Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects.

abstract：:The AML1 gene, located on chromosome 21, is involved in several distinct chromosomal translocations in human leukemia. In t(8;21) acute myelogenous leukemia (AML), the AML1 gene is juxtaposed to the ETO gene located on chromosome 8, generating an AML1/ETO fusion protein. Both AML1/ETO and the AML1 proteins recognize t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klampfer L,Zhang J,Zelenetz AO,Uchida H,Nimer SD

更新日期：1996-11-26 00:00:00

abstract：:We present evidence that the JAK-STAT signal transduction pathway regulates multiple developmental processes in Drosophila. We screened for second-site mutations that suppress the phenotype of the hyperactive hopTum-1 Jak kinase, and recovered a mutation that meiotically maps to the known chromosomal position of D-Sta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan R,Luo H,Darnell JE Jr,Dearolf CR

更新日期：1996-06-11 00:00:00

abstract：:Adeno-associated virus (AAV) vector delivery of an Apaf-1-dominant negative inhibitor was tested for its antiapoptotic effect on degenerating nigrostriatal neurons in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of Parkinson's disease. The wild-type caspase recruitment domain of Apaf-1 was used as a dom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mochizuki H,Hayakawa H,Migita M,Shibata M,Tanaka R,Suzuki A,Shimo-Nakanishi Y,Urabe T,Yamada M,Tamayose K,Shimada T,Miura M,Mizuno Y

更新日期：2001-09-11 00:00:00

abstract：:The RNA virus, hepatitis E virus (HEV) is the most or second-most important cause of acute clinical hepatitis in adults throughout much of Asia, the Middle East, and Africa. In these regions it is an important cause of acute liver failure, especially in pregnant women who have a mortality rate of 20-30%. Until recentl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla P,Nguyen HT,Torian U,Engle RE,Faulk K,Dalton HR,Bendall RP,Keane FE,Purcell RH,Emerson SU

更新日期：2011-02-08 00:00:00

abstract：:Besides ethanol, acetic acid is produced in naturally fermenting sweet resources and is a significant environmental stress for fruit-breeding Drosophila populations and species. Although not related to the presence of an active alcohol dehydrogenase, adult acetic acid tolerance was found to correlate with ethanol tole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chakir M,Peridy O,Capy P,Pla E,David JR

更新日期：1993-04-15 00:00:00

abstract：:Asymmetric epoxidation of various styrenes using carbocyclic oxazolidinone-containing ketone 3 has been investigated. High enantioselectivity (89-93% enantiomeric excess) has been attained for this challenging class of alkenes. Mechanistic studies show that substituents on the ketone catalyst can have electronic influ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hickey M,Goeddel D,Crane Z,Shi Y

更新日期：2004-04-20 00:00:00

abstract：:Mutational processes of simple sequence repeats (SSRs) in complex genomes are poorly understood. We examined these processes by introducing a two-phase mutation model. In this model, most mutations are single-step changes, but infrequent large jumps in repeat number also occur. We used computer simulations to determin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Di Rienzo A,Peterson AC,Garza JC,Valdes AM,Slatkin M,Freimer NB

更新日期：1994-04-12 00:00:00

abstract：:Unilateral stimulation of human peripheral nerves activates the primary somatosensory cortex (SI) contralaterally and the secondary somatosensory cortex (SII) bilaterally. We aimed at characterizing phase locking between SI and SII in response to electric stimuli applied once every 3 s to the right median nerve at the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simões C,Jensen O,Parkkonen L,Hari R

更新日期：2003-03-04 00:00:00

abstract：:Vertebrate remains recovered from a limestone fissure filling on Antigua, Lesser Antilles, are associated with radiocarbon dates ranging from 4300 to 2500 yr B.P., contemporaneous with the earliest aboriginal human occupation of the island. Nine taxa of lizards, snakes, birds, bats, and rodents (one-third of the total...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steadman DW,Pregill GK,Olson SL

更新日期：1984-07-01 00:00:00

abstract：:We demonstrate here that yeast killer viruses, previously thought to be transmitted only by cytoplasmic mixing during division, mating, or other induced forms of cell fusion, are capable of extracellular transmission. Viral particles from standard K1 and K2 killer strains were used to inoculate sensitive cells of Sacc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： el-Sherbeini M,Bostian KA

更新日期：1987-06-01 00:00:00

abstract：:Fungi that cause brown rot of wood are essential biomass recyclers and also the principal agents of decay in wooden structures, but the extracellular mechanisms by which they degrade lignocellulose remain unknown. To test the hypothesis that brown-rot fungi use extracellular free radical oxidants as biodegradative too...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kerem Z,Bao W,Hammel KE

更新日期：1998-09-01 00:00:00

abstract：:The frequencies of diverse rearrangements of variable (V)lambda to joining (J)lambda gene segments were examined by Southern blot hybridization in 30 murine B-cell lines, each producing an immunoglobulin lambda light chain of known subtype (lambda 1, lambda 2, or lambda 3). For 11 out of 12 lambda 1 chains, the rearra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reilly EB,Blomberg B,Imanishi-Kari T,Tonegawa S,Eisen HN

更新日期：1984-04-01 00:00:00

abstract：:Porcine and bovine GH receptor (GHR) cDNAs were stably expressed in mouse L cells, which normally do not possess detectable levels of mouse GHR. Expression of the GHR cDNAs resulted in specific binding of 125I-labeled GH by these cell lines. To study GHR-related signaling events in these cells, protein tyrosine phosph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Xu B,Souza SC,Kopchick JJ

更新日期：1994-02-15 00:00:00

abstract：:Kabuki syndrome is a Mendelian intellectual disability syndrome caused by mutations in either of two genes (KMT2D and KDM6A) involved in chromatin accessibility. We previously showed that an agent that promotes chromatin opening, the histone deacetylase inhibitor (HDACi) AR-42, ameliorates the deficiency of adult neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benjamin JS,Pilarowski GO,Carosso GA,Zhang L,Huso DL,Goff LA,Vernon HJ,Hansen KD,Bjornsson HT

更新日期：2017-01-03 00:00:00

abstract：:In the antennal lobe of Drosophila, information about odors is transferred from olfactory receptor neurons (ORNs) to projection neurons (PNs), which then send axons to neurons in the lateral horn of the protocerebrum (LHNs) and to Kenyon cells (KCs) in the mushroom body. The transformation from ORN to PN responses can...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo SX,Axel R,Abbott LF

更新日期：2010-06-08 00:00:00

abstract：:The nicotinic acetylcholine (ACh) receptor (nAChR) plays a crucial role in excitatory neurotransmission and is an important target for drugs and insecticides. Diverse nAChR subtypes with various subunit combinations confer differential selectivity for nicotinic drugs. We investigated the subtype selectivity of nAChR a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tomizawa M,Maltby D,Talley TT,Durkin KA,Medzihradszky KF,Burlingame AL,Taylor P,Casida JE

更新日期：2008-02-05 00:00:00

abstract：:Ca(2+) influx triggers the fusion of synaptic vesicles at the presynaptic active zone (AZ). Here we demonstrate a role of Ras-related in brain 3 (Rab3)-interacting molecules 2α and β (RIM2α and RIM2β) in clustering voltage-gated CaV1.3 Ca(2+) channels at the AZs of sensory inner hair cells (IHCs). We show that IHCs of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung S,Oshima-Takago T,Chakrabarti R,Wong AB,Jing Z,Yamanbaeva G,Picher MM,Wojcik SM,Göttfert F,Predoehl F,Michel K,Hell SW,Schoch S,Strenzke N,Wichmann C,Moser T

更新日期：2015-06-16 00:00:00

abstract：:Two additional peptides with inhibin-like activity have been isolated from human seminal plasma. One consists of 52 amino acids and the other, 92 amino acids. They are designated alpha-inhibin-52 and alpha-inhibin-92. Sequence analyses show that the NH2-terminal 31 amino acids of alpha-inhibin-52 are identical to the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li CH,Hammonds RG Jr,Ramasharma K,Chung D

更新日期：1985-06-01 00:00:00

abstract：:Saccharomyces cerevisiae possesses a high-affinity estrogen binding protein and an endogenous ligand that displaces [3H]estradiol from both the yeast binding protein and mammalian estrogen receptors. Semipurified preparations of this ligand have been shown to exhibit estrogenic activity in mammalian systems. We now de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldman D,Tökés LG,Stathis PA,Miller SC,Kurz W,Harvey D

更新日期：1984-08-01 00:00:00

abstract：:Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide transport is instrumental in managing human contamination. Here we show that siderocalin, a mammal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Allred BE,Rupert PB,Gauny SS,An DD,Ralston CY,Sturzbecher-Hoehne M,Strong RK,Abergel RJ

更新日期：2015-08-18 00:00:00

abstract：:Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsilioni I,Pantazopoulos H,Conti P,Leeman SE,Theoharides TC

更新日期：2020-07-14 00:00:00

abstract：:Biomass burning drives changes in greenhouse gases, climate-forcing aerosols, and global atmospheric chemistry. There is controversy about the magnitude and timing of changes in biomass burning emissions on millennial time scales from preindustrial to present and about the relative importance of climate change and hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicewonger MR,Aydin M,Prather MJ,Saltzman ES

更新日期：2018-12-04 00:00:00

abstract：:Absorbance changes reflecting the formation of a transient radical-pair state, P(F), were measured in reaction centers from Rhodopseudomonas sphaeroides under conditions that blocked electron transfer to a later carrier (a quinone, Q). The temperature dependence of the absorbance changes suggests that P(F) is an equil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shuvalov VA,Parson WW

更新日期：1981-02-01 00:00:00

abstract：:The nit-2 major nitrogen regulatory gene of Neurospora crassa turns on the expression of various unlinked structural genes that specify nitrogen-catabolic enzymes under nitrogen-limitation conditions. The nit-2 gene encodes a protein of 1036 amino acid residues with a single zinc finger and a downstream basic region t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu YH,Marzluf GA

更新日期：1990-07-01 00:00:00

abstract：:The opportunistic pathogen Candida albicans can undergo phenotypic switching between a benign, unicellular phenotype and an invasive, multicellular form that causes candidiasis. Increasingly, strains of Candida are becoming resistant to antifungal drugs, making the treatment of candidiasis difficult, especially in imm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchida M,McDermott G,Wetzler M,Le Gros MA,Myllys M,Knoechel C,Barron AE,Larabell CA

更新日期：2009-11-17 00:00:00

abstract：:A variety of agricultural plant species, including corn, respond to insect herbivore damage by releasing large quantities of volatile compounds and, as a result, become highly attractive to parasitic wasps that attack the herbivores. An elicitor of plant volatiles, N-(17-hydroxylinolenoyl)-L-glutamine, named volicitin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paré PW,Alborn HT,Tumlinson JH

更新日期：1998-11-10 00:00:00

abstract：:Interdigital webbing has evolved repeatedly in tropical salamanders (bolitoglossines). This derived foot morphology is only one of many homoplastic traits in this diverse amphibian clade. Indeed, few if any morphological traits sort lineages within this clade. We investigate the processes underlying the homoplastic ev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaekel M,Wake DB

更新日期：2007-12-18 00:00:00

abstract：:Ca2+, pheromones, sweet taste compounds, and the main neurotransmitters glutamate and gamma-aminobutyric acid activate G protein-coupled receptors (GPCRs) that constitute the GPCR family 3. These receptors are dimers, and each subunit has a large extracellular domain called a Venus flytrap module (VFTM), where agonist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bessis AS,Rondard P,Gaven F,Brabet I,Triballeau N,Prezeau L,Acher F,Pin JP

更新日期：2002-08-20 00:00:00

abstract：:The evolutionary stability of cooperation is a problem of fundamental importance for the biological and social sciences. Different claims have been made about this issue: whereas Axelrod and Hamilton's [Axelrod, R. & Hamilton, W. (1981) Science 211, 1390-1398] widely recognized conclusion is that cooperative rules suc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bendor J,Swistak P

更新日期：1995-04-11 00:00:00

abstract：:Explanations for primate brain expansion and the evolution of human cognition and culture remain contentious despite extensive research. While multiple comparative analyses have investigated variation in brain size across primate species, very few have addressed why primates vary in how much they use social learning. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Street SE,Navarrete AF,Reader SM,Laland KN

更新日期：2017-07-25 00:00:00