Abstract:
:The nuclear envelope is a unique topological structure formed by lipid membranes in eukaryotic cells. Unlike other membrane structures, the nuclear envelope comprises two concentric membrane shells fused at numerous sites with toroid-shaped pores that impart a "geometric" genus on the order of thousands. Despite the intriguing architecture and vital biological functions of the nuclear membranes, how they achieve and maintain such a unique arrangement remains unknown. Here, we used the theory of elasticity and differential geometry to analyze the equilibrium shape and stability of this structure. Our results show that modest in- and out-of-plane stresses present in the membranes not only can define the pore geometry, but also provide a mechanism for destabilizing membranes beyond a critical size and set the stage for the formation of new pores. Our results suggest a mechanism wherein nanoscale buckling instabilities can define the global topology of a nuclear envelope-like structure.
journal_name
Proc Natl Acad Sci U S Aauthors
Torbati M,Lele TP,Agrawal Adoi
10.1073/pnas.1604777113subject
Has Abstractpub_date
2016-10-04 00:00:00pages
11094-11099issue
40eissn
0027-8424issn
1091-6490pii
1604777113journal_volume
113pub_type
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