat brain. The fluoride-dependent adenylate cyclase stimulator (FCS) is nondialyzable, trypsin-labile, and stable at 90 degrees C for 10 min. FCS stimula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rasenick MM,Bitensky MW

更新日期：1980-08-01 00:00:00

abstract：:The gene encoding latent-infection membrane protein 1 (LMP1) was specifically mutated in Epstein-Barr virus (EBV) recombinants by inserting a nonsense linker after codon 9 or codon 84 or into an intron 186 bp 3' to the latter insertion site. EBV recombinants with the LMP1 intron mutation were wild type for LMP1 expres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaye KM,Izumi KM,Kieff E

更新日期：1993-10-01 00:00:00

abstract：:Cellular progenitors of the coronary vasculature are believed to enter the chicken heart during epicardial morphogenesis between stages 17 and 27 (days 3-5) of egg incubation. To trace cells which give rise to the coronary arteries in vivo, we applied retroviral cell tagging procedures and analyzed clonal populations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mikawa T,Fischman DA

更新日期：1992-10-15 00:00:00

abstract：:In many naturally occurring habitats, bacteria live in micrometer-size confined spaces. Although bacterial growth and motility in such constrictions is of great interest to fields as varied as soil microbiology, water purification, and biomedical research, quantitative studies of the effects of confinement on bacteria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Männik J,Driessen R,Galajda P,Keymer JE,Dekker C

更新日期：2009-09-01 00:00:00

abstract：:The size of an organism reflects its metabolic rate, growth rate, mortality, and other important characteristics; therefore, the distribution of body size is a major determinant of ecosystem structure and function. Body-size distributions often are multimodal, with several peaks of abundant sizes, and previous studies...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampert A,Tlusty T

更新日期：2013-01-02 00:00:00

abstract：:Recent evidence implicates dysregulation of metabotropic glutamatergic receptor 5 (mGluR5) in pathophysiology of PTSD and suicidality. Using positron emission tomography and [18F]FPEB, we quantified mGluR5 availability in vivo in individuals with PTSD (n = 29) and MDD (n = 29) as a function of suicidal ideation (SI) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis MT,Hillmer A,Holmes SE,Pietrzak RH,DellaGioia N,Nabulsi N,Matuskey D,Angarita GA,Carson RE,Krystal JH,Esterlis I

更新日期：2019-06-04 00:00:00

abstract：:We introduced radioactive precursors directly into identified neurons of Aplysia californica. [(3)H]-Choline and L-[(3)H]tryptophan were injected with pressure into nerve cell bodies to study synthesis of acetylcholine and serotonin. We confirmed the cholinergic nature of R2, L10, and L11, identified neurons of the ab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenstadt M,Goldman JE,Kandel ER,Koike H,Koester J,Schwartz JH

更新日期：1973-12-01 00:00:00

abstract：:Ab initio multi-reference second-order perturbation theory computations are used to explore the photochemical behavior of two ion pairs constituted by a chloride counterion interacting with either a rhodopsin or bacteriorhodopsin chromophore model (i.e., the 4-cis-gamma-methylnona-2,4,6,8-tetraeniminium and all-trans-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cembran A,Bernardi F,Olivucci M,Garavelli M

更新日期：2005-05-03 00:00:00

abstract：:In both randomly moving Dictyostelium and mammalian cells, phosphatidylinositol (3,4,5)-trisphosphate and F-actin are known to propagate as waves at the membrane and act to push out the protruding edge. To date, however, the relationship between the wave geometry and the patterns of amoeboid shape change remains elusi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taniguchi D,Ishihara S,Oonuki T,Honda-Kitahara M,Kaneko K,Sawai S

更新日期：2013-03-26 00:00:00

abstract：:Membrane proteins of cytotoxic T cells specifically reorganize to form an immunological synapse (IS) on interaction with their specific target. In this paper, we investigated the redistribution of Kv1.3 channels, which are the dominant voltage-gated potassium channels, in the plasma membrane of allogen-activated human...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Panyi G,Vámosi G,Bacsó Z,Bagdány M,Bodnár A,Varga Z,Gáspár R,Mátyus L,Damjanovich S

更新日期：2004-02-03 00:00:00

abstract：:Saccharomyces cerevisiae is an ideal host from which to obtain high levels of posttranslationally modified eukaryotic proteins for x-ray crystallography. However, extensive replacement of methionine by selenomethionine for anomalous dispersion phasing has proven intractable in yeast. We report a general method to inco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malkowski MG,Quartley E,Friedman AE,Babulski J,Kon Y,Wolfley J,Said M,Luft JR,Phizicky EM,DeTitta GT,Grayhack EJ

更新日期：2007-04-17 00:00:00

abstract：:Zachariae Isstrøm (ZI) and Nioghalvfjerdsfjorden (79N) are marine-terminating glaciers in northeast Greenland that hold an ice volume equivalent to a 1.1-m global sea level rise. ZI lost its floating ice shelf, sped up, retreated at 650 m/y, and experienced a 5-gigaton/y mass loss. Glacier 79N has been more stable des...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： An L,Rignot E,Wood M,Willis JK,Mouginot J,Khan SA

更新日期：2021-01-12 00:00:00

abstract：:Chlamydia trachomatis is a bacterial pathogen that infects the eyes and urogenital tract. Ocular infection by this organism is the leading cause of preventable blindness worldwide. The infection is also a leading cause of sexually transmitted disease in the United States. As obligate intracellular pathogens, chlamydia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lad SP,Li J,da Silva Correia J,Pan Q,Gadwal S,Ulevitch RJ,Li E

更新日期：2007-02-20 00:00:00

abstract：:The gel filtration behavior, in the presence of detergents, of membrane-bound IgM from normal mouse spleen B lymphocytes was compared to that of secretory IgM from mouse plasma cells. The proteins were labeled either by surface radioiodination or biosynthetically with radioactive amino acids. Cell lysates were fractio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vassalli P,Tedghi R,Lisowska-Bernstein B,Tartakoff A,Jaton JC

更新日期：1979-11-01 00:00:00

abstract：:Urea (200-400 milliosmolar) activates transcription, translation of, and trans-activation by the immediate-early gene transcription factor Egr-1 in a renal epithelial cell-specific fashion. The effect at the transcriptional level has been attributed to multiple serum response elements and their adjacent Ets motifs loc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen DM

更新日期：1996-10-01 00:00:00

abstract：:A genetic analysis is necessary to gain a greater understanding of the complex developmental processes in mammals. Toward this end, an insertional transgenic mouse mutant has been isolated that results in abnormal germ-cell development. This recessive mutation manifests as infertility in both males and females and is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pellas TC,Ramachandran B,Duncan M,Pan SS,Marone M,Chada K

更新日期：1991-10-01 00:00:00

abstract：:Enhanced transductional recombination between specialized transducing phage lambda plac5 and plasmid F42lac depends on cis- and trans-acting factors. By constructing a series of recombinant molecules, the cis-acting site required for enhanced recombination has been identified as oriT, the origin of conjugational trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seifert HS,Porter RD

更新日期：1984-12-01 00:00:00

abstract：:CD11c, also known as integrin alpha X, is the most widely used defining marker for dendritic cells (DCs). CD11c can bind complement iC3b and mediate phagocytosis in vitro, for which it is also referred to as complement receptor 4. However, the functions of this prominent marker protein in DCs, especially in vivo, rema...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Wu H,An J,Ballantyne CM,Cyster JG

更新日期：2018-06-26 00:00:00

abstract：:Cocaine exposure in utero causes severe alterations in the development of the central nervous system. To study the basis of these teratogenic effects in vitro, we have used cocultures of neurons and glial cells from mouse embryonic brain. Cocaine selectively affected embryonic neuronal cells, causing first a dramatic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nassogne MC,Evrard P,Courtoy PJ

更新日期：1995-11-21 00:00:00

abstract：:Arguably the most foundational principle in perception research is that our experience of the world goes beyond the retinal image; we perceive the distal environment itself, not the proximal stimulation it causes. Shape may be the paradigm case of such "unconscious inference": When a coin is rotated in depth, we infer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morales J,Bax A,Firestone C

更新日期：2020-06-30 00:00:00

abstract：:To elucidate the function of the two nerve growth factor (NGF) receptors, p75NGFR and p140trk, chimeric molecules were constructed of tumor necrosis factor (TNF) and NGF receptors. Rat PC12 pheochromocytoma cells transiently transfected with TNF-p140trk chimeras, which contain the extracellular domain of TNF receptor ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rovelli G,Heller RA,Canossa M,Shooter EM

更新日期：1993-09-15 00:00:00

abstract：:Production of mature erythrocytes requires multiple growth factors, but we do not know how their actions are coordinated. Here we show that erythroid progenitors from erythropoietin receptor (Epo-R)-/- fetal livers, infected in vitro with a retrovirus expressing the wild-type Epo-R, require addition of both Epo and st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu H,Klingmüller U,Acurio A,Hsiao JG,Lodish HF

更新日期：1997-03-04 00:00:00

abstract：:Epilepsy is characterized by recurrent synchronizations of neuronal activity, which are both a cardinal clinical symptom and a debilitating phenomenon. Although the temporal dynamics of epileptiform synchronizations are well described at the macroscopic level using electrophysiological approaches, less is known about ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldt Muldoon S,Soltesz I,Cossart R

更新日期：2013-02-26 00:00:00

abstract：:Cyclic AMP (cAMP) and calcium are ubiquitous, interdependent second messengers that regulate a wide range of cellular processes. During development of neuronal networks they are critical for the first step of circuit formation, transducing signals required for axon pathfinding. Surprisingly, the spatial and temporal c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicol X,Hong KP,Spitzer NC

更新日期：2011-08-16 00:00:00

abstract：:Thyroid cancer is a common endocrine malignancy that encompasses well-differentiated as well as dedifferentiated cancer types. The latter tumors have high mortality and lack effective therapies. Using a paired-end RNA-sequencing approach, we report the discovery of rearrangements involving the anaplastic lymphoma kina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly LM,Barila G,Liu P,Evdokimova VN,Trivedi S,Panebianco F,Gandhi M,Carty SE,Hodak SP,Luo J,Dacic S,Yu YP,Nikiforova MN,Ferris RL,Altschuler DL,Nikiforov YE

更新日期：2014-03-18 00:00:00

abstract：:Our purpose is to investigate the feasibility of imaging tumor metabolism in breast cancer patients using 13C magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized 13C label exchange between injected [1-13C]pyruvate and the endogenous tumor lactate pool. Treatment-naïve breast cancer patients were recruite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallagher FA,Woitek R,McLean MA,Gill AB,Manzano Garcia R,Provenzano E,Riemer F,Kaggie J,Chhabra A,Ursprung S,Grist JT,Daniels CJ,Zaccagna F,Laurent MC,Locke M,Hilborne S,Frary A,Torheim T,Boursnell C,Schiller A,Pa

更新日期：2020-01-28 00:00:00

abstract：:Adult rats were trained to detect the occurrence of a two-element sound sequence in a background of nine other nontarget sound pairs. Training resulted in a modest, enduring, static expansion of the cortical areas of representation of both target stimulus sounds. More importantly, once the initial stimulus A in the ta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou X,de Villers-Sidani E,Panizzutti R,Merzenich MM

更新日期：2010-08-17 00:00:00

abstract：:Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2',5'-oligoadenylate (2-5A) synthetases (OASs) and ribonuclease (RNase) L are components of a potent host antiviral pathway. We previously showed that murine coronavirus (MHV) accessory protein n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,Jha BK,Ogden KM,Dong B,Zhao L,Elliott R,Patton JT,Silverman RH,Weiss SR

更新日期：2013-08-06 00:00:00

abstract：:Fibrosis is caused by scar tissue formation in internal organs and is associated with 45% of deaths in the United States. Two closely related human serum proteins, serum amyloid P (SAP) and C-reactive protein (CRP), strongly affect fibrosis. In multiple animal models, and in Phase 1 and Phase 2 clinical trials, SAP af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox N,Pilling D,Gomer RH

更新日期：2015-07-07 00:00:00