Interaction between beta-adrenergic receptors and guanine nucleotide sites in turkey erythrocyte membranes.

abstract：:We previously identified a stromal cell-derived inducing activity (SDIA), which induces differentiation of neural cells, including midbrain tyrosine hydroxylase-positive (TH(+)) dopaminergic neurons, from mouse embryonic stem cells. We report here that SDIA induces efficient neural differentiation also in primate embr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawasaki H,Suemori H,Mizuseki K,Watanabe K,Urano F,Ichinose H,Haruta M,Takahashi M,Yoshikawa K,Nishikawa S,Nakatsuji N,Sasai Y

更新日期：2002-02-05 00:00:00

abstract：:The majority of outer membrane proteins (OMPs) from gram-negative bacteria and many of mitochondria and chloroplasts are β-barrels. Insertion and assembly of these proteins are catalyzed by the Omp85 protein family in a seemingly conserved process. All members of this family exhibit a characteristic N-terminal polypep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sommer MS,Daum B,Gross LE,Weis BL,Mirus O,Abram L,Maier UG,Kühlbrandt W,Schleiff E

更新日期：2011-08-16 00:00:00

abstract：:Previous findings of intact remote autobiographical memory in patients with medial temporal lobe damage have been questioned on the grounds that the narrative recollections were impoverished and fact-like and that the methods were not sufficiently sensitive to detect an impairment. We adopted a newer method, the Autob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirwan CB,Bayley PJ,Galván VV,Squire LR

更新日期：2008-02-19 00:00:00

abstract：:Escherichia coli DnaK acts as a molecular chaperone through its ATP-regulated binding and release of polypeptide substrates. Overexpressing a C-terminal fragment (CTF) of DnaK (Gly-384 to Lys-638) containing the polypeptide substrate binding domain is lethal in wild-type E. coli. This dominant-negative phenotype may r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burkholder WF,Zhao X,Zhu X,Hendrickson WA,Gragerov A,Gottesman ME

更新日期：1996-10-01 00:00:00

abstract：:Metal cation homeostasis is essential for plant nutrition and resistance to toxic heavy metals. Many plant metal transporters remain to be identified at the molecular level. In the present study, we have isolated AtNramp cDNAs from Arabidopsis and show that these genes complement the phenotype of a metal uptake defici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomine S,Wang R,Ward JM,Crawford NM,Schroeder JI

更新日期：2000-04-25 00:00:00

abstract：:Nucleotide excision repair proteins have been implicated in genetic recombination by experiments in Saccharomyces cerevisiae and Drosophila melanogaster, but their role, if any, in mammalian cells is undefined. To investigate the role of the nucleotide excision repair gene ERCC1, the hamster homologue to the S. cerevi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sargent RG,Rolig RL,Kilburn AE,Adair GM,Wilson JH,Nairn RS

更新日期：1997-11-25 00:00:00

abstract：:An enzyme that catalyzes the conversion of bovine proinsulin to insulin has been purified from a bovine pancreatic extract. The product of conversion was identified as insulin by aminoacid analysis and determination of carboxyl terminal aminoacid residues. The purified enzyme preparation showed one major protein band ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yip CC

更新日期：1971-06-01 00:00:00

abstract：:One of the technical bottlenecks in producing nonhuman primate models is that current assisted reproductive techniques, such as in vitro culture and frozen conservation of multicell-stage embryos, often result in poor embryo quality and subsequently lead to low birth rates. We investigated whether pronuclear embryo tr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun Q,Dong J,Yang W,Jin Y,Yang M,Wang Y,Wang PL,Hu Y,Tsien JZ

更新日期：2008-09-02 00:00:00

abstract：:Leaf-cutting ants combine large-scale herbivory with fungus farming to sustain advanced societies. Their stratified colonies are major evolutionary achievements and serious agricultural pests, but the crucial adaptations that allowed this mutualism to become the prime herbivorous component of neotropical ecosystems ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Fine Licht HH,Schiøtt M,Rogowska-Wrzesinska A,Nygaard S,Roepstorff P,Boomsma JJ

更新日期：2013-01-08 00:00:00

abstract：:Niemann-Pick C1 (NPC1) and NPC2 proteins are indispensable for the export of LDL-derived cholesterol from late endosomes. Mutations in these proteins result in Niemann-Pick type C disease, a lysosomal storage disease. Despite recent reports of the NPC1 structure depicting its overall architecture, the function of its ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Lu F,Trinh MN,Schmiege P,Seemann J,Wang J,Blobel G

更新日期：2017-08-22 00:00:00

abstract：:Recent advances in metabolic engineering have demonstrated that microbial biosynthesis can provide a viable alternative to chemical synthesis for the production of bulk and fine chemicals. Introduction of a new biosynthetic pathway typically requires the expression of multiple heterologous enzymes in the production ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michener JK,Nielsen J,Smolke CD

更新日期：2012-11-20 00:00:00

abstract：:We tested the possibility that insulin-like growth factor I (IGF-I) acts as a neuromodulator in the adult cerebellar cortex since previous observations indicated that IGF-I is located in the olivo-cerebellar system encompassing the inferior olive and Purkinje cells. We found that conjoint administration of IGF-I and g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castro-Alamancos MA,Torres-Aleman I

更新日期：1993-08-01 00:00:00

abstract：:The six-layered neocortex is a uniquely mammalian structure with evolutionary origins that remain in dispute. One long-standing hypothesis, based on similarities in neuronal connectivity, proposes that homologs of the layer 4 input and layer 5 output neurons of neocortex are present in the avian forebrain, where they ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dugas-Ford J,Rowell JJ,Ragsdale CW

更新日期：2012-10-16 00:00:00

abstract：:Clinical data showing correlations between low thyroid-stimulating hormone (TSH) levels and high bone turnover markers, low bone mineral density, and an increased risk of osteoporosis-related fractures are buttressed by mouse genetic and pharmacological studies identifying a direct action of TSH on the skeleton. Here ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun L,Zhu LL,Lu P,Yuen T,Li J,Ma R,Baliram R,Moonga SS,Liu P,Zallone A,New MI,Davies TF,Zaidi M

更新日期：2013-06-11 00:00:00

abstract：:Eukaryotic cells irradiated with high doses of UV exhibit cell-cycle responses referred to as G(1)/S, intraS, and G(2)/M checkpoints. After a moderate UV dose that approximates sunlight exposure and is lethal to fission yeast checkpoint mutants, we found unexpectedly that these cell-cycle responses do not occur. Inste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Callegari AJ,Kelly TJ

更新日期：2006-10-24 00:00:00

abstract：:The INT6 gene has been implicated in human breast cancer formation, but its function is unknown. We isolated an Int6 homolog from fission yeast, Yin6, by its binding to a conserved protein in the Ras pathway, Moe1. Yin6 and Moe1 converge on the same protein complex to promote microtubule instability/disassembly. Yin6 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yen HC,Chang EC

更新日期：2000-12-19 00:00:00

abstract：:In Saccharomyces cerevisiae Mediator, a subgroup of proteins (Srb8, Srb9, Srb10, and Srb11) form a module, which is involved in negative regulation of transcription. Homologues of Srb10 and Srb11 are found in some mammalian Mediator preparations, whereas no clear homologues have been reported for Srb8 and Srb9. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuelsen CO,Baraznenok V,Khorosjutina O,Spahr H,Kieselbach T,Holmberg S,Gustafsson CM

更新日期：2003-05-27 00:00:00

abstract：:Under fasting conditions, increases in circulating glucagon maintain glucose balance by promoting hepatic gluconeogenesis. Triggering of the cAMP pathway stimulates gluconeogenic gene expression through the PKA-mediated phosphorylation of the cAMP response element binding (CREB) protein and via the dephosphorylation o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai WW,Niessen S,Goebel N,Yates JR 3rd,Guccione E,Montminy M

更新日期：2013-05-28 00:00:00

abstract：:Trypanosomosis, or sleeping sickness, is a major disease constraint on livestock productivity in sub-Saharan Africa. To identify quantitative trait loci (QTL) controlling resistance to trypanosomosis in cattle, an experimental cross was made between trypanotolerant African N'Dama (Bos taurus) and trypanosusceptible im...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hanotte O,Ronin Y,Agaba M,Nilsson P,Gelhaus A,Horstmann R,Sugimoto Y,Kemp S,Gibson J,Korol A,Soller M,Teale A

更新日期：2003-06-24 00:00:00

abstract：:Cellular regulation by certain growth factor receptors and protooncogene products involves tyrosine kinase activity with the resultant tyrosine phosphorylation of protein substrates. In the present report we describe the distribution of phosphotyrosine-containing material detected by immunocytochemistry (ICC) in the r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moss AM,Unger JW,Moxley RT,Livingston JN

更新日期：1990-06-01 00:00:00

abstract：:In vitro recombination of cloned H-2 genes resulted in two allogeneically novel mouse transplantation antigens in which the C2 domains of H-2Ld and H-2Dd were exchanged. These genes were introduced into mouse L cells by DNA-mediated gene transfer. We have used these transformed fibroblast lines, expressing recombinant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozato K,Evans GA,Shykind B,Margulies DH,Seidman JG

更新日期：1983-04-01 00:00:00

abstract：:Recent reports on the dystrophic mouse mutant suggest that the prominent extracellular matrix component of peripheral nerve tissues plays an important role in peripheral nerve development. We have examined the disposition of two prominent extracellular matrix components, fibronectin and laminin, both in mature periphe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cornbrooks CJ,Carey DJ,McDonald JA,Timpl R,Bunge RP

更新日期：1983-06-01 00:00:00

abstract：:Deamidation of asparaginyl and glutaminyl residues causes time-dependent changes in charge and conformation of peptides and proteins. Quantitative and experimentally verified predictive calculations of the deamidation rates of 1,371 asparaginyl residues in a representative collection of 126 human proteins have been pe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson NE,Robinson AB

更新日期：2001-10-23 00:00:00

abstract：:URF13 is a mitochondrially encoded, integral membrane protein found only in maize carrying the cms-T cytoplasm. URF13 is associated with cytoplasmic male sterility, Texas type, and causes susceptibility to the fungal pathogens Bipolaris maydis race T and Phyllosticta maydis. URF13 is predicted to contain three transme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rhoads DM,Kaspi CI,Levings CS 3rd,Siedow JN

更新日期：1994-08-16 00:00:00

abstract：:Studies have shown that hemophilia B (Christmas disease; factor IX deficiency) results from many different mutations in the factor IX gene, of which greater than 95% are single nucleotide substitutions. This study has identified a previously unreported form of hemophilia B in a patient who was a somatic mosaic for a g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor SA,Deugau KV,Lillicrap DP

更新日期：1991-01-01 00:00:00

abstract：:Rap phosphatases are a recently discovered family of protein aspartate phosphatases that dephosphorylate the Spo0F--P intermediate of the phosphorelay, thus preventing sporulation of Bacillus subtilis. They are regulators induced by physiological processes that are antithetical to sporulation. The RapA phosphatase is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Perego M,Hoch JA

更新日期：1996-02-20 00:00:00

abstract：:We utilized the presence of hepatic receptors for galactose-terminal glycoproteins to achieve specific rescue of differentiated hepatocytes from methotrexate toxicity. This was accomplished by administration of a conjugate formed by covalent coupling of the methotrexate antagonist, folinic acid (leucovorin), to galact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu GY,Wu CH,Stockert RJ

更新日期：1983-05-01 00:00:00

abstract：:Intracellular proteolytic processing of precursor polypeptides is an essential step in the maturation of many proteins, including plasma proteins, hormones, neuropeptides, and growth factors. Most frequently, propeptide cleavage occurs after paired basic amino acid residues. To date, no mammalian propeptide processing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wise RJ,Barr PJ,Wong PA,Kiefer MC,Brake AJ,Kaufman RJ

更新日期：1990-12-01 00:00:00

abstract：:Nuclear RNA of high molecular weight, approximately 15 to 30 x 10(3) nucleotides long, isolated from rat ascites cells, has been shown previously to contain both middle repetitive and single-copy sequences. However, it was not known whether these sequences were located on separate molecules or whether they were inters...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes DS,Bonner J

更新日期：1974-04-01 00:00:00

abstract：:CR1 is a short interspersed repetitive DNA element originally identified in the domestic chicken (Gallus gallus). However, unlike virtually all other such sequences described to date, CR1 is not confined to one or a few closely related species. It is probably a ubiquitous component of the avian genome, having been det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen ZQ,Ritzel RG,Lin CC,Hodgetts RB

更新日期：1991-07-01 00:00:00