Correlation of enterohemorrhagic Escherichia coli O157 prevalence in feces, hides, and carcasses of beef cattle during processing.

abstract：:Brain areas' functional repertoires are shaped by their incoming and outgoing structural connections. In empirically measured networks, most connections are short, reflecting spatial and energetic constraints. Nonetheless, a small number of connections span long distances, consistent with the notion that the functiona...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Betzel RF,Bassett DS

更新日期：2018-05-22 00:00:00

abstract：:Exposure of cholera toxin to membrane particles prepared from sarcoma 180 cells gives rise to a variety of fragments which are capable of activating adenylate cyclase [ATP:pyrophosphate-lyase (cyclizing), EC 4.6.1.1]. A major component of these fragments has an apparent molecular weight in the 8,000-10,000 range. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matuo Y,Wheeler MA,Bitensky MW

更新日期：1976-08-01 00:00:00

abstract：:The amyloid beta-protein precursor (AbetaPP) is best known as the parent molecule to the amyloid beta-peptide that accumulates in the brains of patients with Alzheimer's disease. Secreted isoforms of AbetaPP that contain the Kunitz proteinase inhibitor domain are analogous to the previously identified cell-secreted pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu F,Davis J,Miao J,Previti ML,Romanov G,Ziegler K,Van Nostrand WE

更新日期：2005-12-13 00:00:00

abstract：:Aminoglycoside ototoxicity has been related to a surprisingly large number of cellular structures and metabolic pathways. The finding that patients with mutations in mitochondrial rRNA are hypersusceptible to aminoglycoside-induced hearing loss has indicated a possible role for mitochondrial protein synthesis. To stud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie SN,Akshay S,Kalapala SK,Bruell CM,Shcherbakov D,Böttger EC

更新日期：2008-12-30 00:00:00

abstract：:beta 1-Adrenergic receptors from turkey erythrocyte membranes have been identified by specific binding of the radiolabeled antagonist (-)-[3H]dihydroalprenolol. These receptors are inactivated by the alkylating agent N-ethylmaleimide when occupied by beta-adrenergic agonists but not when occupied by antagonists or whe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vauquelin G,Bottari S,Andre C,Jacobsson B,Strosberg AD

更新日期：1980-07-01 00:00:00

abstract：:We have previously shown that nuclear transcripts of the multifunctional enzyme, carbamoyl-phosphate synthetase, aspartate transcarbamylase, dihydroorotase RNA can be released from nuclei of Syrian hamster cells as compact ribonucleoprotein (RNP) particles that sediment at the 200S region in a sucrose gradient. The 20...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spann P,Feinerman M,Sperling J,Sperling R

更新日期：1989-01-01 00:00:00

abstract：:The development of antimicrobials is critical in this time of increasing antibiotic resistance of most clinically relevant bacteria. To date, all current antibiotics focus on inhibiting crucial enzymatic activities of their protein targets (i.e., trimethoprim for dihydrofolate reductase), thus disrupting in vitro esse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shakhnovich EA,Hung DT,Pierson E,Lee K,Mekalanos JJ

更新日期：2007-02-13 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease in critical need of new therapeutic strategies. Here, we report that the stress-inducible 78-kDa glucose-regulated protein (GRP78/HSPA5), a key regulator of endoplasmic reticulum homeostasis and PI3K/AKT signaling, is overexpressed in the acini an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen J,Ha DP,Zhu G,Rangel DF,Kobielak A,Gill PS,Groshen S,Dubeau L,Lee AS

更新日期：2017-05-16 00:00:00

abstract：:A juvenile male zebra finch, Taeniopygia guttata, kept singly with its father develops a fairly complete imitation of the father's song. The imitation is less complete when other male siblings are present, possibly because as imitation commences, model abundance increases. Here we examine the consequences of allowing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tchernichovski O,Lints T,Mitra PP,Nottebohm F

更新日期：1999-10-26 00:00:00

abstract：:Osteoclasts, bone-resorptive multinucleated cells derived from hematopoietic stem cells, are associated with many bone-related diseases, such as osteoporosis. Osteoclast-targeting small-molecule inhibitors are valuable tools for studying osteoclast biology and for developing antiresorptive agents. Here, we have discov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawatani M,Okumura H,Honda K,Kanoh N,Muroi M,Dohmae N,Takami M,Kitagawa M,Futamura Y,Imoto M,Osada H

更新日期：2008-08-19 00:00:00

abstract：:The imino sugar N-butyldeoxynojirimycin (NBDNJ) is a potent inhibitor of the oligosaccharide-trimming enzyme alpha-glucosidase I. Hepatitis B virus (HBV) contains three surface proteins (HBs proteins) of different sizes that are singly or doubly N-glycosylated and are essential for the formation of infectious virus. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Block TM,Lu X,Platt FM,Foster GR,Gerlich WH,Blumberg BS,Dwek RA

更新日期：1994-03-15 00:00:00

abstract：:Historical collapse of ancient states or civilizations has raised new awareness about its possible relevance to current issues of sustainability, in the context of global change. This Special Feature examines 12 case studies of societies under stress, of which seven suffered severe transformation. Outcomes were comple...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Butzer KW,Endfield GH

更新日期：2012-03-06 00:00:00

abstract：:The conformation of the pressure-dissociated monomer of Arc repressor was characterized by 1H NMR spectroscopy. The NMR spectra of the monomer under pressure (up to 5.0 kbar; 1 bar = 100 kPa) are typical of a molten globule and they are considerably different from those of the native dimer and thermally denatured mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peng X,Jonas J,Silva JL

更新日期：1993-03-01 00:00:00

abstract：:Sal-like 4 (SALL4) is a nuclear factor central to the maintenance of stem cell pluripotency and is a key component in hepatocellular carcinoma, a malignancy with no effective treatment. In cancer cells, SALL4 associates with nucleosome remodeling deacetylase (NuRD) to silence tumor-suppressor genes, such as PTEN. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu BH,Jobichen C,Chia CSB,Chan THM,Tang JP,Chung TXY,Li J,Poulsen A,Hung AW,Koh-Stenta X,Tan YS,Verma CS,Tan HK,Wu CS,Li F,Hill J,Joy J,Yang H,Chai L,Sivaraman J,Tenen DG

更新日期：2018-07-24 00:00:00

abstract：:The complex prokaryote, Myxococcus xanthus, undergoes a program of multicellular development when starved for nutrients, culminating in sporulation. M. xanthus makes MglA, a 22-kDa, soluble protein that is required for both multicellular development and gliding motility. MglA is similar in sequence to the Saccharomyce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartzell PL

更新日期：1997-09-02 00:00:00

abstract：:We have cloned two species of EcoRI-cleaved DNA segments that together cover the entire sequence for the human interleukin 2 gene and have determined the nucleotide sequence of the gene and its flanking regions. The gene contains three introns and the exon sequences can be aligned with the previously reported cDNA seq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujita T,Takaoka C,Matsui H,Taniguchi T

更新日期：1983-12-01 00:00:00

abstract：:Awareness that our planet is a self-supporting biosphere with sunlight as its major source of energy for life has resulted in a long-term historical fascination with the workings of self-supporting ecological systems. However, the studies of such systems have never entered the canon of ecological or evolutionary tools...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rillig MC,Antonovics J

更新日期：2019-06-04 00:00:00

abstract：:Secretions of the uterus support survival and growth of the conceptus (embryo/fetus and associated membranes) during pregnancy. Galectin-15, also known as OVGAL11 and a previously uncharacterized member of the galectin family of secreted beta-galactoside lectins containing a conserved carbohydrate recognition domain a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gray CA,Adelson DL,Bazer FW,Burghardt RC,Meeusen EN,Spencer TE

更新日期：2004-05-25 00:00:00

abstract：:Several natural isolate E. coli strains highly resistant to sulfonamides and antibiotics are shown to contain a sulfonamide-resistant dihydropteroate synthase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase, EC 2.5.1.15) in add...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise EM Jr,Abou-Donia MM

更新日期：1975-07-01 00:00:00

abstract：:During genome transcription in rotavirus, as with many segmented double-stranded RNA viruses, mRNA is transcribed within the intact subviral particle and translocated through specific channels in the capsid. To understand how the conformation of the capsid affects the efficiency of transcriptional events in the viral ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawton JA,Estes MK,Prasad BV

更新日期：1999-05-11 00:00:00

abstract：:Lysine to methionine (K-to-M) mutations in genes encoding histone H3 are thought to drive a subset of pediatric brain and bone cancers. These high-frequency K-to-M mutations occur at sites of methylation on histone H3, and tumors containing the mutant histones exhibit a global loss of specific histone methylation mark...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jayaram H,Hoelper D,Jain SU,Cantone N,Lundgren SM,Poy F,Allis CD,Cummings R,Bellon S,Lewis PW

更新日期：2016-05-31 00:00:00

abstract：:The in vivo biological activities of IgG antibodies result from their bifunctional nature, in which antigen recognition by the Fab is coupled to the effector and immunomodulatory diversity found in the Fc domain. This diversity, resulting from both amino acid and glycan heterogeneity, is translated into cellular respo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith P,DiLillo DJ,Bournazos S,Li F,Ravetch JV

更新日期：2012-04-17 00:00:00

abstract：:Mitochondrial DNAs were prepared from maize lines with normal cytoplasm and with the T, C, S, and EP sources of male-sterile cytoplasms. Agarose gel electrophoresis of these preparations revealed a main high-molecular-weight DNA band. In addition, the S cytoplasm was characterized by the presence of two faster migrati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pring DR,Levings CS,Hu WW,Timothy DH

更新日期：1977-07-01 00:00:00

abstract：:The atmospheric and deep sea reservoirs of carbon dioxide are linked via physical, chemical, and biological processes. The last of these include photosynthesis, particle settling, and organic matter remineralization, and are collectively termed the "biological carbon pump." Herein, we present results from a 13-y (1992...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karl DM,Church MJ,Dore JE,Letelier RM,Mahaffey C

更新日期：2012-02-07 00:00:00

abstract：:Language is classically thought to be supported by perisylvian cortical regions. Here we provide intracranial evidence linking the hippocampal complex to linguistic processing. We used direct recordings from the hippocampal structures to investigate whether theta oscillations, pivotal in memory function, track the amo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piai V,Anderson KL,Lin JJ,Dewar C,Parvizi J,Dronkers NF,Knight RT

更新日期：2016-10-04 00:00:00

abstract：:Increased understanding of the precise molecular mechanisms involved in cell survival and cell death signaling pathways offers the promise of harnessing these molecules to eliminate cancer cells without damaging normal cells. Tyrosine kinase oncoproteins promote the genesis of leukemias through both increased cell pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurokawa M,Ito T,Yang CS,Zhao C,Macintyre AN,Rizzieri DA,Rathmell JC,Deininger MW,Reya T,Kornbluth S

更新日期：2013-02-05 00:00:00

abstract：:The strong consistency of least squares estimates in multiple regression models with independent errors is obtained under minimal assumptions on the design and weak moment conditions on the errors. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai TL,Robbins H,Wei CZ

更新日期：1978-07-01 00:00:00

abstract：:We have used X-ray diffraction on the rhombohedral phospholipid phase to reconstruct stalk structures in different pure lipids and lipid mixtures with unprecedented resolution, enabling a quantitative analysis of geometry, as well as curvature and hydration energies. Electron density isosurfaces are used to study shap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aeffner S,Reusch T,Weinhausen B,Salditt T

更新日期：2012-06-19 00:00:00

abstract：:Collective intelligence refers to the ability of groups to outperform individual decision makers when solving complex cognitive problems. Despite its potential to revolutionize decision making in a wide range of domains, including medical, economic, and political decision making, at present, little is known about the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurvers RH,Herzog SM,Hertwig R,Krause J,Carney PA,Bogart A,Argenziano G,Zalaudek I,Wolf M

更新日期：2016-08-02 00:00:00

abstract：:While the concept of intercellular mechanical communication has been revealed, the mechanistic insights have been poorly evidenced in the context of myofibroblast-fibroblast interaction during fibrosis expansion. Here we report and systematically investigate the mechanical force-mediated myofibroblast-fibroblast cross...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Yu H,Zhao H,Wu Z,Long Y,Zhang J,Yan X,You Z,Zhou L,Xia T,Shi Y,Xiao B,Wang Y,Huang C,Du Y

更新日期：2020-05-19 00:00:00