Abstract:
:The T cell alphabeta receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development of peptide-specific T cells is not intrinsic to thymocytes that undergo thymic-positive selection but is an outcome of eliminating, through negative selection, thymocytes bearing TCRs with extensive peptide cross-reactivity. Hence, thymic-negative selection imposes peptide specificity on the mature T cell repertoire.
journal_name
Proc Natl Acad Sci U S Aauthors
Huseby ES,Crawford F,White J,Kappler J,Marrack Pdoi
10.1073/pnas.1934636100keywords:
subject
Has Abstractpub_date
2003-09-30 00:00:00pages
11565-70issue
20eissn
0027-8424issn
1091-6490pii
1934636100journal_volume
100pub_type
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