Abstract:
:The six-layered neocortex is a uniquely mammalian structure with evolutionary origins that remain in dispute. One long-standing hypothesis, based on similarities in neuronal connectivity, proposes that homologs of the layer 4 input and layer 5 output neurons of neocortex are present in the avian forebrain, where they contribute to specific nuclei rather than to layers. We devised a molecular test of this hypothesis based on layer-specific gene expression that is shared across rodent and carnivore neocortex. Our findings establish that the layer 4 input and the layer 5 output cell types are conserved across the amniotes, but are organized into very different architectures, forming nuclei in birds, cortical areas in reptiles, and cortical layers in mammals.
journal_name
Proc Natl Acad Sci U S Aauthors
Dugas-Ford J,Rowell JJ,Ragsdale CWdoi
10.1073/pnas.1204773109subject
Has Abstractpub_date
2012-10-16 00:00:00pages
16974-9issue
42eissn
0027-8424issn
1091-6490pii
1204773109journal_volume
109pub_type
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