Programmable motion of DNA origami mechanisms.

abstract：:Lifelong interactions between host and the ubiquitous and persistent cytomegalovirus (CMV) have been proposed to contribute to the age-related decline in immunity. Prior work from us and others found some support for that idea, yet evidence that this led to increased vulnerability to other infections was not obtained....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smithey MJ,Venturi V,Davenport MP,Buntzman AS,Vincent BG,Frelinger JA,Nikolich-Žugich J

更新日期：2018-07-17 00:00:00

abstract：:Host-encoded factors play an important role in virus multiplication, acting in concert with virus-encoded factors. However, information regarding the host factors involved in this process is limited. Here we report the map-based cloning of an Arabidopsis thaliana gene, TOM1, which is necessary for the efficient multip...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamanaka T,Ohta T,Takahashi M,Meshi T,Schmidt R,Dean C,Naito S,Ishikawa M

更新日期：2000-08-29 00:00:00

abstract：:Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such "generalists" can be hard to evolve, outcompeted by specialists fitter in any particular environment. Here, inspired by the search for broadly neutralizing antibodies during B cell affinity maturation, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sachdeva V,Husain K,Sheng J,Wang S,Murugan A

更新日期：2020-06-09 00:00:00

abstract：:Flagellar microtubules from Chlamydomonas and sea urchin sperm were used as in vitro assembly sites for chick brain tubulin. Brain microtubules assembled onto the A-tubules, central tubules, and, to a limited extent, onto the distal ends of the axonemes at low tubulin concentrations and onto distal and proximal ends a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Binder LI,Dentler WL,Rosenbaum JL

更新日期：1975-03-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AhR) knockout mice raised in the laboratory of Fujii-Kuriyama have been under investigation for several years because of the presence in their urinary bladder of large, yellowish stones. The stones are composed of uric acid and become apparent in the bladders as tiny stones when mice are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butler R,Inzunza J,Suzuki H,Fujii-Kuriyama Y,Warner M,Gustafsson JÅ

更新日期：2012-01-24 00:00:00

abstract：:The Hurler syndrome (alpha-L-iduronidase deficiency disease) is a severe lysosomal storage disorder that is potentially amenable to enzyme-replacement therapy. Availability of a canine model of the disease and a sufficient supply of corrective enzyme have permitted a therapeutic trial lasting 3 mo. Recombinant human a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shull RM,Kakkis ED,McEntee MF,Kania SA,Jonas AJ,Neufeld EF

更新日期：1994-12-20 00:00:00

abstract：:The interactions between cancer cells and the surrounding host stromal tissue play a critical role in tumor progression and metastasis, but the molecular nature of this relationship remains largely uncharacterized. Furthermore, although genetic changes of neoplastic cells in tumors contribute significantly to tumor pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pelham RJ,Rodgers L,Hall I,Lucito R,Nguyen KC,Navin N,Hicks J,Mu D,Powers S,Wigler M,Botstein D

更新日期：2006-12-26 00:00:00

abstract：:We have previously described a gene delivery system based upon the receptor-mediated endocytosis of DNA complexed with transferrin-polycation conjugates. This delivery system has been found to be very effective for both the internalization and the expression of genetic material in cells that have many transferrin rece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner E,Cotten M,Foisner R,Birnstiel ML

更新日期：1991-05-15 00:00:00

abstract：:Calcium sensitivity of myosin cross-bridge activation in striated muscles commonly varies during ontogeny and in response to alterations in muscle usage, but the consequences for whole-organism physiology are not well known. Here we show that the relative abundances of alternatively spliced transcripts of the calcium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marden JH,Fitzhugh GH,Wolf MR,Arnold KD,Rowan B

更新日期：1999-12-21 00:00:00

abstract：:Substrate rigidity affects many physiological processes through mechanochemical signals from focal adhesion (FA) complexes that subsequently modulate gene expression. We find that shuttling of the LIM domain (domain discovered in the proteins, Lin11, Isl-1, and Mec-3) protein four-and-a-half LIM domains 2 (FHL2) betwe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakazawa N,Sathe AR,Shivashankar GV,Sheetz MP

更新日期：2016-11-01 00:00:00

abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. The Rag heterodimer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen K,Sabatini DM

更新日期：2018-09-18 00:00:00

abstract：:In the rhesus monkey (Macaca mulatta), the frequency of pulsatile gonadotropic hormone release is relatively constant in the face of widely varying levels of estradiol (E2) in the peripheral circulation--e.g., in the course of the follicular phase of the menstrual cycle and after ovariectomy. This suggests that modula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kesner JS,Wilson RC,Kaufman JM,Hotchkiss J,Chen Y,Yamamoto H,Pardo RR,Knobil E

更新日期：1987-12-01 00:00:00

abstract：:Bacteriophage lambda integrates into the chromosome of its Escherichia coli host by means of a site-specific recombination between a locus on the phage chromosome (phage att site) and a locus on the bacterial chromosome (bacterial att site). The nucleotide sequence of four lambda att sites altered in site-specific rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoess RH,Landy A

更新日期：1978-11-01 00:00:00

abstract：:The murine T-cell surface molecules Lyt-2 and L3T4 play a role in the activation of antigen-specific T cells. The currently accepted model for the function of these molecules proposes that Lyt-2 and L3T4 increase the overall avidity of the interaction between the T-cell antigen receptor and antigen in association with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fazekas de St Groth B,Gallagher PF,Miller JF

更新日期：1986-04-01 00:00:00

abstract：:Intracellular calcium-binding proteins are abundantly expressed in many neuronal populations. Previous evidence suggests that calcium-binding proteins can modulate various neuronal properties, presumably by their action as calcium buffers. The importance of calcium-binding proteins for nervous system function in an in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Airaksinen MS,Eilers J,Garaschuk O,Thoenen H,Konnerth A,Meyer M

更新日期：1997-02-18 00:00:00

abstract：:Inherited retinal degeneration (RD) is a devastating and currently untreatable neurodegenerative condition that leads to loss of photoreceptor cells and blindness. The vast genetic heterogeneity of RD, the lack of "druggable" targets, and the access-limiting blood-retinal barrier (BRB) present major hurdles toward eff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vighi E,Trifunović D,Veiga-Crespo P,Rentsch A,Hoffmann D,Sahaboglu A,Strasser T,Kulkarni M,Bertolotti E,van den Heuvel A,Peters T,Reijerkerk A,Euler T,Ueffing M,Schwede F,Genieser HG,Gaillard P,Marigo V,Ekström P,Pa

更新日期：2018-03-27 00:00:00

abstract：:Various proteins with different biological activities have been observed to be translocated from the nucleus to the cytoplasm in an energy- and signal-dependent manner in eukaryotic cells. This nuclear export is directed by nuclear export signals (NESs), typically characterized by hydrophobic, primarily leucine, amino...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elfgang C,Rosorius O,Hofer L,Jaksche H,Hauber J,Bevec D

更新日期：1999-05-25 00:00:00

abstract：:This communication reports an analysis of Tn5/IS50 target site selection by using an extensive collection of Tn5 and IS50 insertions in two relatively small regions of DNA (less than 1 kb each). For both regions data were collected resulting from in vitro and in vivo transposition events. Since the data sets are consi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goryshin IY,Miller JA,Kil YV,Lanzov VA,Reznikoff WS

更新日期：1998-09-01 00:00:00

abstract：:We show that an electric field can drive single-stranded RNA and DNA molecules through a 2.6-nm diameter ion channel in a lipid bilayer membrane. Because the channel diameter can accommodate only a single strand of RNA or DNA, each polymer traverses the membrane as an extended chain that partially blocks the channel. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kasianowicz JJ,Brandin E,Branton D,Deamer DW

更新日期：1996-11-26 00:00:00

abstract：:Deep aquifers in South and Southeast Asia are increasingly exploited as presumed sources of pathogen- and arsenic-free water, although little is known of the processes that may compromise their long-term viability. We analyze a large area (>1,000 km(2)) of the Mekong Delta, Vietnam, in which arsenic is found pervasive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Erban LE,Gorelick SM,Zebker HA,Fendorf S

更新日期：2013-08-20 00:00:00

abstract：:Documented cases of convergent molecular evolution due to selection are fairly unusual, and examples to date have involved only a few amino acid positions. However, because convergence mimics shared ancestry and is not accommodated by current phylogenetic methods, it can strongly mislead phylogenetic inference when it...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castoe TA,de Koning AP,Kim HM,Gu W,Noonan BP,Naylor G,Jiang ZJ,Parkinson CL,Pollock DD

更新日期：2009-06-02 00:00:00

abstract：:An acid extract of pedal ganglia of the mollusc Mytilus edulis was fractionated by high-pressure liquid chromatography with a reverse-phase column. Peak fractions with retention times of those of [Met]- and [Leu]enkephalin were subjected to binding assays in both invertebrate and vertebrate tissues. The results showed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung MK,Stefano GB

更新日期：1984-02-01 00:00:00

abstract：:The Nod-like receptor family in man contains proteins that recognize invasive bacteria. Nod1, a member of this family, is activated by specific peptidoglycan-derived muropeptides that contain meso-diaminopimelic acid. Plants contain a large family of proteins known as resistance (R) proteins that have common structura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： da Silva Correia J,Miranda Y,Leonard N,Ulevitch R

更新日期：2007-04-17 00:00:00

abstract：:A survey was performed to estimate the frequency of enterohemorrhagic Escherichia coli O157:H7 or O157:nonmotile (EHEC O157) in feces and on hides within groups of fed cattle from single sources (lots) presented for slaughter at meat processing plants in the Midwestern United States, as well as frequency of carcass co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elder RO,Keen JE,Siragusa GR,Barkocy-Gallagher GA,Koohmaraie M,Laegreid WW

更新日期：2000-03-28 00:00:00

abstract：:Sensory information from the external world is inherently ambiguous, necessitating prior experience as a constraint on perception. Prolonged experience (adaptation) induces perception of ambiguous morph faces as a category different from the adapted category, suggesting sensitivity in underlying neural codes to differ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furl N,van Rijsbergen NJ,Treves A,Friston KJ,Dolan RJ

更新日期：2007-08-14 00:00:00

abstract：:mRNA for the large subunit (LS) of ribulose-1,5-bisphosphate carboxylase [3-phospho-D-glycerate carboxylase (dimerizing), EC 4.1.1.39] of Zea mays is complementary to an uninterrupted 1600-base-pair-long chloroplast DNA sequence that has been mapped precisely within the 4350-base-pair-long chloroplast DNA fragment Bam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Link G,Bogorad L

更新日期：1980-04-01 00:00:00

abstract：:Inhibitory interneurons regulate the responses of cortical circuits. In auditory cortical areas, inhibition from these neurons narrows spectral tuning and shapes response dynamics. Acute disruptions of inhibition expand spectral receptive fields. However, the effects of long-term perturbations of inhibitory circuitry ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seybold BA,Stanco A,Cho KK,Potter GB,Kim C,Sohal VS,Rubenstein JL,Schreiner CE

更新日期：2012-08-21 00:00:00

abstract：:Conventional digital computers can execute advanced operations by a sequence of elementary Boolean functions of 2 or more bits. As a result, complicated tasks such as solving a linear system or solving a differential equation require a large number of computing steps and an extensive use of memory units to store indiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun Z,Pedretti G,Ambrosi E,Bricalli A,Wang W,Ielmini D

更新日期：2019-03-05 00:00:00

abstract：:Studies of perception usually emphasize processes that are largely universal across observers and--except for short-term fluctuations--stationary over time. Here we test the universality and stationarity assumptions with two families of ambiguous visual stimuli. Each stimulus can be perceived in two different ways, pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wexler M,Duyck M,Mamassian P

更新日期：2015-12-01 00:00:00

abstract：:Hepatitis C virus subverts liver-specific microRNA, miR-122, to upregulate viral RNA abundance in both infected cultured cells and in the liver of infected chimpanzees. These findings have identified miR-122 as an attractive antiviral target. Thus, it is imperative to know whether a distinct functional complex exists ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machlin ES,Sarnow P,Sagan SM

更新日期：2011-02-22 00:00:00