Phase geometries of two-dimensional excitable waves govern self-organized morphodynamics of amoeboid cells.

abstract：:The C2 domain containing protein extended synaptotagmin (E-Syt) plays important roles in both lipid homeostasis and the intracellular signaling; however, its role in physiology remains largely unknown. Here, we show that hypothalamic E-Syt3 plays a critical role in diet-induced obesity (DIO). E-Syt3 is characteristica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Guan Y,Pan S,Yan L,Wang P,Chen Z,Shen Q,Zhao F,Zhang X,Li J,Li J,Cai D,Zhang G

更新日期：2020-08-18 00:00:00

abstract：:The human papillomavirus E7 protein is phosphorylated at the two serines in positions 31/32, which are part of a consensus sequence for casein kinase II (CKII). In this study, we have investigated the effect of CKII phosphorylation site mutations, all of which lead to unphosphorylated E7 proteins. The replacement of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Firzlaff JM,Lüscher B,Eisenman RN

更新日期：1991-06-15 00:00:00

abstract：:T cells must respond differently to antigens of varying affinity presented at different doses. Previous attempts to map peptide MHC (pMHC) affinity onto T-cell responses have produced inconsistent patterns of responses, preventing formulations of canonical models of T-cell signaling. Here, a systematic analysis of T-c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lever M,Lim HS,Kruger P,Nguyen J,Trendel N,Abu-Shah E,Maini PK,van der Merwe PA,Dushek O

更新日期：2016-10-25 00:00:00

abstract：:Titania, which exhibits superwetting under light illumination, has been widely used as an ideal material for environmental solution such as self-cleaning, water-air purification, and antifogging. There have been various studies to understand such superhydrophilic conversion. The origin of superwetting has not been cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee K,Kim Q,An S,An J,Kim J,Kim B,Jhe W

更新日期：2014-04-22 00:00:00

abstract：:We present here a brief review of direct force measurements between hydrophobic surfaces in aqueous solutions. For almost 70 years, researchers have attempted to understand the hydrophobic effect (the low solubility of hydrophobic solutes in water) and the hydrophobic interaction or force (the unusually strong attract...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer EE,Rosenberg KJ,Israelachvili J

更新日期：2006-10-24 00:00:00

abstract：:Recent epidemics demonstrate the global threat of Zika virus (ZIKV), a flavivirus transmitted by mosquitoes. Although infection is usually asymptomatic or mild, newborns of infected mothers can display severe symptoms, including neurodevelopmental abnormalities and microcephaly. Given the large-scale spread, symptom s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esswein SR,Gristick HB,Jurado A,Peace A,Keeffe JR,Lee YE,Voll AV,Saeed M,Nussenzweig MC,Rice CM,Robbiani DF,MacDonald MR,Bjorkman PJ

更新日期：2020-05-05 00:00:00

abstract：:Turkey erythrocyte membranes showed specific binding of [(3)H]epinephrine. The concentration of hormone required for half-maximal binding (30 muM) was the same as that required for half-maximal activation of the adenylate cyclase located in the same membrane preparation. The binding reaction at 37 degrees C reached co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schramm M,Feinstein H,Naim E,Lang E,Lasser M

更新日期：1972-02-01 00:00:00

abstract：:Intermolecular electronic coupling dictates the optical properties of molecular aggregate systems. Of particular interest are photosynthetic pigment-protein complexes that absorb sunlight then efficiently direct energy toward the photosynthetic reaction center. Two-dimensional (2D) ultrafast spectroscopy has been used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Read EL,Engel GS,Calhoun TR,Mancal T,Ahn TK,Blankenship RE,Fleming GR

更新日期：2007-09-04 00:00:00

abstract：:To define the T-cell receptor signal transduction motif, we have transfected human and murine T-cell lines with a chimeric receptor consisting of the extracellular and transmembrane domains of human CD8 alpha and the membrane-proximal portion of CD3 zeta containing at its C terminus either an 18-amino acid segment (NQ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koyasu S,Tse AG,Moingeon P,Hussey RE,Mildonian A,Hannisian J,Clayton LK,Reinherz EL

更新日期：1994-07-05 00:00:00

abstract：:A new class of Escherichia coli mutants, referred to as grn, has been isolated by localized mutagenesis. These mutations affect the sigma subunit of DNA-dependent RNA polymerase (ribonucleoside 5'-triphosphate:RNA nucleotidyltransferase, EC 2.7.7.6) by abolishing the expression of the lambda N gene, and they are close...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,Kurihara T,Saito H,Uchida H

更新日期：1979-09-01 00:00:00

abstract：:Germ cells are required for the successful propagation of sexually reproducing species. Understanding the mechanisms by which these cells are specified and how their totipotency is established and maintained has important biomedical and evolutionary implications. Freshwater planarians serve as fascinating models for s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,Zayas RM,Guo T,Newmark PA

更新日期：2007-04-03 00:00:00

abstract：:Understanding the transmission ability of newly emerging influenza viruses is central to the development of public health preparedness and prevention strategies. Animals are used to model influenza virus infection and transmission, but the routinely used intranasal inoculation of a liquid virus suspension does not ref...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustin KM,Belser JA,Wadford DA,Pearce MB,Katz JM,Tumpey TM,Maines TR

更新日期：2011-05-17 00:00:00

abstract：:The T cell alphabeta receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development of peptide-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huseby ES,Crawford F,White J,Kappler J,Marrack P

更新日期：2003-09-30 00:00:00

abstract：:This paper is a theoretical study of dynamic self assembly in a system of millimeter-sized magnetized disks floating at a liquid-air interface and spinning under the influence of a rotating magnetic field. Equations of motions are derived that account for the hydrodynamic and magnetic forces acting in the system. Nume...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grzybowski BA,Stone HA,Whitesides GM

更新日期：2002-04-02 00:00:00

abstract：:Disulfide bond formation is catalyzed in the periplasm of Escherichia coli. This process involves at least two proteins: DsbA and DsbB. Recent evidence suggests that DsbA, a soluble periplasmic protein directly catalyzes disulfide bond formation in proteins, whereas DsbB, an inner membrane protein, is involved in the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guilhot C,Jander G,Martin NL,Beckwith J

更新日期：1995-10-10 00:00:00

abstract：:Insulin resistance is a key factor in the etiology of type 2 diabetes. Insulin-stimulated glucose uptake is mediated by the glucose transporter 4 (GLUT4), which is expressed mainly in skeletal muscle and adipose tissue. Insulin-stimulated translocation of GLUT4 from its intracellular compartment to the plasma membrane...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baeza-Raja B,Li P,Le Moan N,Sachs BD,Schachtrup C,Davalos D,Vagena E,Bridges D,Kim C,Saltiel AR,Olefsky JM,Akassoglou K

更新日期：2012-04-10 00:00:00

abstract：:There are many occasions in which humans and other animals must inhibit the production of some behavior or inhibit the processing of some internal representation. Success in inhibitory processing under normal circumstances can be revealed by the fact that certain brain pathologies render inhibitory processing ineffect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jonides J,Smith EE,Marshuetz C,Koeppe RA,Reuter-Lorenz PA

更新日期：1998-07-07 00:00:00

abstract：:A gamma-trace variant protein is the major constituent of the amyloid fibrils in patients from Iceland with hereditary cerebral hemorrhage with amyloidosis. The protein consists of 110 residues and is similar to human urinary gamma-trace basic protein (or cystatin C) beginning at its 11th amino-terminal residue. It ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghiso J,Jensson O,Frangione B

更新日期：1986-05-01 00:00:00

abstract：:The AG dinucleotide at the 3' splice sites of metazoan nuclear pre-mRNAs plays a critical role in catalytic step II of the splicing reaction. Previous studies have shown that replacement of the guanine by adenine in the AG (AG --> GG) inhibits this step. We find that the second step was even more severely inhibited by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaur RK,Beigelman L,Haeberli P,Maniatis T

更新日期：2000-01-04 00:00:00

abstract：:To examine the in vivo role(s) of type I interferons (IFNs) and to determine the role of a component of the type I IFN receptor (IFNAR1) in mediating responses to these IFNs, we generated mice with a null mutation (-/-) in the IFNAR1 gene. Despite compelling evidence for modulation of cell proliferation and differenti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang SY,Hertzog PJ,Holland KA,Sumarsono SH,Tymms MJ,Hamilton JA,Whitty G,Bertoncello I,Kola I

更新日期：1995-11-21 00:00:00

abstract：:The electrical response of a pigmented lipid bilayer to a short laser pulse is measured by a tunable voltage clamp method. In this method, a variable access impedance permits "tuning" of the observed relaxations for optimal measurements. Analysis of the data so obtained leads to an equivalent circuit that contains a n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hong FT,Mauzerall D

更新日期：1974-04-01 00:00:00

abstract：:The x-ray sensitive hamster cell line xrs-6 is deficient in DNA double-strand break (DSB) repair and exhibits impaired V(D)J recombination. The molecular defect in this line is in the 80-kDa subunit of the Ku autoantigen, a protein that binds to DNA ends and recruits the DNA-dependent protein kinase to DNA. Using an I...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang F,Romanienko PJ,Weaver DT,Jeggo PA,Jasin M

更新日期：1996-08-20 00:00:00

abstract：:Neurotrophins (NTs) have recently been found to regulate synaptic transmission in the hippocampus. Whole-cell and single-channel recordings from cultured hippocampal neurons revealed a mechanism responsible for enhanced synaptic strength. Specifically, brain-derived neurotrophic factor augmented glutamate-evoked, but ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine ES,Crozier RA,Black IB,Plummer MR

更新日期：1998-08-18 00:00:00

abstract：:The S100A8/S100A9 heterodimer calprotectin (CP) functions in the host response to pathogens through a mechanism termed "nutritional immunity." CP binds Mn(2+) and Zn(2+) with high affinity and starves bacteria of these essential nutrients. Combining biophysical, structural, and microbiological analysis, we identified ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damo SM,Kehl-Fie TE,Sugitani N,Holt ME,Rathi S,Murphy WJ,Zhang Y,Betz C,Hench L,Fritz G,Skaar EP,Chazin WJ

更新日期：2013-03-05 00:00:00

abstract：:Cell signaling systems sense and respond to ligands that bind cell surface receptors. These systems often respond to changes in the concentration of extracellular ligand more rapidly than the ligand equilibrates with its receptor. We demonstrate, by modeling and experiment, a general "systems level" mechanism cells us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura AC,Bush A,Vasen G,Goldín MA,Burkinshaw B,Bhattacharjee N,Folch A,Brent R,Chernomoretz A,Colman-Lerner A

更新日期：2014-09-16 00:00:00

abstract：:Sessile marine organisms are prolific sources of biologically active natural products. However, these compounds are often found in highly variable amounts, with the abiotic and biotic factors governing their production remaining poorly understood. We present an approach that permits monitoring of in vivo natural produ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esquenazi E,Jones AC,Byrum T,Dorrestein PC,Gerwick WH

更新日期：2011-03-29 00:00:00

abstract：:Oligosaccharide moieties of cell-surface glycoconjugates are thought to be involved in recognition events associated with tumor metastasis and invasion. Using swainsonine (SW), an inhibitor of Golgi alpha-mannosidase II that results in the formation of hybrid-type oligosaccharides on N-linked glycoproteins, we have te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Humphries MJ,Matsumoto K,White SL,Olden K

更新日期：1986-03-01 00:00:00

abstract：:Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization of G-protein-coupled receptors. Herein we describe the generation of monoclonal antibodies (mAbs) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oppermann M,Diversé-Pierluissi M,Drazner MH,Dyer SL,Freedman NJ,Peppel KC,Lefkowitz RJ

更新日期：1996-07-23 00:00:00

abstract：:Suppressor of variegation 3-9 homolog 1 (SUV39H1), a histone methyltransferase, catalyzes histone 3 lysine 9 trimethylation and is involved in heterochromatin organization and genome stability. However, the mechanism for regulation of the enzymatic activity of SUV39H1 in cancer cells is not yet well known. In this stu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang D,Zhou J,Liu X,Lu D,Shen C,Du Y,Wei FZ,Song B,Lu X,Yu Y,Wang L,Zhao Y,Wang H,Yang Y,Akiyama Y,Zhang H,Zhu WG

更新日期：2013-04-02 00:00:00

abstract：:Differential rates of AIDS development and/or T4 lymphocyte depletion in HIV-1-infected individuals remain unexplained. The hypothesis that qualitative differences in selection pressure in vivo may account for different rates of disease progression was addressed in nine eligible study participants from a cohort of 315...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang WK,Essex M,McLane MF,Mayer KH,Hsieh CC,Brumblay HG,Seage G,Lee TH

更新日期：1996-06-25 00:00:00